Loading video...

Video Failed to Load

There was a problem loading this video. This could be due to a temporary network issue or the video might be unavailable.

Is biological aging actually reversible? De Grey believes it will eventually be possible. Kaeberlein is the complete opposite: "I think it's almost impossible, if not impossible, to completely reverse biological aging." His reason is simple. "You can't reverse entropy." However, does believe you can improve health and parts of... show more

Julian Issa

1,652 subscribers

23,617 views • 12 days ago •via X (Twitter)

Anya Rossi• Live Now

Private livecam show

0 Comments

No comments available

Comments from the original post will appear here

Related Videos

Aubrey de Grey: there will be no cure for aging because it is a side effect of being alive

Aubrey de Grey: there will be no cure for aging because it is a side effect of being alive

Tsarathustra

22,228 views • 2 years ago

I love this take. Elon Musk looks at aging like an engineer, not like a mystic. Exactly the same mindset as Aubrey de Grey. Core ideas that really hit: •Aging is not chaos. The whole body degrades in sync, so there must be a central mechanism. •If everything decays together, there is a biological clock or program behind it. •Programs can be rewritten. Aging is not destiny, it is code. •Other species already solved it. Whales reach 200 years, Greenland sharks up to 500. •That means it is not magic. It is biology and engineering. What I truly hope: •That Elon uses his capital, influence, and engineering culture to seriously push aging research. •If not full lifespan extension, then at least curing age related diseases. •Cancer, neurodegeneration, cardiovascular decay should be optional, not inevitable. If aging is engineered, it can be reverse engineered. That idea alone changes everything.

I love this take. Elon Musk looks at aging like an engineer, not like a mystic. Exactly the same mindset as Aubrey de Grey. Core ideas that really hit: •Aging is not chaos. The whole body degrades in sync, so there must be a central mechanism. •If everything decays together, there is a biological clock or program behind it. •Programs can be rewritten. Aging is not destiny, it is code. •Other species already solved it. Whales reach 200 years, Greenland sharks up to 500. •That means it is not magic. It is biology and engineering. What I truly hope: •That Elon uses his capital, influence, and engineering culture to seriously push aging research. •If not full lifespan extension, then at least curing age related diseases. •Cancer, neurodegeneration, cardiovascular decay should be optional, not inevitable. If aging is engineered, it can be reverse engineered. That idea alone changes everything.

VraserX e/acc

391,297 views • 6 months ago

IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.

IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.

Yuri Deigin

15,038 views • 1 year ago

Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.

Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.

SciTech Era

17,777 views • 26 days ago

Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which Prof Steve Horvath believes is one of the strongest pieces of evidence that simple interventions (that also likely correct a deficiency) are powerful ways to slow or reverse the aging process. We discuss this study and more in the latest episode of the FoundMyFitness podcast.

Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which Prof Steve Horvath believes is one of the strongest pieces of evidence that simple interventions (that also likely correct a deficiency) are powerful ways to slow or reverse the aging process. We discuss this study and more in the latest episode of the FoundMyFitness podcast.

Dr. Rhonda Patrick

486,338 views • 1 month ago

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Wall Street Apes

489,432 views • 6 months ago

A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and Prof Steve Horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.

A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and Prof Steve Horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.

Dr. Rhonda Patrick

56,174 views • 1 month ago

I interviewed Aubrey de Grey on why neither billionaires nor AI will solve aging. And why a single mouse breakthrough could be the ChatGPT moment for longevity. 0:00 - Longevity Field 20 Years On 08:58 - Are Billionaires Getting It Wrong? 17:13 - Bryan Johnson vs Peter Thiel 23:42 - ChatGPT Moment for Longevity 28:52 - Biological Age vs Lifespan 34:44 - Influencers Will Save Us 39:36 - AI x Science Breakthroughs 48:14 - Sam Altman on Aging 53:39 - Genesis Mission 56:45 - Systems Will Collapse 1:08:55 - GLP-1s & Human Enhancement

I interviewed Aubrey de Grey on why neither billionaires nor AI will solve aging. And why a single mouse breakthrough could be the ChatGPT moment for longevity. 0:00 - Longevity Field 20 Years On 08:58 - Are Billionaires Getting It Wrong? 17:13 - Bryan Johnson vs Peter Thiel 23:42 - ChatGPT Moment for Longevity 28:52 - Biological Age vs Lifespan 34:44 - Influencers Will Save Us 39:36 - AI x Science Breakthroughs 48:14 - Sam Altman on Aging 53:39 - Genesis Mission 56:45 - Systems Will Collapse 1:08:55 - GLP-1s & Human Enhancement

Mgoes (bio/acc 🤖💉)

45,396 views • 5 months ago

Elon Musk says that extending human life and even reversing aging is highly possible "I've never seen someone with an old left arm and a young right arm ever in my life. That means there must be a synchronizing clock that is synchronizing across 35 trillion cells in your body," If our cells are aging in perfect unison, it means aging is driven by a central, coordinated biological mechanism rather than random, subtle decay "When we figure out what causes aging, I think we'll find it's incredibly obvious it’s not a subtle thing it's just a solvable engineering problem"

Elon Musk says that extending human life and even reversing aging is highly possible "I've never seen someone with an old left arm and a young right arm ever in my life. That means there must be a synchronizing clock that is synchronizing across 35 trillion cells in your body," If our cells are aging in perfect unison, it means aging is driven by a central, coordinated biological mechanism rather than random, subtle decay "When we figure out what causes aging, I think we'll find it's incredibly obvious it’s not a subtle thing it's just a solvable engineering problem"

X Freeze

225,444 views • 3 months ago

We asked Max Marchione: what happens after we solve obesity? "We still have all of the things that cause aging." "We haven't really been able to slow aging. Aging is very systemic." "Even if you take the Bryan Johnson approach to aging, you maybe only add an extra 10 years to life, which is not an awful amount." "I think the kind of 10-year plus primary therapeutic modality is likely going to be genomic medicine." "If you can modify the genome, you can actually modify how DNA encodes for RNA, which produces proteins and peptides. So you can actually change the proteins and peptides your body produces by modifying DNA."

We asked Max Marchione: what happens after we solve obesity? "We still have all of the things that cause aging." "We haven't really been able to slow aging. Aging is very systemic." "Even if you take the Bryan Johnson approach to aging, you maybe only add an extra 10 years to life, which is not an awful amount." "I think the kind of 10-year plus primary therapeutic modality is likely going to be genomic medicine." "If you can modify the genome, you can actually modify how DNA encodes for RNA, which produces proteins and peptides. So you can actually change the proteins and peptides your body produces by modifying DNA."

MTS

71,587 views • 2 months ago

STARSEEDS AGE IN REVERSE …it is not a legend… Did you know that ? It’s disconcerting, and most of you are completely thrown off… You don’t understand what’s happening inside you… You’re getting younger… Your body is aging more slowly, and a spirit is animating it more and more. Listen carefully to the video all the way to the end… “he gives a key.“

STARSEEDS AGE IN REVERSE …it is not a legend… Did you know that ? It’s disconcerting, and most of you are completely thrown off… You don’t understand what’s happening inside you… You’re getting younger… Your body is aging more slowly, and a spirit is animating it more and more. Listen carefully to the video all the way to the end… “he gives a key.“

AuroraArabella

24,120 views • 2 months ago

This is WILD! Ray Kurzweil, the futurist who predicted the internet, smartphones, and AI says aging ends by 2032 (Save this) Kurzweil, now 78 years old, told a live audience that humanity will reach longevity escape velocity by 2032 and he explained exactly what that means with mathematical precision. Right now, for every year you live, you get back approximately five months of life expectancy from medical and scientific progress meaning you are losing roughly seven months of net life per calendar year. Longevity escape velocity is the threshold where that ratio flips, for every year you live, you get back a full year or more from scientific progress, meaning your biological clock starts running backward. Kurzweil's prediction is that threshold hits by 2032 and beyond that point, you do not simply stop dying of aging, you actively get younger every year. The mechanism is AI-driven drug discovery at a scale that was physically impossible five years ago. By 2030, Kurzweil argues, AI will be able to take a biological problem, generate millions of potential drug candidates, screen all of them, and run trials on simulated digital populations compressing decades of clinical research into weeks. This is already happening. David Sinclair's lab at Harvard used AI to virtually screen 8 billion molecules against aging targets and is now preparing human trials moving from $400,000 gene therapies toward a $100 pill that can reset biological age by 50 to 95% in four weeks. Sinclair has already demonstrated the ability to reverse aging in mammals restoring sight in mice with optic nerve damage and reversing Alzheimer's symptoms in lab models. Kurzweil's track record is what makes the 2032 claim impossible to dismiss. He predicted the internet's global dominance in 1990, the defeat of a world chess champion by a computer in 1998, pocket-sized devices as primary communications tools in 1999, and AI passing professional exams in the mid-2020s, all before anyone else was saying it publicly. If you are under 60 and in reasonable health, his message is stay alive, stay healthy, and get to 2032. The tools on the other side of that date will be unlike anything medicine has ever produced.

This is WILD! Ray Kurzweil, the futurist who predicted the internet, smartphones, and AI says aging ends by 2032 (Save this) Kurzweil, now 78 years old, told a live audience that humanity will reach longevity escape velocity by 2032 and he explained exactly what that means with mathematical precision. Right now, for every year you live, you get back approximately five months of life expectancy from medical and scientific progress meaning you are losing roughly seven months of net life per calendar year. Longevity escape velocity is the threshold where that ratio flips, for every year you live, you get back a full year or more from scientific progress, meaning your biological clock starts running backward. Kurzweil's prediction is that threshold hits by 2032 and beyond that point, you do not simply stop dying of aging, you actively get younger every year. The mechanism is AI-driven drug discovery at a scale that was physically impossible five years ago. By 2030, Kurzweil argues, AI will be able to take a biological problem, generate millions of potential drug candidates, screen all of them, and run trials on simulated digital populations compressing decades of clinical research into weeks. This is already happening. David Sinclair's lab at Harvard used AI to virtually screen 8 billion molecules against aging targets and is now preparing human trials moving from $400,000 gene therapies toward a $100 pill that can reset biological age by 50 to 95% in four weeks. Sinclair has already demonstrated the ability to reverse aging in mammals restoring sight in mice with optic nerve damage and reversing Alzheimer's symptoms in lab models. Kurzweil's track record is what makes the 2032 claim impossible to dismiss. He predicted the internet's global dominance in 1990, the defeat of a world chess champion by a computer in 1998, pocket-sized devices as primary communications tools in 1999, and AI passing professional exams in the mid-2020s, all before anyone else was saying it publicly. If you are under 60 and in reasonable health, his message is stay alive, stay healthy, and get to 2032. The tools on the other side of that date will be unlike anything medicine has ever produced.

Milk Road AI

960,557 views • 1 month ago

In 1961, aliens allegedly abducted Betty and Barney Hill. During the abduction, the aliens removed Barney's dentures then ran to Betty confused about why her teeth wouldn't come out too. She had to explain human aging to them. Betty and Barney said small gray beings in uniforms took them aboard and ran experiments (took biological samples and physical exams). But, for some reason, it was something about teeth that completely confused the aliens. What does this say about the abductors biology if aging is a completely foreign concept to them? Full conversation with Swedish UFO researcher Clas Svahn 👇

In 1961, aliens allegedly abducted Betty and Barney Hill. During the abduction, the aliens removed Barney's dentures then ran to Betty confused about why her teeth wouldn't come out too. She had to explain human aging to them. Betty and Barney said small gray beings in uniforms took them aboard and ran experiments (took biological samples and physical exams). But, for some reason, it was something about teeth that completely confused the aliens. What does this say about the abductors biology if aging is a completely foreign concept to them? Full conversation with Swedish UFO researcher Clas Svahn 👇

American Alchemy

43,011 views • 5 months ago

4 supplements that give you the biggest bang for your buck: • Multivitamin — 3 large RCTs show it reduces brain aging by ~2 years and reverses episodic memory aging by ~5 years in older adults • Omega-3s — a high omega-3 index (8%+) is linked to 5 years of increased life expectancy and 90% lower risk of sudden cardiac death • Magnesium — a cofactor for 300+ biological processes including DNA repair and energy production; 60%+ of the US population is deficient • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years

4 supplements that give you the biggest bang for your buck: • Multivitamin — 3 large RCTs show it reduces brain aging by ~2 years and reverses episodic memory aging by ~5 years in older adults • Omega-3s — a high omega-3 index (8%+) is linked to 5 years of increased life expectancy and 90% lower risk of sudden cardiac death • Magnesium — a cofactor for 300+ biological processes including DNA repair and energy production; 60%+ of the US population is deficient • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years

FoundMyFitness Clips

145,455 views • 5 months ago

Ilya Sutskever says the real challenge of AI is how fast and extreme its growth will be it still has limits, but it already speaks, codes, and interacts in ways once impossible soon, perhaps within 3 to 10 years, AI will be able to do everything humans can do the reason: "the human brain is a biological computer, so why can't a digital brain do the same?"

Ilya Sutskever says the real challenge of AI is how fast and extreme its growth will be it still has limits, but it already speaks, codes, and interacts in ways once impossible soon, perhaps within 3 to 10 years, AI will be able to do everything humans can do the reason: "the human brain is a biological computer, so why can't a digital brain do the same?"

Haider.

144,938 views • 1 year ago

ARE YOU READY: 🚨 Musk reveals "semi immortality is a solvable problem" and believes that in 10 years the LIFE SPAN will significantly increase, but not quite DOUBLE. Elon Musk recently highlighted aging and human longevity as an "extremely solvable" scientific challenge, sparking fresh discussion about dramatically extended lifespans. In a January 2026 appearance on the Moonshots podcast with Peter Diamandis, Musk described "longevity or semi-immortality" as not particularly hard from a biological perspective. He pointed to the highly synchronized way the human body ages: every part degrades in lockstep, with no one having, for example, an old left arm paired with a young right arm. This suggests an underlying "biological clock" or programmed mechanism that's waiting to be understood and potentially rewritten. "I've long thought that longevity or semi-mortality is an extremely solvable problem. I don't think it's a particularly hard problem... You're pre-programmed to die. And so if you change the program, you will live longer." He added that once scientists identify the root cause of aging, it will likely seem "incredibly obvious" rather than subtle.

ARE YOU READY: 🚨 Musk reveals "semi immortality is a solvable problem" and believes that in 10 years the LIFE SPAN will significantly increase, but not quite DOUBLE. Elon Musk recently highlighted aging and human longevity as an "extremely solvable" scientific challenge, sparking fresh discussion about dramatically extended lifespans. In a January 2026 appearance on the Moonshots podcast with Peter Diamandis, Musk described "longevity or semi-immortality" as not particularly hard from a biological perspective. He pointed to the highly synchronized way the human body ages: every part degrades in lockstep, with no one having, for example, an old left arm paired with a young right arm. This suggests an underlying "biological clock" or programmed mechanism that's waiting to be understood and potentially rewritten. "I've long thought that longevity or semi-mortality is an extremely solvable problem. I don't think it's a particularly hard problem... You're pre-programmed to die. And so if you change the program, you will live longer." He added that once scientists identify the root cause of aging, it will likely seem "incredibly obvious" rather than subtle.

TRENDING ➞ 911

43,313 views • 6 days ago

I’m sorry but this is very shocking and will be hard to wrap your minds around. It was for me Many celebrities and elites seem to be aging in reverse. I always thought it was because of plastic surgery, but it’s more nefarious. It’s because of adrenochrome! Adrenochrome is created from adrenalized blood which is believed to be harvested from terrified children. Consuming adrenochrome reverses the aging in people! When you understand what adrenochrome is then you begin to understand why all the children are trafficked not just for perverted ways, but it’s the fountain of youth! They are harming children literally to appease their own vanity. How disgusting is that?

I’m sorry but this is very shocking and will be hard to wrap your minds around. It was for me Many celebrities and elites seem to be aging in reverse. I always thought it was because of plastic surgery, but it’s more nefarious. It’s because of adrenochrome! Adrenochrome is created from adrenalized blood which is believed to be harvested from terrified children. Consuming adrenochrome reverses the aging in people! When you understand what adrenochrome is then you begin to understand why all the children are trafficked not just for perverted ways, but it’s the fountain of youth! They are harming children literally to appease their own vanity. How disgusting is that?

🌺🌸🇺🇸✝️MAR✝️🇺🇸🌸🌺

18,068 views • 4 months ago

New episode with Dr. Steve Horvath (Prof Steve Horvath), a pioneer in the field of epigenetic aging clocks. Steve developed the original Horvath clock, one of the first tools to show that DNA methylation carries a remarkably reliable signal of aging across human tissues. In this episode, he explains what biological clocks actually measure, why different clocks can disagree, and how to interpret a biological-age result without treating it like a literal lifespan forecast. We talk about chronological age vs. biological age, and we also get into the intervention evidence on exercise and VO2 max, calorie restriction, omega-3s, vitamin D, multivitamins, and weight loss/GLP-1 therapy, among other topics! The big theme is that biological clocks can be useful dashboards, but they are not diagnoses, fortune-telling tools, or proof that one supplement has reversed aging. This was Steve's second appearance on the podcast and he did not disappoint. You won't want to miss this episode. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:59 - Biological vs. chronological age 7:33 - Why one clock isn't enough 13:16 - PhenoAge vs. GrimAge 15:21 - GrimAge & mortality risk 19:04 - Epigenome as stress memory 23:02 - Can stress be inherited? 25:06 - Why clocks fail in sperm 26:30 - Can lifestyle reverse GrimAge? 28:18 - DunedinPACE as an odometer 32:20 - Judging longevity interventions 34:41 - Clocks as mortality surrogates 38:28 - Most validated interventions 41:25 - 5 years younger in 7 months? 45:43 - Can GrimAge predict death? 47:30 - Translating GrimAge to lifespan 52:16 - Blind spots of aging clocks 58:20 - More than inflammation 1:00:56 - Young blood, transient effects 1:04:46 - Calorie restriction 1:08:54 - GLP-1 drugs & weight loss 1:12:24 - Can a multivitamin slow aging? 1:21:05 - Omega-3, vitamin D, & exercise 1:28:55 - Removing an aging accelerator 1:31:24 - Vegetables vs. exercise 1:36:58 - Does red meat age you? 1:38:38 - Hard training moves the clock 1:45:59 - Heat as an exercise mimetic 1:47:23 - When cold slows the clock 1:49:48 - Does poor sleep speed aging? 1:51:19 - Can friendship slow aging? 1:57:49 - Are consumer tests worth it? 2:02:46 - Choosing a reliable test 2:07:33 - Different clocks, different lenses 2:12:21 - Can AI build better clocks? 2:13:53 - Partial reprogramming 2:17:47 - What reprogramming can't fix 2:22:37 - Do DNA mutations drive aging? 2:24:53 - The silver bullet problem 2:29:23 - Limits of polygenic risk 2:33:32 - Steve's longevity routine 2:38:05 - How stress affects aging

New episode with Dr. Steve Horvath (Prof Steve Horvath), a pioneer in the field of epigenetic aging clocks. Steve developed the original Horvath clock, one of the first tools to show that DNA methylation carries a remarkably reliable signal of aging across human tissues. In this episode, he explains what biological clocks actually measure, why different clocks can disagree, and how to interpret a biological-age result without treating it like a literal lifespan forecast. We talk about chronological age vs. biological age, and we also get into the intervention evidence on exercise and VO2 max, calorie restriction, omega-3s, vitamin D, multivitamins, and weight loss/GLP-1 therapy, among other topics! The big theme is that biological clocks can be useful dashboards, but they are not diagnoses, fortune-telling tools, or proof that one supplement has reversed aging. This was Steve's second appearance on the podcast and he did not disappoint. You won't want to miss this episode. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:59 - Biological vs. chronological age 7:33 - Why one clock isn't enough 13:16 - PhenoAge vs. GrimAge 15:21 - GrimAge & mortality risk 19:04 - Epigenome as stress memory 23:02 - Can stress be inherited? 25:06 - Why clocks fail in sperm 26:30 - Can lifestyle reverse GrimAge? 28:18 - DunedinPACE as an odometer 32:20 - Judging longevity interventions 34:41 - Clocks as mortality surrogates 38:28 - Most validated interventions 41:25 - 5 years younger in 7 months? 45:43 - Can GrimAge predict death? 47:30 - Translating GrimAge to lifespan 52:16 - Blind spots of aging clocks 58:20 - More than inflammation 1:00:56 - Young blood, transient effects 1:04:46 - Calorie restriction 1:08:54 - GLP-1 drugs & weight loss 1:12:24 - Can a multivitamin slow aging? 1:21:05 - Omega-3, vitamin D, & exercise 1:28:55 - Removing an aging accelerator 1:31:24 - Vegetables vs. exercise 1:36:58 - Does red meat age you? 1:38:38 - Hard training moves the clock 1:45:59 - Heat as an exercise mimetic 1:47:23 - When cold slows the clock 1:49:48 - Does poor sleep speed aging? 1:51:19 - Can friendship slow aging? 1:57:49 - Are consumer tests worth it? 2:02:46 - Choosing a reliable test 2:07:33 - Different clocks, different lenses 2:12:21 - Can AI build better clocks? 2:13:53 - Partial reprogramming 2:17:47 - What reprogramming can't fix 2:22:37 - Do DNA mutations drive aging? 2:24:53 - The silver bullet problem 2:29:23 - Limits of polygenic risk 2:33:32 - Steve's longevity routine 2:38:05 - How stress affects aging

Dr. Rhonda Patrick

86,691 views • 1 month ago

Ilya Sutskever explains why AI will do 100% the work that human can do within few years. "Slowly but surely, or maybe not so slowly, AI will keep getting better. The day will come when AI will do all of our, all the things that we can do, not just some of them, but all of them. Anything which I can learn, anything which any one of you can learn, the AI could do as well. How do we know this, by the way? How can I be so sure? How can I be so sure of that? The reason is that all of us have a brain, and the brain is a biological computer. That's why we have a brain; the brain is a biological computer. So why can't the digital computer, a digital brain, do the same things? This is the one-sentence summary for why AI will be able to do all those things: because we have a brain, and the brain is a biological computer." --- Full Video on 'University of Toronto' YT Channel (link in comment)

Ilya Sutskever explains why AI will do 100% the work that human can do within few years. "Slowly but surely, or maybe not so slowly, AI will keep getting better. The day will come when AI will do all of our, all the things that we can do, not just some of them, but all of them. Anything which I can learn, anything which any one of you can learn, the AI could do as well. How do we know this, by the way? How can I be so sure? How can I be so sure of that? The reason is that all of us have a brain, and the brain is a biological computer. That's why we have a brain; the brain is a biological computer. So why can't the digital computer, a digital brain, do the same things? This is the one-sentence summary for why AI will be able to do all those things: because we have a brain, and the brain is a biological computer." --- Full Video on 'University of Toronto' YT Channel (link in comment)

Rohan Paul

334,691 views • 10 months ago

Coffee can literally slow your aging. Rhonda Patrick says 1–3 cups a day is linked to 30% lower all-cause mortality, delays biological aging by about a year on epigenetic clocks, and lowers risk of heart disease, diabetes, and more. Caffeine matters most for dementia protection (decaf doesn’t cut it the same), but polyphenols help too. Just make sure you filter it, unfiltered raises LDL. Large meta-analyses involving hundreds of thousands of people consistently show these benefits, with the strongest effects seen in people drinking 2–4 cups daily. Small habit. Surprisingly powerful payoff. How many cups do you have, and do you filter yours?

Coffee can literally slow your aging. Rhonda Patrick says 1–3 cups a day is linked to 30% lower all-cause mortality, delays biological aging by about a year on epigenetic clocks, and lowers risk of heart disease, diabetes, and more. Caffeine matters most for dementia protection (decaf doesn’t cut it the same), but polyphenols help too. Just make sure you filter it, unfiltered raises LDL. Large meta-analyses involving hundreds of thousands of people consistently show these benefits, with the strongest effects seen in people drinking 2–4 cups daily. Small habit. Surprisingly powerful payoff. How many cups do you have, and do you filter yours?

Camus

23,169 views • 1 month ago