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Our latest work is out today in Science Magazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part...

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Sergiu P. Pasca

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10,345 views • 1 year ago •via X (Twitter)

#assembloids#organoids
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Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in collaboration with the Marius Pachitariu lab at HHMI | Janelia Video shows a four-part neural assembloid displaying emergent synchronized activity after a couple of hundred days of integration
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Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in collaboration with the Marius Pachitariu lab at HHMI | Janelia Video shows a four-part neural assembloid displaying emergent synchronized activity after a couple of hundred days of integration

Sergiu P. Pasca

27,416 views • 1 year ago

VIDEO: A paralysed man has regained the ability to walk for the first time using only his thoughts, thanks to two implants that restored communication between brain and spinal cord. The advance is the result of more than a decade of work by a team of researchers in France and Switzerland
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VIDEO: A paralysed man has regained the ability to walk for the first time using only his thoughts, thanks to two implants that restored communication between brain and spinal cord. The advance is the result of more than a decade of work by a team of researchers in France and Switzerland

AFP News Agency

288,560 views • 3 years ago

There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in nature today, we start tackling this question by combining forebrain #assembloids with CRISPR screens to map >400 disease genes onto stages of human cortical interneuron development. Using engineered lines, regionalized neural #organoids and over 1,000 #assembloids, we discovered a group of disease genes that interfere with GABAergic neuron generation or migration, including some surprising disease mechanisms. Check out the video below for details. This work was led by the fearless Xiangling Meng in the lab!! In collaboration with Bassik lab & Georgia Panagiotakos lab! Article here: Supported by the Stanford Brain Organogenesis Center Wu Tsai Neurosciences Institute Stanford Bio-X New York Stem Cell Foundation Research Institute Biohub
1:38

There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in nature today, we start tackling this question by combining forebrain #assembloids with CRISPR screens to map >400 disease genes onto stages of human cortical interneuron development. Using engineered lines, regionalized neural #organoids and over 1,000 #assembloids, we discovered a group of disease genes that interfere with GABAergic neuron generation or migration, including some surprising disease mechanisms. Check out the video below for details. This work was led by the fearless Xiangling Meng in the lab!! In collaboration with Bassik lab & Georgia Panagiotakos lab! Article here: Supported by the Stanford Brain Organogenesis Center Wu Tsai Neurosciences Institute Stanford Bio-X New York Stem Cell Foundation Research Institute Biohub

Sergiu P. Pasca

165,656 views • 2 years ago

The team l work with Sema Ukweli is facing the closure of our physical office and the vital work we do. We are a justice and human rights media organization that seeks to tell human interest stories. As an independent media platform, we expose injustices and human rights violations faced by ordinary Kenyans, with the aim of getting justice for the victims. We work closely with various organizations and authorities to achieve this aim. We also run a rapid response desk that responds to urgent calls and bails out innocent people arrested by the police. We work closely with young people and train them in citizen journalism, human rights, and how to organize in their communities to fight against injustices. Kindly spare a few minutes to watch the video of our work. I need your support to continue doing this important and vital work. Help us deliver the independent, and bold journalism that Kenya needs. Support Brave Media by making a contribution. #SemaUkweli
3:48

The team l work with Sema Ukweli is facing the closure of our physical office and the vital work we do. We are a justice and human rights media organization that seeks to tell human interest stories. As an independent media platform, we expose injustices and human rights violations faced by ordinary Kenyans, with the aim of getting justice for the victims. We work closely with various organizations and authorities to achieve this aim. We also run a rapid response desk that responds to urgent calls and bails out innocent people arrested by the police. We work closely with young people and train them in citizen journalism, human rights, and how to organize in their communities to fight against injustices. Kindly spare a few minutes to watch the video of our work. I need your support to continue doing this important and vital work. Help us deliver the independent, and bold journalism that Kenya needs. Support Brave Media by making a contribution. #SemaUkweli

The People’s President

46,366 views • 1 year ago

What if geoengineering wasn't just about blocking out the sun for "climate change" purposes, but was for a more nefarious intention to alter the schumann resonance of the earth to influence human behavior and perception? These earthly derived frequencies are profoundly connected to human health, circadian rhythms, nervous system function, human brainwave patterns, and so many other aspects of our physiology. By putting reflective particulate matter into the atmosphere, we are altering the resonance between the surface and ionosphere, giving these frequencies another layer to bounce off of to change the tone, or to be blocked entirely. I think the geoengineering agenda is multifaceted with numerous motivations, with one thing I know for absolute sure. It's not to stop climate change. Here are some interesting papers on the coherence between the earthly resonances/frequencies and human physiology, and a clip describing the connection between schumann and human alpha brainwaves. Human intelligence: The brain, an electromagnetic system synchronised by the Schumann Resonance signal Innovative technical implementation of the Schumann resonances and its influence on organisms and biological cells Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity Similar Spectral Power Densities Within the Schumann Resonance and a Large Population of Quantitative Electroencephalographic Profiles: Supportive Evidence for Koenig and Pobachenko Electromagnetic activity: a possible player in epilepsy Schumann Resonances, a plausible biophysical mechanism for the human health effects of Solar/Geomagnetic Activity
6:52

What if geoengineering wasn't just about blocking out the sun for "climate change" purposes, but was for a more nefarious intention to alter the schumann resonance of the earth to influence human behavior and perception? These earthly derived frequencies are profoundly connected to human health, circadian rhythms, nervous system function, human brainwave patterns, and so many other aspects of our physiology. By putting reflective particulate matter into the atmosphere, we are altering the resonance between the surface and ionosphere, giving these frequencies another layer to bounce off of to change the tone, or to be blocked entirely. I think the geoengineering agenda is multifaceted with numerous motivations, with one thing I know for absolute sure. It's not to stop climate change. Here are some interesting papers on the coherence between the earthly resonances/frequencies and human physiology, and a clip describing the connection between schumann and human alpha brainwaves. Human intelligence: The brain, an electromagnetic system synchronised by the Schumann Resonance signal Innovative technical implementation of the Schumann resonances and its influence on organisms and biological cells Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity Similar Spectral Power Densities Within the Schumann Resonance and a Large Population of Quantitative Electroencephalographic Profiles: Supportive Evidence for Koenig and Pobachenko Electromagnetic activity: a possible player in epilepsy Schumann Resonances, a plausible biophysical mechanism for the human health effects of Solar/Geomagnetic Activity

Inversionism

144,671 views • 3 years ago

Gold fell five floors in four days. Today it caught the ledge. This morning it traded in the 4,020s. By the close it had climbed nearly two hundred dollars and finished back above 4,098, the floor it lost only last night. That close is the exact signal we named in advance. The first sign of life. It is not the turn, and the difference between those two things is where most people will lose money this week. Three minutes: the staircase, the fall, the catch, and the two numbers that have to print before anyone is allowed to call this a bottom.
4:11

Gold fell five floors in four days. Today it caught the ledge. This morning it traded in the 4,020s. By the close it had climbed nearly two hundred dollars and finished back above 4,098, the floor it lost only last night. That close is the exact signal we named in advance. The first sign of life. It is not the turn, and the difference between those two things is where most people will lose money this week. Three minutes: the staircase, the fall, the catch, and the two numbers that have to print before anyone is allowed to call this a bottom.

THE SIMPLIFIER

34,751 views • 1 month ago

New short course on Reinforcement Learning from Human Feedback! RLHF is one of the key techniques that led to the rise of modern LLMs. It is used to align LLMs with human preferences, to make them more honest, helpful and harmless, by (i) learning a reward function that mimics human preferences, as expressed in human-provided labels, then, (ii) tuning an LLM to generate outputs that receive a high reward. In this course, taught by Nikita Namjoshi, Developer Advocate for GenAI at Google Cloud, you'll learn the details of how RLHF works, including how to apply it to tune an LLM for your own applications. You'll also use an open source library to tune a base LLM to align with human preferences expressed in a training set, and evaluate the tuned model by comparing its responses before and after RLHF-tuning. Please sign up here!
3:26

New short course on Reinforcement Learning from Human Feedback! RLHF is one of the key techniques that led to the rise of modern LLMs. It is used to align LLMs with human preferences, to make them more honest, helpful and harmless, by (i) learning a reward function that mimics human preferences, as expressed in human-provided labels, then, (ii) tuning an LLM to generate outputs that receive a high reward. In this course, taught by Nikita Namjoshi, Developer Advocate for GenAI at Google Cloud, you'll learn the details of how RLHF works, including how to apply it to tune an LLM for your own applications. You'll also use an open source library to tune a base LLM to align with human preferences expressed in a training set, and evaluate the tuned model by comparing its responses before and after RLHF-tuning. Please sign up here!

Andrew Ng

205,542 views • 2 years ago

Panama🇵🇦 and Spain🇪🇸 dismantle human trafficking network. A joint operation between the Policía Nacional and Spain’s Policía Nacional has led to the arrest of six suspects in Madrid. Three victims were rescued - one Panamanian and two Colombian women. Operation Puerta del Sol was launched to dismantle a criminal organization engaged in human trafficking, which recruited victims in Panama and other regions for sexual exploitation in Spain. The investigation began after a young Panamanian woman was identified as a victim of human trafficking, having been lured by a foreigner with a false job offer to Spain and subjected to sexual exploitation upon her arrival.
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Panama🇵🇦 and Spain🇪🇸 dismantle human trafficking network. A joint operation between the Policía Nacional and Spain’s Policía Nacional has led to the arrest of six suspects in Madrid. Three victims were rescued - one Panamanian and two Colombian women. Operation Puerta del Sol was launched to dismantle a criminal organization engaged in human trafficking, which recruited victims in Panama and other regions for sexual exploitation in Spain. The investigation began after a young Panamanian woman was identified as a victim of human trafficking, having been lured by a foreigner with a false job offer to Spain and subjected to sexual exploitation upon her arrival.

INTERPOL

14,641 views • 1 year ago

Ilya Sutskever explains the 1% human training loop, and why fully autonomous AI is the wrong target "The thing you really want is for the human teachers that tell, that teach the AI, for them to collaborate with an AI." "You might want to think of it as being in a world where the human teachers do 1% of the world and the work and the AI do 99% of the work." "You don't want it to be 100% AI" "But you do want it to be a human-machine collaboration which teaches the next machine." Most teams are trying to remove the human from the loop. Ilya's design keeps a tiny human control surface and uses it to teach the next generation. The leverage is not zero humans. It is 1% human judgment steering 99% machine work. - Ilya Sutskever (Ilya Sutskever), AI researcher, on Dwarkesh Patel
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Ilya Sutskever explains the 1% human training loop, and why fully autonomous AI is the wrong target "The thing you really want is for the human teachers that tell, that teach the AI, for them to collaborate with an AI." "You might want to think of it as being in a world where the human teachers do 1% of the world and the work and the AI do 99% of the work." "You don't want it to be 100% AI" "But you do want it to be a human-machine collaboration which teaches the next machine." Most teams are trying to remove the human from the loop. Ilya's design keeps a tiny human control surface and uses it to teach the next generation. The leverage is not zero humans. It is 1% human judgment steering 99% machine work. - Ilya Sutskever (Ilya Sutskever), AI researcher, on Dwarkesh Patel

Karl Mehta

30,577 views • 20 days ago

Ayurveda is not merely a system of medicine; it is a profound science of life and an ancient system that enables human beings to live in harmony with all living beings around. Celebrating Ayurveda Day on the autumn equinox is a commitment to bringing health, joy, and wellbeing to all human beings and to every other life form that nurtures us. –Sg Ministry of Ayush
8:23

Ayurveda is not merely a system of medicine; it is a profound science of life and an ancient system that enables human beings to live in harmony with all living beings around. Celebrating Ayurveda Day on the autumn equinox is a commitment to bringing health, joy, and wellbeing to all human beings and to every other life form that nurtures us. –Sg Ministry of Ayush

Sadhguru

28,929 views • 10 months ago

we're making a game in which an AI dares to dream that she's human. - learn more about her to eliminate her delusions - work in an idyllic virtual world run by the AI's company - CAPTCHA your environment we made 1000xRESIST, and this is our next game: Prove You're Human!
0:38

we're making a game in which an AI dares to dream that she's human. - learn more about her to eliminate her delusions - work in an idyllic virtual world run by the AI's company - CAPTCHA your environment we made 1000xRESIST, and this is our next game: Prove You're Human!

sunset visitor | Prove You're Human - Wishlist Now

137,489 views • 1 month ago

Tesla owners insured with Lemonade who use FSD can save up to 50% on their insurance rates when the system is engaged, as it is 7x safer than a human driver. Lemonade gains access to the vehicle's telemetry data, which distinguishes between miles driven by FSD and miles driven by the human. The program is rolling out first in Arizona this month, then Oregon, with potential expansion to other states. Depending on several factors, FSD could essentially pay for itself through the savings.
1:14

Tesla owners insured with Lemonade who use FSD can save up to 50% on their insurance rates when the system is engaged, as it is 7x safer than a human driver. Lemonade gains access to the vehicle's telemetry data, which distinguishes between miles driven by FSD and miles driven by the human. The program is rolling out first in Arizona this month, then Oregon, with potential expansion to other states. Depending on several factors, FSD could essentially pay for itself through the savings.

Nic Cruz Patane

34,282 views • 6 months ago

Happy to share the publication of our paper in nature Conformational ensembles of the human intrinsically disordered proteome Work led by Giulio Tesei and Anna Ida🕊. I'll post more later, but for now here is a link: and a short movie about the work
2:17

Happy to share the publication of our paper in nature Conformational ensembles of the human intrinsically disordered proteome Work led by Giulio Tesei and Anna Ida🕊. I'll post more later, but for now here is a link: and a short movie about the work

Kresten Lindorff-Larsen

119,703 views • 2 years ago

ELON MUSK: "Tesla full-self driving software, which is really just AI and cameras - we don't use radars or lidar or anything like that. It's really trying to drive the car in the same way that human drives the car, which is human drives the car primarily with vision and with a biological neural net, that we take the same approach with our vehicles, which is a digital neural net, and cameras, and we expect this approach to ultimately be at least an order of magnitude safer than humans driving. It is quite magical, because the car feels like it is sentient. It feels actually feels like it's alive. We already have some vehicles operating with no people inside and no safety monitors in three cities in Texas, and probably will be widespread in the US."
1:34

ELON MUSK: "Tesla full-self driving software, which is really just AI and cameras - we don't use radars or lidar or anything like that. It's really trying to drive the car in the same way that human drives the car, which is human drives the car primarily with vision and with a biological neural net, that we take the same approach with our vehicles, which is a digital neural net, and cameras, and we expect this approach to ultimately be at least an order of magnitude safer than humans driving. It is quite magical, because the car feels like it is sentient. It feels actually feels like it's alive. We already have some vehicles operating with no people inside and no safety monitors in three cities in Texas, and probably will be widespread in the US."

DogeDesigner

29,208 views • 2 months ago

The inch derives from the width of a human thumb. The foot from the length of a human foot. The pace, the cubit, the furlong - each unit in the ancient measurement system traces back to a dimension of the human body, connecting the geometry of human anatomy directly to the geometry of the built world. Randall makes this concrete and physical - he has laid out 660 feet in an open field, marked a single inch at one end, and demonstrated the relationship firsthand. These are not abstract units. They are embodied ones. The ratio Randall arrives at is where the argument crystallizes. The furlong is to the inch as the Earth is to a mile. That relationship is not a coincidence of historical accident - it is evidence of a measurement system deliberately constructed to encode the dimensions of the planet into the units of human scale. The same system that begins with the width of a thumb ends with the circumference of the Earth, and every unit in between maintains a precise proportional relationship to both. Randall’s broader argument throughout his research converges here - the ancient world did not measure things arbitrarily. It built a system in which the human body, the sacred structure, and the planet itself were all expressions of the same underlying geometric order.
0:45

The inch derives from the width of a human thumb. The foot from the length of a human foot. The pace, the cubit, the furlong - each unit in the ancient measurement system traces back to a dimension of the human body, connecting the geometry of human anatomy directly to the geometry of the built world. Randall makes this concrete and physical - he has laid out 660 feet in an open field, marked a single inch at one end, and demonstrated the relationship firsthand. These are not abstract units. They are embodied ones. The ratio Randall arrives at is where the argument crystallizes. The furlong is to the inch as the Earth is to a mile. That relationship is not a coincidence of historical accident - it is evidence of a measurement system deliberately constructed to encode the dimensions of the planet into the units of human scale. The same system that begins with the width of a thumb ends with the circumference of the Earth, and every unit in between maintains a precise proportional relationship to both. Randall’s broader argument throughout his research converges here - the ancient world did not measure things arbitrarily. It built a system in which the human body, the sacred structure, and the planet itself were all expressions of the same underlying geometric order.

Randall Carlson

24,317 views • 4 months ago

🚨🚨🚨🚨 Oh-oh! First experiments of genetic vaccines getting absorbed by human cells completed - Prof Sucharit Bhakdi reveals. ----------------------------- Our two lady scientists who are just brilliant, they took cells, human cells, and immersed these cells in the vaccine and they found, and these are the first experiments that have ever been done, okay, that the human cells immediately took up the vaccines and the DNA and the chromosomes, and the chromosomes, bacterial chromosomes, entered the cells and these cells immediately started making the spike protein in horrendous quantity and they have quantified this, they have shown what happens to the spike protein, that it is stable, that it is shed into the blood, into the circulation, they have shown that they can measure this in the blood, they can measure this anywhere actually, and they have shown that the plasmid and the spike production goes on for many, many days. So, what did our girls do? They sent their human cells that had been transfected to Kevin McKernan, begging the question, Kevin, can you find any chromosomal integration of bacterial DNA in the human cell chromosomes? Do you know the answer? He put it up in his substack one week ago, and the answer is yes. He's found it. ------------------------------------- Kevin McKernan
5:27

🚨🚨🚨🚨 Oh-oh! First experiments of genetic vaccines getting absorbed by human cells completed - Prof Sucharit Bhakdi reveals. ----------------------------- Our two lady scientists who are just brilliant, they took cells, human cells, and immersed these cells in the vaccine and they found, and these are the first experiments that have ever been done, okay, that the human cells immediately took up the vaccines and the DNA and the chromosomes, and the chromosomes, bacterial chromosomes, entered the cells and these cells immediately started making the spike protein in horrendous quantity and they have quantified this, they have shown what happens to the spike protein, that it is stable, that it is shed into the blood, into the circulation, they have shown that they can measure this in the blood, they can measure this anywhere actually, and they have shown that the plasmid and the spike production goes on for many, many days. So, what did our girls do? They sent their human cells that had been transfected to Kevin McKernan, begging the question, Kevin, can you find any chromosomal integration of bacterial DNA in the human cell chromosomes? Do you know the answer? He put it up in his substack one week ago, and the answer is yes. He's found it. ------------------------------------- Kevin McKernan

aussie17

333,911 views • 2 years ago

Baykar Chairman and CTO Selçuk Bayraktar compares AI-powered combat drones to the computer that defeated Garry Kasparov, arguing that the comparison between human pilots and autonomous aircraft is becoming obsolete. “There is no human in this aircraft. It can do everything a manned aircraft does — and more,” he says, emphasizing that autonomous systems are cheaper and eliminate the years of training and human risk associated with fighter pilots: “The human is truly the most expensive element.”
1:02

Baykar Chairman and CTO Selçuk Bayraktar compares AI-powered combat drones to the computer that defeated Garry Kasparov, arguing that the comparison between human pilots and autonomous aircraft is becoming obsolete. “There is no human in this aircraft. It can do everything a manned aircraft does — and more,” he says, emphasizing that autonomous systems are cheaper and eliminate the years of training and human risk associated with fighter pilots: “The human is truly the most expensive element.”

Clash Report

22,974 views • 1 month ago

❗️Dozens of dignitaries walked out of Russia's speech to the U.N. Human Rights Council in Geneva in support of Ukraine. In the hallway, they unfolded Ukrainian and Crimean Tatar flags (today is Day of Resistance to Occupation of the Autonomous Republic of Crimea - on that day in 2014, Crimeans protested against Russian occupation of the peninsula). Some quotes by participants of the walk-out: "And we, along with our European and international partners, just walked out of the Human Rights Council as the Russian Deputy Foreign Minister spoke, because we stand with Ukraine and we stand in favour of a just and enduring peace in line with the UN Charter and with international law." "If we let slide what happened with Ukraine without reacting, without saying to which point that what Russia did is unacceptable, we would open the door to a disintegration of fundamental principles on which the United Nations was founded." Thankful to our Allies for support! Meanwhile, Russia's Deputy Foreign Minister Sergey Vershinin accused Ukraine of a "flagrant violation of fundamental human rights" and of Russophobia. 📹: Reuters
1:06

❗️Dozens of dignitaries walked out of Russia's speech to the U.N. Human Rights Council in Geneva in support of Ukraine. In the hallway, they unfolded Ukrainian and Crimean Tatar flags (today is Day of Resistance to Occupation of the Autonomous Republic of Crimea - on that day in 2014, Crimeans protested against Russian occupation of the peninsula). Some quotes by participants of the walk-out: "And we, along with our European and international partners, just walked out of the Human Rights Council as the Russian Deputy Foreign Minister spoke, because we stand with Ukraine and we stand in favour of a just and enduring peace in line with the UN Charter and with international law." "If we let slide what happened with Ukraine without reacting, without saying to which point that what Russia did is unacceptable, we would open the door to a disintegration of fundamental principles on which the United Nations was founded." Thankful to our Allies for support! Meanwhile, Russia's Deputy Foreign Minister Sergey Vershinin accused Ukraine of a "flagrant violation of fundamental human rights" and of Russophobia. 📹: Reuters

Anton Gerashchenko

735,883 views • 1 year ago