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Reading the subtle difference in color between grayish tumor and white matter is the key to separating spinal ependymoma from normal spinal cord, plus a delicate touch to gently work the pathology free. Sight and feel working in harmony with high stakes - this is the essence of microneurosurgery...

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Michael T. Lawton, MD

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167,587 görüntüleme • 9 gün önce •via X (Twitter)

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Our latest work is out today in Science Magazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by Massimo Onesto with Neal Amin

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