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#Postdoc Opportunity: Do you love #mechanobiology, #microscopy, and #cellmigration? Join our team at Cornell Biomedical Engineering and Weill Institute for Cell & Molecular Biology to investigate how cells squeeze their nucleus through tight spaces and how this affects nuclear structure and function.

39,353 görüntüleme • 2 yıl önce •via X (Twitter)

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Lammerding Lab profil fotoğrafı
Lammerding Lab2 yıl önce

@CornellBME @weillinstitute Interesting question. We haven’t looked for this yet.

Edgar Gonzalez-Kozlova profil fotoğrafı
Edgar Gonzalez-Kozlova2 yıl önce

@CornellBME @weillinstitute where is this cell going and have you guys looked at extracellular vesicles role in cell migration?

Lammerding Lab profil fotoğrafı
Lammerding Lab2 yıl önce

@CornellBME @weillinstitute For some experiments, we use chemotactic gradients, but many cancer cells will also migrate without them. We have not yet looked at extracellular vesicles, but it is a good point.

Raffaele Di Giacomo, PhD profil fotoğrafı
Raffaele Di Giacomo, PhD2 yıl önce

Sounds like an incredible opportunity for those passionate about #mechanobiology and #cellmigration! How do you plan to explore the impact on nuclear structure and function specifically? Anyone interested should definitely check out Also, for more in-depth biomedical questions, look into AI-driven platform is a treasure trove for generating high-quality biomedical reviews. #Microscopy #Medicine. #OpenAI Sciqst powered by OpenAI.

Lammerding Lab profil fotoğrafı
Lammerding Lab2 yıl önce

@NCIYaminiDalal @CornellBME @weillinstitute @JeremiahHsia @NCIResearchCtr Thank you for the kind words!

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This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

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