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Intermittent fasting protocol, benefits & myths: - Around 11-12 hours of fasting depletes liver glycogen, forcing the body to shift from burning carbohydrates to burning fat and producing ketone bodies. - Ketones are a cleaner fuel source. They generate less oxidative stress and require less energy to metabolize than...

56,190 Aufrufe • vor 2 Monaten •via X (Twitter)

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A 72-hour water fast (drinking water but consuming no calories) can trigger several changes in the body. Some are well supported by research, while others are still being studied. Potential benefits 1. Autophagy may increase * Autophagy is the process by which cells break down and recycle damaged components. * Animal studies show fasting can stimulate autophagy, and in humans it is thought to increase during prolonged fasting, although exactly when and by how much varies and is still being researched. 2. Ketosis * After around 24–48 hours, most people begin producing ketones from stored fat. * By 72 hours, many people are in deeper ketosis, which can: * Increase fat burning. * Provide an alternative fuel source for the brain. * Reduce hunger in some people once ketosis is established. 3. Improved insulin sensitivity * Fasting lowers insulin levels. * Short-term fasting can improve insulin sensitivity after the fast, which may help with blood sugar regulation in some individuals. 4. Reduced inflammation * Some studies have found short-term fasting can lower certain inflammatory markers, although results vary. 5. Weight loss * You’ll lose weight during a 72-hour fast. * Part of this is fat, but a significant amount is also water and depleted glycogen stores. * Some weight is regained once you eat normally again. 6. Lower blood sugar * Blood glucose typically falls during fasting, particularly in people without diabetes. 7. Potential cardiovascular benefits * Temporary reductions in blood pressure may occur. * Triglycerides may improve in some people. * Long-term benefits depend more on overall diet and lifestyle than occasional fasting. 8. Mental clarity * Some people report improved focus and concentration after the first 24–48 hours, possibly related to ketone production. * Others experience fatigue or brain fog instead. 9. Digestive rest * The digestive system gets a break from processing food

Anthony Fowler

84,521 Aufrufe • vor 1 Monat

Fasting's the most underrated longevity hack on Earth. Doctors said skipping meals destroys your metabolism... Yet fasting is proven to boost your hormones, burn toxic fat, and repair DNA damage naturally. Here are 7 insane fasting benefits (bookmark this):👇️️️️️️ 1. Activates Autophagy Autophagy kicks in after 12–16 hours of fasting. It's your built-in cleanup system, recycling toxic and old cells into new, fresh ones. It also removes toxic debris linked to Alzheimer's, cancer, & accelerated aging. 2. Burns excess fat Fasting flips your body's fuel switch. When glycogen runs low, it start breaking down stored fat into ketones for energy. And the fact that no more calories are coming in your body... Means you're now forced to burn your own fat. 3. Boosts your hormones Fasting increases human growth hormone (HGH) by up to 5x baseline levels. Higher HGH means: - Faster fat loss - Enhanced recovery - Preserved lean muscle It also improves testosterone in men by reducing insulin resistance. 4. Repairs DNA damage With no food to process, your cells focus on SURVIVAL: - Repairing DNA strands - Cleaning out broken parts - Recycling damaged proteins Fasting's one of the few medicines that helps you rebuild from the inside out naturally. 5. Enhances Insulin Sensitivity Fasting gives your pancreas a break from constant insulin production. Over time, your cells become more responsive to insulin → better glucose control & lower diabetes risk. One study found 16:8 fasting improved insulin sensitivity by ~30% in just 8 weeks. I've found a supplement that increases fasting's benefits by 5X. It keeps insulin low, stabilizes energy, even lets you stay lean year-round. It allows me to stay at 10–12% body fat all year effortlessly, without energy crashes. Here's the one I use (AMAZON PRODUCT LINK): 6. Lowers Inflammation Fasting suppresses inflammatory cytokines like IL-6 and TNF-alpha — the molecular triggers behind: - Brain fog - Chronic pain - Slow recovery By quieting that response, your body heals faster and ages slower. I use fasting daily for the past year and here's exactly why: It gives me: - More energy - Leaner body - Better focus And I feel more alive than EVER. I've made a guide with my fasting protocol. Comment "Fasting" and I'll send it over. (Must Follow so I can DM) 🤝 *Every body works differently, this is not medical advice, just what worked on me." *Always consult a health expert before following any protocols." *Affiliate links included.*

Achilleas

66,492 Aufrufe • vor 9 Monaten

The Dangerous Cult of 'Fasting' Influencers. Fasting has its anecdotal benefits, yes. But it is overrated. And water fasting is highly overrated. But this video featuring a Cardiologist is amusingly nonsense. There is no study from Boston (from a "University?" - how vague!) that says 7-days water fasting reduces risk of cancer (what cancer?) by 70%. And there is no proof that fasting kills cancer cells in humans. Here is what fasting does to cancers in humans. Nothing. Fasting is now become a sort of religion-like cult for wellness influencers to rake in views and engagement. From a scientific standpoint, there are no realistically good human studies to prove anything from fasting that benefits cancers. I know, I know, "autophagy" and all that. Autophagy: Autophagy is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components. Yes, its a legit term and all. But in the context of cancer reduction and fasting in humans, it sounds like "immunity boosting," another wellness fraud term. The effects of fasting on cancer cells are all based on MOUSE studies, and none explicitly translated to humans. See this paper: everything is based on cells and tissues and small animal experiments: "While research on the subject is tantalizing, there’s little clinical evidence involving humans to substantiate the claims. Studies on the potential impacts on cancer treatment from various forms of fasting or calorie restriction, including the possibility that they reduce side effects, have been limited." "Fasting may not be appropriate for malnourished individuals or those with cancer cachexia, which results in a continuing loss of skeletal muscle mass, or for people with chronic diseases. Those with diabetes need to be very careful, because of the risk of hypoglycemia." "Based on our systematic review and meta-analysis, there is currently no evidence supporting the superiority of therapeutic fasting over non-fasting in preventing chemotherapy toxicity." - see here: Even intermittent fasting (IF) is overrated in cancer. "IF may be considered in adults seeking cancer-prevention benefits through means of weight management, butwhether IF itself affects cancer-related metabolic and molecular pathways remains unanswered. See here: Also this: "Fasting for short periods does not have any beneficial effect on the quality of life of cancer patients during treatment. Evidence on fasting regimes reducing side effects and toxicities of chemotherapy is missing." See here: The whole aspect of "fasting reducing cancer incidence" in the real world is just due to weight loss. Obesity is associated with at least 13 types of cancers and reversing obesity reduces risk of cancer - nothing to do with fasting killing off cancers cells in the body. And one can lose weight even without fasting. See here: Everything from prevention of adverse events of cancer, to reduction in side effects from chemotherapy, to slowing cancer growth by reducing glucose levels, to promoting cell regeneration by affecting autophagy is all LAB BASED MOLECULAR LEVEL HYPOTHESIS that has not been proven conclusively in humans. See here: Cancer patients must not starve. They must remain hydrated and they must eat a well balanced diet because cancer condition is highly demanding. And dont water fast for 7 days. Easy for people to make reels on it, but in real life, it may prove disastrous. Water fast does make you lose weight (because of starvation) but it is not at all a healthy way to lose weight. Stop with this fasting and cancer madness already.

TheLiverDoc™

269,527 Aufrufe • vor 2 Jahren

Fasting is NOT Superior for Autophagy Autophagy has become the biggest buzzword in nutrition in the last 5 years & whenever I do videos or posts on intermittent fasting & why it is a useful tool for fat loss, but NOT superior to other calorie equated diets, people invariably say that ‘tHeSe StUdIeS dOn’T aCcOuNt FoR aUtoPhAgY!’ When I cite studies showing that normal calorie restriction gets the same benefits as calorie equated fasting diets, people often say that fasting gets you the benefits WITHOUT calorie restriction. Well, a very highly controlled study showed that this is NOT the case Well this study did (PMID: 34135111). They had people follow one of 3 diets: 1) Alternate day fasting without calorie restriction where they ate 200% of their maintenance calories on feeding days, & 0% the next day (200:0) & continued to alternate them throughout the course of the study 2) Alternate day fasting with 25% calorie restriction where they ate 150% of their maintenance calories on feeding days & 0% the next day (150:0) & continued to alternate those throughout the course of the study or 3) Continuous calorie restriction where they had people eat 75% of their maintenance calories every day for the duration of the study (75:75) Both the 150:0 & 75:75 diets reduced body weight to the same extent, but the 75:75 group lost slightly more fat mass & retained slightly more lean mass than the 150:0 fasting group. Both restricted groups lost more body fat & weight than the 200:0 group which did not lose weight or fat. Markers of autophagy were also equivalent between the 150:0 & 75:75 groups as well as other adipose tissue genes, gut hormones, and markers of cardiometabolic health This study demonstrates that it is the caloric restriction that drives these improvements in health & the changes in autophagy, NOT because fasting has some magical effect on autophagy that exists outside of the caloric restriction it imposes I am NOT saying fasting is bad. I’m not saying it’s not a useful tool or that you can’t lose fat with it. You can & it can be a great tool for many people… it’s just not magic like many proponents of fasting try to make it out to be Tired of the diet wars & not knowing how to make sense of all the contradictory information out there? Comment ‘FRAMEWORK’ and I’ll send you my simplified guide on how to lose fat & build muscle for FREE

Layne Norton, PhD

29,887 Aufrufe • vor 1 Jahr

What happens when you voluntarily stop eating for 3 days? The body's transformation is a masterpiece of survival. Here's a timeline of the incredible process: 🕒 6-10 Hours In: Fuel tanks are emptying. The last bits of dietary carbs are gone. The pancreas sounds the alarm with glucagon, releasing stored glucose. Hunger hormones spike. 🕒 10 Hours In: The pituitary gland unleashes human growth hormone, a powerful shield to protect precious muscle mass. The metabolic thermostat begins to dip. 🕒 16 Hours In: A pivotal shift. The body, a resilient machine, transitions into a primary fat-burning state. This is where the deep energy shift begins. 🕒 18-24 Hours In: Cellular spring cleaning commences. Autophagy kicks into high gear. The body intelligently seeks out and recycles damaged cells, old proteins, and invaders—a natural detox from within. 🕒 24-32 Hours In: The sugar reserves are officially depleted. The body is now running almost entirely on stored fat. To preserve muscle, protein breakdown is dramatically slowed. 🕒 48 Hours In: Mental clarity arrives. Many report a surge in alertness, a sense of tranquility, and an unexpected elevation in mood. The mind becomes sharp. ⚠️ 72 Hours In (The 3-Day Mark): This is a critical juncture. The body's expert muscle-sparing measures begin to wane. The risk of muscle breakdown becomes more significant, and nutrient deficiencies can slowly emerge. The human body is not fragile. It's a sophisticated, self-regulating system designed to endure and adapt. Fasting unveils this profound intelligence, layer by metabolic layer. Note: This is a physiological summary. Extended fasting should only be undertaken with proper knowledge and, ideally, medical supervision.

Camus

17,035 Aufrufe • vor 9 Monaten

Can people in power/ authority kindly stop with this absolute BS on "fasting killing cancer cells" and citing religious nonsense to appeal to peoples emotions? Fasting is really quite dangerous for cancer patients in real life. Let me explain and bury this myth once and for all, especially for science illiterates like this guy. [1] The most common argument is that fasting "starves" cancer by cutting off its sugar (glucose) supply. While it is true that cancer cells consume vast amounts of glucose, they are biologically aggressive survivalists. If you stop eating, your body eventually switches to burning fat and breaking down muscle for energy. Cancer cells are highly adaptable; when glucose is low, many types of cancer can mutate to feed on other fuel sources, such as lactate, amino acids (from your muscles), or fatty acids. You cannot simply "starve" a tumor without starving the patient first. [2] Fasting is dangerous for cancer patients because of cancer cachexia - a wasting syndrome where the body loses muscle and fat rapidly. Cachexia is responsible for up to 30% of cancer deaths. Cancer puts the body in a hyper-metabolic state (burning energy fast). If a patient fasts, they risk accelerating muscle loss and weakening their immune system. A weak body cannot tolerate life-saving treatments like chemotherapy or radiation, nor can it fight off infections. [3] Most claims about fasting curing cancer come from studies on mice or cells in a petri dish. In a dish: You can kill cancer cells with almost anything (lemon juice, bleach, starvation, even shooting a bullet at it at close point or using a grenade to destroy the entire lab) because they have no immune system or body to protect them. In a human: The biology is infinitely more complex. Human metabolism, hormonal fluctuations, and tumor micro-environments mean that what shrinks a tumor in a mouse often fails completely in human trials. [4] Proponents often cite "autophagy" (the body's cellular recycling process triggered by fasting) as the cure. They claim it cleans out cancerous cells. Science shows that autophagy is a double-edged sword. -In all people, autophagy is a normal physiological process - whether fasting or not, which help in cleaning up damaged cells. -But in patients with cancer, once a tumor exists, cancer cells can actually hijack autophagy to survive stress (like chemotherapy) and repair themselves. In this context, fasting could theoretically help the cancer survive the treatment intended to kill it. [5] "Cancer" is not one disease; it is over 200 different diseases characterized by uncontrolled cell growth. Some cancers are driven by hormones, some by genetic mutations, and some by viruses. A fasting protocol that slows down one specific type of breast cancer might have zero effect on pancreatic cancer, or worse, accelerate a different type. The most lethal aspect of this misinformation is the delay in treatment. Cancer is a time-sensitive disease. While a patient spends months trying to fast the cancer away based on religious or alternative advice, the cancer often metastasizes (spreads) to other organs. Once cancer spreads, it often moves from being curable to being terminal. Relying solely on fasting wastes the critical window where medical intervention could have saved a life. Suggesting a single "ancient cure" for 200 complex genetic diseases is scientifically illogical... ...and generally stupid, as this video proves.

TheLiverDoc™

193,652 Aufrufe • vor 7 Monaten

Intermittent Fasting Destroys Your Gains?! A new study (PMID: 40241374) on intermittent fasting (IF) out of Grant Tinsley, PhD lab in collaboration with other colleagues of mine on social media like Menno Henselmans & Andy Galpin, PhD looked to examine the effects of continuous meal feeding pattern (CMF) vs. IF on body composition, strength, & performance, in well-trained men & women over 8 weeks. Several other studies have examined CMF vs. IF but this was the first study to have people eat in a calorie surplus (10% above maintenance calories) & eat a high protein diet (2.2g/kg body weight). The people in the IF group performed their exercise fasted & then ate their first meal after training & kept all their meals within an 8 hour feeding window The results of the study were mixed in favor of CMF & IF. There were no differences between the groups in the amount of fat free mass added, but there were differences in various other measures. The IF group did not gain as much strength on the squat as people following CMF. The group following IF also was not able to complete as many repetitions overall through the course of study, which makes sense because the IF group also reported feeling more fatigued that the CMF group. However, the IF group also gained less body fat than the CMF group The difference in fat mass is in opposition to other studies examining IF vs. CMF that equate calories & protein showing no difference in fat mass changes (PMID: 31614992) however, none of those studies were looking at resistance training in a calorie surplus. So does that mean IF magically reduces fat gain in these conditions? I spoke to Menno about this & his take was the same as mine: it is likely that the people in the IF group ate less without realizing it Overall this study adds to the body of literature that demonstrates normal IF like 16:8 produces similar outcomes in muscle gain compared to CMF. Other more extreme forms of IF like alternate day fasting do show worse lean mass outcomes compared to CMF (PMID: 34135111). The differences in performance & body fat are interesting but we need more research before drawing strong conclusions

Layne Norton, PhD

53,232 Aufrufe • vor 1 Jahr

If your parent is showing signs of Alzheimer's and you want to do something about it, put them on the ketogenic diet. This diet puts their body into a state of ketosis, where instead of their brain burning sugar for fuel, it burns fat and produces something called ketones. Ketones become an alternative fuel source for their brains. Most people with Alzheimer's have brain cells that are insulin resistant. It can no longer efficiently pull glucose from the bloodstream for fuel. Even though glucose is available, the insulin delivery system is broken. Brain cells are starving and can no longer power themselves properly, causing brain fog, memory loss, cognitive decline, and even depression. Ketones bypass this broken system entirely. They cross the blood-brain barrier without needing insulin, feeding your brain cells directly. They produce less cellular waste than glucose. And even act as natural antioxidants exactly where your brain needs them most. Here's Dr. Dale Bredesen's ketogenic protocol from his latest clinical trial on Alzheimer's: • Cut simple carbohydrates. • Fast for at least 12 hours overnight. • Plant-rich diet high in healthy fats (a mildly ketogenic diet - best if starting out) 90% of his patients improved following these rules. Some went from impaired cognitive scores to perfect ones. And results were 7x greater than the leading Alzheimer's drugs. The ketogenic diet is one of the protocols families use to treat their parent's Alzheimer's in our online community. More on this in the comments below.

A Paradise for Parents

47,033 Aufrufe • vor 4 Monaten

Up to 30% of the weight lost while dieting can come from lean muscle mass—but the right training and nutrition can help you preserve muscle, which is key for metabolic health and reducing the risk of sarcopenia. You can lose fat and gain muscle at the same time—a process called body recomposition—if you train and eat strategically. The most important factor is resistance training. Lifting heavy 2–3 times per week is essential for maintaining and building muscle while losing fat. Without it, muscle mass inevitably declines. Nutrition also plays a major role. Eating in a slight calorie deficit—around 10–20% below maintenance—allows for steady fat loss without sacrificing muscle, energy levels, or training performance. Protein intake is another key priority. Research shows that consuming 1.8 to 2.2 grams of protein per kilogram of body weight per day is optimal for muscle retention and growth during a calorie deficit, and going even higher may provide additional benefits. Beyond training and nutrition, recovery is just as crucial. Adequate sleep, stress management, and tracking progress help ensure you’re making real, sustainable changes. Get this right and you have a powerful strategy to build muscle and lose fat. If you want to learn more about optimizing body recomposition, improving VO2 max, and enhancing brain health, tune into the latest episode of the FoundMyFitness podcast, where and I break it all down with insights from top experts. Link to the full episode on YouTube:

Dr. Rhonda Patrick

120,402 Aufrufe • vor 1 Jahr

The Science of Fasting - 2012 Documentary There is a reason so many religions and cultures across the world advocate for fasting to resolve health issues, and think every human being on earth should fast intermittently to help repair and detoxify themselves in this incredibly toxic world where we are being inundated from every vector. Obviously fasting can be detrimental if done excessively and the nutrition is inadequate in between fasting stints, but overall if done right, it's so obviously a great tool for our health that we should all take advantage of. It can by intermittent fasting with 18/6 or 16/8 schedules, it can be 1-2 days a month, it can be 1 week every 6 months, or whatever works best for your individual situation and health goals, but we should all be doing a little bit of fasting every now and again. Considering a large portion of the US is brutally addicted to food and severely overweight and unhealthy with countless diseases and ailments, we should be investing in fasting clinics such as the one shown in this documentary to help them break the addiction and get healthy. Robert F. Kennedy Jr has discussed detox clinics for drug abuse, and hope he can consider the same for obesity and chronic disease with fasting clinics. Many people are not disciplined and strong enough to not eat at home for a few days because of all the temptation, but if they had a place to stay with rules and restrictions, they could learn that discipline and then do it on their own. For anyone that thinks it's dangerous to fast for a long period of time, you should lookup the story of the scottish man back in 1965 who was over 450lbs and fasted for a year straight. If you have body fat on you, you can fast until it's gone, as long as you have water to drink.

Inversionism

292,918 Aufrufe • vor 2 Jahren

Detoxing to increase life expectancy and liver health:How legit medical practitioners are being comical (and very wrong) about health information. I like Dr. Pal Manickam. He is a Gastroenterologist from California. He makes really comical videos. Some of them make me laugh out loud. But I wish he would be more serious about the content inside his videos because a lot of it are heavy on the misinformation side. I chose to discuss this video because 1) it has garnered millions of views on Instagram and liked by more than 10K people and 2) it talks about detoxing and the liver and 3) it is standard clinician's creed/code to correct health misinformation. In the video, Dr. Pal speaks about endotoxins and exotoxins. Endotoxins he says are toxins within our body like urea and feces and exotoxins are packaged foods. I am deeply worried about his inaccuracies despite being a board certified Gastroenterologist in the USA. Endotoxins are the main component of the outer membrane of the cell wall of a specific type of bacteria - called the Gram-negative group of bacteria or GNB. GNB's are so called because do not retain the crystal violet stain used in the Gram staining method (invested by Danish microbiologist Hans Christian Gram). GNB's are characterized by their cell envelopes, which are composed of a thin peptidoglycan (made of sugars+amino acids) cell wall sandwiched between an inner cell membrane and a bacterial outer membrane. Endotoxins are literally "poisons." Their production in the body leads to inflammatory responses at the cell, tissue, organ and systems level which is taken care (neutralized) of by a series of complex process that start in the gut and involving the liver in healthy persons. Example of endotoxin is lipopolysaccharide. Urea is not an endotoxin. It is a substance formed by the breakdown of protein in the liver. The kidneys filter urea out of the blood and into the urine. Urea is the major constituent of the urine and the principal means for disposal of nitrogen derived from amino acid metabolism. Feces are not endotoxins, even though they contain endotoxins. In simple terms, feces, or excrement, is the waste matter remaining after food has been digested, absorbed and thereafter discharged from the bowels. Exotoxins are also toxins secreted by bacteria. An exotoxin can cause damage to the host by destroying cells or disrupting normal cellular metabolism. They are highly potent and can cause major damage to the host. Exotoxins may be secreted, or, similar to endotoxins, may be released when bacteria dies. Example of exotoxin is Botulinum toxin secreted by bacteria Clostridium botulinum. This toxin is notorious for causing a paralytic disease called botulism in infants when they are fed honey at birth. Packaged foods are not exotoxins. They are sources of carbohydrates, proteins and fats and have nutritive value. Toxins do not have nutritive value. In the video, Dr. Pal says our liver will clear all the toxins. He also speaks about sunrise to sunset method - eating from 7AM to 7PM and fasting from 7PM to 7AM which will help detox the body and there is no requirement for "fancy detox diets." He then advises a 24 hour water fasting once a month to detox the body. The liver does not clean all toxins. The lungs, kidneys and skin are also important "detoxifiers" in the body. A lot of misinformation is spread by doctors who "detach organ systems" from the "whole" to sell their agenda of a special practice (like gut detox diet) or sell a supplement that will help improve organ health (such as liver detox drugs) completely ignoring the fact that the "The Whole (body) is Greater than the Sum of its Parts (organs)." The Sunset-Sunrise method is a type of time-restricted eating and a "fancy diet" which Dr.Pal himself is advocating against. A recent high quality study in the New England Journal of Medicine showed that time-restricted feeding DID NOT have any benefits over calorie restriction alone in the context of weight loss, body fat changes or metabolic risk factors. Water Fasting is an extreme form of "fancy dieting" and a possibly detrimental "fad diet" which has no conclusive benefits and is not recommended by any clinical societies in the world. It is only recommended by people with anecdotal experience on the same or by those who ignorantly advocate the same without understanding scientific evidence on it, like Dr.Pal himself. An 8-day water fasting only led to sense of well-being and did not affect metabolic factors. It increased uric acid, ketosis, lowered glucose and dehydrated people and can lead to lifethreatening metabolic derangements. Prolonged water-fasting increased triglycerides and insulin resistance after refeeding, the detrimental effects of which remain unknown in long term. All the current available studies on water-fasting is on minimum 5 day to almost 6 weeks of intermittent water-fast and NONE on single day a month fasting as mentioned by Dr.Pal. Again, this advise is just bluff and there is no evidence that it would led to healthier outcomes or improve disease conditons. There is NO evidence that water fasting or time-restricted diets DETOX the body. Detox is a wellness marketing fraud term which is thrown around by people, including doctors, who deeply lack scientific temper, critical thinking and rationality.

TheLiverDoc™

248,925 Aufrufe • vor 3 Jahren