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How much control do we actually have over how we age?? David Sinclair has spent decades studying the biology of ageing, and what actually drives it at a cellular level. David is a professor of genetics at Harvard Medical School and one of the leading researchers in the field...

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Steven Bartlett

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67,272 просмотров • 4 месяцев назад •via X (Twitter)

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David Wilcock’s recent death has sparked lots of conspiracy theories about what might have happened… But how much of it actually holds up? I take a closer look — and breaks down what we know.
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David Wilcock’s recent death has sparked lots of conspiracy theories about what might have happened… But how much of it actually holds up? I take a closer look — and breaks down what we know.

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🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair
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🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

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Serbia's President Aleksandar Vučić on Serbia's neutral stance: What is it that we have to reproach Ukraine for? They are at war against them. That is why we did not impose sanctions on Russia and why we want peace and we do not want the victory of one side or the other. And we are the only country that wants only peace and nothing more than that. Is my job to protect the interests of Serbia or to protect the interests of all other countries? What is it actually that you want from me?
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Serbia's President Aleksandar Vučić on Serbia's neutral stance: What is it that we have to reproach Ukraine for? They are at war against them. That is why we did not impose sanctions on Russia and why we want peace and we do not want the victory of one side or the other. And we are the only country that wants only peace and nothing more than that. Is my job to protect the interests of Serbia or to protect the interests of all other countries? What is it actually that you want from me?

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🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair
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🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

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I’ve been trying to better understand how our thinking actually works. Not in theory, but in practice. What shapes it? What changes it? How much control that we really have over it? So to help me understand this, I’m sitting down with neuroscientist Dr David Eagleman. I didn’t expect this conversation to make me question something as basic as how I experience reality but it did. David is a Stanford professor whose work focuses on how to the brain builds our perception of the world and how it rewires itself based on experience. With rising global tensions and the rapid growth of AI, I wanted to have this conversation to show how uncertainty and risk affect the brain and how people process fear and stress. We discussed things like: - How to deal with existential fear. - Why constantly challenging yourself is the best thing you can do for your mind. - How to get learning and adapting as you get older. - Why memory is not as reliable as we assume? What became clear the longer that we spoke is that your brain is not a fixed system. It’s constantly adjusting itself depending on what you focus on, what you repeat and what you expose yourself to. It was truly illuminating speaking to David and I'm sure my neural pathways have expanded in really important ways because of him! For anyone that wants to know how to change your life by changing your brain, I recommend listening/watching this conversation.
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DAVID SACKS: “I understand that there is a lot of concern about [AI] job disruption or job loss. That's not what we're seeing in the data so far. What we're actually seeing is job creation … We have a 4% GDP growth number right now, and half of that is attributable to AI.”

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The economist who predicted the 2008 financial crash is warning something bigger is coming. So what does he see that most people don’t? Professor Steve Keen joins me today on The Diary Of A CEO to tell us what he sees for us in the near future… Steve is an economist and author who has been critical of how traditional economic models explain the world. His work focuses on how debt, energy, and real world constraints shape the system we live in. He has spent decades challenging mainstream economics, and in 2005 he warned that rising private debt would trigger a global financial crisis three years before it happened. Now, he’s looking at a combination of factors like war, energy, and technology, and arguing that we may be underestimating how connected these risks really are. As we get into this conversation, what becomes clear is that a lot of what we assume about how the economy works which may not actually reflect how it behaves under pressure.

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"I think among a lot of Democrats there's this kind of what psychologists would call 'learned helplessness' where you just think, 'Well we can't do anything about it. We have to wait till 2029' ... In New York with some people it's just like, 'Well we just have to do our things in New York and not worry about the rest of the country.' It does not work that way. We are one country. Our democracy can rise or fall on what this man is doing. And, it's not just our democracy. ... It directly affects our lives. The stability of our economy depends on the belief in the rule of law that people think we have a stable legal system, and it's hard to believe that today"

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.President Donald J. Trump on munitions supply: "We have more than we've ever had, actually, because all over the world we have inventory, and we can take that if we need it... now what happened is Biden came in like a stupid fool, and he gave a lot of what we had to Ukraine."

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Most of us have been taught that creatine is strictly for sports performance. The clinical data tells a completely different story. It's the most researched supplement on earth. Studied for nearly 200 years, but are we still missing the point? This is why I sat down with Dr Darren Candow. He is one of the world’s most published researchers on creatine and ageing. He’s published more than 175 scientific papers, over 115 of them focused specifically on creatine and longevity. I was shown the data on why muscle loss starts happening decades earlier than we think, the exact mistake millions of us make with protein as we get older and what the clinical evidence actually says about creatine for women, children, and brain health. We discussed things like: - 5 biggest myths about creatine. - Why creatine is no longer just for athletes. - What women need to know about creatine. - Is creatine is safe for children? - How muscle loss begins much earlier than most people realise. - The protein mistake many people make as they age. What blew my mind during this chat is how far the science goes beyond sport and that creatine might be one of the most misunderstood supplements in the world. But Darren’s research points to something much bigger… If you care about staying strong and independent as you get older, I think this conversation is worth your time.
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Most of us have been taught that creatine is strictly for sports performance. The clinical data tells a completely different story. It's the most researched supplement on earth. Studied for nearly 200 years, but are we still missing the point? This is why I sat down with Dr Darren Candow. He is one of the world’s most published researchers on creatine and ageing. He’s published more than 175 scientific papers, over 115 of them focused specifically on creatine and longevity. I was shown the data on why muscle loss starts happening decades earlier than we think, the exact mistake millions of us make with protein as we get older and what the clinical evidence actually says about creatine for women, children, and brain health. We discussed things like: - 5 biggest myths about creatine. - Why creatine is no longer just for athletes. - What women need to know about creatine. - Is creatine is safe for children? - How muscle loss begins much earlier than most people realise. - The protein mistake many people make as they age. What blew my mind during this chat is how far the science goes beyond sport and that creatine might be one of the most misunderstood supplements in the world. But Darren’s research points to something much bigger… If you care about staying strong and independent as you get older, I think this conversation is worth your time.

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David Letterman: “What about those idiots at CBS? The CBS News is a wreck, it’s just gone. The integrity of CBS News has been trampled on, pissed on, and eviscerated by these idiots that have taken it over.”

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