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Here’s a podcast about mitochondrial dysfunction. From all my years of using ketogenic diets like the lion diet for health, getting impacted by mold, experiencing SSRI induced withdrawal/damage, it finally appears like the root cause is mitochondrial dysfunction at a cellular level. The research into this is cutting edge...

234,440 Aufrufe • vor 3 Monaten •via X (Twitter)

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My entire SSRI series in one video. What doctors never tell you about SSRI withdrawal. Chris Masterjohn, PhD, Founder and Scientific Director of explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression. These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis. On the other hand, 20-50% of people who go off experience SSRI discontinuation syndrome. This can involve irritability, anxiety, mood problems, crying, dread, suicidal ideation, insomnia, nightmares, excessive dreaming, lethargy, fatigue, headache, tremor, sweating, anorexia, flu-like symptoms, nausea, vomiting, diarrhea, pain, numbness, tingling, feeling like something is crawling on the skin, electric shocks running through the brain or body, rushing noises, visual traces (seeing something persist when it is no longer there, or seeing moving objects leaving illusory streaks of light behind them, etc), dizziness, light-headedness, "brain zaps," vertigo, confusion, difficulty concentrating, amnesia, genital hypersensitivity, and premature ejaculation. A closely related problem is post-SSRI sexual dysfunction (PSSD), which can cause total inability to feel the penis for males or for females the genitals and nipples, loss of sexual pleasure, weak orgasms, decreased libido, erectile dysfunction, and premature ejaculation. PSSD is often associated with general anhedonia, apathy, and poor mood. In this video, I maintain that the reason there are no good solutions to these problems is because we have completely misunderstood the role of serotonin and SSRIs. Serotonin's role is to help mitochondria adapt to changing demands for oxygen-based energy production. SSRIs enhance some of the mechanisms, and interfere with others. They enter the cell and stimulate independent mechanisms of mitochondrial stress adaptation, but in doing so they turn a cyclical and rhythmic pathway into a constantly stimulated one, creating mitochondrial dependence and making mitochondria vulnerable to new-onset dysfunction upon withdrawal. Once they make it to the mitochondria itself, the SSRIs act as mitochondrial toxins. Scientific references for everything can be found in the series on my web site. 0:30 SSRI Side Effects 1:00 SSRI Discontinuation Syndrome and PSSD 11:33 The Problem With Primary Care Doctors and Psychiatrists 14:56 The Reason We Don’t Have Good Solutions Is Because We Don’t Understand the Problem 16:22 Prozac Is a Performance-Enhancing Drug 18:40 Depression and Altitude 19:36 The Truth About Serotonin 25:10 How Serotonin Helps Us Breathe 30:05 Hypoxia Explains Why Serotonin Is So Abundant In the Gut 33:55 Serotonin, Melatonin, and the Mitochondria 35:50 Serotonin and Light 39:25 Intermittent Hypobaric Hypoxia Training 42:56 SSRIs Are Whole-Body, Primarily Non-Brain, Non-Neuronal, Mitochondrial Drugs 44:00 SSRIs and Birth Defects 46:37 SSRIs Deplete Serotonin 48:50 SSRIs Distort the Sigma-1 Receptor From a Cyclical to a Constant Activation 51:10 Different SSRIs Promote Different Ratios of Mitophagy and Mitochondrial Biogenesis 54:00 Going Off SSRIs Causes New-Onset Mitochondrial Dysfunction 58:30 Slow and Parabolic Tapers 1:02:10 What to Do About SSRI Withdrawal Mitochondrial Dysfunction Do You Have Hidden Mitochondrial Dysfunction? Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it here at Mitome™

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The Hidden Secret to Never Getting Cancer: Protect Your Mitochondria Cancer doesn’t just appear out of nowhere—it starts when a normal cell’s mitochondria break down and become dysfunctional. According to Dr. Eric Berg, the key to cancer prevention lies in safeguarding these cellular powerhouses. Here’s how: 1. Optimize Vitamin D Levels Maintain blood levels of 70–80 ng/mL. Vitamin D is a mitochondrial supercharger, bolstering your immune system and keeping cells functioning optimally. 2. Harness the Power of Fasting Regular intermittent fasting, combined with periodic prolonged fasts (like a 2-day water fast monthly), triggers autophagy—your body’s natural cleanup process—removing damaged cells and rejuvenating mitochondria. 3. Cut Refined Carbs & Starches High-carb diets are mitochondrial kryptonite. Switch to a low-carb approach to reduce oxidative stress and protect cellular energy production. 4. Load Up on Mitochondria-Boosting Foods Garlic, onions, and cruciferous veggies (broccoli, kale, Brussels sprouts) are packed with sulfur compounds that detoxify and fortify mitochondria. 5. Avoid Excess Iron Iron overload—from supplements, fortified foods, or cast-iron cookware—accelerates mitochondrial damage. Monitor your intake to keep iron in check. 6. Exercise Consistently Movement isn’t just for fitness; it’s a mitochondrial elixir. Regular exercise enhances their efficiency, reduces inflammation, and lowers cancer risk. The science is clear: Cancer thrives in a body with weak mitochondria. Strengthen them, and you build an impenetrable defense. Your health is in your hands.

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SUPPLEMENTING YOUR WORK ENVIRONMENT WITH AN INCANDESCENT LIGHT BULB IMPROVES MITOCHONDRIAL FUNCTION! - A brand new (Jan 23th, 2026) paper published by Glen Jeffery and Edward Barrett demonstrates how adding a 60 W incandescent lamp to participants work desk dramatically improves color contrast, or a proxy for color vision. The intervention here is simply placing an incandescent lightbulb on the desk without direct irradiation on participants. And this is huge: “we have obtained significant balanced improvements in both the protan and tritan range. Previously, exposure to restricted experimental 670 nm resulted in improvements biased strongly in favour of only tritan function. Hence, exposure to full spectrum lighting results in a balanced pattern of improvement in visual performance.” The mechanism seems to be mitochondrial in nature. Short wavelength light, which is dominated in standard LED lighting, reduces mitochondrial function. There’s a reduction in mitochondria ATP production, and therefore a reduced demand for glucose. This intern can increase body weight and serum cytokinin levels. Also, with short wavelength blue light, there is an increase probability of cell aging and death. “It is suggested that this is partly due to 420–450 nm light, dominant in LEDs, being absorbed by porphyrin and the subsequent production of oxygen singlets driving inflammation.” “Conversely, exposure to longer wavelengths is associated with increased mitochondrial membrane potential and increased concentration of mitochondrial complex proteins that have declined with ageing and disease. This in turn is associated with elevated ATP, reduced inflammation and extended average lifespan.“ So, for the love of mitochondria, get long-wavelength light! This can be done in many ways: -sunlight/daylight exposure (does not need to be direct sunlight) -fire light -incandescent light bulbs -LEDs that emit long-wavelength light (yes, LEDs CAN emit red and near-infrared, but most don’t)

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65,208 Aufrufe • vor 6 Monaten

Retatrutide forever, watch this (Spoiler alert science agrees) Here’s everything you need (it’s free!) Think of it like this… Biology is a building… Drugs are trying to fix one room Retatrutide handles everything… At the same time Most doctors and Instaexperts talk about it without actually understanding biology or what they're doing… 2023 Cell Metabolism proved retatrutide wasn’t just about weight loss… it rewires how cells process energy at the mitochondrial level 2021 Aging Cell showed glucagon signaling cranks up autophagy specifically in neurons and hepatocytes… brain cells and liver cells The cells that matter most for longevity 2023 Nature Metabolism proved weekly pulsatile signaling activates more downstream pathways than multiple weekly signaling Why? Because cells have memory Receptor sensitivity actually increases if you give the signal, then let it recover then signal again So weekly 0.1 mg? Actually more effective than microdosing 2-3x a week And here's the best part… At 0.1 mg weekly… no weight loss unless you have significant metabolic dysfunction but cells will upgrade mitochondria increase autophagy and reduce systemic inflammation Biology is aging more slowly FYI 2024 Nature Communications… they applied retatrutide to cancer cells and the cancer cells died Why? Because cancer cells are metabolically distinct from normal cells They rely on a different energy pathway the Warburg effect and bypass normal mitochondrial ATP production It’s a cancer predator, period The 2025 follow-up study showed existing tumors exposed to retatrutide had 67 % tumor shrinkage You're making biology hostile to cancer at the cellular level Do what you want to do… I’m here to help you Because I actually care Never Miss Dr Trevor Bachmeyer The Spartan

Dr Trevor Bachmeyer

22,492 Aufrufe • vor 23 Tagen

🧬 Why does ☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 say “Food doesn’t matter”? Imagine a solar-powered battery: Sunlight charges the battery. Water holds the charge. Magnetism organizes the charge. The battery powers the engine. The engine burns the fuel. Food is a fuel. If the battery is empty or the wiring is broken, the engine cannot burn the fuel correctly. Changing the fuel will not fix the battery. Fix the battery first, then any fuel can be used. 🤔 Understanding 🔥 1. The ENGINE comes before the FUEL If the mitochondrial engine is not working, the fuel doesn’t matter. Why? Because in our modern world, we are trying to fix a physics problem with food ideology. It will never work. Mitochondria are the engine that burns the fuel. If the engine is damaged, all fuels become incomplete, misinterpreted, or even toxic. 👎🏻Most people today have engines damaged by: blue light EMFs indoor living poor redox lack of DHA no morning sunlight circadian mismatch ❌When the engine is broken, these things happen: electrons cannot move efficiently ATP production slows inflammation rises ROS becomes uncontrolled hormones lose coherence fasting becomes stressful diets fail again and again Food does not fix any of this. ☀️ 2. LIGHT controls metabolism more deeply than any diet ever could Jack’s central point for 15 years: “Food is seasonal information. Light is the master instruction.” Morning sunlight programs: dopamine cortisol melatonin leptin mitochondrial timing thyroid signaling This means two people on the same diet can have completely different results depending on their light environment. Example: Someone living indoors under LEDs with low redox tries carnivore. They struggle. Someone living by the ocean with daily sunrise exposure builds strong redox. Carnivore works for them Keto works Carbs work seasonally Fasting works The diet didn’t change. The redox did. Diet is just light in disguise. 🌊 3. Mitochondria run on ELECTRONS, not on food quantity Jack always says: “You don’t need more supplements. You need more electrons.” Food is only an electron donor. But electrons only work when the biology is prepared to receive them in the same environment nature designed. The key factors that prepare the system are: DHA in cell membranes structured water created by sunlight a magnetic field that aligns proton flow circadian signals that control timing cold exposure that increases electron efficiency minimal blue light at night When these conditions are damaged: Electrons get stuck. Energy drops. Inflammation rises. Hormones lose rhythm. Detoxification breaks. Again: diet never fixes the foundation. 🧠 4. Why diet “gurus” are always fighting, and always missing the point. Carnivore gurus… Low-carb communities… Metabolic bros… Vegan influencers… Mediterranean… All of them fight about the fuel while ignoring the engine. It’s like watching the mechanics scream about gasoline quality while the engine has: no oil no spark plugs a dead battery Jack’s message is brutally simple: “Fix the mitochondrial environment first, and most diets will begin to work.” Without fixing the environment, no diet can save you. 🐟 5. Why DHA is the diet Kruse actually cares about. DHA is the molecule that lets sunlight become a direct electrical current inside your cell membranes. DHA is the antenna. If the antenna is broken, the light signal becomes distorted. Every metabolic pathway fails. This is why: “A vegan in Norway is committing mitochondrial suicide.” “Food is a distraction. Sunlight is the real nutrient.” DHA + sunlight is the diet nature designed for humans. DHA is an antenna. And an antenna is useless without the signal. 🔥 Remember Your mitochondrial redox decides your fate; not your diet. Your light environment writes the rules for your metabolism. Your DHA status determines how well you can read the rules. This is why all food fights are meaningless 🤭 The mitochondria decide everything long before the fork ever reaches your mouth.

Light Me Away ☀️

42,199 Aufrufe • vor 8 Monaten