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Omega-3 supplementation alone slowed epigenetic aging. Combined with vitamin D and resistance training, it reduced invasive cancer risk by 66%. — Andrew D. Huberman, Ph.D. & Dr. Rhonda Patrick

180,443 次观看 • 4 个月前 •via X (Twitter)

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Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Dr. Rhonda Patrick

245,490 次观看 • 1 年前