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It’s absolutely criminal when doctors don’t fully inform patients about the downstream effects of taking cholesterol blocking drugs. Dr. Stephen Hussey, DC explains how these drugs can interrupt basic biological processes.

48,583 views • 7 months ago •via X (Twitter)

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New episode of HARD DRUGS! Should everyone be taking statins? Statins have revolutionised heart disease and they're one of many reasons for the long-term decline in cardiovascular mortality. Clinical trials suggest that the more you reduce LDL cholesterol levels, the more you reduce the risks of heart attacks and strokes, with no signal of harms even at the lowest levels. So scientists recommend the earlier they're taken the better, and the lower LDL levels you reach the better. Statins do have some rare side effects – such as muscle weakness and muscle loss in rare cases – but meta-analyses of RCTs find that most other side effects listed on statins' labels do not actually have higher risks than placebo. In this episode, Jacob Trefethen and I chat about all this and much more! - Why it took almost a century for scientists to come to consensus on "the lipid hypothesis": that higher levels of plasma LDL cholesterol causes higher risks of heart disease and that reducing it saves lives. - Drugs that effectively reduce cholesterol levels beyond the effect of statins, such as PCSK9 inhibitors, most of which are monoclonal antibodies, as well as newer siRNA drugs and the macrocyclic peptide enlicitide, which recently completed phase 3 trials, and Lp(a) drugs. - What the future holds for cholesterol drugs Timestamps: 0:00:00 Introduction 13:35 The decline in heart disease mortality 31:02 Surprising cholesterol trivia 55:40 The lipid hypothesis: 7 lines of evidence for the harms of LDL cholesterol 1:22:15 How cholesterol works 1:30:40 The discovery of statins 1:48:44 Should everyone be on statins? 1:57:10 PCSK9 drugs and beyond 2:22:56 Summary: how we got here and the future of cholesterol drugs Watch, listen, or read wherever you get your podcasts. Spotify: Apple: YouTube: Transcript:

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Dr. Aseem Malhotra exposes statins: A 1% benefit with hidden costs—time for informed consent Dr. Aseem Malhotra, a renowned cardiologist, has raised critical concerns about statins, one of the most prescribed drugs globally, with 30 million users in the U.S. and up to a billion worldwide. In a recent discussion, he unpacked the shocking truth about their efficacy, urging patients to question the widespread use of these cholesterol-lowering medications. Drawing from industry-sponsored trial data, Dr. Malhotra highlights that for most people—those not at high risk of heart attack—taking a statin daily for five years offers just a 1% chance of preventing a non-fatal heart attack or non-disabling stroke. Critically, this comes with no evidence of prolonging life by even a single day. He emphasizes that this information, available at is rarely communicated to patients due to systemic gaps in medical training, where doctors are not taught to interpret and convey such data effectively. Dr. Malhotra advocates for informed consent, presenting patients with these facts without coercion. Many, he notes, are dismayed by the minimal benefit when weighed against potential side effects, which affect 20-50% of users. These include muscle pain, fatigue, brain fog, erectile dysfunction, joint pain, and stomach issues. Strikingly, he has witnessed elderly patients misdiagnosed with dementia or frailty regain memory and vitality weeks after discontinuing statins. This is not a call to stop medication abruptly, but a plea for patients to engage in informed discussions with their doctors. Dr. Malhotra’s book, A Statin-Free Life, available on Amazon, delves deeper into these findings, offering a comprehensive resource for those seeking clarity on cholesterol management and drug benefits. For evidence-based insights on statins and other medications, visit Dr. Malhotra’s mission is clear: empower patients with knowledge to make health decisions that align with their values and quality of life.

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