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Retatrutide is the ultimate gateway peptide. Once you try it, everything changes. Appetite obliterated, fat melting off, energy steady, and it opens the door to the full biohacking stack. I’m down 31 lbs in 11 weeks. This isn’t just another GLP-1 — it’s next level.

23,346 views • 23 days ago •via X (Twitter)

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There's a question that keeps coming up: is retatrutide better than tirzepatide? In my experience, this is the wrong question. It's like asking whether steak or chicken is better. Steak is arguably more nutrient-dense, but some people do better on chicken, and there's no reason you wouldn't vary your protein sources. It's the same with GLPs. It's not either/or, you have to experiment. > Tirzepatide is a dual agonist. It hits GLP-1 and GIP receptors. > Retatrutide is a triple agonist. It hits GLP-1, GIP, and glucagon receptors. That glucagon piece is the key difference. It changes how your body uses fuel in a way tirzepatide simply doesn't. In clinical trials, retatrutide produced 24% average weight loss in 48 weeks. Tirzepatide produced 21% in 72 weeks. Reta produced better results in almost half the time. The glucagon receptor drives thermogenesis and fat oxidation, which you don't get with a dual agonist. But retatrutide comes with a tradeoff. It raises resting heart rate by 5-10 BPM, driven by the glucagon receptor, and happens at every dose level. Reta peaks around week 24 and reverses when you stop. This doesn't happen with tirzepatide. And that's exactly why you shouldn't be on either of these indefinitely. The problem is that most people are scared to cycle off because they've heard the horror stories about weight rebound. As a result, they stay on way too long. This isn't medical advice, but I believe the right approach is to be 12-16 weeks on, 8-10 weeks off. You cycle, monitor, and adjust. If you don't know how to properly come off a GLP, you have no business being on one. On top of that, if you're running the experiment but not tracking it, you're wasting it. - Get labs done: fasting insulin, blood glucose, A1C, etc. - Wear a tracker: monitor heart rate and HRV These compounds impact metabolic markers that matter way more than bodyweight. If you have weight to lose and you're interested in GLPs, run at least one cycle of each. See how your body responds to retatrutide. Then see how it responds to tirzepatide. Compare the data, and that's how you'll find what works. Because in performance healthcare, data wins, not the math. Comment "FATLOSS" below, and I'll send you my 70-page Peptide Bible. P.S. None of this is medical advice nor a recommendation.

Michael Morelli

39,227 views • 2 months ago

RETATRUTIDE is NOT JUST for WEIGHT LOSS… …and the fact that that’s what everyone is obsessing over tells me we’re still missing the point. 🙃 Because what I’m looking at? It’s not just the scale. It’s what’s happening underneath it. We’re talking 24% body weight reduction in trials… sure. BUT ALSO: 47% drop in inflammatory markers in 12 weeks. 2.1% drop in HbA1c. 42% reduction in visceral fat (the dangerous kind hugging your organs). 🫁 And then it gets uncomfortable… 31% lower cardiovascular mortality. 28% fewer heart attacks. 22% fewer strokes. Like… pause there. Because if this was just about weight loss… those numbers wouldn’t exist. This is metabolism. This is inflammation. This is mitochondrial signaling. 🧬 And THIS is where I start side-eyeing the narrative. Because you’ve been told this is about “calories” and “willpower.” Meanwhile your body is sitting there like— “Hey… I’m inflamed. I’m insulin resistant. I’m storing for a reason.” 👀 And instead of asking why… We’ve been handed drugs and told to shrink. But here’s the part nobody’s talking about… What happens when you stop? With semaglutide (Ozempic)… about 72% of people regain the weight. Tirzepatide? Around 60%. Retatrutide? ONLY 5–10%. That’s not a small difference. That’s a completely different conversation. Because now we’re NOT just talking about weight suppression… We’re talking about whether the terrain (esp hormones and body talk) actually changed. And if you’ve ever felt like you’re doing everything right… but your body keeps pulling you back… this matters more than you think. Because your body isn’t trying to sabotage you. It’s responding to something deeper. If you want me to break down what this actually means… and how peptides are shifting the entire conversation— Comment PEPTIDES and I’ll send you the full breakdown. 💡 #peptides #biohacking #womenshealth #hormones #healthandwellbeing

Dr Diane Kazer

78,308 views • 2 months ago