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Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it...

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The All-In Podcast

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Bret Scher, MD profil fotoğrafı
Bret Scher, MD1 yıl önce

@friedberg Great discussion about the recent research in mitochondria. I was fortunate enough to interview the author of one of the studies, @MitoPsychoBio If you’re interested in mitochondria, you definitely want to know Dr. Picard!

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World Transformation Movement2 yıl önce

The holy grail of insight needed to rehabilitate the human race! Leading psychiatrist says “this is the most important interview of all time, it solves the human condition, ends suffering & turmoil at its source & finally makes sense of our lives!”

Phil Walker profil fotoğrafı
Phil Walker1 yıl önce

@friedberg I would highly recommend interviewing Dr Roger Seheult. Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. Natural sun exposure improving mitochondria and curing severe covid.

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The Blanco1 yıl önce

@friedberg Very impressed that @friedberg is an @AphexTwin fan.

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crs1 yıl önce

@friedberg I’m assembling a team to make angiogenesis abundant. @Nicole_Paulk x @JessLaMae x @Jiankui_He x @foundmyfitness

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Average Joe1 yıl önce

@friedberg In most cases loss of mitochondria is an effect of inflammation not a cause of the disease. It may delay cell death in some cases, which is a big positive, but it isn’t going to cure the disease.

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Jason Kimball1 yıl önce

@friedberg Mitochondrial peptides are probably the most readily accessible mitochondrial therapy at the moment. And of course injectable NAD+, which arguably has its most profound effect in the mitochondria, has exploded in popularity.

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Jae Davis1 yıl önce

science corner is quickly becoming my favorite segment of the pod. would love to hear interviews with people like neil riordan or scotty nelson/ed clay, and go deeper into the specific stem cell therapies they offer. also would be great to hear more about how red light therapy repairs mitochondria.

Jilong | We provide AI marketer - 24/7 marketing profil fotoğrafı
Jilong | We provide AI marketer - 24/7 marketing1 yıl önce

@friedberg mitochondria = cell's powerhouse, data = marketing's powerhouse. tested 100+ accounts, optimizing engagement is like cellular energy—precise inputs, measurable outputs. friedberg's insights always spark new angles!

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Jeep Gypsy ✌🏻1 yıl önce

@friedberg Fasting causes the body to do this naturally.

Somewhere in the Middle profil fotoğrafı
Somewhere in the Middle1 yıl önce

@friedberg Now show us how mitochondria was created out of nothing at the same time the cell was created. The complexity of this is beyond accidents.

Benzer Videolar

I had Tom Benson, CEO of Mitrix on to discuss mitochondrial transplantation. We covered what mitochondria are, the discovery that your body is constantly delivering fresh mitochondria through your bloodstream (people didn’t know that mitochondria were transferred outside the cell until recently!), why we age, what kills mitochondria (stress, smoking, radiation, chemotherapy and certain antibiotics like fluoroquinolones, psych meds), why COVID destroys mitochondria and what that means for long COVID, the Alzheimer's and Parkinson's brain tissue regeneration research their company has already done in mice, what mitochondrial transplantation actually is and how it has already been used in pediatric heart surgery, what a bioreactor growing mitochondria for personal use might look like, and more.
1:13:59

I had Tom Benson, CEO of Mitrix on to discuss mitochondrial transplantation. We covered what mitochondria are, the discovery that your body is constantly delivering fresh mitochondria through your bloodstream (people didn’t know that mitochondria were transferred outside the cell until recently!), why we age, what kills mitochondria (stress, smoking, radiation, chemotherapy and certain antibiotics like fluoroquinolones, psych meds), why COVID destroys mitochondria and what that means for long COVID, the Alzheimer's and Parkinson's brain tissue regeneration research their company has already done in mice, what mitochondrial transplantation actually is and how it has already been used in pediatric heart surgery, what a bioreactor growing mitochondria for personal use might look like, and more.

Mikhaila Peterson

22,561 görüntüleme • 5 ay önce

How purpose and fulfillment physically change your brain's mitochondria: "People who felt more purpose in life and who felt more connected to others, it seemed like that was sufficient to increase the energy transformation capacity of the mitochondria in their brain." "If you tweak the mitochondria in a rat brain, you can change the behavior of that animal from more submissive to more dominant or from more dominant to more submissive." "Chronically stressful things actually damage the mitochondria in the brain, there are fewer mitochondria and they don't transform energy as well." "The human experience is the most direct way in which you can know whether the content of your life matches your energy and matches what matters for you." "Energy flow is the lynch pin between matter, the stuff of biology, and experiences." Martin Picard on Andrew D. Huberman, Ph.D.
9:31

How purpose and fulfillment physically change your brain's mitochondria: "People who felt more purpose in life and who felt more connected to others, it seemed like that was sufficient to increase the energy transformation capacity of the mitochondria in their brain." "If you tweak the mitochondria in a rat brain, you can change the behavior of that animal from more submissive to more dominant or from more dominant to more submissive." "Chronically stressful things actually damage the mitochondria in the brain, there are fewer mitochondria and they don't transform energy as well." "The human experience is the most direct way in which you can know whether the content of your life matches your energy and matches what matters for you." "Energy flow is the lynch pin between matter, the stuff of biology, and experiences." Martin Picard on Andrew D. Huberman, Ph.D.

Huberman Lab Clips

24,487 görüntüleme • 3 ay önce

People who felt more purpose in life had mitochondria in their brain that transformed energy more efficiently. The reverse may also be true: Having mitochondria that flow energy more easily may change how you see life. This is the finding Martin Picard — Columbia University professor of behavioural medicine & pioneer of mitochondrial psychobiology — and his team uncovered. They studied the brains of people after they died. Every year before death, participants reported how much purpose they felt, how connected they felt to others, how optimistic they were about the future. Then Picard & his team looked at their mitochondria. Specifically in the dorsolateral prefrontal cortex — the region involved in executive function and active reasoning. The people who felt more purpose had mitochondria with greater energy transformation capacity (specifically higher abundance of Complex I proteins). In Picard’s terms: lower energy resistance — energy flowing more easily through the brain tissue involved in how you think and decide. The human study couldn't tell which direction caused which. But animal studies suggest the relationship can run both ways. Chronic stress and defeat change mitochondria in the brain — Picard and others showed this in animal studies. Stress the animal, make it feel defeated, and the mitochondria in its brain change. Then reverse it. Boost or inhibit mitochondrial function directly in the brain. Anxiety shifts. Social behavior changes. Picard's conclusion: "How you feel can change mitochondria. The mitochondria can change probably how you feel."
1:46

People who felt more purpose in life had mitochondria in their brain that transformed energy more efficiently. The reverse may also be true: Having mitochondria that flow energy more easily may change how you see life. This is the finding Martin Picard — Columbia University professor of behavioural medicine & pioneer of mitochondrial psychobiology — and his team uncovered. They studied the brains of people after they died. Every year before death, participants reported how much purpose they felt, how connected they felt to others, how optimistic they were about the future. Then Picard & his team looked at their mitochondria. Specifically in the dorsolateral prefrontal cortex — the region involved in executive function and active reasoning. The people who felt more purpose had mitochondria with greater energy transformation capacity (specifically higher abundance of Complex I proteins). In Picard’s terms: lower energy resistance — energy flowing more easily through the brain tissue involved in how you think and decide. The human study couldn't tell which direction caused which. But animal studies suggest the relationship can run both ways. Chronic stress and defeat change mitochondria in the brain — Picard and others showed this in animal studies. Stress the animal, make it feel defeated, and the mitochondria in its brain change. Then reverse it. Boost or inhibit mitochondrial function directly in the brain. Anxiety shifts. Social behavior changes. Picard's conclusion: "How you feel can change mitochondria. The mitochondria can change probably how you feel."

no.mind

18,728 görüntüleme • 2 ay önce

New research in nature showing mitochondria can split into two different forms resolves a longstanding mystery of how mitochondria can simultaneously provide cells with energy and essential building blocks, even when resources are limited.
4:18

New research in nature showing mitochondria can split into two different forms resolves a longstanding mystery of how mitochondria can simultaneously provide cells with energy and essential building blocks, even when resources are limited.

Nature Portfolio

15,997 görüntüleme • 2 yıl önce

Mitochondria aren’t just the powerhouses of our cells. They are the link between energy and the human experience. This week, we published a video on The Science and Experience of Energy YouTube channel that gives an overview of this idea. Interested in learning more? Below are two articles from our Substack archives that touch on this topic and may stimulate your thinking while we’re on our summer publishing pause this month. • A New View of Mental Illnesses as Disorders of Brain Energy: • Feeling Energy and Bringing People Together: Thank you for being part of this movement to highlight the importance of mitochondria and energy in our health and what it means to be human!
3:15

Mitochondria aren’t just the powerhouses of our cells. They are the link between energy and the human experience. This week, we published a video on The Science and Experience of Energy YouTube channel that gives an overview of this idea. Interested in learning more? Below are two articles from our Substack archives that touch on this topic and may stimulate your thinking while we’re on our summer publishing pause this month. • A New View of Mental Illnesses as Disorders of Brain Energy: • Feeling Energy and Bringing People Together: Thank you for being part of this movement to highlight the importance of mitochondria and energy in our health and what it means to be human!

Martin Picard

12,846 görüntüleme • 3 ay önce

Every second, trillions of flowing cells transporting oxygen to your respiring mitochondria The blood is the bridge between breath and flowing electrons in your mitochondria So beautiful !
1:06

Every second, trillions of flowing cells transporting oxygen to your respiring mitochondria The blood is the bridge between breath and flowing electrons in your mitochondria So beautiful !

Martin Picard

87,605 görüntüleme • 1 yıl önce

THE CONTRASTING EFFECTS OF BLUE AND RED/NIR LIGHT ON THE MITOCHONDRIA. - Recent research published this year in Nature: Scientific Reports demonstrates the effects that light in the built environment has on human health. Our modern build environment is dominated by short-wavelength light from LEDs and fluorescent lighting. This can have deleterious effects on the mitochondria. Adding to this effect is the lack of long-wavelength light from sources like the sun and incandescent lighting bulbs. These long light wavelengths have a beneficial effect on mitochondria function and overall human health. The lack of them in our modern built environment, seems to be impacting public health in a delirious fashion. Two recent papers to read: 1. 2.
4:30

THE CONTRASTING EFFECTS OF BLUE AND RED/NIR LIGHT ON THE MITOCHONDRIA. - Recent research published this year in Nature: Scientific Reports demonstrates the effects that light in the built environment has on human health. Our modern build environment is dominated by short-wavelength light from LEDs and fluorescent lighting. This can have deleterious effects on the mitochondria. Adding to this effect is the lack of long-wavelength light from sources like the sun and incandescent lighting bulbs. These long light wavelengths have a beneficial effect on mitochondria function and overall human health. The lack of them in our modern built environment, seems to be impacting public health in a delirious fashion. Two recent papers to read: 1. 2.

Jonathan Jarecki

17,958 görüntüleme • 8 ay önce

Martin Picard — one of the leading scientists studying mitochondria — doesn't take any mitochondrial supplements. No NAD. No CoQ10. No antioxidant supplements. No Urolithin A. He's skeptical of the hype cycles around all of them. His reasoning: "Mitochondria have dozens of functions." Antioxidants were heavily promoted 10–20 years ago. Then we learned that too much can impair normal adaptation and signaling. Even on Urolithin A, where he says the science is fairly compelling: "I trust the wisdom of my body and my mitochondria more than I trust the pharma company that's trying to make and sell this." Another leading mitochondrial researcher who studies mitochondria for a living and doesn't take supplements himself. Nick Lane doesn't either. A pattern hard to ignore. The deeper these researchers study mitochondria, the less interested they seem in trying to outsmart their biology with a supplement stack.
0:51

Martin Picard — one of the leading scientists studying mitochondria — doesn't take any mitochondrial supplements. No NAD. No CoQ10. No antioxidant supplements. No Urolithin A. He's skeptical of the hype cycles around all of them. His reasoning: "Mitochondria have dozens of functions." Antioxidants were heavily promoted 10–20 years ago. Then we learned that too much can impair normal adaptation and signaling. Even on Urolithin A, where he says the science is fairly compelling: "I trust the wisdom of my body and my mitochondria more than I trust the pharma company that's trying to make and sell this." Another leading mitochondrial researcher who studies mitochondria for a living and doesn't take supplements himself. Nick Lane doesn't either. A pattern hard to ignore. The deeper these researchers study mitochondria, the less interested they seem in trying to outsmart their biology with a supplement stack.

no.mind

224,563 görüntüleme • 2 ay önce

Well-being is about energetics. You can look fine on the outside & still feel terrible. Medicine studies anatomy. But almost no one studies the system that powers it: mitochondria & bioenergetics. A cadaver can have perfect anatomy — yet it’s dead. Why? Because it lacks energy. Doug Wallace: “The important question is whether your mitochondria are functional or not. You have 10¹⁷ mitochondria, each with ~0.5 volts of membrane potential. The amount of energy in your body right now is the equivalent, as Nick Lane says, of a lightning bolt. The difference between being alive and dead is when that membrane potential collapses. We need to understand that as a central concept of what it is to be healthy and have health and well-being.”
2:01

Well-being is about energetics. You can look fine on the outside & still feel terrible. Medicine studies anatomy. But almost no one studies the system that powers it: mitochondria & bioenergetics. A cadaver can have perfect anatomy — yet it’s dead. Why? Because it lacks energy. Doug Wallace: “The important question is whether your mitochondria are functional or not. You have 10¹⁷ mitochondria, each with ~0.5 volts of membrane potential. The amount of energy in your body right now is the equivalent, as Nick Lane says, of a lightning bolt. The difference between being alive and dead is when that membrane potential collapses. We need to understand that as a central concept of what it is to be healthy and have health and well-being.”

no.mind

14,165 görüntüleme • 7 ay önce

Research reveals how mitochondria and the cell nucleus coordinate to create proteins
1:44

Research reveals how mitochondria and the cell nucleus coordinate to create proteins

Harvard Medical School

108,894 görüntüleme • 2 yıl önce

All sex hormone synthesis originates in the inner mitochondrial membrane, where an enzyme called P450scc cleaves a hydrocarbon chain from cholesterol to form pregnenolone. That means same cholesterol your physician (erroneously) says will kill you is what your body uses to make testosterone. Moreover, P450scc absorbs light. Why would an enzyme that acts inside the mitochondria respond to a blue wavelength of light that can never reach that far inside the body? Because the blue light that energizes P450scc is coming from inside the body. It is produced by the mitochondria itself. The implications of this understanding are massive. To maintain high sex hormone levels as you age, you must have high levels of LDL cholesterol and healthy, active mitochondria. Cold plunge therapy not only stimulates mitobiogenesis for production of new mitochondria, but also creates light -- e.g., inside brown adipose tissue (BAT) -- that energize the enzymes responsible for steroidogenesis. You might have heard online that there is no way to stop the inevitable decline of total testosterone as you age. I'm telling you that's bullshit.
4:58

All sex hormone synthesis originates in the inner mitochondrial membrane, where an enzyme called P450scc cleaves a hydrocarbon chain from cholesterol to form pregnenolone. That means same cholesterol your physician (erroneously) says will kill you is what your body uses to make testosterone. Moreover, P450scc absorbs light. Why would an enzyme that acts inside the mitochondria respond to a blue wavelength of light that can never reach that far inside the body? Because the blue light that energizes P450scc is coming from inside the body. It is produced by the mitochondria itself. The implications of this understanding are massive. To maintain high sex hormone levels as you age, you must have high levels of LDL cholesterol and healthy, active mitochondria. Cold plunge therapy not only stimulates mitobiogenesis for production of new mitochondria, but also creates light -- e.g., inside brown adipose tissue (BAT) -- that energize the enzymes responsible for steroidogenesis. You might have heard online that there is no way to stop the inevitable decline of total testosterone as you age. I'm telling you that's bullshit.

Thomas P Seager, PhD

54,149 görüntüleme • 1 yıl önce

Some professionals recognize that cancer cells ferment in the cytoplasm, but few acknowledge that all major forms of cancer also ferment inside the mitochondria. If we are to make meaningful progress in cancer management, we must understand it all begins in the mitochondria. Watch the full interview: Read the full publication:
1:18

Some professionals recognize that cancer cells ferment in the cytoplasm, but few acknowledge that all major forms of cancer also ferment inside the mitochondria. If we are to make meaningful progress in cancer management, we must understand it all begins in the mitochondria. Watch the full interview: Read the full publication:

Thomas N. Seyfried

38,714 görüntüleme • 1 yıl önce

Nick Lane — one of the world's leading biochemists on mitochondria and the origin of life — doesn't take supplements. His reasoning: "So if you're thinking about taking supplements or whatever it may be, you've got to think — what are the long-term consequences of doing this? We don't really have any good information on how that's going to work out in the long run. And you don't know what you're missing. So that's why I don't do it personally." Your biology operates as a system. Affect one variable and you affect everything connected to it. Take antioxidants as an example. For decades, health advice pushed them as the fix for aging — on the assumption that free radicals are cellular garbage to be swept away. According to Lane, that assumption is wrong. At normal levels, free radicals act as signals. When mitochondria run into metabolic stress, those signals alter transcription factors in the nucleus — proteins that switch genes on and off. They tell the cell what to do next: build fresh mitochondria, activate its own antioxidant defenses, or trigger apoptosis — programmed cell death — if the damage is beyond repair. Flooding the system with antioxidant supplements mutes that signal. It leaves the cell blind to its own internal state. But there's a second problem — independent of the signaling issue. Researcher Gustavo Barja traced most free radical leakage to one specific subunit inside Complex I — out of more than 40 subunits in that single complex. Free radicals leak directly into the space right next to mitochondrial DNA. There are tens of thousands of complexes per mitochondrion. Hundreds of mitochondria per cell. Roughly 50 trillion cells in the body. Hitting that exact site with enough antioxidant concentration is close to impossible. Antioxidant supplements don't fail only because they mute a signal. They fail because the target is unreachable. You cannot supplement your way out of a systems problem.
1:26

Nick Lane — one of the world's leading biochemists on mitochondria and the origin of life — doesn't take supplements. His reasoning: "So if you're thinking about taking supplements or whatever it may be, you've got to think — what are the long-term consequences of doing this? We don't really have any good information on how that's going to work out in the long run. And you don't know what you're missing. So that's why I don't do it personally." Your biology operates as a system. Affect one variable and you affect everything connected to it. Take antioxidants as an example. For decades, health advice pushed them as the fix for aging — on the assumption that free radicals are cellular garbage to be swept away. According to Lane, that assumption is wrong. At normal levels, free radicals act as signals. When mitochondria run into metabolic stress, those signals alter transcription factors in the nucleus — proteins that switch genes on and off. They tell the cell what to do next: build fresh mitochondria, activate its own antioxidant defenses, or trigger apoptosis — programmed cell death — if the damage is beyond repair. Flooding the system with antioxidant supplements mutes that signal. It leaves the cell blind to its own internal state. But there's a second problem — independent of the signaling issue. Researcher Gustavo Barja traced most free radical leakage to one specific subunit inside Complex I — out of more than 40 subunits in that single complex. Free radicals leak directly into the space right next to mitochondrial DNA. There are tens of thousands of complexes per mitochondrion. Hundreds of mitochondria per cell. Roughly 50 trillion cells in the body. Hitting that exact site with enough antioxidant concentration is close to impossible. Antioxidant supplements don't fail only because they mute a signal. They fail because the target is unreachable. You cannot supplement your way out of a systems problem.

no.mind

138,167 görüntüleme • 2 ay önce

Dr. Andrew Huberman just confirmed a “wild conspiracy theory” about incandescent lights and LED bulbs. The long wavelengths found in incandescents increase your metabolism and “charge your mitochondria.” Conversely, the LED bulbs that most of you have in your house are “causing disruptions in mitochondrial function.” DR. ANDREW HUBERMAN: “Your mitochondria function better, you increase ATP production, your metabolism increases in the presence of red light, long wavelength light to the skin.” “Shine long wavelength light on somebody, watch blood glucose levels in a blood glucose test, and it’s blunted.” “Now, the LED lights that are commonly used now… that short wavelength light, in the absence of long wavelength light, has been shown to damage the mitochondria.” “This used to be considered crazy. This was like chemtrail crazy, right?” “But now we’re starting to see from animal studies and human studies, from Glenn Jeffreys and others, that people’s vision gets better when they get in front of an incandescent bulb once a day.” “If they get sunlight, which also has long-wavelength light, your vision improves because of improvements in mitochondria.” The Biden administration quietly pushed incandescents out of the market through aggressive energy regulations. But you can still find them online today if you look hard enough. If that health insight stood out to you, there’s a lot more where that came from.
2:15

Dr. Andrew Huberman just confirmed a “wild conspiracy theory” about incandescent lights and LED bulbs. The long wavelengths found in incandescents increase your metabolism and “charge your mitochondria.” Conversely, the LED bulbs that most of you have in your house are “causing disruptions in mitochondrial function.” DR. ANDREW HUBERMAN: “Your mitochondria function better, you increase ATP production, your metabolism increases in the presence of red light, long wavelength light to the skin.” “Shine long wavelength light on somebody, watch blood glucose levels in a blood glucose test, and it’s blunted.” “Now, the LED lights that are commonly used now… that short wavelength light, in the absence of long wavelength light, has been shown to damage the mitochondria.” “This used to be considered crazy. This was like chemtrail crazy, right?” “But now we’re starting to see from animal studies and human studies, from Glenn Jeffreys and others, that people’s vision gets better when they get in front of an incandescent bulb once a day.” “If they get sunlight, which also has long-wavelength light, your vision improves because of improvements in mitochondria.” The Biden administration quietly pushed incandescents out of the market through aggressive energy regulations. But you can still find them online today if you look hard enough. If that health insight stood out to you, there’s a lot more where that came from.

A Midwestern Doctor

420,483 görüntüleme • 4 ay önce

A cell videoed through a microscope. The powerhouses/overlords of the cell, mitochondria, are shown in yellow. The nucleus is shown in cyan and actin filaments are shown in magenta. #CellBiology
0:29

A cell videoed through a microscope. The powerhouses/overlords of the cell, mitochondria, are shown in yellow. The nucleus is shown in cyan and actin filaments are shown in magenta. #CellBiology

Dylan Burnette

392,814 görüntüleme • 2 yıl önce