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New research in nature showing mitochondria can split into two different forms resolves a longstanding mystery of how mitochondria can simultaneously provide cells with energy and essential building blocks, even when resources are limited.

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15,997 views • 1 year ago •via X (Twitter)

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Dr. Robert Thompson1 year ago

@Nature Fascinating discovery! The complexity of mitochondrial function is still being uncovered.

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Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

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How purpose and fulfillment physically change your brain's mitochondria: "People who felt more purpose in life and who felt more connected to others, it seemed like that was sufficient to increase the energy transformation capacity of the mitochondria in their brain." "If you tweak the mitochondria in a rat brain, you can change the behavior of that animal from more submissive to more dominant or from more dominant to more submissive." "Chronically stressful things actually damage the mitochondria in the brain, there are fewer mitochondria and they don't transform energy as well." "The human experience is the most direct way in which you can know whether the content of your life matches your energy and matches what matters for you." "Energy flow is the lynch pin between matter, the stuff of biology, and experiences." Martin Picard on Andrew D. Huberman, Ph.D.

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Every second, trillions of flowing cells transporting oxygen to your respiring mitochondria The blood is the bridge between breath and flowing electrons in your mitochondria So beautiful !

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