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New research in nature showing mitochondria can split into two different forms resolves a longstanding mystery of how mitochondria can simultaneously provide cells with energy and essential building blocks, even when resources are limited.

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15,997 次观看 • 1 年前 •via X (Twitter)

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Dr. Robert Thompson1 年前

@Nature Fascinating discovery! The complexity of mitochondrial function is still being uncovered.

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Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

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Mitochondria do more than power our cells: they shape how we think, feel, and experience the world. In this interview, Martin Picard breaks down his new research that illuminates how mitochondria affect brain energy, brain networks, mental health, and ultimately, our quality of life. Dr. Picard walks us through his team's revolutionary brain mapping study, which examined over 700 sections of the human brain to uncover how mitochondria are distributed and specialized by brain region and cell type. The results have profound implications for how we understand, cognitive decline, and psychiatric disorders like depression bipolar disorder and schizophrenia. In this episode, you'll learn: - Why mitochondrial health is essential for brain function - How different brain regions rely on different types of mitochondria - Why people respond so differently to the same metabolic dysfunction - How future scans and biomarkers could help us measure brain energy non-invasively - What it means to think of ourselves as “energetic beings” rather than just biological machines When it comes to metabolic psychiatry, mitochondria are a key player. This research is a huge step towards better understanding these tiny organelles and the role they play in mental health and cognitive function. Expert Featured: Dr. Martin Picard Martin Picard Resources Mentioned: Three Ways to Keep Your Mitochondria Healthy - A human brain map of mitochondrial respiratory capacity and diversity - CMEs Mentioned: Managing Major Mental Illness with Dietary Change: The New Science of Hope - Brain Energy: The Metabolic Theory of Mental Illness - Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at

Mitochondria do more than power our cells: they shape how we think, feel, and experience the world. In this interview, Martin Picard breaks down his new research that illuminates how mitochondria affect brain energy, brain networks, mental health, and ultimately, our quality of life. Dr. Picard walks us through his team's revolutionary brain mapping study, which examined over 700 sections of the human brain to uncover how mitochondria are distributed and specialized by brain region and cell type. The results have profound implications for how we understand, cognitive decline, and psychiatric disorders like depression bipolar disorder and schizophrenia. In this episode, you'll learn: - Why mitochondrial health is essential for brain function - How different brain regions rely on different types of mitochondria - Why people respond so differently to the same metabolic dysfunction - How future scans and biomarkers could help us measure brain energy non-invasively - What it means to think of ourselves as “energetic beings” rather than just biological machines When it comes to metabolic psychiatry, mitochondria are a key player. This research is a huge step towards better understanding these tiny organelles and the role they play in mental health and cognitive function. Expert Featured: Dr. Martin Picard Martin Picard Resources Mentioned: Three Ways to Keep Your Mitochondria Healthy - A human brain map of mitochondrial respiratory capacity and diversity - CMEs Mentioned: Managing Major Mental Illness with Dietary Change: The New Science of Hope - Brain Energy: The Metabolic Theory of Mental Illness - Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at

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How purpose and fulfillment physically change your brain's mitochondria: "People who felt more purpose in life and who felt more connected to others, it seemed like that was sufficient to increase the energy transformation capacity of the mitochondria in their brain." "If you tweak the mitochondria in a rat brain, you can change the behavior of that animal from more submissive to more dominant or from more dominant to more submissive." "Chronically stressful things actually damage the mitochondria in the brain, there are fewer mitochondria and they don't transform energy as well." "The human experience is the most direct way in which you can know whether the content of your life matches your energy and matches what matters for you." "Energy flow is the lynch pin between matter, the stuff of biology, and experiences." Martin Picard on Andrew D. Huberman, Ph.D.

How purpose and fulfillment physically change your brain's mitochondria: "People who felt more purpose in life and who felt more connected to others, it seemed like that was sufficient to increase the energy transformation capacity of the mitochondria in their brain." "If you tweak the mitochondria in a rat brain, you can change the behavior of that animal from more submissive to more dominant or from more dominant to more submissive." "Chronically stressful things actually damage the mitochondria in the brain, there are fewer mitochondria and they don't transform energy as well." "The human experience is the most direct way in which you can know whether the content of your life matches your energy and matches what matters for you." "Energy flow is the lynch pin between matter, the stuff of biology, and experiences." Martin Picard on Andrew D. Huberman, Ph.D.

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Naheed Nenshi

21,599 次观看 • 2 个月前

A banana in January in New York floods your mitochondria with deuterium. Your body has no tools to handle it. Dr. Laszlo Boros — former professor of pediatrics at the UCLA School of Medicine & pioneer of deutonomics — explains why seasonal & local eating isn't just a dietary preference. It's a fundamental requirement for mitochondrial function. Three independent mechanisms explain why. 1) Sunlight and photon pressure: Tropical fruits are naturally high in deuterium — the heavy isotope of hydrogen that causes ATP synthase nanomotors inside your mitochondria to stutter and break. In equatorial regions, high-intensity red and infrared sunlight penetrates the body and decreases the viscosity of water inside mitochondria — allowing the nanomotors to keep spinning despite the deuterium load. Eat that same banana in a dark New York winter — without the corresponding sunlight — and your mitochondria receive the heavy fuel without the light needed to process it. The nanomotors stall. 2) Microbiome desynchronization: Your gut microbiome is your primary deuterium filter. Here's the mechanism most people miss: Bacteria actively collect deuterium to fuel their own division. They run their nanomotors in reverse — pumping clean protons out while trapping heavy deuterons inside their cells. As they ferment your food, they strip out the deuterium and release deuterium-depleted metabolites — short-chain fatty acids and ketone bodies — back into your gut for clean energy production. The trapped deuterium gets excreted in your stool. But this filtering mechanism only works when your microbiome is adapted to the food you're eating. Bacteria are highly specialized. They only efficiently metabolize a narrow range of substrates. When you eat a consistent local diet — your microbiome develops a stable tailored population that knows exactly how to extract deuterium from those specific local foods. When you introduce an imported tropical fruit in winter — your gut bacteria are caught off guard. They haven't adapted to this foreign substrate. They can't ferment it efficiently. They can't trap the deuterium fast enough. It slips past the gut's mucosal barrier directly into your circulation — and into your mitochondria. 3) Nanomotor stutter and metabolic crowding: Inside your mitochondria are ATP synthase nanomotors — spinning at up to ~9,000 rotations per minute to pump protons and produce energy. A deuteron is twice as large and twice as heavy as a normal proton. When it enters these fast-spinning motors — it acts like a medicine ball thrown into a precision engine. It becomes stuck. The nanomotors stutter and break. The consequence is metabolic crowding. With the motors destroyed, protons can no longer return to the mitochondrial matrix to mix with oxygen and form metabolic water. Complete biological combustion stops. Just like an engine choked with fuel but lacking a working exhaust — your mitochondria can no longer fully burn incoming carbohydrates, fats, and proteins into their natural end products of carbon dioxide and water. The unburned fuel backs up and piles up inside your cells. Your body stores it as visceral fat, excessive glycogen, or abnormal proteins. This is metabolic crowding. And it is the biochemical root of obesity, diabetes, and cancer. Boros: "When you walk into a department store and you see those shiny apples and watermelons from wherever they're from — it's really not your food. First of all, it doesn't grow there, especially not in that season. And when you eat it, you don't have the light exposure, the oxygen partial pressure, and you name it." Eating locally and seasonally isn't a wellness trend. It's what your mitochondria were built for.

A banana in January in New York floods your mitochondria with deuterium. Your body has no tools to handle it. Dr. Laszlo Boros — former professor of pediatrics at the UCLA School of Medicine & pioneer of deutonomics — explains why seasonal & local eating isn't just a dietary preference. It's a fundamental requirement for mitochondrial function. Three independent mechanisms explain why. 1) Sunlight and photon pressure: Tropical fruits are naturally high in deuterium — the heavy isotope of hydrogen that causes ATP synthase nanomotors inside your mitochondria to stutter and break. In equatorial regions, high-intensity red and infrared sunlight penetrates the body and decreases the viscosity of water inside mitochondria — allowing the nanomotors to keep spinning despite the deuterium load. Eat that same banana in a dark New York winter — without the corresponding sunlight — and your mitochondria receive the heavy fuel without the light needed to process it. The nanomotors stall. 2) Microbiome desynchronization: Your gut microbiome is your primary deuterium filter. Here's the mechanism most people miss: Bacteria actively collect deuterium to fuel their own division. They run their nanomotors in reverse — pumping clean protons out while trapping heavy deuterons inside their cells. As they ferment your food, they strip out the deuterium and release deuterium-depleted metabolites — short-chain fatty acids and ketone bodies — back into your gut for clean energy production. The trapped deuterium gets excreted in your stool. But this filtering mechanism only works when your microbiome is adapted to the food you're eating. Bacteria are highly specialized. They only efficiently metabolize a narrow range of substrates. When you eat a consistent local diet — your microbiome develops a stable tailored population that knows exactly how to extract deuterium from those specific local foods. When you introduce an imported tropical fruit in winter — your gut bacteria are caught off guard. They haven't adapted to this foreign substrate. They can't ferment it efficiently. They can't trap the deuterium fast enough. It slips past the gut's mucosal barrier directly into your circulation — and into your mitochondria. 3) Nanomotor stutter and metabolic crowding: Inside your mitochondria are ATP synthase nanomotors — spinning at up to ~9,000 rotations per minute to pump protons and produce energy. A deuteron is twice as large and twice as heavy as a normal proton. When it enters these fast-spinning motors — it acts like a medicine ball thrown into a precision engine. It becomes stuck. The nanomotors stutter and break. The consequence is metabolic crowding. With the motors destroyed, protons can no longer return to the mitochondrial matrix to mix with oxygen and form metabolic water. Complete biological combustion stops. Just like an engine choked with fuel but lacking a working exhaust — your mitochondria can no longer fully burn incoming carbohydrates, fats, and proteins into their natural end products of carbon dioxide and water. The unburned fuel backs up and piles up inside your cells. Your body stores it as visceral fat, excessive glycogen, or abnormal proteins. This is metabolic crowding. And it is the biochemical root of obesity, diabetes, and cancer. Boros: "When you walk into a department store and you see those shiny apples and watermelons from wherever they're from — it's really not your food. First of all, it doesn't grow there, especially not in that season. And when you eat it, you don't have the light exposure, the oxygen partial pressure, and you name it." Eating locally and seasonally isn't a wellness trend. It's what your mitochondria were built for.

no.mind

117,632 次观看 • 2 个月前