Loading video...

Video Failed to Load

Go Home

How much control do we actually have over how we age?? David Sinclair has spent decades studying the biology of ageing, and what actually drives it at a cellular level. David is a professor of genetics at Harvard Medical School and one of the leading researchers in the field...

StevenBartlett's profile picture

Steven Bartlett

412,874 subscribers

67,272 views • 5 months ago •via X (Twitter)

Health & WellnessEducationScience & Technology
LIVE

Anya Rossi• Live Now

Private livecam show

0 Comments

No comments available

Comments from the original post will appear here

Related Videos

Why do people often get the wrong impression of us? Today’s guest believes it’s because most of us have no idea how we’re actually coming across. Alison Wood Brooks is a professor at Harvard Business School who studies conversation and emotion. Her research focuses on everyday communication and the subtle ways our words shape how people respond. We spend a huge part of our lives talking to people, yet most of us never learn how conversation actually works, or why it so often goes wrong. Alison’s work shows that there’s often a gap between what we intend to communicate and what people actually hear. That gap influences how confident we seem and how likeable we come across.
1:30

Why do people often get the wrong impression of us? Today’s guest believes it’s because most of us have no idea how we’re actually coming across. Alison Wood Brooks is a professor at Harvard Business School who studies conversation and emotion. Her research focuses on everyday communication and the subtle ways our words shape how people respond. We spend a huge part of our lives talking to people, yet most of us never learn how conversation actually works, or why it so often goes wrong. Alison’s work shows that there’s often a gap between what we intend to communicate and what people actually hear. That gap influences how confident we seem and how likeable we come across.

Steven Bartlett

28,712 views • 8 months ago

"If we believe that the rapture could happen at any time and we say we do, and we clap when we say it, if we believe it could happen today, what that means is all of these things that I'm talking about couldn't be any further into the future than a seven year period." . Cashless Society and Bible Prophecy: Dr. David Jeremiah on the Last Days
0:37

"If we believe that the rapture could happen at any time and we say we do, and we clap when we say it, if we believe it could happen today, what that means is all of these things that I'm talking about couldn't be any further into the future than a seven year period." . Cashless Society and Bible Prophecy: Dr. David Jeremiah on the Last Days

David Jeremiah

19,782 views • 5 months ago

We acknowledge KMPDC's emphasis on evidence-based medicine and the legitimate risks of unverified practices. It is also important that we clarify what actually happens in the Ministry of Repentance and Holiness, under the leadership of The Prophet Dr. David Owuor. There seems to be a significant gap between what people might assume about faith healing ministries and how WE actually operate. > 1/4
3:07

We acknowledge KMPDC's emphasis on evidence-based medicine and the legitimate risks of unverified practices. It is also important that we clarify what actually happens in the Ministry of Repentance and Holiness, under the leadership of The Prophet Dr. David Owuor. There seems to be a significant gap between what people might assume about faith healing ministries and how WE actually operate. > 1/4

The Ministry of Repentance and Holiness

63,176 views • 7 months ago

David Wilcock’s recent death has sparked lots of conspiracy theories about what might have happened… But how much of it actually holds up? I take a closer look — and breaks down what we know.
2:56

David Wilcock’s recent death has sparked lots of conspiracy theories about what might have happened… But how much of it actually holds up? I take a closer look — and breaks down what we know.

Julian Dorey

29,591 views • 3 months ago

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair
3:56

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

KanekoaTheGreat

1,232,850 views • 21 days ago

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair
3:42

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

KanekoaTheGreat

499,733 views • 21 days ago

Serbia's President Aleksandar Vučić on Serbia's neutral stance: What is it that we have to reproach Ukraine for? They are at war against them. That is why we did not impose sanctions on Russia and why we want peace and we do not want the victory of one side or the other. And we are the only country that wants only peace and nothing more than that. Is my job to protect the interests of Serbia or to protect the interests of all other countries? What is it actually that you want from me?
0:33

Serbia's President Aleksandar Vučić on Serbia's neutral stance: What is it that we have to reproach Ukraine for? They are at war against them. That is why we did not impose sanctions on Russia and why we want peace and we do not want the victory of one side or the other. And we are the only country that wants only peace and nothing more than that. Is my job to protect the interests of Serbia or to protect the interests of all other countries? What is it actually that you want from me?

Clash Report

35,304 views • 19 days ago

Arteta: “We know what is at stake and the fact that, as a club, we haven't done it for so long is a reason for that. It talks about the difficulty but I just want to focus on the things that we can control, dominate, and we have done. “It's not that we have to do a lot of new things that we haven't done. No, no, no, let's keep doing a lot of it or almost all the things that we've done for nine months, because that's what has taken us all the way there. “On Wednesday, I saw a lot of them. And today we've gone back so we need to learn, we need to be very critical of ourselves, and then pick ourselves up because on Wednesday we have a big one coming up.”
0:36

Arteta: “We know what is at stake and the fact that, as a club, we haven't done it for so long is a reason for that. It talks about the difficulty but I just want to focus on the things that we can control, dominate, and we have done. “It's not that we have to do a lot of new things that we haven't done. No, no, no, let's keep doing a lot of it or almost all the things that we've done for nine months, because that's what has taken us all the way there. “On Wednesday, I saw a lot of them. And today we've gone back so we need to learn, we need to be very critical of ourselves, and then pick ourselves up because on Wednesday we have a big one coming up.”

Connor Humm

21,397 views • 4 months ago

I’ve been trying to better understand how our thinking actually works. Not in theory, but in practice. What shapes it? What changes it? How much control that we really have over it? So to help me understand this, I’m sitting down with neuroscientist Dr David Eagleman. I didn’t expect this conversation to make me question something as basic as how I experience reality but it did. David is a Stanford professor whose work focuses on how to the brain builds our perception of the world and how it rewires itself based on experience. With rising global tensions and the rapid growth of AI, I wanted to have this conversation to show how uncertainty and risk affect the brain and how people process fear and stress. We discussed things like: - How to deal with existential fear. - Why constantly challenging yourself is the best thing you can do for your mind. - How to get learning and adapting as you get older. - Why memory is not as reliable as we assume? What became clear the longer that we spoke is that your brain is not a fixed system. It’s constantly adjusting itself depending on what you focus on, what you repeat and what you expose yourself to. It was truly illuminating speaking to David and I'm sure my neural pathways have expanded in really important ways because of him! For anyone that wants to know how to change your life by changing your brain, I recommend listening/watching this conversation.
1:30

I’ve been trying to better understand how our thinking actually works. Not in theory, but in practice. What shapes it? What changes it? How much control that we really have over it? So to help me understand this, I’m sitting down with neuroscientist Dr David Eagleman. I didn’t expect this conversation to make me question something as basic as how I experience reality but it did. David is a Stanford professor whose work focuses on how to the brain builds our perception of the world and how it rewires itself based on experience. With rising global tensions and the rapid growth of AI, I wanted to have this conversation to show how uncertainty and risk affect the brain and how people process fear and stress. We discussed things like: - How to deal with existential fear. - Why constantly challenging yourself is the best thing you can do for your mind. - How to get learning and adapting as you get older. - Why memory is not as reliable as we assume? What became clear the longer that we spoke is that your brain is not a fixed system. It’s constantly adjusting itself depending on what you focus on, what you repeat and what you expose yourself to. It was truly illuminating speaking to David and I'm sure my neural pathways have expanded in really important ways because of him! For anyone that wants to know how to change your life by changing your brain, I recommend listening/watching this conversation.

Steven Bartlett

21,490 views • 4 months ago

What if AI is the last invention we ever make? Only a few people have thought about this more deeply than today’s guest. It’s a question that I’m sure has crossed a lot of our minds. It does make you wonder, can we actually do something about it? Dr Roman Yampolskiy, welcome to The Diary Of A CEO. Dr Roman is one of the world’s leading experts on AI safety who has spent decades warning that AI could surpass human intelligence, and once it does, we may lose control forever…
1:42

What if AI is the last invention we ever make? Only a few people have thought about this more deeply than today’s guest. It’s a question that I’m sure has crossed a lot of our minds. It does make you wonder, can we actually do something about it? Dr Roman Yampolskiy, welcome to The Diary Of A CEO. Dr Roman is one of the world’s leading experts on AI safety who has spent decades warning that AI could surpass human intelligence, and once it does, we may lose control forever…

Steven Bartlett

29,448 views • 11 months ago

DAVID SACKS: “I understand that there is a lot of concern about [AI] job disruption or job loss. That's not what we're seeing in the data so far. What we're actually seeing is job creation … We have a 4% GDP growth number right now, and half of that is attributable to AI.”
1:05

DAVID SACKS: “I understand that there is a lot of concern about [AI] job disruption or job loss. That's not what we're seeing in the data so far. What we're actually seeing is job creation … We have a 4% GDP growth number right now, and half of that is attributable to AI.”

Chief Nerd

206,382 views • 8 months ago

The economist who predicted the 2008 financial crash is warning something bigger is coming. So what does he see that most people don’t? Professor Steve Keen joins me today on The Diary Of A CEO to tell us what he sees for us in the near future… Steve is an economist and author who has been critical of how traditional economic models explain the world. His work focuses on how debt, energy, and real world constraints shape the system we live in. He has spent decades challenging mainstream economics, and in 2005 he warned that rising private debt would trigger a global financial crisis three years before it happened. Now, he’s looking at a combination of factors like war, energy, and technology, and arguing that we may be underestimating how connected these risks really are. As we get into this conversation, what becomes clear is that a lot of what we assume about how the economy works which may not actually reflect how it behaves under pressure.
1:36

The economist who predicted the 2008 financial crash is warning something bigger is coming. So what does he see that most people don’t? Professor Steve Keen joins me today on The Diary Of A CEO to tell us what he sees for us in the near future… Steve is an economist and author who has been critical of how traditional economic models explain the world. His work focuses on how debt, energy, and real world constraints shape the system we live in. He has spent decades challenging mainstream economics, and in 2005 he warned that rising private debt would trigger a global financial crisis three years before it happened. Now, he’s looking at a combination of factors like war, energy, and technology, and arguing that we may be underestimating how connected these risks really are. As we get into this conversation, what becomes clear is that a lot of what we assume about how the economy works which may not actually reflect how it behaves under pressure.

Steven Bartlett

150,312 views • 4 months ago

"I think among a lot of Democrats there's this kind of what psychologists would call 'learned helplessness' where you just think, 'Well we can't do anything about it. We have to wait till 2029' ... In New York with some people it's just like, 'Well we just have to do our things in New York and not worry about the rest of the country.' It does not work that way. We are one country. Our democracy can rise or fall on what this man is doing. And, it's not just our democracy. ... It directly affects our lives. The stability of our economy depends on the belief in the rule of law that people think we have a stable legal system, and it's hard to believe that today"
1:26

"I think among a lot of Democrats there's this kind of what psychologists would call 'learned helplessness' where you just think, 'Well we can't do anything about it. We have to wait till 2029' ... In New York with some people it's just like, 'Well we just have to do our things in New York and not worry about the rest of the country.' It does not work that way. We are one country. Our democracy can rise or fall on what this man is doing. And, it's not just our democracy. ... It directly affects our lives. The stability of our economy depends on the belief in the rule of law that people think we have a stable legal system, and it's hard to believe that today"

George Conway ⚖️🇺🇸

80,959 views • 3 months ago

Willie Fritz worked to make sure his University of Houston program is a football laboratory where his coordinators Slade Nagle and Austin Armstrong can concentrate on what matters. "We've got so many coaches at this level," Fritz says. "One of the things I try to do is take a lot of things off the plate of my coordinators, my coaches, so that they can work on football. "And that's what they do. They love football. They're talking football all day, every day. "A lot of that is how can we enhance our scheme. And what does our guys do best. What do we need to stay away from. What do we need to do more of. How can we teach this fundamental better."
0:47

Willie Fritz worked to make sure his University of Houston program is a football laboratory where his coordinators Slade Nagle and Austin Armstrong can concentrate on what matters. "We've got so many coaches at this level," Fritz says. "One of the things I try to do is take a lot of things off the plate of my coordinators, my coaches, so that they can work on football. "And that's what they do. They love football. They're talking football all day, every day. "A lot of that is how can we enhance our scheme. And what does our guys do best. What do we need to stay away from. What do we need to do more of. How can we teach this fundamental better."

Chris Baldwin

29,201 views • 1 month ago

.President Donald J. Trump on munitions supply: "We have more than we've ever had, actually, because all over the world we have inventory, and we can take that if we need it... now what happened is Biden came in like a stupid fool, and he gave a lot of what we had to Ukraine."
1:13

.President Donald J. Trump on munitions supply: "We have more than we've ever had, actually, because all over the world we have inventory, and we can take that if we need it... now what happened is Biden came in like a stupid fool, and he gave a lot of what we had to Ukraine."

Rapid Response 47

60,035 views • 3 months ago

Chamath says Silicon Valley lost what made it great and only cares about money now "Silicon Valley has completely lost what made it great. It was a place for weirdos, for people at the fringes, for people that really were idealistic. And it has become something that's far from that now. It is the equivalent of what Harvard used to be. It's a credentialing place." "When we came, we used to aspire to meet the Bill Campbells of the world, Mike Moritz, John Doerr. Those folks are gone. We used to aspire to work for Steve Jobs. He's not here." "And in that breach, all we have done is focused on making money in every single way that we can, hand over fist. And there's nothing wrong with that. Except now it’s at a point where we need to do a better job of acknowledging it and trying to do a little bit better.” “Every time we don't, and we're given a chance to be better, and we're not, the hatred builds, the animus builds. And that's what we're seeing now."
1:09

Chamath says Silicon Valley lost what made it great and only cares about money now "Silicon Valley has completely lost what made it great. It was a place for weirdos, for people at the fringes, for people that really were idealistic. And it has become something that's far from that now. It is the equivalent of what Harvard used to be. It's a credentialing place." "When we came, we used to aspire to meet the Bill Campbells of the world, Mike Moritz, John Doerr. Those folks are gone. We used to aspire to work for Steve Jobs. He's not here." "And in that breach, all we have done is focused on making money in every single way that we can, hand over fist. And there's nothing wrong with that. Except now it’s at a point where we need to do a better job of acknowledging it and trying to do a little bit better.” “Every time we don't, and we're given a chance to be better, and we're not, the hatred builds, the animus builds. And that's what we're seeing now."

dnap

3,811,640 views • 7 days ago

Most of us have been taught that creatine is strictly for sports performance. The clinical data tells a completely different story. It's the most researched supplement on earth. Studied for nearly 200 years, but are we still missing the point? This is why I sat down with Dr Darren Candow. He is one of the world’s most published researchers on creatine and ageing. He’s published more than 175 scientific papers, over 115 of them focused specifically on creatine and longevity. I was shown the data on why muscle loss starts happening decades earlier than we think, the exact mistake millions of us make with protein as we get older and what the clinical evidence actually says about creatine for women, children, and brain health. We discussed things like: - 5 biggest myths about creatine. - Why creatine is no longer just for athletes. - What women need to know about creatine. - Is creatine is safe for children? - How muscle loss begins much earlier than most people realise. - The protein mistake many people make as they age. What blew my mind during this chat is how far the science goes beyond sport and that creatine might be one of the most misunderstood supplements in the world. But Darren’s research points to something much bigger… If you care about staying strong and independent as you get older, I think this conversation is worth your time.
1:29

Most of us have been taught that creatine is strictly for sports performance. The clinical data tells a completely different story. It's the most researched supplement on earth. Studied for nearly 200 years, but are we still missing the point? This is why I sat down with Dr Darren Candow. He is one of the world’s most published researchers on creatine and ageing. He’s published more than 175 scientific papers, over 115 of them focused specifically on creatine and longevity. I was shown the data on why muscle loss starts happening decades earlier than we think, the exact mistake millions of us make with protein as we get older and what the clinical evidence actually says about creatine for women, children, and brain health. We discussed things like: - 5 biggest myths about creatine. - Why creatine is no longer just for athletes. - What women need to know about creatine. - Is creatine is safe for children? - How muscle loss begins much earlier than most people realise. - The protein mistake many people make as they age. What blew my mind during this chat is how far the science goes beyond sport and that creatine might be one of the most misunderstood supplements in the world. But Darren’s research points to something much bigger… If you care about staying strong and independent as you get older, I think this conversation is worth your time.

Steven Bartlett

177,717 views • 2 months ago

"Old men who were in charge until the age of Dianne Feinstein and Ruth Ginsburg, they were age limited by mortality. And there were actually ways that older societies had with dealing with cognitive decline in their leaders that we don't. But I think what happened is that we have created a kind of medical miracle that allows a lot these folks not just to stay in office, but at a high level of functioning for much longer than was historically possible." Samuel Moyn 🔭 VIDEO PREMIERE‼️
3:32

"Old men who were in charge until the age of Dianne Feinstein and Ruth Ginsburg, they were age limited by mortality. And there were actually ways that older societies had with dealing with cognitive decline in their leaders that we don't. But I think what happened is that we have created a kind of medical miracle that allows a lot these folks not just to stay in office, but at a high level of functioning for much longer than was historically possible." Samuel Moyn 🔭 VIDEO PREMIERE‼️

Briahna Joy Gray

40,160 views • 3 months ago