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Introducing Mantis, a two-in-one microscope designed at #CZBiohubSF that enables rapid high-dimensional imaging of molecular dynamics in the context of cell morphology. 🧵1/7 Preprint: ⬇️

Chan Zuckerberg Biohub Network

17,291 subscribers

64,860 views • 2 years ago •via X (Twitter)

Education Science & Technology #CZBiohubSF

Anya Rossi• Live Now

Private livecam show

6 Comments

Chan Zuckerberg Biohub Network2 years ago

The mantis shrimp, our microscope’s namesake, boasts high-dimensional vision and quick reflexes. Mantis combines qualitative label-free technology with oblique light-sheet fluorescence microscopy. 2/7

Chan Zuckerberg Biohub Network2 years ago

When combined with shrimPy, our high-throughput imaging & analysis software, and VisCy, our deep-learning software for virtual staining of label-free data, Mantis lets us see 6 channels of info while acquiring only 4. 🤩 3/7 Access the tools ⬇️

Chan Zuckerberg Biohub Network2 years ago

Cells are like an underwater city; instead of landmarks and buildings, they are made of large and small organelles. Understanding how cells work requires imaging and analyzing the dynamic interactions between organelles in 4D, i.e., in 3D space over time. 4/7

Chan Zuckerberg Biohub Network2 years ago

Mantis enables high-throughput imaging of the dynamics of labeled organelles and proteins, in the context of virtually stained landmarks of nuclei and membranes. Virtual staining rescues occasional loss of label too! 5/7

Chan Zuckerberg Biohub Network2 years ago

The gentle nature of Mantis allowed us to profile how infection by a coronavirus alters the molecular and morphological dynamics of cells. 6/7

Chan Zuckerberg Biohub Network2 years ago

Great collaborative effort by the #CZBiohubSF team (@ieivanov1, @edyoshikun, @talonchandler, @ZW_Liu, Chad Liu, @LeonettiManuel, @mattersoflight) working with @BoHuangLab of @UCSF. Feedback on the preprint is welcome! 7/7

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Technical Innovations • Molecular Imaging and Energy Discrimination: Unlike traditional CT, which simply measures the total absorbed energy, PCCT counts individual X-ray photons and differentiates their energy levels. This allows for precise molecular imaging, revealing the composition of tissues and materials at a biochemical level. By distinguishing between different tissue types and contrast agents, PCCT opens up new diagnostic possibilities, such as identifying molecular biomarkers in tumors or distinguishing between stable and unstable plaque in coronary arteries. This capability shifts the focus of imaging from purely anatomical to both anatomical and molecular, offering more comprehensive diagnostic information. • Ultra-High Spatial Resolution: PCCT features significantly smaller detector elements compared to conventional CT scanners, allowing for ultra-high resolution imaging. This means clinicians can visualize fine structures such as microcalcifications in arteries, small lesions in soft tissues, or the intricate architecture of bones. This level of detail was previously unattainable with traditional CT. When combined with molecular imaging, this ultra-high resolution allows for the precise localization and characterization of disease at very early stages, which is essential for early diagnosis and intervention. • Functional Imaging Capabilities: PCCT also excels as a functional imaging modality. By capturing energy-resolved information, PCCT can provide insights into tissue functionality and dynamic physiological processes. For instance, it can detect changes in blood flow, tissue perfusion, and oxygenation without the need for additional contrast agents or scans. 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Radiologists and technicians need specialized training to interpret and analyze multi-energy datasets that include molecular and functional information. PCCT produces a vast amount of detailed data, requiring clinicians to adopt new imaging protocols and refine their diagnostic approaches to fully leverage its capabilities. • Post-Processing and Data Management: PCCT generates richer, more complex datasets, which necessitates advanced post-processing tools and data management systems. Existing PACS and imaging software may not be equipped to handle such large volumes of data or to process functional and molecular information effectively. This means healthcare institutions must invest in robust IT infrastructure, including upgraded software and storage solutions, as well as provide additional training for staff on new imaging analysis techniques. • Revised Clinical Protocols: The molecular, functional, and ultra-high resolution imaging capabilities of PCCT will likely prompt changes in clinical protocols. For instance, the need for contrast agents may be reduced, simplifying patient preparation and decreasing the risk of adverse reactions. Additionally, the ability to monitor physiological functions in real-time through functional imaging could lead to more dynamic diagnostic procedures, such as assessing the effectiveness of interventions or treatments in real-time. 3. 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