My co-founder Toni and I each recently swallowed a camera. Today we're launching Zaniah Health so you can see what's happening inside your gut too. The gut is the body's largest immune interface, and research keeps linking the gut to health far beyond digestion. We track sleep, HRV, bloodwork,... and our microbiome, yet we've been overlooking the most powerful way to measure gut health: Directly looking at it. Zaniah provides at-home, physician-supervised capsule endoscopy. You swallow a small capsule that takes ~30,000 pictures of your GI tract. One of our gastroenterologists reviews the images and sends you a report with findings you can actually see, rather than a dashboard of numbers and scores that you have to decode. Here's what our capsules found: >Toni's capsule showed findings in her terminal ileum consistent with Crohn's disease. After more than 30 years of unexplained GI symptoms, she's now getting the workup to confirm it. >My capsule showed a small nodule in my stomach. Probably nothing, and I'm getting an upper endoscopy to make sure. Nearly 10 years ago I co-founded Virgo, where we've built the world's largest endoscopy video library, more than 4 million upper endoscopy and colonoscopy procedures. We also trained EndoDINO, a foundation model for endoscopy, using over 130,000 of those videos. Zaniah is where we put that AI to work with capsule endoscopy. Right now, Zaniah is for adults who want to see what's happening inside their gut. Longer term, we're researching how the gut can reveal early signs of disease beyond the GI tract. Zaniah doesn't require a referral or insurance coverage, and it's HSA/FSA eligible. Our physicians review eligibility before the kit ships. The waitlist is now open. Join by December 31st to lock in the $1,499 launch price. It goes up to $1,999 after then, and there's no payment required to join. Waitlist link below. Follow along Zaniah Healthshow more

@MrsToniToomey Congrats!

@MrsToniToomey Thanks, Liron! Appreciate your advice on this!

@MrsToniToomey Very interesting, congrats. Is the business/use case you envision similar to consumer full body MRI?

@MrsToniToomey Thanks! That's definitely the closest analogy! Though we do expect that a decent number of patients choosing Zaniah will have known GI symptoms vs. just pure preventive use case.

@MrsToniToomey So if no lesion is found, you stay calm about your digestive future?

@MrsToniToomey I think we've got a lot of data to capture before being able to make a claim like that. But each exam can be used by clinicians for future decision making.

@MrsToniToomey 30 years of unexplained symptoms before anyone looked directly at the ileum. That's not a diagnostics gap, that's a listening failure. Glad this exists. I hope her workup goes smoothly.

@MrsToniToomey Congratulations!

@MrsToniToomey Thank you! Bringing better gut health tools to the masses!

@MrsToniToomey for the curious, following is the first one back from a decade ago. It was a huge innovation that just disappeared suddenly with no direct replacement. Now @ZaniahHealth is basically originating a novel replacement with even better technology!

@MrsToniToomey Congrats on the launch! 🚀

@MrsToniToomey Thanks Stephane! Bringing gut health imaging to the masses!

@MrsToniToomey do they offer discounts for cameras on their second trip?

@MrsToniToomey Haha well we do envision capsules being done at the scale of millions per year, so it will make sense to get the cost down….

@MrsToniToomey you are going to save lives with this and achieve dreams we all envy, even those of us with a 12 year old's sense of humour.

@MrsToniToomey Thanks, Dave! One of the nice things about working in the GI space, is that the field itself has a nice sense of humor :) Doesn't hurt to laugh a little while working on saving lives, detecting cancer earlier, and improving care for chronic diseases!

@MrsToniToomey This is huge for gut health, carry on the good work!

@MrsToniToomey Thank you! Really appreciate it!

@MrsToniToomey Congrats on the launch! Great approach to make gut health data more accessible!

@MrsToniToomey Thank you! We’re big believers that GI imaging can tell us a ton about gut health and beyond. Excited to bring this to the masses!

@MrsToniToomey curious how the visuals will correlate with standard markers like zonulin and fecal calprotectin. it's the part that would let someone track change quantitatively, not just visually. have you run any of those correlations yet?beh

@MrsToniToomey Amazing question. Answer is not yet BUT we’re running an observational study from day 1 to capture medical history, blood labs, microbiome, and fecal calprotectin data. Our AI foundation model is perfectly suited for correlating visual changes with exactly these metrics.

@MrsToniToomey Great to finally see, congrats! I've been waiting for something like this ever since in ~2024 my gastro at @nyulangone told me they no longer offered the og gold standard "Smartpill"... because @Medtronic simply stopped making it (?!). You're patching a real clinical need/gap!

@MrsToniToomey @nyulangone @Medtronic Thank you! Capsule endoscopy is amazing technology and we believe it should be much more widely available for patient access. Even if your GI doc offers it, insurance won’t usually cover it unless you’ve already had an upper endoscopy and colonoscopy. Backwards!

@MrsToniToomey Congrats on your launch. I assume this is not a replacement for a colonoscopy. Is it meant for those under the age of 50 w/o a family history of colon cancer?

Thanks! And that’s right, definitely not a replacement for colonoscopy or recommended colorectal cancer screening. It’s intended for patients who are interested in their gut health, longevity, and preventive medicine to get better data on their GI tract. Ultimately up to patients, their doctors, and our doctors. We expect a lot of patients with chronic lingering GI issues will be interested!

@MrsToniToomey This is awesome! Quick question for you - with the rise of GLP use, does the slow down of motility from these drugs impact your device or increase risk at all for using the pill?

Thank you! And very astute question! There are reports of longer capsule transit time with GLP use. Something our clinical team will be tracking closely. Also very interesting early research on GLP impact in IBD. We’ll be looking at whether capsule can assess inflammatory changes associated with GLP use.

@MrsToniToomey Very cool! I enrolled on the site! I think this is awesome what you guys are doing. You guys should try to partner with @prenuvo - I think this would complement what they are doing a lot.

@MrsToniToomey @prenuvo Amazing thanks for signing up! And totally agree… the more data the better!