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Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬 Shiori Iida Masa A. Shimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗 (1/3)

Kazuhiro Maeshima

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27,080 просмотров • 1 год назад •via X (Twitter)

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Our new preprint is out＠bioRxiv: Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

Our new preprint is out＠bioRxiv: Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

Kazuhiro Maeshima

15,626 просмотров • 1 год назад

7 Compelling Reasons Why Ivermectin Is a ‘Powerful Drug’ for Fighting Cancer Ivermectin is often recognized–2nd to penicillin–for having the greatest impact on human health. Its discovery even won the Nobel Prize. It is safer than Tylenol and brought river blindness to the brink of extinction, but the propagandists told you it was a “dangerous horse dewormer.” Well, it now turns out that ivermectin is not only an effective treatment for COVID-19, but it could also be a “powerful drug” for fighting cancer. Here are 7 reasons why. 1. Multiple Anti-Cancer Effects: Ivermectin impacts at least nine well-defined cancer targets, according to Dr. Alfonso Dueñas-González, an oncologist and senior researcher. He states, "There are at least nine perfectly defined cancer targets affected by ivermectin." 2. Enhances Effects of Chemotherapy and Radiation: Ivermectin not only targets tumor stem cells and promotes cancer cell death but also "enhances the effects of chemo and radiation therapy." This broad impact on the immune system increases the offense against cancers, making it a versatile adjunct to conventional treatments. 3. Inhibits Cancer Cell Cycles: The drug prevents the formation of new cancer cells by inhibiting cancer cell cycles and inducing mitochondrial stress, which leads to the killing of cancer cells. This mechanism is crucial for stopping the proliferation of cancerous cells. 4. Prevents Formation of New Blood Vessels Near Cancer Cells: Ivermectin prevents cancer survival by inhibiting the formation of new blood vessels that transport energy and fuel to cancers. This action starves the cancer cells, hindering their growth and spread. 5. Synergizes with Immunotherapy: Dr. Peter P. Lee, chair of immuno-oncology at the City of Hope, found that ivermectin could synergize with immune checkpoint inhibitor anti-PD1, enhancing the body's immune response to fight cancer. "What we’re learning is that ivermectin is going to be a very powerful drug in the context of really carefully developed immunotherapy combinations," he said. 6. Targets Cancer Stem Cells: Ivermectin preferentially targets cancer stem cells, which are a driver of cancer tumors and relapses. By focusing on these cells, ivermectin attacks the root of cancer's resilience and ability to recur. 7. The Curious Case of Rick Alderson: Mr. Alderson, a retired sawmill worker, “was a dead man walking” and given 6 months to live after his terminal colon cancer had metastasized and spread to his liver, where it had formed 25 distinct tumors. After starting ivermectin, Rick Alderson's carcinoembryonic antigen (CEA) levels, which are markers for tumor activity, dropped significantly from 1,498 ng/mL to 13.9 ng/mL in a matter of months. Of the 25 tumors in Mr. Alderson's liver, only three remained after his treatment with ivermectin and chemotherapy, indicating a substantial reduction in tumor burden. Mr. Alderson lived for two more years beyond his initial six-month prognosis, which his wife attributes to the use of ivermectin alongside chemotherapy.

7 Compelling Reasons Why Ivermectin Is a ‘Powerful Drug’ for Fighting Cancer Ivermectin is often recognized–2nd to penicillin–for having the greatest impact on human health. Its discovery even won the Nobel Prize. It is safer than Tylenol and brought river blindness to the brink of extinction, but the propagandists told you it was a “dangerous horse dewormer.” Well, it now turns out that ivermectin is not only an effective treatment for COVID-19, but it could also be a “powerful drug” for fighting cancer. Here are 7 reasons why. 1. Multiple Anti-Cancer Effects: Ivermectin impacts at least nine well-defined cancer targets, according to Dr. Alfonso Dueñas-González, an oncologist and senior researcher. He states, "There are at least nine perfectly defined cancer targets affected by ivermectin." 2. Enhances Effects of Chemotherapy and Radiation: Ivermectin not only targets tumor stem cells and promotes cancer cell death but also "enhances the effects of chemo and radiation therapy." This broad impact on the immune system increases the offense against cancers, making it a versatile adjunct to conventional treatments. 3. Inhibits Cancer Cell Cycles: The drug prevents the formation of new cancer cells by inhibiting cancer cell cycles and inducing mitochondrial stress, which leads to the killing of cancer cells. This mechanism is crucial for stopping the proliferation of cancerous cells. 4. Prevents Formation of New Blood Vessels Near Cancer Cells: Ivermectin prevents cancer survival by inhibiting the formation of new blood vessels that transport energy and fuel to cancers. This action starves the cancer cells, hindering their growth and spread. 5. Synergizes with Immunotherapy: Dr. Peter P. Lee, chair of immuno-oncology at the City of Hope, found that ivermectin could synergize with immune checkpoint inhibitor anti-PD1, enhancing the body's immune response to fight cancer. "What we’re learning is that ivermectin is going to be a very powerful drug in the context of really carefully developed immunotherapy combinations," he said. 6. Targets Cancer Stem Cells: Ivermectin preferentially targets cancer stem cells, which are a driver of cancer tumors and relapses. By focusing on these cells, ivermectin attacks the root of cancer's resilience and ability to recur. 7. The Curious Case of Rick Alderson: Mr. Alderson, a retired sawmill worker, “was a dead man walking” and given 6 months to live after his terminal colon cancer had metastasized and spread to his liver, where it had formed 25 distinct tumors. After starting ivermectin, Rick Alderson's carcinoembryonic antigen (CEA) levels, which are markers for tumor activity, dropped significantly from 1,498 ng/mL to 13.9 ng/mL in a matter of months. Of the 25 tumors in Mr. Alderson's liver, only three remained after his treatment with ivermectin and chemotherapy, indicating a substantial reduction in tumor burden. Mr. Alderson lived for two more years beyond his initial six-month prognosis, which his wife attributes to the use of ivermectin alongside chemotherapy.

The Vigilant Fox 🦊

532,851 просмотров • 2 лет назад

We’re thrilled to share that our MERFISH+ preprint is now live on bioRxiv!👉 In this work, the Bintu and Zhu labs (UCSD) developed MERFISH+, a next-generation spatial genomics platform that combines genome-wide RNA and epigenetic imaging over a large field of view. By introducing acrydite-modified probes covalently anchored to hydrogels, MERFISH+ achieves remarkable imaging stability and enables >1,800-gene, multi-modal, and multi-month experiments. With this platform, they, together with the Chi lab at UCSD, profiled a whole developing human heart at 12 post-conception week with merely two slides, resulting in a total of 53 slides, 3.1 million single cells and more than 30 cell types. Building upon our previous 3D reconstruction and modeling framework, Spateo ( we reconstruct the 3D human heart that nicely captures the anatomical structure of the heart, including the intricate vasculature network. Sophisticated analyses provide a holistic view of an entire organ and enable systematic characterization of 3D cellular neighborhoods and transcriptional gradients of substructures such as the descending arteries. Furthermore, using a generative integration framework for spatial multimodal data (Spateo-VI), we harmonized these MERFISH+ transcriptomic and chromatin data to reconstruct a 3D spatially-resolved multi-omics atlas of the developing human heart, shared at and MERFISH+ thus sets a new standard for large-format, multi-omic spatial profiling, enabling holistic, 3D characterization of organs at subcellular resolution. Huge congratulations to first authors Colin Kern, qingquan Zhang, Yifan Lu , and Jacqueline Eschbach, and to all collaborators from the Bintu, Zhu, Chi, and Qiu labs for this amazing team effort. Thanks for your diligence, creativity, and hard work on this project. We’re grateful for support from Arc Institute and our generous donors. Our lab is expanding—if you’re excited about building the next generation of single-cell and spatial genomics techniques and predictive single cell and spatial foundation models, we’re hiring! If you are interested, please reach out to me via direct message or email at xiaojie@stanford.edu. We are excited for any potential collaborations along this line of research in Stanford, UCSF and Berkeley and other labs as well.

We’re thrilled to share that our MERFISH+ preprint is now live on bioRxiv!👉 In this work, the Bintu and Zhu labs (UCSD) developed MERFISH+, a next-generation spatial genomics platform that combines genome-wide RNA and epigenetic imaging over a large field of view. By introducing acrydite-modified probes covalently anchored to hydrogels, MERFISH+ achieves remarkable imaging stability and enables >1,800-gene, multi-modal, and multi-month experiments. With this platform, they, together with the Chi lab at UCSD, profiled a whole developing human heart at 12 post-conception week with merely two slides, resulting in a total of 53 slides, 3.1 million single cells and more than 30 cell types. Building upon our previous 3D reconstruction and modeling framework, Spateo ( we reconstruct the 3D human heart that nicely captures the anatomical structure of the heart, including the intricate vasculature network. Sophisticated analyses provide a holistic view of an entire organ and enable systematic characterization of 3D cellular neighborhoods and transcriptional gradients of substructures such as the descending arteries. Furthermore, using a generative integration framework for spatial multimodal data (Spateo-VI), we harmonized these MERFISH+ transcriptomic and chromatin data to reconstruct a 3D spatially-resolved multi-omics atlas of the developing human heart, shared at and MERFISH+ thus sets a new standard for large-format, multi-omic spatial profiling, enabling holistic, 3D characterization of organs at subcellular resolution. Huge congratulations to first authors Colin Kern, qingquan Zhang, Yifan Lu , and Jacqueline Eschbach, and to all collaborators from the Bintu, Zhu, Chi, and Qiu labs for this amazing team effort. Thanks for your diligence, creativity, and hard work on this project. We’re grateful for support from Arc Institute and our generous donors. Our lab is expanding—if you’re excited about building the next generation of single-cell and spatial genomics techniques and predictive single cell and spatial foundation models, we’re hiring! If you are interested, please reach out to me via direct message or email at [email protected]. We are excited for any potential collaborations along this line of research in Stanford, UCSF and Berkeley and other labs as well.

evo-devo

42,289 просмотров • 9 месяцев назад

This is insane. An AI agent can run every boring job in outbound. We spent the last 6 months building ours. Here are my 8 favorite agents to build: Replies get sorted before we open the inbox. Campaigns go live from one command. Weak inboxes pull themselves out before they hurt a domain. Here are the agents behind it: 1. Reply Agent Reads every reply and drafts the response. A human reviews, edits, and sends. 2. Mailbox Health Agent Watches inbox and domain health. It predicts when you need new mailboxes, then buys and warms them. 3. Campaign Optimizer Agent Checks every live campaign every 6 hours. If 500+ leads were emailed and replies are under 4%, it tests new copy, replaces inboxes replying under 1%, and shifts sending to better hours. 4. Lead Qualification Agent Scores each lead by company size, industry, and tech stack. It enriches the record, updates your CRM, and only loads qualified leads into campaigns. High-priority prospect? You get a Slack ping. 5. Meeting Booking Agent Finds meeting requests inside replies. It books the slot, writes prep notes using the lead's background, sends reminders, and logs the outcome. 6. Pipeline Progression Agent Tracks opens, clicks, and website visits. It moves the CRM stage, triggers the next sequence, and creates a task when a lead shows real intent. 7. Copywriting Agent Writes cold emails and follow-ups in the campaign's voice. 8. Analytics Agent Watches campaign metrics in real time and explains what to fix in plain language. We built ours with custom code. Smartlead's SmartAgents let you build agents like these from a plain-English prompt, inside the platform where your campaigns already run. If you repeat an outbound task more than twice a week, that is an agent you have not built yet. Which one would you build first?

This is insane. An AI agent can run every boring job in outbound. We spent the last 6 months building ours. Here are my 8 favorite agents to build: Replies get sorted before we open the inbox. Campaigns go live from one command. Weak inboxes pull themselves out before they hurt a domain. Here are the agents behind it: 1. Reply Agent Reads every reply and drafts the response. A human reviews, edits, and sends. 2. Mailbox Health Agent Watches inbox and domain health. It predicts when you need new mailboxes, then buys and warms them. 3. Campaign Optimizer Agent Checks every live campaign every 6 hours. If 500+ leads were emailed and replies are under 4%, it tests new copy, replaces inboxes replying under 1%, and shifts sending to better hours. 4. Lead Qualification Agent Scores each lead by company size, industry, and tech stack. It enriches the record, updates your CRM, and only loads qualified leads into campaigns. High-priority prospect? You get a Slack ping. 5. Meeting Booking Agent Finds meeting requests inside replies. It books the slot, writes prep notes using the lead's background, sends reminders, and logs the outcome. 6. Pipeline Progression Agent Tracks opens, clicks, and website visits. It moves the CRM stage, triggers the next sequence, and creates a task when a lead shows real intent. 7. Copywriting Agent Writes cold emails and follow-ups in the campaign's voice. 8. Analytics Agent Watches campaign metrics in real time and explains what to fix in plain language. We built ours with custom code. Smartlead's SmartAgents let you build agents like these from a plain-English prompt, inside the platform where your campaigns already run. If you repeat an outbound task more than twice a week, that is an agent you have not built yet. Which one would you build first?

Hosun Chung

156,050 просмотров • 1 месяц назад

New chapter! Context problems. Who can solve these by hand ✍️? Download PDF: The first five: 1. Mark the context: the window as cells you can count 2. What fills the window: the system prompt, the user, the model's reply 3. Turn by turn: every turn is the same block, and most of it is the reply 4. Will it fit? Number a new message into what's left, and see it run out 5. Turns until full: how many rounds before there is no room Previously, I shared Chapter 1: Token Problems 1 ~ 20 Why am I designing these math problems? AI is making people (including me) think less. It's just too easy to ask AI a few questions about a new concept and start to believe I get it. We used to practice on a coding problem, but now AI writes the code, and solving it technically is not the same as knowing anything. So I recast each concept as a simple math problem you have to work with pen and paper. Using our hands is one way to motivate ourselves to start thinking again. ✍️ If you solve them by hand, leave a comment to let me know. I will give you a shout out in my next post. Download, print, solve, and learn. ✍️ ~ Prof. Tom Yeh

New chapter! Context problems. Who can solve these by hand ✍️? Download PDF: The first five: 1. Mark the context: the window as cells you can count 2. What fills the window: the system prompt, the user, the model's reply 3. Turn by turn: every turn is the same block, and most of it is the reply 4. Will it fit? Number a new message into what's left, and see it run out 5. Turns until full: how many rounds before there is no room Previously, I shared Chapter 1: Token Problems 1 ~ 20 Why am I designing these math problems? AI is making people (including me) think less. It's just too easy to ask AI a few questions about a new concept and start to believe I get it. We used to practice on a coding problem, but now AI writes the code, and solving it technically is not the same as knowing anything. So I recast each concept as a simple math problem you have to work with pen and paper. Using our hands is one way to motivate ourselves to start thinking again. ✍️ If you solve them by hand, leave a comment to let me know. I will give you a shout out in my next post. Download, print, solve, and learn. ✍️ ~ Prof. Tom Yeh

Tom Yeh

11,641 просмотров • 18 дней назад

A new way of working. And a scary one at that. Memory Store is one of a group of new kinds of AI-first companies that can turn you into a Fast Company. I’m using several of them on my desktop and they are a dramatically new way to work. It builds a memory for: 1. Your AI agents. 2. Any employee using it. 3. The company itself. I sit down with founder Diwank Singh Tomer, Diwank Singh Tomer, who both freaks me out as well as shows how AI can radically help workers as well as managers. First, why does it freak me out? Well, his AI watches nearly everything a worker does and keeps a “memory” of it. It watches your email. Your calendar. Your Slack. And a whole lot of other things. This can really freak out workers if “forced” on them. And leads to a whole new set of security issues companies need to consider before adopting these things. Such data about a company could give a competitor a HUGE advantage, if leaked. They would know how a company “thinks.” It really is a surveillance system for employees and the company itself. OK, now why would anyone ever use such a thing? Because it gives employees super powers. It makes them more productive. Shows workers a lot of things about themselves, and helps them work and stay on task. It also gives the company super powers. Institutional memory stays with the AI now, even if an employee dies or leaves. As companies move to “AI First” approaches, they will increasingly see the value in companies like Memory Store. It prepares employees for meetings. It helps them remember things. It shows them what they should be working on, and helps them do it. Memory Store builds a memory for: 1. Your agents. 2. Your company. 3. Yourself, or any employee on it. This helps all three work better together. Diwank Singh Tomer and I go in depth about what it does and how deeply it improves working at a company that deploys it. But to get the ultimate benefits you gotta convince your coworkers to use it. And your managers to approve it. Which means you have to get over your fears and get everyone you work with over theirs too. Which will be the challenge for Diwank. Luckily for him his first customers are raving about how good it is and how much his platform helped their companies. Increases sales. Makes teams more productive. Decreases errors and unnecessary costs. Which tells me everyone soon will be using systems like this. This is what the new way of working looks like. Once I got over my fears it sure is an amazing way to work. Will you try working this way?

A new way of working. And a scary one at that. Memory Store is one of a group of new kinds of AI-first companies that can turn you into a Fast Company. I’m using several of them on my desktop and they are a dramatically new way to work. It builds a memory for: 1. Your AI agents. 2. Any employee using it. 3. The company itself. I sit down with founder Diwank Singh Tomer, Diwank Singh Tomer, who both freaks me out as well as shows how AI can radically help workers as well as managers. First, why does it freak me out? Well, his AI watches nearly everything a worker does and keeps a “memory” of it. It watches your email. Your calendar. Your Slack. And a whole lot of other things. This can really freak out workers if “forced” on them. And leads to a whole new set of security issues companies need to consider before adopting these things. Such data about a company could give a competitor a HUGE advantage, if leaked. They would know how a company “thinks.” It really is a surveillance system for employees and the company itself. OK, now why would anyone ever use such a thing? Because it gives employees super powers. It makes them more productive. Shows workers a lot of things about themselves, and helps them work and stay on task. It also gives the company super powers. Institutional memory stays with the AI now, even if an employee dies or leaves. As companies move to “AI First” approaches, they will increasingly see the value in companies like Memory Store. It prepares employees for meetings. It helps them remember things. It shows them what they should be working on, and helps them do it. Memory Store builds a memory for: 1. Your agents. 2. Your company. 3. Yourself, or any employee on it. This helps all three work better together. Diwank Singh Tomer and I go in depth about what it does and how deeply it improves working at a company that deploys it. But to get the ultimate benefits you gotta convince your coworkers to use it. And your managers to approve it. Which means you have to get over your fears and get everyone you work with over theirs too. Which will be the challenge for Diwank. Luckily for him his first customers are raving about how good it is and how much his platform helped their companies. Increases sales. Makes teams more productive. Decreases errors and unnecessary costs. Which tells me everyone soon will be using systems like this. This is what the new way of working looks like. Once I got over my fears it sure is an amazing way to work. Will you try working this way?

Robert Scoble

25,975 просмотров • 3 месяцев назад

Unfortunately, Tonfa sucks in Nioh 3 for me, because Tonfa without Fluxes are half the fun :/ Tonfa really gives its best with Fluxes. They were one of my favorite weapons in Nioh 1 & 2, super fun to play, and now they feel really frustrating 😢 This basically is my almost only main complain about Nioh 3, otherwise it's a 11/10 game for me. The main issue why I simply can't enjoy Tonfa on Nioh 3 is muscle memory. My fingers are so used to do Fluxes 2, they want to do Fluxes 2 — and not being able to do it makes me mad. Especially because Tonfa animations and moveset are still very similar to the previous games, so my body sees the animation and instinctively tries to Flux… but Ninja Style can’t do Fluxes 😭 With weapons like Kusarigama, which got a heavy rework, this problem doesn’t exist: animations are different, so muscle memory doesn’t clash. With Tonfa, instead, everything looks familiar, but a core mechanic is missing. Honestly, they should have either: -heavily reworked Tonfa animations for Ninja Style (for example somthing similar to Ninja Gaiden Tonfa Moveset) or -kept Tonfa in Samurai Style with stances and Fluxes like in Nioh 1 & 2 I don’t want Tonfa to disappear from Ninja Style — some people might enjoy them there — but I really wish Tonfa were available in Samurai Style as well, so everyone could enjoy the weapon in their own way. Please Team NINJA, give us back our beloved Tonfa in Samurai Style too 😭

Unfortunately, Tonfa sucks in Nioh 3 for me, because Tonfa without Fluxes are half the fun :/ Tonfa really gives its best with Fluxes. They were one of my favorite weapons in Nioh 1 & 2, super fun to play, and now they feel really frustrating 😢 This basically is my almost only main complain about Nioh 3, otherwise it's a 11/10 game for me. The main issue why I simply can't enjoy Tonfa on Nioh 3 is muscle memory. My fingers are so used to do Fluxes 2, they want to do Fluxes 2 — and not being able to do it makes me mad. Especially because Tonfa animations and moveset are still very similar to the previous games, so my body sees the animation and instinctively tries to Flux… but Ninja Style can’t do Fluxes 😭 With weapons like Kusarigama, which got a heavy rework, this problem doesn’t exist: animations are different, so muscle memory doesn’t clash. With Tonfa, instead, everything looks familiar, but a core mechanic is missing. Honestly, they should have either: -heavily reworked Tonfa animations for Ninja Style (for example somthing similar to Ninja Gaiden Tonfa Moveset) or -kept Tonfa in Samurai Style with stances and Fluxes like in Nioh 1 & 2 I don’t want Tonfa to disappear from Ninja Style — some people might enjoy them there — but I really wish Tonfa were available in Samurai Style as well, so everyone could enjoy the weapon in their own way. Please Team NINJA, give us back our beloved Tonfa in Samurai Style too 😭

MasterNinjaRyu

35,109 просмотров • 6 месяцев назад

I taught my Primary 2 students magnetic fields, and how they help us determine magnetic north and bearings using a compass. At the later half of the class, the students did a small experiment that used a magnet and compass to test what we learned. This is what Nigeria can take away from this: 1. LANGUAGE: Using Chinese to explain magnetic fields was so easy for them to understand, and took less than 4 mins. They never have to worry about understanding the grammar or remembering new vocabulary if another language was used. Language skill is not for everyone, just like technical and creative skills. While you or your son can learn a new language fast, others might be more technically inclined. Nigeria should use native languages to teach primary school children right from the first day in school. With many native languages, autonomous regions with different official languages will be ideal, with an option for international classes which are more English focused. 2. CURRICULUM: Unless we are really oblivious, there is no way a Nigerian primary 6 student can compete with my primary 2 students. These are kids that first came to our school so tiny and sometimes crying, many of them don’t even know how to write their names. A Nigerian taught them most of what they know today in less than 2 years, and because we have a curriculum that is modern, targets what the students really need to know, and its always modified to reflect their realities, they have acquired so much knowledge about how the world around them works like electricity, engines, space, aerodynamics, mechanics and environmental protection in a short time. What they are learning is directly linked to where their economy is headed, so by the time they are in university, they can easily understand advanced practical and theoretical knowledge and be useful to their economic development after graduation. Our curriculums in Nigeria are old and mostly useless to the growth of our economy, so let’s do the needful. Don’t wait for miracles to change them for you. We must demand this change. 3. GROUP WORK: Students are encouraged to work in groups, divide tasks and roles and they mentored to understand their strengths and challenges and resolve conflicts. They learn to work with others who are different from them, giving them a diverse perspective and mindset about working together. Nigeria cannot succeed without all of us uniting and learning to work with each other, irrespective of tribe, religion, region and family background. When we win as individuals, we will still be surrounded by helpless people, but when we win as a society, everyone develops. 4. TEACHERS: Here in China, we are always happy and encouraged to learn new things and ways to teach our students. We are free from worrying about food, shelter and pocket money. We are paid more than enough, so we have enough time and mental space to throughly research information and knowledge, and also design useful and interesting lessons for our students. Nigerian teachers should be paid a minimum of 800k to 1 million Naira per month. Primary school teachers lay down the crucial foundations for our economic growth, development and future. It is one of the most important professions in the country and the compensation and benefits MUST be more than senators and representatives. Liking, commenting and retweeting are nice because they help spread the message, however what’s more important is us uniting as Nigerians with our common interest to ensure that our needs are addressed.

I taught my Primary 2 students magnetic fields, and how they help us determine magnetic north and bearings using a compass. At the later half of the class, the students did a small experiment that used a magnet and compass to test what we learned. This is what Nigeria can take away from this: 1. LANGUAGE: Using Chinese to explain magnetic fields was so easy for them to understand, and took less than 4 mins. They never have to worry about understanding the grammar or remembering new vocabulary if another language was used. Language skill is not for everyone, just like technical and creative skills. While you or your son can learn a new language fast, others might be more technically inclined. Nigeria should use native languages to teach primary school children right from the first day in school. With many native languages, autonomous regions with different official languages will be ideal, with an option for international classes which are more English focused. 2. CURRICULUM: Unless we are really oblivious, there is no way a Nigerian primary 6 student can compete with my primary 2 students. These are kids that first came to our school so tiny and sometimes crying, many of them don’t even know how to write their names. A Nigerian taught them most of what they know today in less than 2 years, and because we have a curriculum that is modern, targets what the students really need to know, and its always modified to reflect their realities, they have acquired so much knowledge about how the world around them works like electricity, engines, space, aerodynamics, mechanics and environmental protection in a short time. What they are learning is directly linked to where their economy is headed, so by the time they are in university, they can easily understand advanced practical and theoretical knowledge and be useful to their economic development after graduation. Our curriculums in Nigeria are old and mostly useless to the growth of our economy, so let’s do the needful. Don’t wait for miracles to change them for you. We must demand this change. 3. GROUP WORK: Students are encouraged to work in groups, divide tasks and roles and they mentored to understand their strengths and challenges and resolve conflicts. They learn to work with others who are different from them, giving them a diverse perspective and mindset about working together. Nigeria cannot succeed without all of us uniting and learning to work with each other, irrespective of tribe, religion, region and family background. When we win as individuals, we will still be surrounded by helpless people, but when we win as a society, everyone develops. 4. TEACHERS: Here in China, we are always happy and encouraged to learn new things and ways to teach our students. We are free from worrying about food, shelter and pocket money. We are paid more than enough, so we have enough time and mental space to throughly research information and knowledge, and also design useful and interesting lessons for our students. Nigerian teachers should be paid a minimum of 800k to 1 million Naira per month. Primary school teachers lay down the crucial foundations for our economic growth, development and future. It is one of the most important professions in the country and the compensation and benefits MUST be more than senators and representatives. Liking, commenting and retweeting are nice because they help spread the message, however what’s more important is us uniting as Nigerians with our common interest to ensure that our needs are addressed.

Dan Bello

161,014 просмотров • 2 лет назад

Ep. 18 | Free the Money | How to Live Entirely on Crypto in 2026 with Joël Valenzuela Joel Valenzuela from Dash joins me to break down what it really looks like to live entirely on crypto and why is becoming easier than ever. From getting paid in Bitcoin in 2015 to today’s evolving ecosystem, Joël explains how bill pay services, reloadable cards, QR payments, and platforms where users can lend, borrow, and earn yield are making crypto usable in everyday life. Beyond crypto, we explore the Free State Project and why New Hampshire has become a magnet for liberty minded individuals. From policies that support homeschooling to local action creating real change, it reflects a bigger trend described in The Sovereign Individual: in a world where people and capital can move freely, governments must compete to attract them. As individuals and businesses leave high cost, restrictive states like California and New York, places like New Hampshire are positioning themselves as compelling alternatives. At the core is one question: what happens when trust in institutions breaks down? For many, it already has and that’s driving a shift toward choice in money, education, and ultimately where and how you live. Open a Crypto, Gold & Silver IRA with ITrustCapital and get a $100 funding bonus when you use my link below. See why so many people are using tax-advantaged accounts to diversify their future. Joël’s How To Privately Live on Crypto article: 0:00 Joël’s Background 3:05 The Evolution of Crypto Adoption 5:59 The Ultimate Guide to Living Off Crypto 12:59 Why DeFi Is Bigger Than Speculation 15:48 The Self-Custody Problem Holding Crypto Back 19:19 Dash Usernames, Contacts, and Encrypted Payments 23:40 Dash’s Integration with NEAR Intents 28:53 AI Agents, Blockchain Surveillance, & Financial Privacy 33:19 Inside the Free State Project 39:05 The Bill That Could Make New Hampshire #1 for Homeschooling 42:52 The Role in Choice of Education and Governance. Exodus from CA & NY 49:17 Dash Pay Wallet and Dash’s Privacy Upgrade

Ep. 18 | Free the Money | How to Live Entirely on Crypto in 2026 with Joël Valenzuela Joel Valenzuela from Dash joins me to break down what it really looks like to live entirely on crypto and why is becoming easier than ever. From getting paid in Bitcoin in 2015 to today’s evolving ecosystem, Joël explains how bill pay services, reloadable cards, QR payments, and platforms where users can lend, borrow, and earn yield are making crypto usable in everyday life. Beyond crypto, we explore the Free State Project and why New Hampshire has become a magnet for liberty minded individuals. From policies that support homeschooling to local action creating real change, it reflects a bigger trend described in The Sovereign Individual: in a world where people and capital can move freely, governments must compete to attract them. As individuals and businesses leave high cost, restrictive states like California and New York, places like New Hampshire are positioning themselves as compelling alternatives. At the core is one question: what happens when trust in institutions breaks down? For many, it already has and that’s driving a shift toward choice in money, education, and ultimately where and how you live. Open a Crypto, Gold & Silver IRA with ITrustCapital and get a $100 funding bonus when you use my link below. See why so many people are using tax-advantaged accounts to diversify their future. Joël’s How To Privately Live on Crypto article: 0:00 Joël’s Background 3:05 The Evolution of Crypto Adoption 5:59 The Ultimate Guide to Living Off Crypto 12:59 Why DeFi Is Bigger Than Speculation 15:48 The Self-Custody Problem Holding Crypto Back 19:19 Dash Usernames, Contacts, and Encrypted Payments 23:40 Dash’s Integration with NEAR Intents 28:53 AI Agents, Blockchain Surveillance, & Financial Privacy 33:19 Inside the Free State Project 39:05 The Bill That Could Make New Hampshire #1 for Homeschooling 42:52 The Role in Choice of Education and Governance. Exodus from CA & NY 49:17 Dash Pay Wallet and Dash’s Privacy Upgrade

Bri Teresi

46,287 просмотров • 5 месяцев назад

🚨 NEW VEWORLD FEATURE 🚨 Introducing integrated Usernames for your VeWorld wallet, powered by vet.domains! This new function makes interactions in Web3 much more simple, transforming your public address in to a personalised name of your choosing! Not only that, but you claim a free Web2 subdomain, too (eg: 🥳 Why use human readable addresses? - Say goodbye to confusing wallet addresses - Share your a simplified username for simpler interactions! - Stand out in and leverage your identity or brand on-chain. - Avoid errors when receiving funds by using a clear, human-readable name instead of cryptic wallet strings. How to Get Started Open your VeWorld wallet (Note: Live on VeWorld extension, mobile version coming soon). Tap on 'Claim Your Username'. Input your preferred username - if it’s available, it’s yours! Share your new subdomain with the world here on X and make some Web3 frens. Breaking Barriers to Adoption We’re continuing on our mission to transform VeWorld in to a super app-hub - an intuitive and user-friendly experience that caters for beginners and pros alike, exposing them to a new world of Web3 applications. Stay tuned - we'll soon unveil another VeWorld integration that breaks those barriers even further! The future is powered by Web3 🫡

VeChain

23,483 просмотров • 1 год назад

Soccer Headers Damage Brains Even Without Concussions, Large Study Finds | Carly Cassella, ScienceAlert The world's most popular sport is reckoning with serious health concerns. The largest study of its kind has now found that repetitively heading a soccer ball can negatively impact the brain, even in amateur players who don't report concussions. Among 352 amateur adult soccer players, those who took more than a thousand headers a year showed microscopic changes to the outer wrinkles of their brains, right behind their eyes, regardless of their age or sex. These players also performed slightly but significantly worse on memory and learning tests. "What's important about our study is that it shows, really for the first time, that exposure to repeated head impacts causes specific changes in the brain that, in turn, impair cognitive function," explains neuroscientist Michael Lipton at Columbia University. Lipton's lab has been leading research on how soccer heading impacts the brain for over a decade now. Contact sports, like American football, Australian rules football, and rugby, are also contending with the downsides of repetitive head trauma, but in these cases, the discussion is often framed as a concussion crisis typically reserved for professionals. Lipton's research at Columbia University suggests that even mild bumps to the head can add up, and it's not just professional athletes or those who report concussions who are affected. Previous studies by Lipton have shown alterations to white matter among amateur soccer players compared to swimmers. Meanwhile, other studies have found white matter changes even without a history of concussion. But linking these brain changes to clear alterations in cognitive function has proven tricky. Lipton and his team have now developed a novel method that detects damage in the outermost wrinkles of the brain – a tricky spot to study using diffusion magnetic resonance imaging (dMRI). This layer is called the cortical gray matter–white matter interface (GWI), and until recently, not much was known about it. Using their new imaging technique, Lipton and his team scanned the brains of amateur soccer players, who had played for at least five years and within the last six months. Those who said they took more headers showed significant changes in the GWI at the front of their brains – a spot consistent with the trajectory of a soccer ball during a header. The authors suspect that this injury site reflects a contrecoup force – a sort of bruise to the brain that occurs on the opposite side of the skull. Injuries to the GWI may have gone undetected or underestimated in other imaging studies, which is possibly why there are conflicting results on the neurological impact of soccer headers. A graduate student in Lipton's lab, Joan Song, developed a way to characterize what they were seeing in the MRI scans. "In healthy individuals, there's a sharp transition between these tissues," Song explains. "Here, we studied if an attenuation of this transition may occur with minor impacts caused by heading." Sure enough, the boundary between white and grey matter was fuzzier in those who took more headers. "It's very strong evidence that these microstructural changes are likely to be a cause of cognitive deficits," Lipton says. Further investigation is needed, but the findings suggest that the GWI is a good place to image in future studies on soccer heading impacts. It may even be associated with disorders like chronic traumatic encephalopathy (CTE). Read more:

Soccer Headers Damage Brains Even Without Concussions, Large Study Finds | Carly Cassella, ScienceAlert The world's most popular sport is reckoning with serious health concerns. The largest study of its kind has now found that repetitively heading a soccer ball can negatively impact the brain, even in amateur players who don't report concussions. Among 352 amateur adult soccer players, those who took more than a thousand headers a year showed microscopic changes to the outer wrinkles of their brains, right behind their eyes, regardless of their age or sex. These players also performed slightly but significantly worse on memory and learning tests. "What's important about our study is that it shows, really for the first time, that exposure to repeated head impacts causes specific changes in the brain that, in turn, impair cognitive function," explains neuroscientist Michael Lipton at Columbia University. Lipton's lab has been leading research on how soccer heading impacts the brain for over a decade now. Contact sports, like American football, Australian rules football, and rugby, are also contending with the downsides of repetitive head trauma, but in these cases, the discussion is often framed as a concussion crisis typically reserved for professionals. Lipton's research at Columbia University suggests that even mild bumps to the head can add up, and it's not just professional athletes or those who report concussions who are affected. Previous studies by Lipton have shown alterations to white matter among amateur soccer players compared to swimmers. Meanwhile, other studies have found white matter changes even without a history of concussion. But linking these brain changes to clear alterations in cognitive function has proven tricky. Lipton and his team have now developed a novel method that detects damage in the outermost wrinkles of the brain – a tricky spot to study using diffusion magnetic resonance imaging (dMRI). This layer is called the cortical gray matter–white matter interface (GWI), and until recently, not much was known about it. Using their new imaging technique, Lipton and his team scanned the brains of amateur soccer players, who had played for at least five years and within the last six months. Those who said they took more headers showed significant changes in the GWI at the front of their brains – a spot consistent with the trajectory of a soccer ball during a header. The authors suspect that this injury site reflects a contrecoup force – a sort of bruise to the brain that occurs on the opposite side of the skull. Injuries to the GWI may have gone undetected or underestimated in other imaging studies, which is possibly why there are conflicting results on the neurological impact of soccer headers. A graduate student in Lipton's lab, Joan Song, developed a way to characterize what they were seeing in the MRI scans. "In healthy individuals, there's a sharp transition between these tissues," Song explains. "Here, we studied if an attenuation of this transition may occur with minor impacts caused by heading." Sure enough, the boundary between white and grey matter was fuzzier in those who took more headers. "It's very strong evidence that these microstructural changes are likely to be a cause of cognitive deficits," Lipton says. Further investigation is needed, but the findings suggest that the GWI is a good place to image in future studies on soccer heading impacts. It may even be associated with disorders like chronic traumatic encephalopathy (CTE). Read more:

Owen Gregorian

92,909 просмотров • 11 месяцев назад

When I caught Covid, my friends rushed doses of Ivermectin to me — kicked Covid in 24 hours. Here’s a cancer surgeon revealing her discoveries about the impact of Ivermectin on CANCER… 9 min. must see: Also — Compelling Evidence for Ivermectin in Treating Covid: · Front Line COVID-19 Critical Care Alliance Review — This review, which summarized findings from 27 studies, concluded that ivermectin demonstrates a strong signal of therapeutic efficacy against COVID-19. This includes both prevention and treatment aspects. · Meta-Analysis on Ivermectin — A meta-analysis covering 96 studies and over 135,000 patients suggests that ivermectin has shown effectiveness in combating COVID-19. This analysis points towards ivermectin's role in reducing severity and improving health outcomes. · Antiviral Effect Study — A study aimed at assessing the antiviral effect of high-dose ivermectin found it to have an impact on viral load, suggesting its potential in reducing the severity of the disease by decreasing the viral replication. Evidence for Ivermectin in Treating Cancer as summarized by Dr. William Makis, Radiologist, Oncologist, Cancer Researcher. NEW ARTICLE: IVERMECTIN and Protocols for CANCER Ivermectin has a dozen anti-cancer mechanisms but they can be summarized into two main ones: 1. Inhibits cancer proliferation signaling pathways (Akt, mTOR, Wnt) 2. Inhibits Cancer Stem Cells IVERMECTIN will act against regular CANCER as well as Pfizer and Moderna COVID-19 mRNA Vaccine Induced TURBO CANCER (which is highly resistant to chemo) Here are recent studies on IVERMECTIN use in certain types of cancer: BLADDER CANCER - (2024 Fan et al) - Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and DNA Damage LUNG CANCER - (2024 Man-Yuan Li et al) - Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells GLIOMA - (2024 Xing Hu et al) - Ivermectin as a potential therapeutic strategy for glioma MULTIPLE MYELOMA - (2024 Yang Song et al) - Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma OVARIAN CANCER - (2023 Jawad et al) - Ivermectin augments the anti-cancer activity of pitavastatin in ovarian cancer cells PROSTATE CANCER - (2022 Lu et al) - Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer COLON CANCER - (2022, Alghamdi et al) - Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats PANCREATIC CANCER - (2022 Lee et al) - Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction MELANOMA - (2022 Zhang et al) - Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis IVERMECTIN has proven anti-cancer activity against some 20 cancer types, although these are pre-clinical studies. We will never see clinical studies because Ivermectin is off patent and cheap. Merck, which used to have a patent on Ivermectin, has partnered with Moderna on mRNA Cancer Vaccines. IVERMECTIN is so safe, that in much of the civilized world, it is available over the counter, no prescription needed. Ivermectin is annually taken by close to 250 million people.

When I caught Covid, my friends rushed doses of Ivermectin to me — kicked Covid in 24 hours. Here’s a cancer surgeon revealing her discoveries about the impact of Ivermectin on CANCER… 9 min. must see: Also — Compelling Evidence for Ivermectin in Treating Covid: · Front Line COVID-19 Critical Care Alliance Review — This review, which summarized findings from 27 studies, concluded that ivermectin demonstrates a strong signal of therapeutic efficacy against COVID-19. This includes both prevention and treatment aspects. · Meta-Analysis on Ivermectin — A meta-analysis covering 96 studies and over 135,000 patients suggests that ivermectin has shown effectiveness in combating COVID-19. This analysis points towards ivermectin's role in reducing severity and improving health outcomes. · Antiviral Effect Study — A study aimed at assessing the antiviral effect of high-dose ivermectin found it to have an impact on viral load, suggesting its potential in reducing the severity of the disease by decreasing the viral replication. Evidence for Ivermectin in Treating Cancer as summarized by Dr. William Makis, Radiologist, Oncologist, Cancer Researcher. NEW ARTICLE: IVERMECTIN and Protocols for CANCER Ivermectin has a dozen anti-cancer mechanisms but they can be summarized into two main ones: 1. Inhibits cancer proliferation signaling pathways (Akt, mTOR, Wnt) 2. Inhibits Cancer Stem Cells IVERMECTIN will act against regular CANCER as well as Pfizer and Moderna COVID-19 mRNA Vaccine Induced TURBO CANCER (which is highly resistant to chemo) Here are recent studies on IVERMECTIN use in certain types of cancer: BLADDER CANCER - (2024 Fan et al) - Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and DNA Damage LUNG CANCER - (2024 Man-Yuan Li et al) - Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells GLIOMA - (2024 Xing Hu et al) - Ivermectin as a potential therapeutic strategy for glioma MULTIPLE MYELOMA - (2024 Yang Song et al) - Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma OVARIAN CANCER - (2023 Jawad et al) - Ivermectin augments the anti-cancer activity of pitavastatin in ovarian cancer cells PROSTATE CANCER - (2022 Lu et al) - Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer COLON CANCER - (2022, Alghamdi et al) - Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats PANCREATIC CANCER - (2022 Lee et al) - Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction MELANOMA - (2022 Zhang et al) - Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis IVERMECTIN has proven anti-cancer activity against some 20 cancer types, although these are pre-clinical studies. We will never see clinical studies because Ivermectin is off patent and cheap. Merck, which used to have a patent on Ivermectin, has partnered with Moderna on mRNA Cancer Vaccines. IVERMECTIN is so safe, that in much of the civilized world, it is available over the counter, no prescription needed. Ivermectin is annually taken by close to 250 million people.

Bobby

160,046 просмотров • 1 год назад

🔬 Exciting News! Our manuscript, "scGPT: toward building a foundation model for single-cell multi-omics using generative AI" is now finally published in Nature Methods (Nature Methods) 🎉 !!! (Re-)Introducing scGPT: A transformative foundation model engineered for single-cell omics analysis. Developed through the analysis of over 33 million human cells, scGPT sets a new benchmark for application versatility, offering both fine-tuning and zero-shot capabilities. Since its preprint in May 2023, scGPT has significantly impacted the field, evidenced by 13K+ installations, 600+ GitHub stars 🌟, and 40+ citations before its official publication! scGPT has been validated by numerous benchmark studies as a leading foundation model in single-cell analysis. Its pre-trained embeddings extend its utility beyond single-cell studies, enhancing a variety of downstream tasks including protein enrichment and genetic perturbation predictions. Some key updates lately: ---Expanded zero-shot applications for efficient reference mapping and integration, now with CellXGene census integration. ---Advanced perturbation analysis capabilities, including genome-scale perturb-seq data analysis and bulk sequencing data generalization. ---Upgraded scGPT package, offering versatile model loading compatible with PyTorch and flash-attn, for both GPU and CPU. ---Cloud-based scGPT applications for reference mapping, cell annotation, and gene regulatory network inference are available on ---Integration with Hugging Face for easier model training. Limitations: scGPT is an early foray into foundation models for single-cell omics, facing challenges like limited zero-shot learning in some tasks, pretraining constraints, data quality issues, and evaluation limitations. See our Supplementary Notes for details. 🚀 Future Work? Short-Term Goals: 1. Releasing a Mouse Model for broader analysis. 2. Developing a comprehensive evaluation suite for foundation models in single-cell analysis. 3. Creating a foundation model for single-cell spatial omics. 4. Enhancing zero-shot capacity by integrating scGPT with RAG (e.g., knowledge graphs). Long-Term Goals: 1. Expanding scGPT for comprehensive single-cell multi-omics analysis. 2. Developing an in-silico perturbation model for predicting genetic perturbation effects. 3. Merging scGPT with multi-modal genomic sequence models for a deeper understanding of cell biology. 📚 Access the paper on Nature Methods: 🔬Preprint in Bioarixv: 💻 All our codes/data/weights are open source: Wholehearted congratulations to all the authors, especially the two co-first authors, Haotian (Haotian Cui ) and Chloe (ChloeXWang), who are really the emerging superstars in AI and biology! Vector Institute Peter Munk Cardiac Centre AI U of T Department of Computer Science Department of Laboratory Medicine & Pathobiology University Health Network University of Toronto #scGPT #GenerativeAI #AI4Science #Combio #opensource

🔬 Exciting News! Our manuscript, "scGPT: toward building a foundation model for single-cell multi-omics using generative AI" is now finally published in Nature Methods (Nature Methods) 🎉 !!! (Re-)Introducing scGPT: A transformative foundation model engineered for single-cell omics analysis. Developed through the analysis of over 33 million human cells, scGPT sets a new benchmark for application versatility, offering both fine-tuning and zero-shot capabilities. Since its preprint in May 2023, scGPT has significantly impacted the field, evidenced by 13K+ installations, 600+ GitHub stars 🌟, and 40+ citations before its official publication! scGPT has been validated by numerous benchmark studies as a leading foundation model in single-cell analysis. Its pre-trained embeddings extend its utility beyond single-cell studies, enhancing a variety of downstream tasks including protein enrichment and genetic perturbation predictions. Some key updates lately: ---Expanded zero-shot applications for efficient reference mapping and integration, now with CellXGene census integration. ---Advanced perturbation analysis capabilities, including genome-scale perturb-seq data analysis and bulk sequencing data generalization. ---Upgraded scGPT package, offering versatile model loading compatible with PyTorch and flash-attn, for both GPU and CPU. ---Cloud-based scGPT applications for reference mapping, cell annotation, and gene regulatory network inference are available on ---Integration with Hugging Face for easier model training. Limitations: scGPT is an early foray into foundation models for single-cell omics, facing challenges like limited zero-shot learning in some tasks, pretraining constraints, data quality issues, and evaluation limitations. See our Supplementary Notes for details. 🚀 Future Work? Short-Term Goals: 1. Releasing a Mouse Model for broader analysis. 2. Developing a comprehensive evaluation suite for foundation models in single-cell analysis. 3. Creating a foundation model for single-cell spatial omics. 4. Enhancing zero-shot capacity by integrating scGPT with RAG (e.g., knowledge graphs). Long-Term Goals: 1. Expanding scGPT for comprehensive single-cell multi-omics analysis. 2. Developing an in-silico perturbation model for predicting genetic perturbation effects. 3. Merging scGPT with multi-modal genomic sequence models for a deeper understanding of cell biology. 📚 Access the paper on Nature Methods: 🔬Preprint in Bioarixv: 💻 All our codes/data/weights are open source: Wholehearted congratulations to all the authors, especially the two co-first authors, Haotian (Haotian Cui ) and Chloe (ChloeXWang), who are really the emerging superstars in AI and biology! Vector Institute Peter Munk Cardiac Centre AI U of T Department of Computer Science Department of Laboratory Medicine & Pathobiology University Health Network University of Toronto #scGPT #GenerativeAI #AI4Science #Combio #opensource

Bo Wang

199,747 просмотров • 2 лет назад

First impressions on Muse Glimmer! It's incredibly fast for a dense model, currently running an average of 208tps with a max of 274tps on a single 5090 with their DFLASH config. Comparatively, though, both using Open Code, Qwopus Coder (with thinking off) produced a much better shark survival game than the one I got from Glimmer. Meta's new dense model is currently just lacking some HTML canvas taste, but this is something that can be added via SFT as long as the model is stable and capable from a back-end programming perspective. And it seems to be, without a doubt. The big kicker here is that I ran this at extra high thinking, and it did not take long at all to run. Our current local leader, Qwen 27B 3.6, has a tendency to overthink, but with glimmer, that is not the case. Right now, my recommendation for general local programming (Apps, Games, Websites, Visual Tools) in this class is still Qwopus Coder with thinking disabled, or Qwopus Fusion with thinking enabled. Of course Shark Survival is a very basic domain-specific test, but I find that the result scales very well across many domains. If we're going to be shipping apps generated entirely locally, visual taste is somewhat of a bare minimum requirement, solely in my opinion, and Qwen's models in this class offer significantly more at the moment. That's actually why I initially started getting into finetuning with Qwen 3.5, they were the first base that was able to do really good front-end with some opus-trace fine-tuning. Qwen 3.6 has taste even in the base model, and we know Qwen 3.8 is going to blow us all away! Regardless, this looks like a very tempting new base model. As a first offering from Meta in this class for a long time, I am incredibly impressed and elated to have it. We now finally have a proper Single GPU frontier race, instead of us just begging Qwen for more releases. Single GPU open frontier model race is a VERY good thing. Please keep pushing Meta

First impressions on Muse Glimmer! It's incredibly fast for a dense model, currently running an average of 208tps with a max of 274tps on a single 5090 with their DFLASH config. Comparatively, though, both using Open Code, Qwopus Coder (with thinking off) produced a much better shark survival game than the one I got from Glimmer. Meta's new dense model is currently just lacking some HTML canvas taste, but this is something that can be added via SFT as long as the model is stable and capable from a back-end programming perspective. And it seems to be, without a doubt. The big kicker here is that I ran this at extra high thinking, and it did not take long at all to run. Our current local leader, Qwen 27B 3.6, has a tendency to overthink, but with glimmer, that is not the case. Right now, my recommendation for general local programming (Apps, Games, Websites, Visual Tools) in this class is still Qwopus Coder with thinking disabled, or Qwopus Fusion with thinking enabled. Of course Shark Survival is a very basic domain-specific test, but I find that the result scales very well across many domains. If we're going to be shipping apps generated entirely locally, visual taste is somewhat of a bare minimum requirement, solely in my opinion, and Qwen's models in this class offer significantly more at the moment. That's actually why I initially started getting into finetuning with Qwen 3.5, they were the first base that was able to do really good front-end with some opus-trace fine-tuning. Qwen 3.6 has taste even in the base model, and we know Qwen 3.8 is going to blow us all away! Regardless, this looks like a very tempting new base model. As a first offering from Meta in this class for a long time, I am incredibly impressed and elated to have it. We now finally have a proper Single GPU frontier race, instead of us just begging Qwen for more releases. Single GPU open frontier model race is a VERY good thing. Please keep pushing Meta

Kyle Hessling

17,399 просмотров • 19 дней назад

I've started this private fundraiser to support our Kharkiv team, but it's not moving too well. We have only raised $1,000 out of our $12,000 goal. Please watch the video to understand the conditions these fellas are facing and donate if you can (donation link at the end). Now let me explain why it's important. We have a small team in #Kharkiv that operates a warehouse, a repair workshop for engineering equipment, a machining shop for making parts, and a welding station for making anti-drone protective cages. My brother, vaycartana, has been running it for more than 20 years. My brother-in-law, Danya, was helping produce the anti-drone metal cages; however, he was mobilized to the National Guard 3 weeks ago, so we are now short one worker. Additionally, our main welder, my good friend Tolya, recently cut his arm tendon while using an angle grinder tool and is now recovering. They are working 12-hour shifts under tremendous stress and daily bombardments, repairing excavators, welding cages, and producing parts for our defenders. As you can see, the conditions are really harsh. The roof is leaking, the floors are rough, and daily bombings and a lack of personnel keep them struggling. The least I could do is run a fundraiser to fix and insulate their roof and install concrete, safe floors that can handle the excavators, to keep them warm and safe, especially during the winter. Their work saves millions of dollars of equipment and countless lives of Ukrainian defenders. The warehouse logistics they provide have always been free. The excavators we buy and repair save hundreds of thousands of dollars (new ones cost $100,000+), and the shelters built with these excavators save Ukrainian lives and allow our defenses to hold. 🔗Donation link to support our Kharkiv team:

I've started this private fundraiser to support our Kharkiv team, but it's not moving too well. We have only raised $1,000 out of our $12,000 goal. Please watch the video to understand the conditions these fellas are facing and donate if you can (donation link at the end). Now let me explain why it's important. We have a small team in #Kharkiv that operates a warehouse, a repair workshop for engineering equipment, a machining shop for making parts, and a welding station for making anti-drone protective cages. My brother, vaycartana, has been running it for more than 20 years. My brother-in-law, Danya, was helping produce the anti-drone metal cages; however, he was mobilized to the National Guard 3 weeks ago, so we are now short one worker. Additionally, our main welder, my good friend Tolya, recently cut his arm tendon while using an angle grinder tool and is now recovering. They are working 12-hour shifts under tremendous stress and daily bombardments, repairing excavators, welding cages, and producing parts for our defenders. As you can see, the conditions are really harsh. The roof is leaking, the floors are rough, and daily bombings and a lack of personnel keep them struggling. The least I could do is run a fundraiser to fix and insulate their roof and install concrete, safe floors that can handle the excavators, to keep them warm and safe, especially during the winter. Their work saves millions of dollars of equipment and countless lives of Ukrainian defenders. The warehouse logistics they provide have always been free. The excavators we buy and repair save hundreds of thousands of dollars (new ones cost $100,000+), and the shelters built with these excavators save Ukrainian lives and allow our defenses to hold. 🔗Donation link to support our Kharkiv team:

✙ Constantine ✙

198,535 просмотров • 2 лет назад

Daniel reveals how he bought his $220,000 dream G Wagon with kids channel on YouTube Jack: “What's the craziest way you've made money on YouTube?” Daniel: “I just wrapped up running a channel around like 3 weeks ago for a new YouTube video I made. Essentially, the YouTube video was getting one subscriber equals $1 I can spend on my dream car. And so, I needed to get 220,000 subscribers to buy my dream car, which was a G Wagon for $220,000.” Daniel: “Basically, I ran this channel called Verusi. The videos were kids videos, and we would take these Russian creators' videos, they would make like really funny skits for like 5 year olds and we would put a voice over over them pretty much documenting what was going on in the video in the most 2 year old voice possible with the most simple wording possible.” Daniel: “I bought a pre monetized channel, which essentially meant that I bought the channel with already monetization enabled so that from the first video, we could generate revenue. Second video, 5 million views. Third video, 4 million views.” Daniel: “In the middle of the video, we would abruptly stop and we would be like, 'Subscribe if you want a pizza, like if you want a tomato, comment if you want an apple, and do all if you want your family to like live forever or some shit like that.' It was like really, really, really like brain rot, but it worked so well. We were getting like 100,000 subscribers a week.” Daniel: “I essentially realized that little kids don't have their own devices. They use their parents' devices to watch content. And so when a little kid is using their parents' device to watch a video, their parent is registered as a 30 or 40 year old. And so our entire audience demographic was 80% USA 40 year old viewers. And YouTube would essentially think that these are high trust advertisers.” Daniel: “We essentially tricked YouTube because getting kids to watch videos is super easy. It's not that hard. And our RPM was like 35 cents per video. And in the first week of that channel, we made $4,000. We paid an editor, I promise you, $5 per video. So, for a week, we uploaded seven videos. It costed us 35 bucks and we made $3,000 in our first week and got 150,000 subscribers.” Daniel: “I basically got 220,000 subscribers for the video, bought my car, and in the process made like $6,000 on that channel.”

Daniel reveals how he bought his $220,000 dream G Wagon with kids channel on YouTube Jack: “What's the craziest way you've made money on YouTube?” Daniel: “I just wrapped up running a channel around like 3 weeks ago for a new YouTube video I made. Essentially, the YouTube video was getting one subscriber equals $1 I can spend on my dream car. And so, I needed to get 220,000 subscribers to buy my dream car, which was a G Wagon for $220,000.” Daniel: “Basically, I ran this channel called Verusi. The videos were kids videos, and we would take these Russian creators' videos, they would make like really funny skits for like 5 year olds and we would put a voice over over them pretty much documenting what was going on in the video in the most 2 year old voice possible with the most simple wording possible.” Daniel: “I bought a pre monetized channel, which essentially meant that I bought the channel with already monetization enabled so that from the first video, we could generate revenue. Second video, 5 million views. Third video, 4 million views.” Daniel: “In the middle of the video, we would abruptly stop and we would be like, 'Subscribe if you want a pizza, like if you want a tomato, comment if you want an apple, and do all if you want your family to like live forever or some shit like that.' It was like really, really, really like brain rot, but it worked so well. We were getting like 100,000 subscribers a week.” Daniel: “I essentially realized that little kids don't have their own devices. They use their parents' devices to watch content. And so when a little kid is using their parents' device to watch a video, their parent is registered as a 30 or 40 year old. And so our entire audience demographic was 80% USA 40 year old viewers. And YouTube would essentially think that these are high trust advertisers.” Daniel: “We essentially tricked YouTube because getting kids to watch videos is super easy. It's not that hard. And our RPM was like 35 cents per video. And in the first week of that channel, we made $4,000. We paid an editor, I promise you, $5 per video. So, for a week, we uploaded seven videos. It costed us 35 bucks and we made $3,000 in our first week and got 150,000 subscribers.” Daniel: “I basically got 220,000 subscribers for the video, bought my car, and in the process made like $6,000 on that channel.”

Hribi

387,105 просмотров • 2 месяцев назад

For anyone dealing with cancer(s)... Here are a few helpful tips: 1st, don't have them "test" the tumor. Tumors are the body's way of protecting us from allowing the CA cells to traverse the body and mutate healthy cells. Once it's punctured for "testing", the cells travel and the beasties cause more issues. (Why not right? It's a $ making racquet.) 1A. CANCER IS A PARASITE. Start the Ivermectin (dosage 1am1 pm by bodyweight) & Fenbendazole (dosage 1 222mg pill/day for 6 days, skip the 7th to let the renal system rest). 2nd, STOP ALL SUGARS. CA loves sugar in ALL FORMS. 3rd, HYDROGEN PEROXIDE: H202 has the extra Oxygen molecule that CA can't stand. Put it on a cotton ball, or wash cloth for larger areas and rub all over skin. 3x/day, more-so when you're out of the bath & shower, as your pores are open and more apt to getting it into the bloodstream. The skin absorbs the HP, and kills the CA cells almost immediately. 4th, ALKALINE WATER: CA can't survive in an alkaline body. Start drinking alkaline water w/ lemon consistently thru the day. Lemon is an acid outside of the body, but the hydrochloric acid in your stomach converts it to an alkaline base. This travels through your blood stream and will help to eradicate the crud. 5th, DETOX BATHS: 1 cup Baking Soda, 1 Cup Borax, 1 Cup Epsom Salt, & Bentonite Clay. Draw the hottest bath you can muster... Soak as long as you can, as hot as you can, and it will help to detox the CA and the nano-particulates (gr@phine oxide), out of the body. Do this at least 2-3x a week. 6th, The BIG BOMBER: VITAMIN B17 which NO ONE wants ANYONE to know about! Apple seeds, Apricot, Peach, & Plum Pits, - ALL of it! You can get them on Cabalazon, or any other place online. The B17 vitamin has been removed from our knowledge, because: BIG pHARMa. 1/4teaspoon a day of the powder, or just eating a couple apricot pits thru the day, (like 3 or 4), will also eradicate the CA. I really hate the fact that non-suspecting people are dealing w/ all the bioweapon B.S. The turbo cancers are all a part of it. .. We have LEGIT CURES now. There's no longer a need for Chemo and Radiation which do nothing more than kill the good tissue. 9/10, the patient passes from chemo & radiation poisoning than the actual cancer. Before BIG pHARMa, CA patients were given 2 large bottles of peroxide, and a bag of cotton balls and told to use it daily and return in 2 weeks to find 100% of it was cured.

For anyone dealing with cancer(s)... Here are a few helpful tips: 1st, don't have them "test" the tumor. Tumors are the body's way of protecting us from allowing the CA cells to traverse the body and mutate healthy cells. Once it's punctured for "testing", the cells travel and the beasties cause more issues. (Why not right? It's a $ making racquet.) 1A. CANCER IS A PARASITE. Start the Ivermectin (dosage 1am1 pm by bodyweight) & Fenbendazole (dosage 1 222mg pill/day for 6 days, skip the 7th to let the renal system rest). 2nd, STOP ALL SUGARS. CA loves sugar in ALL FORMS. 3rd, HYDROGEN PEROXIDE: H202 has the extra Oxygen molecule that CA can't stand. Put it on a cotton ball, or wash cloth for larger areas and rub all over skin. 3x/day, more-so when you're out of the bath & shower, as your pores are open and more apt to getting it into the bloodstream. The skin absorbs the HP, and kills the CA cells almost immediately. 4th, ALKALINE WATER: CA can't survive in an alkaline body. Start drinking alkaline water w/ lemon consistently thru the day. Lemon is an acid outside of the body, but the hydrochloric acid in your stomach converts it to an alkaline base. This travels through your blood stream and will help to eradicate the crud. 5th, DETOX BATHS: 1 cup Baking Soda, 1 Cup Borax, 1 Cup Epsom Salt, & Bentonite Clay. Draw the hottest bath you can muster... Soak as long as you can, as hot as you can, and it will help to detox the CA and the nano-particulates (gr@phine oxide), out of the body. Do this at least 2-3x a week. 6th, The BIG BOMBER: VITAMIN B17 which NO ONE wants ANYONE to know about! Apple seeds, Apricot, Peach, & Plum Pits, - ALL of it! You can get them on Cabalazon, or any other place online. The B17 vitamin has been removed from our knowledge, because: BIG pHARMa. 1/4teaspoon a day of the powder, or just eating a couple apricot pits thru the day, (like 3 or 4), will also eradicate the CA. I really hate the fact that non-suspecting people are dealing w/ all the bioweapon B.S. The turbo cancers are all a part of it. .. We have LEGIT CURES now. There's no longer a need for Chemo and Radiation which do nothing more than kill the good tissue. 9/10, the patient passes from chemo & radiation poisoning than the actual cancer. Before BIG pHARMa, CA patients were given 2 large bottles of peroxide, and a bag of cotton balls and told to use it daily and return in 2 weeks to find 100% of it was cured.

Tp

572,459 просмотров • 2 лет назад

wanted to share our first public demo of Aligned wallet as a service. our engineering team has been doing an incredible job. really proud of how fast we’re building this. this is a key product for us. it’s how we help partners like Sovra – The Identity Stack onboard millions of users in a seamless and secure way. still work to do, but we’re on the right path. here’s the demo: 1. sign in with google 2. create a wallet with touch id passkey saved to icloud 3. send usdt on chain signed with your fingerprint 4. open on a new device 5. send another tx immediately how we’re building it: - 2 of 2 multisig where user passkey and server co sign every transaction - erc 4337 account abstraction - auth via google + webauthn passkeys. - passkeys sync across devices via icloud keychain or google password manager - server guardian recovery with timelock + mfa still under development: censorship resistance allowing users to retrieve their encrypted server key independently using their device key + mfa so no one can block access to their wallet we will be sharing more demos in the future and a full blog post explaining the architecture and design decisions.

wanted to share our first public demo of Aligned wallet as a service. our engineering team has been doing an incredible job. really proud of how fast we’re building this. this is a key product for us. it’s how we help partners like Sovra – The Identity Stack onboard millions of users in a seamless and secure way. still work to do, but we’re on the right path. here’s the demo: 1. sign in with google 2. create a wallet with touch id passkey saved to icloud 3. send usdt on chain signed with your fingerprint 4. open on a new device 5. send another tx immediately how we’re building it: - 2 of 2 multisig where user passkey and server co sign every transaction - erc 4337 account abstraction - auth via google + webauthn passkeys. - passkeys sync across devices via icloud keychain or google password manager - server guardian recovery with timelock + mfa still under development: censorship resistance allowing users to retrieve their encrypted server key independently using their device key + mfa so no one can block access to their wallet we will be sharing more demos in the future and a full blog post explaining the architecture and design decisions.

RJ 🟩

55,324 просмотров • 6 месяцев назад