Video yükleniyor...

Video Yüklenemedi

Bu video yüklenirken bir sorun oluştu. Bu geçici bir ağ sorunundan kaynaklanıyor olabilir veya video kullanılamıyor olabilir.

Ana Sayfaya Dön

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). IBEC

Xavier Trepat

7,203 subscribers

31,351 görüntüleme • 1 yıl önce •via X (Twitter)

Bilim & Teknoloji

Anya Rossi• Live Now

Private livecam show

0 Yorum

Yorum bulunmuyor

Orijinal gönderinin yorumları burada görünecek

Benzer Videolar

BREAKING: Scientists just injected a Parkinson's patient with neurons grown from their OWN skin cells. No immune drugs. No donor. No rejection. 12 months later — the cells are ALIVE, producing dopamine, and patients are moving better. This is a thread you need to read 🧵👇 🔗 SOURCE: Aspen Neuroscience Press Release — March 18, 2026

BREAKING: Scientists just injected a Parkinson's patient with neurons grown from their OWN skin cells. No immune drugs. No donor. No rejection. 12 months later — the cells are ALIVE, producing dopamine, and patients are moving better. This is a thread you need to read 🧵👇 🔗 SOURCE: Aspen Neuroscience Press Release — March 18, 2026

Harshi Peiris, Ph.D.

113,626 görüntüleme • 3 ay önce

Meet the next-generation approach to cancer treatment. 💊🌟 Switchable CAR-T (sCAR-T) is a programmable immunotherapy designed to give scientists and clinicians greater control over how—and when—the immune system attacks cancer. This modular CAR-T platform activates engineered immune cells only in the presence of an antibody “switch.” Without the switch, the cells remain inactive, an approach designed to improve precision and lifespan, while potentially reducing the risk of uncontrolled immune responses. Scientists at Scripps Research’s drug development division, Calibr-Skaggs Institute for Innovative Medicines, have completed a Phase 1 clinical trial evaluating the safety of the sCAR-T platform (CLBR001) paired with a CD19-targeted switch (SWI019) for B-cell malignancies (NCT04450069). Initial results announced underscore the potential of this therapy. The technology is now being tested in a Phase 1 clinical trial for metastatic breast cancer, with an additional Phase 1 trial for autoimmune diseases launching this year. #WorldCancerDay #CancerResearch #Immunotherapy #BreastCancerResearch #ClinicalTrials

Meet the next-generation approach to cancer treatment. 💊🌟 Switchable CAR-T (sCAR-T) is a programmable immunotherapy designed to give scientists and clinicians greater control over how—and when—the immune system attacks cancer. This modular CAR-T platform activates engineered immune cells only in the presence of an antibody “switch.” Without the switch, the cells remain inactive, an approach designed to improve precision and lifespan, while potentially reducing the risk of uncontrolled immune responses. Scientists at Scripps Research’s drug development division, Calibr-Skaggs Institute for Innovative Medicines, have completed a Phase 1 clinical trial evaluating the safety of the sCAR-T platform (CLBR001) paired with a CD19-targeted switch (SWI019) for B-cell malignancies (NCT04450069). Initial results announced underscore the potential of this therapy. The technology is now being tested in a Phase 1 clinical trial for metastatic breast cancer, with an additional Phase 1 trial for autoimmune diseases launching this year. #WorldCancerDay #CancerResearch #Immunotherapy #BreastCancerResearch #ClinicalTrials

Scripps Research

17,297 görüntüleme • 6 ay önce

If you have Cancer, this is your visualization. That is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.

If you have Cancer, this is your visualization. That is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.

Brian Roemmele

191,436 görüntüleme • 8 ay önce

🚨 SCIENTISTS JUST REVERSED AGING IN BLOOD STEM CELLS Researchers at Mount Sinai restored old blood stem cells to a youthful state by repairing tiny cellular recycling systems called lysosomes. In mice, aged stem cells regained the ability to: • regenerate healthy blood • rebuild immune cells • reduce inflammation • behave like young stem cells again One treatment increased blood-forming capacity by more than 8x. Why this matters: Your blood stem cells are responsible for constantly rebuilding your immune system and blood supply throughout life. As they age: • immunity weakens • inflammation rises • cancer risk increases • regeneration declines But this study suggests aging inside these cells may not be permanent. Scientists may have found a biological “reset switch.” The future of anti-aging may not come from replacing organs… …but from restoring the cells that rebuild the body itself. Follow for more future physics and biotech breakthroughs.

🚨 SCIENTISTS JUST REVERSED AGING IN BLOOD STEM CELLS Researchers at Mount Sinai restored old blood stem cells to a youthful state by repairing tiny cellular recycling systems called lysosomes. In mice, aged stem cells regained the ability to: • regenerate healthy blood • rebuild immune cells • reduce inflammation • behave like young stem cells again One treatment increased blood-forming capacity by more than 8x. Why this matters: Your blood stem cells are responsible for constantly rebuilding your immune system and blood supply throughout life. As they age: • immunity weakens • inflammation rises • cancer risk increases • regeneration declines But this study suggests aging inside these cells may not be permanent. Scientists may have found a biological “reset switch.” The future of anti-aging may not come from replacing organs… …but from restoring the cells that rebuild the body itself. Follow for more future physics and biotech breakthroughs.

TheNewPhysics

10,676 görüntüleme • 3 ay önce

1/ We're thrilled to share our preprint on Deep3P - a new approach that takes us on a deep dive into the world of brain tumors, using three-photon microscopy and #AI. This exciting endeavor is brought to life together with the amazing Prevedel Lab !

1/ We're thrilled to share our preprint on Deep3P - a new approach that takes us on a deep dive into the world of brain tumors, using three-photon microscopy and #AI. This exciting endeavor is brought to life together with the amazing Prevedel Lab !

Varun Venkataramani

67,507 görüntüleme • 3 yıl önce

Subnet registration and deregistration have returned to Bittensor. The subnet limit will remain at 128 meaning that when a new subnet registers, it will take the place of the lowest performing non-immune subnet. A 4-month immunity for new subnets will allow the time for subnets to get their projects up and running.

Subnet registration and deregistration have returned to Bittensor. The subnet limit will remain at 128 meaning that when a new subnet registers, it will take the place of the lowest performing non-immune subnet. A 4-month immunity for new subnets will allow the time for subnets to get their projects up and running.

Openτensor Foundaτion

71,615 görüntüleme • 10 ay önce

Israel just took a massive leap in the war on cancer. New Phase developed a revolutionary nanotech treatment that uses specially designed nanoparticles to heat and destroy metastatic tumors from the inside, even in hard-to-reach areas, while sparing healthy tissue. The technology is already showing incredible results in clinical trials for late-stage cancer patients. This is precision medicine at the nanoscale, turning the body’s own biology into a targeted weapon against one of humanity’s deadliest diseases. From the lab to saving lives worldwide, Startup Nation at it again. Proud every single day. 🇮🇱 #StartupNation #IsraeliInnovation #Nanotech #CancerTreatment #NewPhase

Israel just took a massive leap in the war on cancer. New Phase developed a revolutionary nanotech treatment that uses specially designed nanoparticles to heat and destroy metastatic tumors from the inside, even in hard-to-reach areas, while sparing healthy tissue. The technology is already showing incredible results in clinical trials for late-stage cancer patients. This is precision medicine at the nanoscale, turning the body’s own biology into a targeted weapon against one of humanity’s deadliest diseases. From the lab to saving lives worldwide, Startup Nation at it again. Proud every single day. 🇮🇱 #StartupNation #IsraeliInnovation #Nanotech #CancerTreatment #NewPhase

Mor Edge Insight

15,196 görüntüleme • 3 ay önce

$🧪 Back in the 1980s and early '90s, researchers started uncovering something suprising inside the aloe vera plant: a sugar molecule called acemannan. It wasn't just soothing burns or helping skin heal faster, it was communicating with the immune system. In lab tests and hospital settings, doctors noticed that aloe's compounds could help white blood cells "wake up" and respond more efficiently without overstimulation. 🦠One doctor working with HIV patients even saw immune markers improve after giving them the pure aloe extract. But as soon as the research gained traction, the story fizzled out. Funding dried up, pharmaceutical interests shifted focus, and the patents for acemannan extraction quietly got tucked away under corporate control. What had started as a promising immune discovery suddenly and conveniently disappeared. 🔒 Today, aloe is marketed mostly for skin care or digestion, but that's only a fraction of what it can do. Beneath its green skin lies a compound so unique that it was once granted "orphan drug status" by the FDA in 1995 for its role in supporting immune recovery in HIV patients. That should've been front page news but instead it was buried under the noise of pharmaceutical progress. 🌱 Interesting how this humble desert plant was quietly doing what billions of research dollars were still trying to replicate (helping the body remember how to heal itself but safely with no side effects, no contraindications and no toxicity levels.... ⭐️ Today only about 130 patents for proper extraction and stabilization exist, the most recent patent having the highest immune modulating 1,100 fractions in the world. This essentially means ideal compatibility for the body to recognize and use acemannan immediately upon taking. ❔ Think about how disruptive this could be if people actually started understanding how incredibly powerful their immune system was when it's function properly... -laurae_ramos$

🧪 Back in the 1980s and early '90s, researchers started uncovering something suprising inside the aloe vera plant: a sugar molecule called acemannan. It wasn't just soothing burns or helping skin heal faster, it was communicating with the immune system. In lab tests and hospital settings, doctors noticed that aloe's compounds could help white blood cells "wake up" and respond more efficiently without overstimulation. 🦠One doctor working with HIV patients even saw immune markers improve after giving them the pure aloe extract. But as soon as the research gained traction, the story fizzled out. Funding dried up, pharmaceutical interests shifted focus, and the patents for acemannan extraction quietly got tucked away under corporate control. What had started as a promising immune discovery suddenly and conveniently disappeared. 🔒 Today, aloe is marketed mostly for skin care or digestion, but that's only a fraction of what it can do. Beneath its green skin lies a compound so unique that it was once granted "orphan drug status" by the FDA in 1995 for its role in supporting immune recovery in HIV patients. That should've been front page news but instead it was buried under the noise of pharmaceutical progress. 🌱 Interesting how this humble desert plant was quietly doing what billions of research dollars were still trying to replicate (helping the body remember how to heal itself but safely with no side effects, no contraindications and no toxicity levels.... ⭐️ Today only about 130 patents for proper extraction and stabilization exist, the most recent patent having the highest immune modulating 1,100 fractions in the world. This essentially means ideal compatibility for the body to recognize and use acemannan immediately upon taking. ❔ Think about how disruptive this could be if people actually started understanding how incredibly powerful their immune system was when it's function properly... -laurae_ramos

𝚃𝙷𝙴 𝚆𝙷𝙸𝚃𝙴 𝚁𝙰𝙱𝙱𝙸𝚃

204,218 görüntüleme • 4 ay önce

Introducing Rivian Green—a color that reflects connection and harmony with the planet and our commitment to leaving it better for generations to come. Created in collaboration with PANTONE, this signature green was thoughtfully refined to live comfortably in nature and stand out on its own. Inspired by the green tones found in our manufacturing process, Rivian Green balances the tension between engineering and nature, evolving our original Launch Green into an enduring pillar of the brand. Explore the story behind the color and our partnership with Pantone:

Rivian

43,946 görüntüleme • 6 ay önce

Introducing Liminal Market Data & Scores. A transparent way to understand assets and markets on Hyperliquid and Liminal. Each asset features detailed metrics and Scores that help users evaluate the assets included in their delta-neutral strategies. Transparency, in motion 👇

Introducing Liminal Market Data & Scores. A transparent way to understand assets and markets on Hyperliquid and Liminal. Each asset features detailed metrics and Scores that help users evaluate the assets included in their delta-neutral strategies. Transparency, in motion 👇

Liminal

23,232 görüntüleme • 9 ay önce

Okay this is really cool. Codex app has a new feature that is really useful. Highlight any text, and you'll notice a new popup. "More Details" uses GPT 5.5 Instant to explain in more detail about the highlighted portion of your text, allowing you to understand the reasoning/concept/statement/etc in greater detail. What's interesting about this versus a side chat is that it's instantaneous, and still retains context from the thread. With /side chat, you'd have to type out a prompt "what are the details on this?" With "more details" the prompt is implicit and the response is instantenous Very nice feature, as I'm always making side chats/branches to expand/learn/understand agent outputs better.

Okay this is really cool. Codex app has a new feature that is really useful. Highlight any text, and you'll notice a new popup. "More Details" uses GPT 5.5 Instant to explain in more detail about the highlighted portion of your text, allowing you to understand the reasoning/concept/statement/etc in greater detail. What's interesting about this versus a side chat is that it's instantaneous, and still retains context from the thread. With /side chat, you'd have to type out a prompt "what are the details on this?" With "more details" the prompt is implicit and the response is instantenous Very nice feature, as I'm always making side chats/branches to expand/learn/understand agent outputs better.

am.will

38,454 görüntüleme • 1 ay önce

Neuralink Integration with ANKTIVA for Revolutionary Immunotherapy Elon Musk, a visionary collaboration opportunity by Dr. Sarabi and Grok. Dear Mr Musk: Good morning sir! I would like to bring to your attention the remarkable work of Dr. Patrick Soon-Shiong, who has developed a groundbreaking therapy, Anktiva, capable of supercharging key immune molecules to combat cancer and COVID-19. In a recent discussion with Tucker Carlson, Dr. Soon-Shiong described this advance as akin to the “E=mc²” of medicine—the discovery of “God’s equation,” a biological key that has eluded us for half a century until now. Just as Tesla has revolutionized the automotive and environmental industries, and SpaceX has advanced the expansion of humanity into a multi-planetary species to ensure our long-term survival, Anktiva represents a comparable paradigm shift in medicine, safeguarding human health and endurance. Given your shared commitment to advancing humanity, I respectfully inquire whether you might consider extending your support to Dr. Soon-Shiong in this critical pursuit. Moreover, I propose exploring the integration of Neuralink, employing the stepwise protocol outlined below, in collaboration with Dr. Soon-Shiong. Such a partnership could propel an unprecedented advancement in medicine and the future of humankind. Grok has developed a preliminary conceptual integration of Neuralink to enhance and supercharge IL-15 production 1/7: Identify Target Neural Circuits • Map the hypothalamic paraventricular nucleus (PVN) and dorsal motor nucleus of the vagus • Trace efferent projections from the PVN to the intermediolateral cell column (IML) in the spinal cord. • Identify sympathetic nerve fibers innervating the spleen and lymph nodes. • Map vagus nerve branches terminating in gut-associated lymphoid tissue and the hepatic portal system. 2/7: Implant Neuralink and Integrate with Neural Pathways • Place Neuralink electrodes in the PVN and dorsal motor nucleus of the vagus, using extended threads for subcortical/brainstem access. • Configure for recording/stimulation to modulate autonomic outflow to the IML at thoracic spinal levels. • Establish central control over peripheral pathways (e.g., splenic/vagus nerves) via targeted brain stimulation. 3/7: Develop Stimulation Protocols • Program Neuralink for high-frequency stimulation to the PVN for sympathetic activation. • Apply low-frequency patterned stimulation to the dorsal motor nucleus to engage feedback loops. • Modulate splenic/vagal pathways with phase-locked cycles through central interfaces. 4/7: Initiate Immune Cell Activation • Stimulate pathways to induce IFN-γ and TNF-α release in spleen/lymph nodes. • Trigger IL-15 transcription/translation in dendritic cells, monocytes, and epithelial cells. • Monitor for increased membrane-bound IL-15/IL-15Rα complex formation. 5/7: Enhance Local IL-15 Presentation • Concentrate stimulation at tumor/inflammation sites. • Promote immune cell clustering via chemokine/adhesion molecule induction. • Sustain localized IL-15/IL-15Rα trans-presentation to NK and CD8+ T cells. 6/7: Implement Real-Time Monitoring and Feedback • Record neural/immune biomarkers continuously via Neuralink telemetry. • Adjust stimulation based on IL-15 levels and NK/T cell activity. • Set safety thresholds to avoid excessive immune activation. 7/7: Synchronize with Immunotherapy • Time stimulation with IL-15 superagonists or adoptive therapies. • Evaluate synergies using immune monitoring/imaging. • Optimize based on patient responses. Thank you! #Neuralink #ANKTIVA #Grok #trendingvideo #cancer #medicalnews #health #trendingnow

Neuralink Integration with ANKTIVA for Revolutionary Immunotherapy Elon Musk, a visionary collaboration opportunity by Dr. Sarabi and Grok. Dear Mr Musk: Good morning sir! I would like to bring to your attention the remarkable work of Dr. Patrick Soon-Shiong, who has developed a groundbreaking therapy, Anktiva, capable of supercharging key immune molecules to combat cancer and COVID-19. In a recent discussion with Tucker Carlson, Dr. Soon-Shiong described this advance as akin to the “E=mc²” of medicine—the discovery of “God’s equation,” a biological key that has eluded us for half a century until now. Just as Tesla has revolutionized the automotive and environmental industries, and SpaceX has advanced the expansion of humanity into a multi-planetary species to ensure our long-term survival, Anktiva represents a comparable paradigm shift in medicine, safeguarding human health and endurance. Given your shared commitment to advancing humanity, I respectfully inquire whether you might consider extending your support to Dr. Soon-Shiong in this critical pursuit. Moreover, I propose exploring the integration of Neuralink, employing the stepwise protocol outlined below, in collaboration with Dr. Soon-Shiong. Such a partnership could propel an unprecedented advancement in medicine and the future of humankind. Grok has developed a preliminary conceptual integration of Neuralink to enhance and supercharge IL-15 production 1/7: Identify Target Neural Circuits • Map the hypothalamic paraventricular nucleus (PVN) and dorsal motor nucleus of the vagus • Trace efferent projections from the PVN to the intermediolateral cell column (IML) in the spinal cord. • Identify sympathetic nerve fibers innervating the spleen and lymph nodes. • Map vagus nerve branches terminating in gut-associated lymphoid tissue and the hepatic portal system. 2/7: Implant Neuralink and Integrate with Neural Pathways • Place Neuralink electrodes in the PVN and dorsal motor nucleus of the vagus, using extended threads for subcortical/brainstem access. • Configure for recording/stimulation to modulate autonomic outflow to the IML at thoracic spinal levels. • Establish central control over peripheral pathways (e.g., splenic/vagus nerves) via targeted brain stimulation. 3/7: Develop Stimulation Protocols • Program Neuralink for high-frequency stimulation to the PVN for sympathetic activation. • Apply low-frequency patterned stimulation to the dorsal motor nucleus to engage feedback loops. • Modulate splenic/vagal pathways with phase-locked cycles through central interfaces. 4/7: Initiate Immune Cell Activation • Stimulate pathways to induce IFN-γ and TNF-α release in spleen/lymph nodes. • Trigger IL-15 transcription/translation in dendritic cells, monocytes, and epithelial cells. • Monitor for increased membrane-bound IL-15/IL-15Rα complex formation. 5/7: Enhance Local IL-15 Presentation • Concentrate stimulation at tumor/inflammation sites. • Promote immune cell clustering via chemokine/adhesion molecule induction. • Sustain localized IL-15/IL-15Rα trans-presentation to NK and CD8+ T cells. 6/7: Implement Real-Time Monitoring and Feedback • Record neural/immune biomarkers continuously via Neuralink telemetry. • Adjust stimulation based on IL-15 levels and NK/T cell activity. • Set safety thresholds to avoid excessive immune activation. 7/7: Synchronize with Immunotherapy • Time stimulation with IL-15 superagonists or adoptive therapies. • Evaluate synergies using immune monitoring/imaging. • Optimize based on patient responses. Thank you! #Neuralink #ANKTIVA #Grok #trendingvideo #cancer #medicalnews #health #trendingnow

Dr. Kash Sarabi

16,057 görüntüleme • 1 yıl önce

NEW: The Sinaloa Cartel is threatening to target American citizens in popular tourist spots like Cabo in response to lab raids and seizures, according to Breitbart. A banner was recently erected addressing FBI Director Kash Patel. "The banner first surfaced on Sunday in Baja California, where gunmen left two banners allegedly signed by Los Chapitos," Breitbart reported. "The banners claim that starting on Sunday, they will be targeting U.S. citizens in Mexico in response to recent lab raids and weapons seizures." The banners were quickly taken down by authorities.

NEW: The Sinaloa Cartel is threatening to target American citizens in popular tourist spots like Cabo in response to lab raids and seizures, according to Breitbart. A banner was recently erected addressing FBI Director Kash Patel. "The banner first surfaced on Sunday in Baja California, where gunmen left two banners allegedly signed by Los Chapitos," Breitbart reported. "The banners claim that starting on Sunday, they will be targeting U.S. citizens in Mexico in response to recent lab raids and weapons seizures." The banners were quickly taken down by authorities.

Collin Rugg

6,083,797 görüntüleme • 10 ay önce

US President Trump mocks putin over response to new US sanctions The kremlin ruler had admitted the sanctions will have "certain consequences" - but insisted they won't have a "significant impact on our economy". When it was put to President Donald J. Trump at a news conference last night that putin had suggested Russia was immune from US sanctions, he offered a sardonic response: "I am glad he feels that way, that's good," President Trump said. It was followed by a slight laugh & with defence secretary Pete Hegseth smiling next to him, he said: "I will let you know about it in six months from now. Let's see how it works out."

US President Trump mocks putin over response to new US sanctions The kremlin ruler had admitted the sanctions will have "certain consequences" - but insisted they won't have a "significant impact on our economy". When it was put to President Donald J. Trump at a news conference last night that putin had suggested Russia was immune from US sanctions, he offered a sardonic response: "I am glad he feels that way, that's good," President Trump said. It was followed by a slight laugh & with defence secretary Pete Hegseth smiling next to him, he said: "I will let you know about it in six months from now. Let's see how it works out."

Sergiy Kyslytsya 🇺🇦

45,121 görüntüleme • 9 ay önce

Italy is set to become the first country to ban lab-grown meat and anyone caught producing or using it could face a fine of €60,000 🚨🚨🚨 🔊 Does anyone really want fake lab-grown meat? These companies don’t share their process of what they are putting into those tanks to grow the meat. I don’t understand where this is coming from that they think this is a market that needs to be addressed.

Italy is set to become the first country to ban lab-grown meat and anyone caught producing or using it could face a fine of €60,000 🚨🚨🚨 🔊 Does anyone really want fake lab-grown meat? These companies don’t share their process of what they are putting into those tanks to grow the meat. I don’t understand where this is coming from that they think this is a market that needs to be addressed.

Wall Street Mav

3,818,740 görüntüleme • 3 yıl önce

Chip or putt? How are you playing this shot? ▶️~63 feet to the hole ▶️Fairways are dry and firm ▶️About 15 feet of fairway to go through ▶️Fairway has a 12 to 18 inch upslope right before green ▶️Green is running about 10 on the stimp ▶️Will be uphill and slow'ish most of the way (except the first couple feet on the green is really running away downhill coming off that knob you need to go over) ▶️Wind is 8-10mph, off the right, and a little help Green book image below is from StrackaGolf Green Reading, Yardage Books, & Stats green books (Use code DATALOU15 to save 15%)

Chip or putt? How are you playing this shot? ▶️~63 feet to the hole ▶️Fairways are dry and firm ▶️About 15 feet of fairway to go through ▶️Fairway has a 12 to 18 inch upslope right before green ▶️Green is running about 10 on the stimp ▶️Will be uphill and slow'ish most of the way (except the first couple feet on the green is really running away downhill coming off that knob you need to go over) ▶️Wind is 8-10mph, off the right, and a little help Green book image below is from StrackaGolf Green Reading, Yardage Books, & Stats green books (Use code DATALOU15 to save 15%)

Lou Stagner (Golf Stat Pro)

103,033 görüntüleme • 2 yıl önce

New paper out! 🚨 We show that vampire bats use amino acids from a recent blood meal to fuel RUNNING - a rare mode of locomotion in bats ideal for stalking prey. I’d worry less about your neck and more about your ankles! 🧛🏻‍♂️ The Welch Lab Royal Society Publishing

New paper out! 🚨 We show that vampire bats use amino acids from a recent blood meal to fuel RUNNING - a rare mode of locomotion in bats ideal for stalking prey. I’d worry less about your neck and more about your ankles! 🧛🏻‍♂️ The Welch Lab Royal Society Publishing

Giulia Rossi

9,137,336 görüntüleme • 1 yıl önce

A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

Niko McCarty.

58,047 görüntüleme • 11 ay önce