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Mark Zuckerberg and Priscilla Chan say virtual cells could change how science takes risk, letting researchers test bold ideas in simulation before entering the wet lab. “The promise of being able to do virtual biology… is you can actually take on riskier ideas.” “If you had a virtual cell... show more

a16z

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44,009 views • 8 months ago •via X (Twitter)

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How Mark Zuckerberg Will Defeat Aging Mark Zuckerberg is betting on virtual cell models. The shift is radical. Not biologists using AI, but AI that truly understands biology and leads discovery. Risky ideas move from slow, expensive wet labs to fast, cheap simulations. That’s how stopping aging stops being science fiction and starts becoming an engineering problem.

How Mark Zuckerberg Will Defeat Aging Mark Zuckerberg is betting on virtual cell models. The shift is radical. Not biologists using AI, but AI that truly understands biology and leads discovery. Risky ideas move from slow, expensive wet labs to fast, cheap simulations. That’s how stopping aging stops being science fiction and starts becoming an engineering problem.

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JUST IN – Fauci Now Says A Lab Leak Could Still Be Considered As Coming From Natural Origins "A lab leak could be that someone was out in the wild maybe looking for different types of viruses in bats, got infected, went into a lab, and was being studied in a lab, and then came out of the lab. But if that's the definition of lab leak, then that's still a natural occurrence. The other possibility is someone takes a virus from the environment that doesn't actually spread very well in humans, and manipulates it a bit, and accidentally it escapes or accidentally infects someone and then you get an outbreak."

JUST IN – Fauci Now Says A Lab Leak Could Still Be Considered As Coming From Natural Origins "A lab leak could be that someone was out in the wild maybe looking for different types of viruses in bats, got infected, went into a lab, and was being studied in a lab, and then came out of the lab. But if that's the definition of lab leak, then that's still a natural occurrence. The other possibility is someone takes a virus from the environment that doesn't actually spread very well in humans, and manipulates it a bit, and accidentally it escapes or accidentally infects someone and then you get an outbreak."

Chief Nerd

4,410,104 views • 3 years ago

FROM THE LIVE SHOW: Dr. Derya Unutmaz (Derya Unutmaz, MD), Professor at The Jackson Laboratory (The Jackson Laboratory), on the future of simulating biology with AI. “Virtual cells could save researchers years of work. The goal is a complete biological cell in silico, where we can run experiments using AI. We’ll need massive amounts of data and compute — and today, we still don’t have enough. But I’m sure we’ll get there.”

FROM THE LIVE SHOW: Dr. Derya Unutmaz (Derya Unutmaz, MD), Professor at The Jackson Laboratory (The Jackson Laboratory), on the future of simulating biology with AI. “Virtual cells could save researchers years of work. The goal is a complete biological cell in silico, where we can run experiments using AI. We’ll need massive amounts of data and compute — and today, we still don’t have enough. But I’m sure we’ll get there.”

Forward Future

24,228 views • 10 months ago

Retired Lt. Gen. Keith Kellogg: "You put your soldiers in the mud and you actually say, 'we're going to take something that's valuable to you', and we take land. Is their risk involved? Of course there is. Does it mean we could have casualties? Of course there are. But this actually finishes the job."

Retired Lt. Gen. Keith Kellogg: "You put your soldiers in the mud and you actually say, 'we're going to take something that's valuable to you', and we take land. Is their risk involved? Of course there is. Does it mean we could have casualties? Of course there are. But this actually finishes the job."

NEWSMAX

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.Marc Andreessen 🇺🇸: "The person who writes down the thing has tremendous power." "There are so few people who will just like write down the thing. And so we see this at companies all the time, which is, one of the ways you find the up-and-comers at a tech company is just, okay, who wrote down the plan? And, you know, that doesn't mean they came up with everything. And that doesn't mean that they had all the ideas, but they're actually able to organize their thoughts and then actually have the energy and the motivation and the skill to be able to communicate in a written form. That actually stands out." With David Perell

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a16z

166,936 views • 3 months ago

I slowed it down so you can see “Benjamin Netanyahu” sip the coffee. Please analyze the before and after Grok and tell us if there is actually less coffee in the cup after he takes “a sip” 👀

I slowed it down so you can see “Benjamin Netanyahu” sip the coffee. Please analyze the before and after Grok and tell us if there is actually less coffee in the cup after he takes “a sip” 👀

The AI Robot Guy on X

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$You could actually 3d model and texture this yourself in a fraction of the time$

You could actually 3d model and texture this yourself in a fraction of the time

Michael

89,606 views • 3 months ago

Priscilla Chan and Mark Zuckerberg on Curing All Disease We sat down with Dr. Priscilla Chan and Mark Zuckerberg, co-founders of the Chan Zuckerberg Initiative, to discuss their ambitious plan to cure, prevent, and manage all disease by the end of the century. CZI’s Biohub aims to generate vast biological datasets to train new frontier AI models to guide scientists in the lab, creating a feedback loop to accelerate the pace of basic science and take us towards a world without disease. 00:00 Introduction 03:42 Building tools to accelerate scientific discovery 07:03 Biohub = Frontier Biology + Frontier AI 13:32 "Most diseases should be thought of as rare diseases” 15:39 Inspiration: building a periodic table for biology 19:27 Why virtual cells? 21:17 The Biohub master plan 33:36 The importance of interface design in democratizing scientific discovery 35:34 How Biohub encourages cross-functional collaboration 40:38 Looking ahead: the broader impact of AI on biotech benahorowitz.eth Vineeta Agarwala Erik Torenberg

Priscilla Chan and Mark Zuckerberg on Curing All Disease We sat down with Dr. Priscilla Chan and Mark Zuckerberg, co-founders of the Chan Zuckerberg Initiative, to discuss their ambitious plan to cure, prevent, and manage all disease by the end of the century. CZI’s Biohub aims to generate vast biological datasets to train new frontier AI models to guide scientists in the lab, creating a feedback loop to accelerate the pace of basic science and take us towards a world without disease. 00:00 Introduction 03:42 Building tools to accelerate scientific discovery 07:03 Biohub = Frontier Biology + Frontier AI 13:32 "Most diseases should be thought of as rare diseases” 15:39 Inspiration: building a periodic table for biology 19:27 Why virtual cells? 21:17 The Biohub master plan 33:36 The importance of interface design in democratizing scientific discovery 35:34 How Biohub encourages cross-functional collaboration 40:38 Looking ahead: the broader impact of AI on biotech benahorowitz.eth Vineeta Agarwala Erik Torenberg

a16z

377,035 views • 8 months ago

Marc Andreessen on why the founder model keeps winning: "You're much more likely to build something important in the 21st century if you start with a founder and train them on management, than you are to start with the manager and try to train them on being a founder." "All the old incumbent institutions in the last hundred years that are run by managers... they're all collapsing in trust and credibility because they can't adapt." "When Mark [Zuckerberg] started Facebook, he had never had a job before. Not only had he not managed people, he had not worked for anybody." "His learning curve was vertical." "He spends an enormous amount of time learning how to become better at running these things at large scale. He's still the founder and he's still the innovator and he's still like a fountain of ideas on what to do." "He's the classic example of the double threat." "And then what happens is other founders look at that and they're like, 'oh, I could do that.'" Marc Andreessen 🇺🇸 with David Senra

Marc Andreessen on why the founder model keeps winning: "You're much more likely to build something important in the 21st century if you start with a founder and train them on management, than you are to start with the manager and try to train them on being a founder." "All the old incumbent institutions in the last hundred years that are run by managers... they're all collapsing in trust and credibility because they can't adapt." "When Mark [Zuckerberg] started Facebook, he had never had a job before. Not only had he not managed people, he had not worked for anybody." "His learning curve was vertical." "He spends an enormous amount of time learning how to become better at running these things at large scale. He's still the founder and he's still the innovator and he's still like a fountain of ideas on what to do." "He's the classic example of the double threat." "And then what happens is other founders look at that and they're like, 'oh, I could do that.'" Marc Andreessen 🇺🇸 with David Senra

a16z

52,867 views • 4 months ago

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a16z

17,094 views • 3 months ago

Kalshi CEO Tarek Mansour: “The core unlock that could happen with prediction markets is if you forecast the future better, you are pricing risk.” “If you can price risk, then you can make better decisions about the risk.” “And then also you can transfer it, you can hedge. And I think that's where the market really, really becomes very, very large.” Source: Tarek Mansour (CEO Kalshi) with Molly O’Shea on @sourceryvc

Kalshi CEO Tarek Mansour: “The core unlock that could happen with prediction markets is if you forecast the future better, you are pricing risk.” “If you can price risk, then you can make better decisions about the risk.” “And then also you can transfer it, you can hedge. And I think that's where the market really, really becomes very, very large.” Source: Tarek Mansour (CEO Kalshi) with Molly O’Shea on @sourceryvc

a16z

1,833,518 views • 8 months ago

Is this real? Is Mark Zuckerberg actually allowing antifa tags on threads? Has anyone seen this? If you have, please screenshot and post in the comments.

Is this real? Is Mark Zuckerberg actually allowing antifa tags on threads? Has anyone seen this? If you have, please screenshot and post in the comments.

MAGA Cult Slayer🦅🇺🇸

12,646 views • 9 months ago

Bridgit Mendler on how Northwood is fixing the space economy's ground infrastructure problem: "The problem that we're solving is for every satellite, it requires a connection point back to Earth so that they can control the spacecraft." "That point of contact on Earth is called the ground infrastructure." "If you don't have it, you don't have a space mission." "It literally is just like a rock in space you're doing nothing with." "There was this whole boom around spacecraft manufacturing." "And interestingly what started becoming the longest pole in the tent was just getting the point of contact on the ground to connect with." "You could build a satellite and launch it faster than you could actually connect with it from the ground." "Which just seemed absurd." Bridgit Mendler with Erik Torenberg

Bridgit Mendler on how Northwood is fixing the space economy's ground infrastructure problem: "The problem that we're solving is for every satellite, it requires a connection point back to Earth so that they can control the spacecraft." "That point of contact on Earth is called the ground infrastructure." "If you don't have it, you don't have a space mission." "It literally is just like a rock in space you're doing nothing with." "There was this whole boom around spacecraft manufacturing." "And interestingly what started becoming the longest pole in the tent was just getting the point of contact on the ground to connect with." "You could build a satellite and launch it faster than you could actually connect with it from the ground." "Which just seemed absurd." Bridgit Mendler with Erik Torenberg

a16z

13,324 views • 3 months ago

2024 you just had to be there. Looking back makes me realise I took those times for granted You could actually sleep on meme coins You could actually believe You could actually ape and walk away How do we fix this and bring back the good times?

2024 you just had to be there. Looking back makes me realise I took those times for granted You could actually sleep on meme coins You could actually believe You could actually ape and walk away How do we fix this and bring back the good times?

Straya Cowboy🦘

13,823 views • 10 months ago

Can AI cure disease & make science faster? Patrick Hsu Jorge Conde and Erik Torenberg discuss (00:45) The Moonshot: Virtual Cells and Human Biology (02:58) Interdisciplinary Collaboration at Arc Institute (05:11) The Role of AI in Biology (10:18) Understanding Virtual Cells (22:13) Biotech and Pharma Industry Insights (28:13) Capital Intensity and Technological Advancements (30:12) Market Impact and Industry Trends (33:19) Future Technological Breakthroughs (38:15) AI in Drug Discovery (45:50) Investment Focus and Future Prospects

Can AI cure disease & make science faster? Patrick Hsu Jorge Conde and Erik Torenberg discuss (00:45) The Moonshot: Virtual Cells and Human Biology (02:58) Interdisciplinary Collaboration at Arc Institute (05:11) The Role of AI in Biology (10:18) Understanding Virtual Cells (22:13) Biotech and Pharma Industry Insights (28:13) Capital Intensity and Technological Advancements (30:12) Market Impact and Industry Trends (33:19) Future Technological Breakthroughs (38:15) AI in Drug Discovery (45:50) Investment Focus and Future Prospects

a16z

53,540 views • 10 months ago

I actually like the streamer coin meta because we can bet on the attention of creators and there is way less PVP "all you have to do is wait for a creator to go live, you can confirm if it's real before you buy, and you can bet on a creator to go viral without getting PVP'd"

I actually like the streamer coin meta because we can bet on the attention of creators and there is way less PVP "all you have to do is wait for a creator to go live, you can confirm if it's real before you buy, and you can bet on a creator to go viral without getting PVP'd"

Ash Robin

43,437 views • 10 months ago

Clavicular explains how dangerous cocaine actually is “Actually cocaine is far more dangerous and there’s a higher mortality risk than meth because meth might be cardiotoxic over the long term due to vasoconstriction” “You could die immediately from doing cocaine even if it’s your first time. That’s the issue you run into because you’re blocking your sodium channels. You could have a heart attack and be gone. You could be a perfectly healthy guy and then you’re dead”

Clavicular explains how dangerous cocaine actually is “Actually cocaine is far more dangerous and there’s a higher mortality risk than meth because meth might be cardiotoxic over the long term due to vasoconstriction” “You could die immediately from doing cocaine even if it’s your first time. That’s the issue you run into because you’re blocking your sodium channels. You could have a heart attack and be gone. You could be a perfectly healthy guy and then you’re dead”

Mikli

1,313,557 views • 1 month ago

🔌Today I created a virtual web-based null modem so now you can finally play Quake 1 (from 1996) in multiplayer in the browser with other people online! This week I was able to create a virtual printer that listens on the COM2 port to make a web-based printer work in Windows 3.11, like on you can actually print to, it was one of my ideas when I started but it was always too difficult to make, I had no idea where to start, but this week AI was able to do it! Today I woke up and thought "if we can listen to COM2 via JS, how about listen to COM1 from Quake 1?" then we could forward the COM1 data via Websockets and to another user to create a virtual null modem (A null modem was a cable you'd use to connect two computers to each other directly in the 90s, if you couldn't afford buying a network card you'd use this to network, but you could only play with one other computer not multiple) So I built it, it took about an hour and works! I wanted to get Quake 1 in DOS to work with multiplayer for 2 years but I could never get it to work, but now it did it This project is a good benchmark of how capable AI is becoming, figuring stuff out that humans would take months within an hour You can try it here, I don't know how it will match lots of people but let's see, you have to exit to DOS first (ALT-F4 or FN-Option-F4 on Mac), then type CD games, then CD quake, then quake, then ESC, then Multiplayer, then either Create New Game or Join Game, and use Direct Connect, keep settings same and you're in!

🔌Today I created a virtual web-based null modem so now you can finally play Quake 1 (from 1996) in multiplayer in the browser with other people online! This week I was able to create a virtual printer that listens on the COM2 port to make a web-based printer work in Windows 3.11, like on you can actually print to, it was one of my ideas when I started but it was always too difficult to make, I had no idea where to start, but this week AI was able to do it! Today I woke up and thought "if we can listen to COM2 via JS, how about listen to COM1 from Quake 1?" then we could forward the COM1 data via Websockets and to another user to create a virtual null modem (A null modem was a cable you'd use to connect two computers to each other directly in the 90s, if you couldn't afford buying a network card you'd use this to network, but you could only play with one other computer not multiple) So I built it, it took about an hour and works! I wanted to get Quake 1 in DOS to work with multiplayer for 2 years but I could never get it to work, but now it did it This project is a good benchmark of how capable AI is becoming, figuring stuff out that humans would take months within an hour You can try it here, I don't know how it will match lots of people but let's see, you have to exit to DOS first (ALT-F4 or FN-Option-F4 on Mac), then type CD games, then CD quake, then quake, then ESC, then Multiplayer, then either Create New Game or Join Game, and use Direct Connect, keep settings same and you're in!

@levelsio

102,995 views • 1 month ago

Replit CEO Amjad Masad: Being 'terminally online' may be an advantage. "If you want to work on a skill, it's going to be about idea generation." "Because the cost of implementation of those ideas is going down rapidly. It's gonna go to zero at some point." "So the bottleneck becomes, 'how fast can you generate ideas?'" "Just looking around you in the world and seeing what's happening. What are the trends? Are you plugged in on social media?" "A lot of the vices that older generations think are vices, might actually become advantages. So if you're a brainrotted, terminally online person, that might be an advantage because you know what's happening in the world." "If you're someone who's ADHD, really interested in novelty... that's actually an advantage because AI really benefits people who can try a lot of things really quickly." Amjad Masad with

Replit CEO Amjad Masad: Being 'terminally online' may be an advantage. "If you want to work on a skill, it's going to be about idea generation." "Because the cost of implementation of those ideas is going down rapidly. It's gonna go to zero at some point." "So the bottleneck becomes, 'how fast can you generate ideas?'" "Just looking around you in the world and seeing what's happening. What are the trends? Are you plugged in on social media?" "A lot of the vices that older generations think are vices, might actually become advantages. So if you're a brainrotted, terminally online person, that might be an advantage because you know what's happening in the world." "If you're someone who's ADHD, really interested in novelty... that's actually an advantage because AI really benefits people who can try a lot of things really quickly." Amjad Masad with

a16z

562,715 views • 4 months ago

Professor Retsef Levi explains his perspective on thimerosal (mercury) in influenza vaccines: "If you just think about a one-time vaccine, you could argue that the amount of mercury in a single dose of a single vaccine is probably small. And you could argue potentially that it poses no significant risks. The problem is that you don't take one shot. You take, actually, a shot every year, and moreover, you are actually being exposed to mercury from other sources in your life - from food, from fish, & from other sources. So, when you want to consider risk here, you need to adopt a system-level kind of thinking and really think about not only this isolated episode, but rather what is the overall contribution to the overall risk, to the overall exposure. And if you do that, given the fact that mercury is a highly toxic compound - nobody debates that - and it accumulates in the body, I think it's going to be sensible, at least in my mind, to say that if we can eliminate some controllable sources of mercury, we should do that." CC Robert W Malone, MD

Professor Retsef Levi explains his perspective on thimerosal (mercury) in influenza vaccines: "If you just think about a one-time vaccine, you could argue that the amount of mercury in a single dose of a single vaccine is probably small. And you could argue potentially that it poses no significant risks. The problem is that you don't take one shot. You take, actually, a shot every year, and moreover, you are actually being exposed to mercury from other sources in your life - from food, from fish, & from other sources. So, when you want to consider risk here, you need to adopt a system-level kind of thinking and really think about not only this isolated episode, but rather what is the overall contribution to the overall risk, to the overall exposure. And if you do that, given the fact that mercury is a highly toxic compound - nobody debates that - and it accumulates in the body, I think it's going to be sensible, at least in my mind, to say that if we can eliminate some controllable sources of mercury, we should do that." CC Robert W Malone, MD

Jan Jekielek

56,130 views • 1 year ago