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Sleep doctor says taking melatonin without understanding what it does can cause serious harm to your body “Melatonin is by prescription only almost everywhere outside the United States. Melatonin is a hormone. There’s a reason you can’t go to CVS and get testosterone and estrogen, right? Hormones affect the... entire system. What you don’t want to do is have somebody just willy-nilly grabbing a hormone and starting to take it without understanding what’s going on with them” “More importantly, melatonin in particular interacts with SSRI medications. An SSRI is a serotonin-specific reuptake inhibitor, an antidepressant, things like Prozac, Zoloft, and Celexa. All of those are medications that can be affected by melatonin ingestion. In addition, melatonin can affect birth control, blood pressure medication, and diabetes medication” “Melatonin is a sleep regulator, not a sleep initiator. Melatonin doesn’t affect sleep drive, it affects sleep rhythm. It mainly affects your brain, telling it when it’s time to go to bed. It does not directly make you sleepy”show more

Mikli

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80,577 Aufrufe • vor 5 Monaten •via X (Twitter)

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15 Kommentare

Profilbild von Dave

Davevor 5 Monaten

dude. i literally just got a text from a parent who gave my 9 yr old one last night at a sleep over because she couldnt sleep!!! what in the fuck! am i in a simulation

Profilbild von Argyle Blue ©️

Argyle Blue ©️vor 5 Monaten

The max dose they tested melatonin with is .25mg without interfering with endocrine function. The lowest dose you see in stores is like 4mg. There needs to be a third neutraceurical pathway like in other countries I think.

Profilbild von Winston Wood

Winston Woodvor 5 Monaten

All the SSRIs these docs have prescribed me fucked me up way worse than melotonin

Profilbild von Nathan Prince

Nathan Princevor 5 Monaten

In other words. Don’t take SSRI. Melatonin is fine.

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Hopium Mastervor 5 Monaten

They should be taking magnesium glycinate, not melatonin

Profilbild von maxinpeen

maxinpeenvor 5 Monaten

This dude is assuming everyone is taking Ssri’s and heart medication. Melatonin is perfectly fine and can save you from a week of fkd up sleep.

Profilbild von Greg BD

Greg BDvor 5 Monaten

Apart from possible drug interactions, melatonin is a great, pretty safe therapeutic. Of course we need to pay attention to timing of dose because it sets our circadian rhythm. It has been used as a therapeutic for sleep, an antioxidant, anti cancer and neuro regeneration.

Profilbild von @moving

@movingvor 5 Monaten

Interesting info about melatonin in these posts:

Profilbild von Mikli

Miklivor 5 Monaten

Feat. @StevenBartlett @thesleepdoctor

Profilbild von Kurly Rose

Kurly Rosevor 5 Monaten

I went crazy on melatonin like mental

Profilbild von Thomas Blum

Thomas Blumvor 5 Monaten

To say that it "interacts" with SSRIs does not mean much, because everything interacts with everything. The question is, does it interact by increasing or decreasing power? Does it help the treatment or hinder? It's fashionable to criticize melatonin but I only see advantages

Profilbild von Xyz Xyz916

Xyz Xyz916vor 5 Monaten

Literally STFU

Profilbild von Tajwan Tamim

Tajwan Tamimvor 5 Monaten

That is a really fair point actually

Profilbild von dr_land

dr_landvor 5 Monaten

So someone taking SSRIs and eating like garbage probably is a bad thing?

Profilbild von Ryzo Labs

Ryzo Labsvor 5 Monaten

This is genuinely important and the doctor is right. Most people treat melatonin like a harmless sleep aid when it's actually a hormone that signals your brain when to sleep — not something that directly induces sleep. The prescription-only status in most countries exists for a reason. If you're on SSRIs, blood pressure meds or birth control this is especially worth taking seriously before grabbing it off a shelf.

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Andrew Huberman had a pretty strong take on melatonin on JRE. He doesn’t recommend it for sleep. High melatonin levels suppress puberty in kids. In animal studies, giving it to male hamsters made their testes shrink from marble-sized to rice-grain-sized in just one week. Females’ ovaries basically shriveled. It might knock you out at first, but it often wears off after a few hours, leaving you staring at the ceiling. And there are real concerns about what it does to testosterone and estrogen balance. I always thought melatonin was harmless because it’s “natural,” but this made me pause. Sleep is everything, but if a popular supplement is messing with hormones without even delivering deep, quality rest, we should probably be smarter about it. What do you use to help you sleep?

Andrew Huberman had a pretty strong take on melatonin on JRE. He doesn’t recommend it for sleep. High melatonin levels suppress puberty in kids. In animal studies, giving it to male hamsters made their testes shrink from marble-sized to rice-grain-sized in just one week. Females’ ovaries basically shriveled. It might knock you out at first, but it often wears off after a few hours, leaving you staring at the ceiling. And there are real concerns about what it does to testosterone and estrogen balance. I always thought melatonin was harmless because it’s “natural,” but this made me pause. Sleep is everything, but if a popular supplement is messing with hormones without even delivering deep, quality rest, we should probably be smarter about it. What do you use to help you sleep?

Camus

47,259 Aufrufe • vor 4 Monaten

Stop downing melatonin like candy. Andrew Huberman is sounding the alarm: High-dose melatonin supplements (20mg, 50mg — yes, people actually take that much) can suppress the hypothalamic-gonadal axis and potentially delay puberty and adolescence, especially in young people. While melatonin is naturally produced in many cells and has antioxidant properties, flooding your system with large supplemental amounts is a bad idea. His practical take: maybe a tiny bit occasionally, but not the mega-doses you see everywhere. It’s a timely reality check for anyone relying on melatonin nightly to fall asleep. Have you ever taken high-dose melatonin? Did it help or cause any weird side effects?

Stop downing melatonin like candy. Andrew Huberman is sounding the alarm: High-dose melatonin supplements (20mg, 50mg — yes, people actually take that much) can suppress the hypothalamic-gonadal axis and potentially delay puberty and adolescence, especially in young people. While melatonin is naturally produced in many cells and has antioxidant properties, flooding your system with large supplemental amounts is a bad idea. His practical take: maybe a tiny bit occasionally, but not the mega-doses you see everywhere. It’s a timely reality check for anyone relying on melatonin nightly to fall asleep. Have you ever taken high-dose melatonin? Did it help or cause any weird side effects?

Camus

26,404 Aufrufe • vor 6 Monaten

My top five tips to battle jet lag. 1. Early morning bright light exposure - This must be outside light from the sun. Aim for 30 minutes minimum. Light is the strongest zeitgeber that synchronizes the brain and body with the time zone you are in and resets your biological clock. The bright light signals to the brain that it's morning and time to wake up, and also activates the cortisol awakening response and inhibits melatonin production. 2. Exercise - Another zeitgeber that helps realign your circadian rhythm (your internal clock). Plus, it's great for your health. 3. High-dose creatine - Creatine can help support brain health in the context of stress. Jet lag is a big stress in the brain. Creatine starts to accumulate in the brain at a dose of 10g per day, and studies have found that 20-25g of creatine can improve brain function in the context of sleep deprivation. May not work for everyone but it works for me. 4. Strategic melatonin timing - A small dose of melatonin a couple of hours before you want to sleep helps signal to the brain it’s time to get ready for bed. This really helps when your internal clock thinks it is still daytime. 5. Avoid blue light exposure during the evening - Blue light inhibits melatonin, which is the last thing you want to do in the evening. Melatonin is the hormone that helps make you feel ready to sleep. Dimming lights or blue light-blocking glasses do the trick.

My top five tips to battle jet lag. 1. Early morning bright light exposure - This must be outside light from the sun. Aim for 30 minutes minimum. Light is the strongest zeitgeber that synchronizes the brain and body with the time zone you are in and resets your biological clock. The bright light signals to the brain that it's morning and time to wake up, and also activates the cortisol awakening response and inhibits melatonin production. 2. Exercise - Another zeitgeber that helps realign your circadian rhythm (your internal clock). Plus, it's great for your health. 3. High-dose creatine - Creatine can help support brain health in the context of stress. Jet lag is a big stress in the brain. Creatine starts to accumulate in the brain at a dose of 10g per day, and studies have found that 20-25g of creatine can improve brain function in the context of sleep deprivation. May not work for everyone but it works for me. 4. Strategic melatonin timing - A small dose of melatonin a couple of hours before you want to sleep helps signal to the brain it’s time to get ready for bed. This really helps when your internal clock thinks it is still daytime. 5. Avoid blue light exposure during the evening - Blue light inhibits melatonin, which is the last thing you want to do in the evening. Melatonin is the hormone that helps make you feel ready to sleep. Dimming lights or blue light-blocking glasses do the trick.

Dr. Rhonda Patrick

86,509 Aufrufe • vor 1 Jahr

$Does using melatonin raise heart failure risk? A preliminary (not peer-reviewed) conference abstract reported that adults with insomnia with ≥1 year of documented melatonin use had a 90% higher 5-year rate of heart failure and 3.5x more hospitalizations than adults without a documented use of melatonin. There are some major caveats: this is observational (an association, not causation), the database mixed countries where melatonin is over-the-counter vs prescription, and insomnia severity and other psychiatric conditions weren’t captured. Importantly, randomized trials in people with established heart failure show no harm from melatonin use and some signals of benefit including better quality of life and improved ejection fraction. This is an interesting real-world signal that merits peer review and careful follow-up, but it is not proof that melatonin causes heart failure.$

Does using melatonin raise heart failure risk? A preliminary (not peer-reviewed) conference abstract reported that adults with insomnia with ≥1 year of documented melatonin use had a 90% higher 5-year rate of heart failure and 3.5x more hospitalizations than adults without a documented use of melatonin. There are some major caveats: this is observational (an association, not causation), the database mixed countries where melatonin is over-the-counter vs prescription, and insomnia severity and other psychiatric conditions weren’t captured. Importantly, randomized trials in people with established heart failure show no harm from melatonin use and some signals of benefit including better quality of life and improved ejection fraction. This is an interesting real-world signal that merits peer review and careful follow-up, but it is not proof that melatonin causes heart failure.

Dr. Rhonda Patrick

70,375 Aufrufe • vor 9 Monaten

If you’ve tried everything—melatonin, magnesium, breathwork, and still can’t sleep, this might be what you’re missing. I started using Hapbee, and it’s a total game-changer. On my 8-hour flight from Dubai, I set it to sleep mode and woke up 8 hours and 2 minutes later, fully rested. No supplements, no grogginess—just deep, natural sleep. Here’s how it works: ✅ Goes under your pillow—no wires, no weird sounds ✅ Uses frequency technology to mimic melatonin, adenosine & even caffeine without actually taking them ✅ Turn it off & the effect stops instantly—no lingering side effects You can even use the caffeine setting in the morning for a boost without drinking coffee Are you giving it a try? LEARN MORE:

If you’ve tried everything—melatonin, magnesium, breathwork, and still can’t sleep, this might be what you’re missing. I started using Hapbee, and it’s a total game-changer. On my 8-hour flight from Dubai, I set it to sleep mode and woke up 8 hours and 2 minutes later, fully rested. No supplements, no grogginess—just deep, natural sleep. Here’s how it works: ✅ Goes under your pillow—no wires, no weird sounds ✅ Uses frequency technology to mimic melatonin, adenosine & even caffeine without actually taking them ✅ Turn it off & the effect stops instantly—no lingering side effects You can even use the caffeine setting in the morning for a boost without drinking coffee Are you giving it a try? LEARN MORE:

Gary Brecka

104,461 Aufrufe • vor 1 Jahr

Bryan Johnson reveals what you MUST do to get the best sleep possible ''Reading a book for 10 minutes before bed is as powerful as sleep medication, on some metrics it's even more powerful than sleep meds'' ''Have your final meal of the day 4 hours before bed, it gives your body time to digest, and when your body has that distance it will lower its body temperature, your blood glucose will be down, melatonin is produced and it gets the body in a more relaxed state'' ''You need like an hour wind down routine, if your bedtime is 10 PM, when 9 PM comes turn off all the screens and spend that hour doing things that relax you, read a book, breath work, meditation, hang out with a friend, anything but be on your screen''

Bryan Johnson reveals what you MUST do to get the best sleep possible ''Reading a book for 10 minutes before bed is as powerful as sleep medication, on some metrics it's even more powerful than sleep meds'' ''Have your final meal of the day 4 hours before bed, it gives your body time to digest, and when your body has that distance it will lower its body temperature, your blood glucose will be down, melatonin is produced and it gets the body in a more relaxed state'' ''You need like an hour wind down routine, if your bedtime is 10 PM, when 9 PM comes turn off all the screens and spend that hour doing things that relax you, read a book, breath work, meditation, hang out with a friend, anything but be on your screen''

Mikli

1,687,061 Aufrufe • vor 7 Monaten

Bryan Johnson reveals what you MUST do to get the best sleep possible ''Reading a book for 10 minutes before bed is as powerful as sleep medication, on some metrics it's even more powerful than sleep meds'' ''Have your final meal of the day 4 hours before bed, it gives your body time to digest, and when your body has that distance it will lower its body temperature, your blood glucose will be down, melatonin is produced and it gets the body in a more relaxed state'' ''You need like an hour wind down routine, if your bedtime is 10 PM, when 9 PM comes turn off all the screens and spend that hour doing things that relax you, read a book, breath work, meditation, hang out with a friend, anything but be on your screen''

Bryan Johnson reveals what you MUST do to get the best sleep possible ''Reading a book for 10 minutes before bed is as powerful as sleep medication, on some metrics it's even more powerful than sleep meds'' ''Have your final meal of the day 4 hours before bed, it gives your body time to digest, and when your body has that distance it will lower its body temperature, your blood glucose will be down, melatonin is produced and it gets the body in a more relaxed state'' ''You need like an hour wind down routine, if your bedtime is 10 PM, when 9 PM comes turn off all the screens and spend that hour doing things that relax you, read a book, breath work, meditation, hang out with a friend, anything but be on your screen''

Teddy - PolyBackTest.com

825,453 Aufrufe • vor 6 Monaten

The only thing worse than Homeopathy? Scientists on the internet without any knowledge on clinical medical practice, selling supplements that they endorse, using misinformation masquerading as "solid peer reviewed science." Check this video out, when Huberman bullshits everyone in just half a minute on the Joe Rogan Experience Podcast. Before I go on, please remember this The Bullshit Asymmetry Principle, also known as Brandolini’s Law, states that the amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it. Which means, I have to put extra effort just to debunk the 36 seconds of that podcast. First, a little about sleep disorders Sleep disorders are of different types and due to different causes. The diagnosis is simply not "I can't sleep" and so here, take this sleep cocktail. Many patients come with sleep disorders that are associated with other conditions. For example, cirrhosis patients have sleep disorders that require management with ammonia lowering therapies and severe cases can only be reversed with a liver transplant. Patients with alcohol use disorders have sleep disorders that require management with de-addiction therapies along with sedatives. Sleep disorders in the ICU set up has different causes. People with mental health disorders have associated sleep disorders. Certain sleep disorders have no identifiable causes and are called "idiopathic." Which means, coming on a podcast and blindly giving out a "sleep cocktail" to millions of viewers, who may be suffering from a sleep disorder which has an as yet unidentified cause, is one of the most foolish things one can do. And Huberman, not being an actual clinical doctor, makes that exact mistake. Huberman claims (very generally and casually), melatonin helps you to go to sleep, but does not maintain sleep. But "solid peer reviewed" studies have much more to say about melatonin. Melatonin improved sleep onset latency and total sleep time in children/adolescents with neurodevelopmental disorders. Melatonin also improved and sleep onset latency and total sleep time in adults with delayed sleep phase disorder. Treatment with melatonin has positive effects on sleep quality in adults with respiratory diseases, metabolic disorders, primary sleep disorders, not with mental disorders, neurodegenerative diseases and other diseases. This meta-analysis demonstrated that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. Another large meta-analysis showed that melatonin dosing and timing matters: for circadian phase advancement, an earlier time and smaller dose, but for sleep quality/consolidation a larger and later dose seemed appropriate. See here: So melatonin does increase total sleep time, total sleep quality and reduces time to sleep and has beneficial effects in specific groups of patients. Now the "solid peer reviewed studies" on the cocktail - which Huberman claims on three supplements - magnesium threonate, apigenin and L-theanine. Unfortunately, such "solid peer-reviewed papers" DO NOT EXIST. Lets see. Magnesium supplements: First of all, there is no conclusive evidence that magnesium, dietary or supplemented has any actual effect on sleep. Randomized clinical trials showed an uncertain association between magnesium supplementation and sleep disorders. See here: Forget sleep, magnesium has absolutely no evidence for involvement even in mood disorders. See here: This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. See here: Apigenin (from Chamomille): The possible sleep inducing effects of apigenin is still speculative. There are absolutely no solid peer reviewed studies or evidence for benefits of apigenin in sleep as Huberman claims. See here: A randomized, double-blind, placebo-controlled pilot trial showed that chamomille DID NOT have conclusive effects on sleep. See here: Even better, a systematic review and meta-analysis of randomized trials and quasi-randomized trials showed that there was very little evidence to show effect of chamomille on insomnia. See here: L-theanine supplements: There is absolutely NO study or data to suggest that L-theanine is useful for sleep induction, improving sleep quality or increasing total sleep time. The only studies that are of "better quality" shows that L-theanine "maybe" useful in reducing anxiety/ stress levels due to caffeine at night. See here and here The only other "study" on L-theanine which was done on mice and not humans showed effects only on brain related biomarkers and were not applicable in the clinical sense to humans - And coming to SOLID EVIDENCE on the "Huberman cocktail" - there is absolutely nothing in published literature to confirm that it works and there is no convincing mode of action of this cocktail in humans. A large systematic review and meta-analysis showed that Cognitive-Behavior Therapy for Insomnia was the best and not some random supplements proclaimed on a podcast by half-baked scientists who are full time supplement sellers. See here: There are basic scientists, with no or half-baked clinical practice knowledge, trying to sell you a bunch of useless supplements that they endorse for a paid-commission, using "science-sounding" words without any practical, rational or logical meaning; and push untested and unregulated therapies that are NEVER recommended, approved or promoted by any active, medical, scientific clinical societies worldwide. They are worse than pseudoscience peddlers. Be aware of where you find your health information. There is pseudoscience, but then there is also another terrible type of misinformation: BAD SCIENCE.

The only thing worse than Homeopathy? Scientists on the internet without any knowledge on clinical medical practice, selling supplements that they endorse, using misinformation masquerading as "solid peer reviewed science." Check this video out, when Huberman bullshits everyone in just half a minute on the Joe Rogan Experience Podcast. Before I go on, please remember this The Bullshit Asymmetry Principle, also known as Brandolini’s Law, states that the amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it. Which means, I have to put extra effort just to debunk the 36 seconds of that podcast. First, a little about sleep disorders Sleep disorders are of different types and due to different causes. The diagnosis is simply not "I can't sleep" and so here, take this sleep cocktail. Many patients come with sleep disorders that are associated with other conditions. For example, cirrhosis patients have sleep disorders that require management with ammonia lowering therapies and severe cases can only be reversed with a liver transplant. Patients with alcohol use disorders have sleep disorders that require management with de-addiction therapies along with sedatives. Sleep disorders in the ICU set up has different causes. People with mental health disorders have associated sleep disorders. Certain sleep disorders have no identifiable causes and are called "idiopathic." Which means, coming on a podcast and blindly giving out a "sleep cocktail" to millions of viewers, who may be suffering from a sleep disorder which has an as yet unidentified cause, is one of the most foolish things one can do. And Huberman, not being an actual clinical doctor, makes that exact mistake. Huberman claims (very generally and casually), melatonin helps you to go to sleep, but does not maintain sleep. But "solid peer reviewed" studies have much more to say about melatonin. Melatonin improved sleep onset latency and total sleep time in children/adolescents with neurodevelopmental disorders. Melatonin also improved and sleep onset latency and total sleep time in adults with delayed sleep phase disorder. Treatment with melatonin has positive effects on sleep quality in adults with respiratory diseases, metabolic disorders, primary sleep disorders, not with mental disorders, neurodegenerative diseases and other diseases. This meta-analysis demonstrated that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. Another large meta-analysis showed that melatonin dosing and timing matters: for circadian phase advancement, an earlier time and smaller dose, but for sleep quality/consolidation a larger and later dose seemed appropriate. See here: So melatonin does increase total sleep time, total sleep quality and reduces time to sleep and has beneficial effects in specific groups of patients. Now the "solid peer reviewed studies" on the cocktail - which Huberman claims on three supplements - magnesium threonate, apigenin and L-theanine. Unfortunately, such "solid peer-reviewed papers" DO NOT EXIST. Lets see. Magnesium supplements: First of all, there is no conclusive evidence that magnesium, dietary or supplemented has any actual effect on sleep. Randomized clinical trials showed an uncertain association between magnesium supplementation and sleep disorders. See here: Forget sleep, magnesium has absolutely no evidence for involvement even in mood disorders. See here: This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. See here: Apigenin (from Chamomille): The possible sleep inducing effects of apigenin is still speculative. There are absolutely no solid peer reviewed studies or evidence for benefits of apigenin in sleep as Huberman claims. See here: A randomized, double-blind, placebo-controlled pilot trial showed that chamomille DID NOT have conclusive effects on sleep. See here: Even better, a systematic review and meta-analysis of randomized trials and quasi-randomized trials showed that there was very little evidence to show effect of chamomille on insomnia. See here: L-theanine supplements: There is absolutely NO study or data to suggest that L-theanine is useful for sleep induction, improving sleep quality or increasing total sleep time. The only studies that are of "better quality" shows that L-theanine "maybe" useful in reducing anxiety/ stress levels due to caffeine at night. See here and here The only other "study" on L-theanine which was done on mice and not humans showed effects only on brain related biomarkers and were not applicable in the clinical sense to humans - And coming to SOLID EVIDENCE on the "Huberman cocktail" - there is absolutely nothing in published literature to confirm that it works and there is no convincing mode of action of this cocktail in humans. A large systematic review and meta-analysis showed that Cognitive-Behavior Therapy for Insomnia was the best and not some random supplements proclaimed on a podcast by half-baked scientists who are full time supplement sellers. See here: There are basic scientists, with no or half-baked clinical practice knowledge, trying to sell you a bunch of useless supplements that they endorse for a paid-commission, using "science-sounding" words without any practical, rational or logical meaning; and push untested and unregulated therapies that are NEVER recommended, approved or promoted by any active, medical, scientific clinical societies worldwide. They are worse than pseudoscience peddlers. Be aware of where you find your health information. There is pseudoscience, but then there is also another terrible type of misinformation: BAD SCIENCE.

TheLiverDoc™

475,648 Aufrufe • vor 3 Jahren

He takes 1,000mg of melatonin. As bulk powder. On purpose. And that's the least of it. This episode is the lab rat's rabbit hole with Richard, the researcher who runs everything through his own body before he'd ever tell you to. In this episode of Down to Health: - Why he calls melatonin the master antioxidant of the mitochondria, not a sleep aid - DNP, the most dangerous thing in the bodybuilding world, and what it was actually like - Where self-experimentation stops being a hobby and starts being a question - The five low-risk things he says anyone can do to call themselves healthy Hosted by Gator | Dentist, Calvin, and TJ Bongiorno. Brought to you by: • NOBS: • The Outgoing Co.: Special guest for this episode: Richard Follow Down To Health for more!

He takes 1,000mg of melatonin. As bulk powder. On purpose. And that's the least of it. This episode is the lab rat's rabbit hole with Richard, the researcher who runs everything through his own body before he'd ever tell you to. In this episode of Down to Health: - Why he calls melatonin the master antioxidant of the mitochondria, not a sleep aid - DNP, the most dangerous thing in the bodybuilding world, and what it was actually like - Where self-experimentation stops being a hobby and starts being a question - The five low-risk things he says anyone can do to call themselves healthy Hosted by Gator | Dentist, Calvin, and TJ Bongiorno. Brought to you by: • NOBS: • The Outgoing Co.: Special guest for this episode: Richard Follow Down To Health for more!

Down To Health

57,239 Aufrufe • vor 3 Monaten

Sleep doctor explains why morning sex is way better than late night “Most people are intimate between 10:30 and 11:30 PM. But here’s what’s interesting: your hormone profile doesn’t look too good at 11:30 PM for having sex. In order to have successful sex, you want estrogen, testosterone, progesterone, adrenaline, and cortisol all to be high, and melatonin to be low. What do you think your hormone profile looks like at 10:30 at night? It’s literally the opposite” “What do most men wake up with in the morning? An erection. If that’s not Mother Nature telling you when to use that thing, I don’t know what is right. We discovered that people actually have greater connection and greater performance when they have sex in the morning. Now, do you have to brush your teeth and throw in a little mouthwash first? Yes, of course you do, let’s be fair to your partner here”

Mikli

1,490,509 Aufrufe • vor 5 Monaten

If you had one question for a sleep expert, what would it be?? Today, Dr Michael Breus answers the questions people are usually too embarrassed to ask… Dr Michael is a clinical psychologist and board-certified sleep specialist. He’s spent the last 26 years helping people fix the one thing that impacts almost everything else - sleep. Michael brought me through the framework he uses with his clients. He started with chronotypes, how your body’s natural rhythm affects everything from energy to focus. Then we looked at blood sugar and how dips in the night can trigger those 3am wakeups. We spoke about why most people use melatonin wrong, and how core body temperature plays a bigger role in sleep than most of us realise!

If you had one question for a sleep expert, what would it be?? Today, Dr Michael Breus answers the questions people are usually too embarrassed to ask… Dr Michael is a clinical psychologist and board-certified sleep specialist. He’s spent the last 26 years helping people fix the one thing that impacts almost everything else - sleep. Michael brought me through the framework he uses with his clients. He started with chronotypes, how your body’s natural rhythm affects everything from energy to focus. Then we looked at blood sugar and how dips in the night can trigger those 3am wakeups. We spoke about why most people use melatonin wrong, and how core body temperature plays a bigger role in sleep than most of us realise!

Steven Bartlett

18,086 Aufrufe • vor 8 Monaten

Insulin sensitivity and glucose handling are most effective in the morning. That’s one reason I’m a fan of early time-restricted eating and not a fan of eating large meals (especially carb-heavy ones) within about 3 hours of bed. You can eat the exact same meal, with the same calories and macros, and get a very different insulin response depending on when you eat it. One reason is melatonin. As melatonin rises in the last few hours before your natural bedtime, it’s signaling to organs, including the pancreas, that it’s time to shift into recovery mode. That means insulin secretion may be less efficient late at night. This is how I prefer to eat, and many people find it to be beneficial. From my discussion with Andrew D. Huberman, Ph.D. earlier this year.

Insulin sensitivity and glucose handling are most effective in the morning. That’s one reason I’m a fan of early time-restricted eating and not a fan of eating large meals (especially carb-heavy ones) within about 3 hours of bed. You can eat the exact same meal, with the same calories and macros, and get a very different insulin response depending on when you eat it. One reason is melatonin. As melatonin rises in the last few hours before your natural bedtime, it’s signaling to organs, including the pancreas, that it’s time to shift into recovery mode. That means insulin secretion may be less efficient late at night. This is how I prefer to eat, and many people find it to be beneficial. From my discussion with Andrew D. Huberman, Ph.D. earlier this year.

Dr. Rhonda Patrick

125,750 Aufrufe • vor 3 Monaten

Waking Up to an Alarm in Mornings can cause a Significant Surge in Blood pressure ➡️Many people routinely use an alarm to wake up. As per a study, waking up to an alarm can result in 74% increase in Blood pressure (BP), as compared to those who wake up naturally (without an alarm). ➡️The increase in BP is greater among those who have slept for less than 7 hours (before waking up). ➡️This surge in BP can increase the risk of heart attack and stroke. ➡️The risk is higher among those who have preexisting heart disease or hypertension. ➡️Alarm can awaken you all of a sudden from deep sleep, and this can result in "sleep inertia", where a person can feel groggy for up to two hours. ➡️Waking up to an alarm can also increase the stress levels. What are the safer alternatives? 1. Avoid using alarm on a regular basis, 2. Sleep adequately (7-8 hours), allowing you to naturally wake up from sleep, 3. Allow natural light to come into your room, so that melatonin (sleep hormone) production in brain can reduce (with light exposure), allowing you to wake up naturally, 4. Maintain a consistent sleep schedule (going to bed at around the same time every night), which is in sync with your circadian rhythm, 5. If you must use an alarm, use a melodic or soothing sound, which are pleasant to listen too. #sleep #alarm #bp #bloodpressure #heartattack #stroke

Waking Up to an Alarm in Mornings can cause a Significant Surge in Blood pressure ➡️Many people routinely use an alarm to wake up. As per a study, waking up to an alarm can result in 74% increase in Blood pressure (BP), as compared to those who wake up naturally (without an alarm). ➡️The increase in BP is greater among those who have slept for less than 7 hours (before waking up). ➡️This surge in BP can increase the risk of heart attack and stroke. ➡️The risk is higher among those who have preexisting heart disease or hypertension. ➡️Alarm can awaken you all of a sudden from deep sleep, and this can result in "sleep inertia", where a person can feel groggy for up to two hours. ➡️Waking up to an alarm can also increase the stress levels. What are the safer alternatives? 1. Avoid using alarm on a regular basis, 2. Sleep adequately (7-8 hours), allowing you to naturally wake up from sleep, 3. Allow natural light to come into your room, so that melatonin (sleep hormone) production in brain can reduce (with light exposure), allowing you to wake up naturally, 4. Maintain a consistent sleep schedule (going to bed at around the same time every night), which is in sync with your circadian rhythm, 5. If you must use an alarm, use a melodic or soothing sound, which are pleasant to listen too. #sleep #alarm #bp #bloodpressure #heartattack #stroke

Dr Sudhir Kumar MD DM

63,666 Aufrufe • vor 2 Jahren

Andrew Huberman says one pep doubled his REM sleep, and here's what he and Dr. Craig Koniver said about it: "For the last 4 to 6 months I've had the opportunity to try pinealon, injectable pinealon combined with glycine. Never before have I found something that can improve the amount of REM sleep that I get." "I'm not doing this every night. I do it occasionally as a little experiment, and I track my sleep with the sleep tracker in Eight Sleep. It's doubling the amount of REM sleep I'm getting, from an hour and 30 to nearly 3 hours." "What's really interesting to me is that it seems to improve my sleep on the nights when I don't take it." Koniver: "It's one of the smallest peptides, but I think it's one of the most profound. I have never ever seen a negative side effect from pinealon." Huberman: "People are going to start selling pinealon, but you need to know you're actually getting pinealon. Maybe they just throw some melatonin in there and call it pinealon." Not medical advice. Talk to a doctor who knows peps before trying anything.

Andrew Huberman says one pep doubled his REM sleep, and here's what he and Dr. Craig Koniver said about it: "For the last 4 to 6 months I've had the opportunity to try pinealon, injectable pinealon combined with glycine. Never before have I found something that can improve the amount of REM sleep that I get." "I'm not doing this every night. I do it occasionally as a little experiment, and I track my sleep with the sleep tracker in Eight Sleep. It's doubling the amount of REM sleep I'm getting, from an hour and 30 to nearly 3 hours." "What's really interesting to me is that it seems to improve my sleep on the nights when I don't take it." Koniver: "It's one of the smallest peptides, but I think it's one of the most profound. I have never ever seen a negative side effect from pinealon." Huberman: "People are going to start selling pinealon, but you need to know you're actually getting pinealon. Maybe they just throw some melatonin in there and call it pinealon." Not medical advice. Talk to a doctor who knows peps before trying anything.

peptidedaily

56,818 Aufrufe • vor 15 Tagen

WHY YOU WAKE UP IN THE MIDDLE OF THE NIGHT Your brain has 20,000 neurons clustered in the hypothalamus. They form the suprachiasmatic nucleus. This is your master clock. It's been running since before birth. At 25, this clock kept you unconscious until morning. At 65, the same clock runs on less melatonin, weaker signals, and a rhythm that physically shifted 2-3 hours earlier. It fires a wake signal between 2-4 a.m. Four systems inside your body shifted with age. They converge at the same hour every night. The thoughts that arrive at 3 a.m. feel different from the same thoughts at 3 p.m. because your brain runs a different program in the dark. The part that would normally tell you those thoughts aren't emergencies is still asleep. THE CLOCK MOVED FORWARD The suprachiasmatic nucleus generates a near 24-hour rhythm controlling when you feel alert and when you feel sleepy. In young adults, peak sleepiness arrives around 11 p.m. Peak alertness arrives around 9-10 a.m. Blue light at 480 nanometers activates melanopsin cells in the retina. These cells send signals directly to the suprachiasmatic nucleus, synchronizing your clock to the day-night cycle. With age, the clock shifts earlier. This is circadian phase advance. The sleepiness signal arrives at 7-8 p.m. instead of 11 p.m. The wake signal arrives at 3-4 a.m. instead of 6-7 a.m. The entire sleep-wake window moves forward 2-3 hours. The suprachiasmatic nucleus itself degrades. Neurons deteriorate. The amplitude of the circadian signal weakens. Peaks become shallower. Troughs become less deep. The radio station loses transmitter power until the signal becomes fuzzy and inconsistent. The clock's sensitivity to light cues diminishes through two mechanisms. The aging lens yellows and thickens, filtering more blue light before it reaches the melanopsin cells. The suprachiasmatic neurons themselves respond less robustly to whatever signal does arrive. Weaker input through a cloudier window. Less responsive neurons processing that input. The clock drifts. When the circadian clock drifts without strong light cues, it drifts earlier. Phase advance is the default direction of an unanchored aging clock. MELATONIN COLLAPSED The pineal gland releases melatonin at night to initiate and maintain sleep. This hormone declines with age. The pineal gland calcifies gradually over decades, reducing functional tissue and capacity to produce melatonin. By 65, nighttime melatonin levels can be one-third to one-quarter of what they were at 30. Sometimes less. Melatonin doesn't just initiate sleep. It maintains depth and continuity across the full night. When melatonin is low, sleep is shallower, more fragmented, more vulnerable to interruption. Even if you fall asleep at a reasonable hour, low melatonin cannot hold you through to morning. Your body tries to put you to sleep at 8 p.m. and wake you at 3 a.m. That's a 7-hour sleep window. It might be enough sleep for your shifted clock. But you fight the 8 o'clock drowsiness. Social life, television, family, habit. You stay up until 10 or 11. The clock doesn't adjust to your social schedule. It fires the wake signal at 3 regardless. The clock runs on light and biology, not preferences. You lost 2-3 hours from the front of your sleep window by staying up late. The alarm still goes off on the original schedule. The 3 a.m. waking isn't a malfunction. It's your shifted clock doing exactly what it was programmed to do. This is social jet lag. The gap between your biological clock time and your social clock time creates the same physiological mismatch as flying across two or three time zones. Your body is in one time zone. Your social life is in another. The drowsiness you fight at 8 p.m. is your body's genuine sleep onset signal. The waking at 3 a.m. is your body's genuine wake signal. The problem isn't the signals. The problem is overriding one without being able to override the other. There's a compounding factor. The shifted clock means your body wants to sleep earlier. The reduced melatonin means it cannot hold sleep as deeply or as long. You're caught between two problems: a clock that fires the wake signal too early and a chemical supply that cannot maintain the sleep signal through the full night. Even if you went to bed at 8, the reduced melatonin might still fail to hold you past 3 or 4. The clock shifted the window. The melatonin shrank it. DEEP SLEEP DISAPPEARED Sleep cycles through stages roughly every 90 minutes. Light sleep, deeper sleep, deeper sleep, then REM. The stage that matters most for feeling rested is slow-wave sleep, stage N3, the deepest phase. Brainwaves drop to large, slow delta oscillations at 0.5-4 hertz. During slow-wave sleep, the glymphatic system activates. Cerebrospinal fluid flushes through brain tissue along channels that open when neurons shrink slightly during deep sleep. This clears metabolic waste: adenosine, the molecule that builds sleep pressure during the day, and amyloid beta proteins, the plaques associated with Alzheimer's disease. Growth hormone pulses during N3. Tissue repair peaks. Memory consolidation occurs. The hippocampus replays the day's experiences and transfers them to long-term cortical storage. This is the sleep that makes you feel like you actually slept. At 25, roughly 20% of the night is spent in slow-wave sleep. By 65, that drops to 10-15%. By 75, some people get almost none. My sleep tracker tells me that I almost never get less than 30%... and I'm 60. It is possible to have restorative deep sleep no matter what your age is. In my case even at lower sleep duration. High energy availability alsp plays a big role. The slow wave generating circuits in the medial prefrontal cortex usually deteriorate with age, producing weaker and less frequent delta oscillations. The deep sleep itself becomes shallower. The waves are smaller. The duration shorter. The restorative process is less complete. If deep sleep is the period when the brain clears amyloid beta, then reduced deep sleep means reduced clearance. Less deep sleep leads to more amyloid, which leads to less deep sleep, which leads to more amyloid. The relationship is bidirectional and self-reinforcing. If you never feel fully rested no matter how many hours you spend in bed, if 8 hours produces the recovery that 6 hours used to produce, if you wake in the morning with the sense that something was missing from the night, the missing component may be slow wave sleep. The hours were there. The depth was not. Slow-wave sleep that remains concentrates in the first half of the night, the first two to three sleep cycles. By 2-3 a.m., most of the deep sleep budget has been spent. What remains for the second half of the night is lighter stage one and stage two sleep, interspersed with REM. Light sleep has a dramatically lower arousal threshold. Stimuli that would not have registered during slow-wave sleep can push you above the waking threshold in light sleep. A slight temperature change in the room. A bathroom urge from a bladder that fills faster with age. A noise from outside. Even the natural shift in body position. You wake at 3 a.m. partly because the sleep you're in at 3 a.m. is physiologically different from the sleep you're in at midnight. The fortress walls got thinner as the night progressed. By 3 o'clock, you're sleeping behind a screen door instead of a vault. You could sleep through thunderstorms at 30. Now you wake at the sound of a refrigerator cycling on. The physics isn't about the noise. It's about the stage of sleep you're in when the noise arrives. At midnight, during slow-wave sleep, your arousal threshold is high. The brain runs delta waves that suppress responsiveness to external stimuli. At 3 a.m. in stage 1 or stage 2, the threshold has dropped to a fraction of its midnight level. The same sound that the sleeping brain would have filtered at midnight wakes you at 3 because the brain is no longer running the program that filters it. CORTISOL ARRIVED EARLY Your body runs a cortisol rhythm called the cortisol awakening response. In the final hours of sleep, the adrenal glands begin increasing cortisol output, preparing the body for waking. Mobilizing glucose into the bloodstream. Priming the immune system for the day's pathogens. Raising blood pressure and heart rate toward daytime operating levels. In a young adult, this cortisol rise begins around 4-5 a.m. and peaks roughly 30-45 minutes after waking. With age, the rise begins earlier. 2-3 a.m. in many older adults. Low-carb diets can also trigger a relatively strong cortisol release, waking you up early.. The same circadian phase advance that shifted the sleep-wake window also shifted the cortisol curve. Every rhythm the suprachiasmatic nucleus controls moves in the same direction. Cortisol alone doesn't wake you. But combined with already light sleep and a shifted circadian clock, the cortisol rise adds a third signal, pushing you toward wakefulness at precisely the hour when the other two systems have already weakened your defenses. Three systems converging on the same window. The clock says wake up. The sleep stage says the walls are thin. The cortisol says the body is preparing for morning. All three signals arrive at 3 a.m. Not by coincidence. All three are governed by the same shifted circadian master clock. If the waking comes at almost exactly the same time every night, not randomly scattered across the early morning hours but clustered within the same 30-minute window, that precision is the signature of a circadian event. Cortisol is antagonistic to melatonin. The two hormones suppress each other. Cortisol inhibits melatonin production. Melatonin suppresses cortisol. In a young person with high melatonin and correctly timed cortisol, the two hormones hand off smoothly. Melatonin dominates the night. Cortisol rises toward morning. The transition is seamless. In an aging body with depleted melatonin and early-arriving cortisol, the handoff happens too soon. When cortisol starts rising at 2-3 a.m. and melatonin is already low, the biochemical conditions for staying asleep collapse. The melatonin that should be holding you under is insufficient. The cortisol that should not be arriving for another two hours is already here. Two hormones that are supposed to hand off like relay runners, one finishing as the other begins, instead collide in the same hour because both shifted on the same aging clock. The balance tips toward waking. THE WORST THOUGHTS ARRIVE When you wake at 6-7 a.m., cortisol is high, light enters your eyes, and your prefrontal cortex comes online in its task-oriented mode. You think about what to do, what to eat, where to go. Executive function engages. The thinking is directed, practical, forward-looking. Problems that exist at 7 a.m. feel like problems to be solved. Manageable, bounded, addressable. When you wake at 3 a.m. in the dark with no tasks to perform and no light to signal daytime, a different network activates. The default mode network. The brain's self-referential processing system fires in the absence of external input and directed task. This is the rumination network. It runs replays of conversations you had years ago. It generates worry scenarios about events that may never happen. It revisits regrets from decades past with a vividness that feels more real than memory should. It rehearses confrontations that will never take place. It asks questions that have no answers at any hour, let alone at 3 a.m. At 3 a.m., the default mode network has nothing competing with it. No light. No task. No external stimulation. No social interaction. And the executive prefrontal cortex that would normally evaluate, contextualize, and override the rumination is still partially offline. The prefrontal cortex is the last brain region to fully activate upon waking. It requires light exposure and time to reach full operating capacity. This is the region that says this thought is not an emergency. This worry is not proportionate to reality. This problem can wait until morning and will look different then. At 3 a.m., that region is sleeping while the default mode network runs at full power. You're awake enough to think. But the thinking is the uncontrolled, self-referential, catastrophizing kind. The system that controls and contextualizes thought has not caught up with the system that generates it. The worry loop feels more intense at 3 a.m. than the same thoughts would feel at 3 p.m. because the brain regions that regulate emotional response and assign proportionality are not yet operational. You're running the worry software without the control software. The thoughts feel urgent and catastrophic because the part of your brain that would tell you they are neither is still asleep. The thoughts are not true in the way they feel true. They're running on hardware that cannot evaluate them yet. The 3 a.m. thoughts have a specific quality that daytime worry doesn't. A sense of certainty. Of inevitability. Of problems being larger and solutions being fewer than they actually are. The distortion isn't emotional. It's architectural. The brain regions that generate worry are online. The brain regions that evaluate worry are not. By 7 a.m., when the prefrontal cortex has fully activated and light has entered the eyes and cortisol has reached its appropriate peak, the same problems that felt catastrophic at 3 a.m. feel manageable. Nothing changed about the problems. Everything changed about which brain regions are processing them. If you've lain in the dark at 3 a.m. and felt that your problems were larger, your regrets sharper, your fears more certain than they would be by breakfast, that wasn't weakness. It wasn't anxiety disorder. It was the default mode network running without prefrontal supervision, amplified by cortisol that arrived early, in a brain that had already run through its deep sleep budget and could not pull you back under. Four systems, all doing what the physics of aging programmed them to do, all converging on the same hour. Subscribers have access to detailed practical applications of remedies in a second attached post.

WHY YOU WAKE UP IN THE MIDDLE OF THE NIGHT Your brain has 20,000 neurons clustered in the hypothalamus. They form the suprachiasmatic nucleus. This is your master clock. It's been running since before birth. At 25, this clock kept you unconscious until morning. At 65, the same clock runs on less melatonin, weaker signals, and a rhythm that physically shifted 2-3 hours earlier. It fires a wake signal between 2-4 a.m. Four systems inside your body shifted with age. They converge at the same hour every night. The thoughts that arrive at 3 a.m. feel different from the same thoughts at 3 p.m. because your brain runs a different program in the dark. The part that would normally tell you those thoughts aren't emergencies is still asleep. THE CLOCK MOVED FORWARD The suprachiasmatic nucleus generates a near 24-hour rhythm controlling when you feel alert and when you feel sleepy. In young adults, peak sleepiness arrives around 11 p.m. Peak alertness arrives around 9-10 a.m. Blue light at 480 nanometers activates melanopsin cells in the retina. These cells send signals directly to the suprachiasmatic nucleus, synchronizing your clock to the day-night cycle. With age, the clock shifts earlier. This is circadian phase advance. The sleepiness signal arrives at 7-8 p.m. instead of 11 p.m. The wake signal arrives at 3-4 a.m. instead of 6-7 a.m. The entire sleep-wake window moves forward 2-3 hours. The suprachiasmatic nucleus itself degrades. Neurons deteriorate. The amplitude of the circadian signal weakens. Peaks become shallower. Troughs become less deep. The radio station loses transmitter power until the signal becomes fuzzy and inconsistent. The clock's sensitivity to light cues diminishes through two mechanisms. The aging lens yellows and thickens, filtering more blue light before it reaches the melanopsin cells. The suprachiasmatic neurons themselves respond less robustly to whatever signal does arrive. Weaker input through a cloudier window. Less responsive neurons processing that input. The clock drifts. When the circadian clock drifts without strong light cues, it drifts earlier. Phase advance is the default direction of an unanchored aging clock. MELATONIN COLLAPSED The pineal gland releases melatonin at night to initiate and maintain sleep. This hormone declines with age. The pineal gland calcifies gradually over decades, reducing functional tissue and capacity to produce melatonin. By 65, nighttime melatonin levels can be one-third to one-quarter of what they were at 30. Sometimes less. Melatonin doesn't just initiate sleep. It maintains depth and continuity across the full night. When melatonin is low, sleep is shallower, more fragmented, more vulnerable to interruption. Even if you fall asleep at a reasonable hour, low melatonin cannot hold you through to morning. Your body tries to put you to sleep at 8 p.m. and wake you at 3 a.m. That's a 7-hour sleep window. It might be enough sleep for your shifted clock. But you fight the 8 o'clock drowsiness. Social life, television, family, habit. You stay up until 10 or 11. The clock doesn't adjust to your social schedule. It fires the wake signal at 3 regardless. The clock runs on light and biology, not preferences. You lost 2-3 hours from the front of your sleep window by staying up late. The alarm still goes off on the original schedule. The 3 a.m. waking isn't a malfunction. It's your shifted clock doing exactly what it was programmed to do. This is social jet lag. The gap between your biological clock time and your social clock time creates the same physiological mismatch as flying across two or three time zones. Your body is in one time zone. Your social life is in another. The drowsiness you fight at 8 p.m. is your body's genuine sleep onset signal. The waking at 3 a.m. is your body's genuine wake signal. The problem isn't the signals. The problem is overriding one without being able to override the other. There's a compounding factor. The shifted clock means your body wants to sleep earlier. The reduced melatonin means it cannot hold sleep as deeply or as long. You're caught between two problems: a clock that fires the wake signal too early and a chemical supply that cannot maintain the sleep signal through the full night. Even if you went to bed at 8, the reduced melatonin might still fail to hold you past 3 or 4. The clock shifted the window. The melatonin shrank it. DEEP SLEEP DISAPPEARED Sleep cycles through stages roughly every 90 minutes. Light sleep, deeper sleep, deeper sleep, then REM. The stage that matters most for feeling rested is slow-wave sleep, stage N3, the deepest phase. Brainwaves drop to large, slow delta oscillations at 0.5-4 hertz. During slow-wave sleep, the glymphatic system activates. Cerebrospinal fluid flushes through brain tissue along channels that open when neurons shrink slightly during deep sleep. This clears metabolic waste: adenosine, the molecule that builds sleep pressure during the day, and amyloid beta proteins, the plaques associated with Alzheimer's disease. Growth hormone pulses during N3. Tissue repair peaks. Memory consolidation occurs. The hippocampus replays the day's experiences and transfers them to long-term cortical storage. This is the sleep that makes you feel like you actually slept. At 25, roughly 20% of the night is spent in slow-wave sleep. By 65, that drops to 10-15%. By 75, some people get almost none. My sleep tracker tells me that I almost never get less than 30%... and I'm 60. It is possible to have restorative deep sleep no matter what your age is. In my case even at lower sleep duration. High energy availability alsp plays a big role. The slow wave generating circuits in the medial prefrontal cortex usually deteriorate with age, producing weaker and less frequent delta oscillations. The deep sleep itself becomes shallower. The waves are smaller. The duration shorter. The restorative process is less complete. If deep sleep is the period when the brain clears amyloid beta, then reduced deep sleep means reduced clearance. Less deep sleep leads to more amyloid, which leads to less deep sleep, which leads to more amyloid. The relationship is bidirectional and self-reinforcing. If you never feel fully rested no matter how many hours you spend in bed, if 8 hours produces the recovery that 6 hours used to produce, if you wake in the morning with the sense that something was missing from the night, the missing component may be slow wave sleep. The hours were there. The depth was not. Slow-wave sleep that remains concentrates in the first half of the night, the first two to three sleep cycles. By 2-3 a.m., most of the deep sleep budget has been spent. What remains for the second half of the night is lighter stage one and stage two sleep, interspersed with REM. Light sleep has a dramatically lower arousal threshold. Stimuli that would not have registered during slow-wave sleep can push you above the waking threshold in light sleep. A slight temperature change in the room. A bathroom urge from a bladder that fills faster with age. A noise from outside. Even the natural shift in body position. You wake at 3 a.m. partly because the sleep you're in at 3 a.m. is physiologically different from the sleep you're in at midnight. The fortress walls got thinner as the night progressed. By 3 o'clock, you're sleeping behind a screen door instead of a vault. You could sleep through thunderstorms at 30. Now you wake at the sound of a refrigerator cycling on. The physics isn't about the noise. It's about the stage of sleep you're in when the noise arrives. At midnight, during slow-wave sleep, your arousal threshold is high. The brain runs delta waves that suppress responsiveness to external stimuli. At 3 a.m. in stage 1 or stage 2, the threshold has dropped to a fraction of its midnight level. The same sound that the sleeping brain would have filtered at midnight wakes you at 3 because the brain is no longer running the program that filters it. CORTISOL ARRIVED EARLY Your body runs a cortisol rhythm called the cortisol awakening response. In the final hours of sleep, the adrenal glands begin increasing cortisol output, preparing the body for waking. Mobilizing glucose into the bloodstream. Priming the immune system for the day's pathogens. Raising blood pressure and heart rate toward daytime operating levels. In a young adult, this cortisol rise begins around 4-5 a.m. and peaks roughly 30-45 minutes after waking. With age, the rise begins earlier. 2-3 a.m. in many older adults. Low-carb diets can also trigger a relatively strong cortisol release, waking you up early.. The same circadian phase advance that shifted the sleep-wake window also shifted the cortisol curve. Every rhythm the suprachiasmatic nucleus controls moves in the same direction. Cortisol alone doesn't wake you. But combined with already light sleep and a shifted circadian clock, the cortisol rise adds a third signal, pushing you toward wakefulness at precisely the hour when the other two systems have already weakened your defenses. Three systems converging on the same window. The clock says wake up. The sleep stage says the walls are thin. The cortisol says the body is preparing for morning. All three signals arrive at 3 a.m. Not by coincidence. All three are governed by the same shifted circadian master clock. If the waking comes at almost exactly the same time every night, not randomly scattered across the early morning hours but clustered within the same 30-minute window, that precision is the signature of a circadian event. Cortisol is antagonistic to melatonin. The two hormones suppress each other. Cortisol inhibits melatonin production. Melatonin suppresses cortisol. In a young person with high melatonin and correctly timed cortisol, the two hormones hand off smoothly. Melatonin dominates the night. Cortisol rises toward morning. The transition is seamless. In an aging body with depleted melatonin and early-arriving cortisol, the handoff happens too soon. When cortisol starts rising at 2-3 a.m. and melatonin is already low, the biochemical conditions for staying asleep collapse. The melatonin that should be holding you under is insufficient. The cortisol that should not be arriving for another two hours is already here. Two hormones that are supposed to hand off like relay runners, one finishing as the other begins, instead collide in the same hour because both shifted on the same aging clock. The balance tips toward waking. THE WORST THOUGHTS ARRIVE When you wake at 6-7 a.m., cortisol is high, light enters your eyes, and your prefrontal cortex comes online in its task-oriented mode. You think about what to do, what to eat, where to go. Executive function engages. The thinking is directed, practical, forward-looking. Problems that exist at 7 a.m. feel like problems to be solved. Manageable, bounded, addressable. When you wake at 3 a.m. in the dark with no tasks to perform and no light to signal daytime, a different network activates. The default mode network. The brain's self-referential processing system fires in the absence of external input and directed task. This is the rumination network. It runs replays of conversations you had years ago. It generates worry scenarios about events that may never happen. It revisits regrets from decades past with a vividness that feels more real than memory should. It rehearses confrontations that will never take place. It asks questions that have no answers at any hour, let alone at 3 a.m. At 3 a.m., the default mode network has nothing competing with it. No light. No task. No external stimulation. No social interaction. And the executive prefrontal cortex that would normally evaluate, contextualize, and override the rumination is still partially offline. The prefrontal cortex is the last brain region to fully activate upon waking. It requires light exposure and time to reach full operating capacity. This is the region that says this thought is not an emergency. This worry is not proportionate to reality. This problem can wait until morning and will look different then. At 3 a.m., that region is sleeping while the default mode network runs at full power. You're awake enough to think. But the thinking is the uncontrolled, self-referential, catastrophizing kind. The system that controls and contextualizes thought has not caught up with the system that generates it. The worry loop feels more intense at 3 a.m. than the same thoughts would feel at 3 p.m. because the brain regions that regulate emotional response and assign proportionality are not yet operational. You're running the worry software without the control software. The thoughts feel urgent and catastrophic because the part of your brain that would tell you they are neither is still asleep. The thoughts are not true in the way they feel true. They're running on hardware that cannot evaluate them yet. The 3 a.m. thoughts have a specific quality that daytime worry doesn't. A sense of certainty. Of inevitability. Of problems being larger and solutions being fewer than they actually are. The distortion isn't emotional. It's architectural. The brain regions that generate worry are online. The brain regions that evaluate worry are not. By 7 a.m., when the prefrontal cortex has fully activated and light has entered the eyes and cortisol has reached its appropriate peak, the same problems that felt catastrophic at 3 a.m. feel manageable. Nothing changed about the problems. Everything changed about which brain regions are processing them. If you've lain in the dark at 3 a.m. and felt that your problems were larger, your regrets sharper, your fears more certain than they would be by breakfast, that wasn't weakness. It wasn't anxiety disorder. It was the default mode network running without prefrontal supervision, amplified by cortisol that arrived early, in a brain that had already run through its deep sleep budget and could not pull you back under. Four systems, all doing what the physics of aging programmed them to do, all converging on the same hour. Subscribers have access to detailed practical applications of remedies in a second attached post.

Metabolic Uncle

12,138 Aufrufe • vor 5 Monaten

The problem with most supplements is the deuterium they deliver. Stephanie Seneff, MIT researcher: "People are loading up on supplements that are actually hurting them — they're not supplying the low deuterium resource that would have happened if it had been biological." Most supplements are made in chemistry labs. The molecules are chemically identical to their natural counterparts. But they lack one critical property: deuterium depletion. Deuterium is a heavy form of hydrogen that damages ATPase pumps in the mitochondria. Melatonin is the clearest example. Your gut produces 400x more melatonin than your pineal gland — most of it inside mitochondria. Seneff: Melatonin is not primarily a sleep hormone. It is a deuterium depletion system. Here's the mechanism: Gut microbes produce hydrogen gas that is 80% deuterium depleted. That gas feeds a chain of conversions — producing methyl and acetyl groups that are severely low in deuterium. Those methyl and acetyl groups get attached to serotonin, converting it into melatonin. Each melatonin molecule now carries depleted hydrogen — ready to be delivered to the mitochondria. Inside gut cells (enterocytes), an enzyme called CYP2C19 strips the methyl group off melatonin. Each time it does, it releases four molecules of deuterium-depleted water directly into the mitochondria — protecting the ATPase pumps that generate your cellular energy. Four depleted water molecules. Per cycle. To the ATPase pumps that need them most. When melatonin is made synthetically — which is virtually all commercial melatonin — the methyl and acetyl groups come from bulk chemicals made in a lab. Random high deuterium content. The biological depletion step never happened. Your body cannot tell the difference. Sleep improves. Antioxidant effects occur. But the deuterium depletion cycle doesn't run. The mitochondria don't get what they actually need. The short-term benefit masks the long-term harm. The TMAO (Trimethylamine N-oxide) evidence: TMAO is a marker for deuterium toxicity — deuterium-loaded methyl groups accumulating systemically. People who ate eggs — no TMAO increase. People who took synthetic choline supplements — elevated TMAO. The mechanism: enzymes that metabolize methyl groups can detect deuterium — and refuse to process it. The trimethylamine survives in the gut. Gets oxidized in the liver. Becomes TMAO in the blood. The same problem applies to: N-acetylcysteine (NAC) — the acetyl group is low deuterium from gut microbes, unpredictable when synthetic. Choline bitartrate — Seneff: "If you're taking choline bitartrate, you need to stop." Methionine — methionine-deficient rats lived longer in one study. Seneff's interpretation: methionine restriction extended lifespan not because methionine itself is harmful — but because the rats stopped receiving deuterium-loaded synthetic methionine. Their gut microbes produced it naturally — low deuterium. The rats getting synthetic methionine wrecked their mitochondria with deuterium-enriched methyl groups. The deficient rats didn't. Methylated B vitamins — likely synthetic, likely the same problem. The studies testing these supplements never account for the fact that they're synthetic. They have no idea that's even a variable worth measuring. What to do instead: - Get methionine from meat, fish and eggs — not synthetic amino acid supplements. - Get choline from eggs and animal foods — not choline bitartrate. - Get tryptophan from food — chicken, turkey, beef, pork, fish, eggs, hard cheeses (parmesan, cheddar). Your gut microbes convert it through the biological pathway naturally, producing depleted melatonin the way biology intended. One study: tryptophan loading increases serum melatonin 4-fold — even in rats without a pineal gland, confirming the melatonin was gut-sourced not pineal-sourced. - Animal fats — butter, tallow — are among the lowest deuterium foods available. Derived from acetate produced by gut microbes from deuterium-depleted hydrogen gas. The same pathway that makes biological methyl groups low in deuterium. - Eat certified organic. Glyphosate disrupts the gut microbiome — which disrupts the entire deuterium management system upstream. - Fermented foods support acetate production and the whole chain. Whenever the food is fermented, the microbes are making nutrients that are low in deuterium. - Keep your gut microbiome healthy. It is your primary deuterium management system. Seneff is 78 years old. Still writing papers. Mentally sharp. Doesn't take any supplements. "I don't take any supplements. None of these organic molecules. None." The supplement industry sells you the molecule. They don't sell you the mechanism biology built into the production process.

The problem with most supplements is the deuterium they deliver. Stephanie Seneff, MIT researcher: "People are loading up on supplements that are actually hurting them — they're not supplying the low deuterium resource that would have happened if it had been biological." Most supplements are made in chemistry labs. The molecules are chemically identical to their natural counterparts. But they lack one critical property: deuterium depletion. Deuterium is a heavy form of hydrogen that damages ATPase pumps in the mitochondria. Melatonin is the clearest example. Your gut produces 400x more melatonin than your pineal gland — most of it inside mitochondria. Seneff: Melatonin is not primarily a sleep hormone. It is a deuterium depletion system. Here's the mechanism: Gut microbes produce hydrogen gas that is 80% deuterium depleted. That gas feeds a chain of conversions — producing methyl and acetyl groups that are severely low in deuterium. Those methyl and acetyl groups get attached to serotonin, converting it into melatonin. Each melatonin molecule now carries depleted hydrogen — ready to be delivered to the mitochondria. Inside gut cells (enterocytes), an enzyme called CYP2C19 strips the methyl group off melatonin. Each time it does, it releases four molecules of deuterium-depleted water directly into the mitochondria — protecting the ATPase pumps that generate your cellular energy. Four depleted water molecules. Per cycle. To the ATPase pumps that need them most. When melatonin is made synthetically — which is virtually all commercial melatonin — the methyl and acetyl groups come from bulk chemicals made in a lab. Random high deuterium content. The biological depletion step never happened. Your body cannot tell the difference. Sleep improves. Antioxidant effects occur. But the deuterium depletion cycle doesn't run. The mitochondria don't get what they actually need. The short-term benefit masks the long-term harm. The TMAO (Trimethylamine N-oxide) evidence: TMAO is a marker for deuterium toxicity — deuterium-loaded methyl groups accumulating systemically. People who ate eggs — no TMAO increase. People who took synthetic choline supplements — elevated TMAO. The mechanism: enzymes that metabolize methyl groups can detect deuterium — and refuse to process it. The trimethylamine survives in the gut. Gets oxidized in the liver. Becomes TMAO in the blood. The same problem applies to: N-acetylcysteine (NAC) — the acetyl group is low deuterium from gut microbes, unpredictable when synthetic. Choline bitartrate — Seneff: "If you're taking choline bitartrate, you need to stop." Methionine — methionine-deficient rats lived longer in one study. Seneff's interpretation: methionine restriction extended lifespan not because methionine itself is harmful — but because the rats stopped receiving deuterium-loaded synthetic methionine. Their gut microbes produced it naturally — low deuterium. The rats getting synthetic methionine wrecked their mitochondria with deuterium-enriched methyl groups. The deficient rats didn't. Methylated B vitamins — likely synthetic, likely the same problem. The studies testing these supplements never account for the fact that they're synthetic. They have no idea that's even a variable worth measuring. What to do instead: - Get methionine from meat, fish and eggs — not synthetic amino acid supplements. - Get choline from eggs and animal foods — not choline bitartrate. - Get tryptophan from food — chicken, turkey, beef, pork, fish, eggs, hard cheeses (parmesan, cheddar). Your gut microbes convert it through the biological pathway naturally, producing depleted melatonin the way biology intended. One study: tryptophan loading increases serum melatonin 4-fold — even in rats without a pineal gland, confirming the melatonin was gut-sourced not pineal-sourced. - Animal fats — butter, tallow — are among the lowest deuterium foods available. Derived from acetate produced by gut microbes from deuterium-depleted hydrogen gas. The same pathway that makes biological methyl groups low in deuterium. - Eat certified organic. Glyphosate disrupts the gut microbiome — which disrupts the entire deuterium management system upstream. - Fermented foods support acetate production and the whole chain. Whenever the food is fermented, the microbes are making nutrients that are low in deuterium. - Keep your gut microbiome healthy. It is your primary deuterium management system. Seneff is 78 years old. Still writing papers. Mentally sharp. Doesn't take any supplements. "I don't take any supplements. None of these organic molecules. None." The supplement industry sells you the molecule. They don't sell you the mechanism biology built into the production process.

no.mind

95,163 Aufrufe • vor 5 Monaten

These two Australians came to America and their main souvenir is… melatonin 😂 They’re literally stocking up because you can get 10mg over the counter here, while back home it’s prescription only and way weaker. They said it makes them fall asleep so fast and gives them the best sleep ever, so they’re loading up before they leave. The excitement over sleep aids is actually hilarious. I wonder what other over-the-counter stuff tourists are secretly stocking up on while they’re here.

These two Australians came to America and their main souvenir is… melatonin 😂 They’re literally stocking up because you can get 10mg over the counter here, while back home it’s prescription only and way weaker. They said it makes them fall asleep so fast and gives them the best sleep ever, so they’re loading up before they leave. The excitement over sleep aids is actually hilarious. I wonder what other over-the-counter stuff tourists are secretly stocking up on while they’re here.

End3of6Days9 (Helen) 🇺🇸

187,666 Aufrufe • vor 3 Monaten