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Supplementing vitamin D could significantly boost memory and attention—even in people already facing cognitive decline Clinical trials found that adults with mild cognitive impairment or Alzheimer’s improved cognition after one year of taking just 800 IU/day vitamin D Patients with Alzheimer’s also saw reduced blood markers linked to disease... show more

FoundMyFitness Clips

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14,130 views • 1 year ago •via X (Twitter)

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FoundMyFitness Clips1 year ago

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MindScape Retreat: Ibogaine Treatment Center1 year ago

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FoundMyFitness Clips1 year ago

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Hobbit1 year ago

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Raffaele Di Giacomo, PhD1 year ago

Intriguing findings on vitamin D's potential impact on cognitive decline! It raises questions about how exactly vitamin D interacts with brain function and whether there are specific biological mechanisms at play. Are dosage adjustments needed for different demographics or those with varying baseline levels of vitamin D? #Medicine For anyone looking to delve deeper into this or any other biomedical inquiries, offers comprehensive biomedical reviews to explore evidence-based insights.

G1 year ago

@grok Is Vitamin D3 (Colecalciferol) a match for the recommendation from the original tweet?

Below The Bramble1 year ago

What about supplementing during spring and summer in New England? Okay or does nothing?

Brandyn W1 year ago

Is this more correlation stuff

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Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Dr. Rhonda Patrick

245,165 views • 1 year ago

For the 1st time, a randomized controlled clinical trial has demonstrated that an intensive lifestyle intervention, without drugs, may significantly improve cognition & function in many patients with mild cognitive impairment or early dementia due to Alzheimer’s disease.

For the 1st time, a randomized controlled clinical trial has demonstrated that an intensive lifestyle intervention, without drugs, may significantly improve cognition & function in many patients with mild cognitive impairment or early dementia due to Alzheimer’s disease.

Dean Ornish, MD

12,832 views • 2 years ago

Supplementing with vitamin D could cut your risk of dementia by nearly half In a study of more than 12,000 older adults, those who supplemented with vitamin D were 40% less likely to develop dementia over the following decade And after just 5 years, 84% of vitamin D users remained dementia-free compared to only 68% of non-users This benefit even extended to people with mild cognitive impairment and the APOE4 gene—a major genetic risk factor for Alzheimer's disease

Supplementing with vitamin D could cut your risk of dementia by nearly half In a study of more than 12,000 older adults, those who supplemented with vitamin D were 40% less likely to develop dementia over the following decade And after just 5 years, 84% of vitamin D users remained dementia-free compared to only 68% of non-users This benefit even extended to people with mild cognitive impairment and the APOE4 gene—a major genetic risk factor for Alzheimer's disease

FoundMyFitness Clips

273,514 views • 1 year ago

Low vitamin D levels are linked to accelerated brain aging MRI studies show low vitamin D significantly increases white matter damage (critical pathways involved in cognition and memory) For every 10 nmol/L decrease in vitamin D blood levels, markers of brain damage rise noticeably Maintaining sufficient vitamin D levels (~40-60 ng/mL) is critical for preserving cognitive function

Low vitamin D levels are linked to accelerated brain aging MRI studies show low vitamin D significantly increases white matter damage (critical pathways involved in cognition and memory) For every 10 nmol/L decrease in vitamin D blood levels, markers of brain damage rise noticeably Maintaining sufficient vitamin D levels (~40-60 ng/mL) is critical for preserving cognitive function

FoundMyFitness Clips

19,553 views • 9 months ago

Supplementing with creatine (20 grams/day) improved cognitive function in Alzheimer’s patients by nearly 5% after just 8 weeks Patients experienced notable gains in memory, fluid cognition, inhibitory control, and attention (likely due to creatine’s key role in brain energy metabolism) Creatine seems to especially benefit the brain under stress (whether Alzheimer's, sleep deprivation, or depression), making it a promising tool for supporting cognitive health

Supplementing with creatine (20 grams/day) improved cognitive function in Alzheimer’s patients by nearly 5% after just 8 weeks Patients experienced notable gains in memory, fluid cognition, inhibitory control, and attention (likely due to creatine’s key role in brain energy metabolism) Creatine seems to especially benefit the brain under stress (whether Alzheimer's, sleep deprivation, or depression), making it a promising tool for supporting cognitive health

FoundMyFitness Clips

114,013 views • 9 months ago

Supplementing with vitamin D could dramatically cut your dementia risk—by as much as 40% A major study of more than 12,000 adults found that after 5 years, 84% of vitamin D supplement users were dementia-free versus just 68% of non-users, with protective effects even among adults at genetic risk (APOE e4 carriers saw a 33% risk reduction) ~70% of people in the U.S. have insufficient vitamin D levels The solution is simple: Consider supplementing with 2,000–4,000 IU/day, and aim for optimal blood levels of 40–80 ng/mL (check with a blood test)

Supplementing with vitamin D could dramatically cut your dementia risk—by as much as 40% A major study of more than 12,000 adults found that after 5 years, 84% of vitamin D supplement users were dementia-free versus just 68% of non-users, with protective effects even among adults at genetic risk (APOE e4 carriers saw a 33% risk reduction) ~70% of people in the U.S. have insufficient vitamin D levels The solution is simple: Consider supplementing with 2,000–4,000 IU/day, and aim for optimal blood levels of 40–80 ng/mL (check with a blood test)

FoundMyFitness Clips

38,755 views • 10 months ago

Vitamin D deficiency may literally accelerate brain aging MRI studies show that low vitamin D increases white matter damage—affecting critical brain pathways involved in cognition and memory Every 10 nmol/L increase in vitamin D is linked to reduced brain damage markers Protecting your brain might be as simple as taking a daily vitamin D supplement

Vitamin D deficiency may literally accelerate brain aging MRI studies show that low vitamin D increases white matter damage—affecting critical brain pathways involved in cognition and memory Every 10 nmol/L increase in vitamin D is linked to reduced brain damage markers Protecting your brain might be as simple as taking a daily vitamin D supplement

FoundMyFitness Clips

11,675 views • 1 year ago

Vitamin D isn't just a vitamin—it's a steroid hormone that regulates over 5% of your entire genome Yet over 70% of Americans don't have adequate vitamin D levels, severely limiting their immune function, mood regulation, and cognitive health Clinical evidence points to blood levels of 40-60 ng/mL being the sweet spot Supplementing with 4,000 IU daily typically moves people from deficiency to sufficient levels (in general, 1,000 IU raises blood levels by roughly 5–10 ng/mL)

Vitamin D isn't just a vitamin—it's a steroid hormone that regulates over 5% of your entire genome Yet over 70% of Americans don't have adequate vitamin D levels, severely limiting their immune function, mood regulation, and cognitive health Clinical evidence points to blood levels of 40-60 ng/mL being the sweet spot Supplementing with 4,000 IU daily typically moves people from deficiency to sufficient levels (in general, 1,000 IU raises blood levels by roughly 5–10 ng/mL)

FoundMyFitness Clips

54,412 views • 1 year ago

Supplementing with vitamin D may be one of the simplest ways to lower your dementia risk Large observational and genetic studies show that vitamin D deficiency is linked to ~80% higher dementia risk in standard cohorts and ~50% higher risk when you look at genetics Yet, roughly 70% of people in the U.S. have insufficient vitamin D levels The solution is simple: consider supplementing with 2,000–4,000 IU/day of and aim for blood levels around 40–80 ng/mL (confirmed with a blood test)

Supplementing with vitamin D may be one of the simplest ways to lower your dementia risk Large observational and genetic studies show that vitamin D deficiency is linked to ~80% higher dementia risk in standard cohorts and ~50% higher risk when you look at genetics Yet, roughly 70% of people in the U.S. have insufficient vitamin D levels The solution is simple: consider supplementing with 2,000–4,000 IU/day of and aim for blood levels around 40–80 ng/mL (confirmed with a blood test)

FoundMyFitness Clips

20,235 views • 6 months ago

Are we underestimating the role of vitamin B12 in brain health? New research suggests that even “normal” levels may contribute to cognitive decline in older adults. Should we be supplementing earlier?

Are we underestimating the role of vitamin B12 in brain health? New research suggests that even “normal” levels may contribute to cognitive decline in older adults. Should we be supplementing earlier?

Neuroscience News

29,621 views • 1 year ago

Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?

Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?

Camus

266,275 views • 2 months ago

For the first time, ultrasound is being used to try and slow down the cognitive decline of Alzheimer’s disease.

For the first time, ultrasound is being used to try and slow down the cognitive decline of Alzheimer’s disease.

60 Minutes

75,038 views • 2 years ago

🚨BREAKING NEWS🚨 The U.S. FDA has granted Eisai an accelerated licence for #lecanemab in people with a confirmed diagnosis of mild cognitive impairment or early-stage Alzheimer’s in the US. Head of Policy, David Thomas, explains more 👇

🚨BREAKING NEWS🚨 The U.S. FDA has granted Eisai an accelerated licence for #lecanemab in people with a confirmed diagnosis of mild cognitive impairment or early-stage Alzheimer’s in the US. Head of Policy, David Thomas, explains more 👇

Alzheimer's Research UK

76,276 views • 3 years ago

Massive new vitamin D study just dropped — and it’s getting zero mainstream attention A 4-year trial with 25,000 adults across the US (led by 140 researchers) found: Vitamin D3 supplementation significantly preserved telomere length (only 1 year of aging in 4 years). This follows a 10-year Canadian study (12,000 people) showing ~40% reduced dementia risk with vitamin D. The message is clear: Start early, preserve what you have — telomeres don’t reverse once shortened. 2:04 clip inside — game-changing science you need to hear.

Massive new vitamin D study just dropped — and it’s getting zero mainstream attention A 4-year trial with 25,000 adults across the US (led by 140 researchers) found: Vitamin D3 supplementation significantly preserved telomere length (only 1 year of aging in 4 years). This follows a 10-year Canadian study (12,000 people) showing ~40% reduced dementia risk with vitamin D. The message is clear: Start early, preserve what you have — telomeres don’t reverse once shortened. 2:04 clip inside — game-changing science you need to hear.

Camus

1,973,017 views • 6 months ago

Caffeinated coffee is a powerful protector against neurodegeneration Regular caffeinated coffee drinkers can cut Parkinson’s disease risk by up to 60%, largely via caffeine blocking adenosine A2A receptors in motor circuits and protecting dopamine-producing neurons Even moderate caffeine intake (~2 cups/day) has been linked to noticeably slower cognitive decline in people with mild cognitive impairment, a common precursor to Alzheimer's For long-term brain protection and day-to-day cognitive performance, caffeinated coffee clearly outperforms decaf

Caffeinated coffee is a powerful protector against neurodegeneration Regular caffeinated coffee drinkers can cut Parkinson’s disease risk by up to 60%, largely via caffeine blocking adenosine A2A receptors in motor circuits and protecting dopamine-producing neurons Even moderate caffeine intake (~2 cups/day) has been linked to noticeably slower cognitive decline in people with mild cognitive impairment, a common precursor to Alzheimer's For long-term brain protection and day-to-day cognitive performance, caffeinated coffee clearly outperforms decaf

FoundMyFitness Clips

175,410 views • 4 months ago

Taking a daily multivitamin can reverse cognitive aging by several years Multiple randomized controlled trials found that older adults who took a basic multivitamin (like Centrum Silver) experienced clear improvements in overall cognitive function This included faster processing speed and dramatically enhanced episodic memory (the memory used to recall personal experiences and events) Far from useless, a simple multivitamin could be one of your strongest allies against cognitive decline

Taking a daily multivitamin can reverse cognitive aging by several years Multiple randomized controlled trials found that older adults who took a basic multivitamin (like Centrum Silver) experienced clear improvements in overall cognitive function This included faster processing speed and dramatically enhanced episodic memory (the memory used to recall personal experiences and events) Far from useless, a simple multivitamin could be one of your strongest allies against cognitive decline

FoundMyFitness Clips

387,068 views • 9 months ago

Here’s why taking 10,000 IU of vitamin D daily is essential: • It’s equivalent to 20 minutes of sun exposure in the summer. • Plastics and chemicals in the environment disrupt vitamin D absorption. • Many people have vitamin D resistance, so they can’t absorb it efficiently.

Here’s why taking 10,000 IU of vitamin D daily is essential: • It’s equivalent to 20 minutes of sun exposure in the summer. • Plastics and chemicals in the environment disrupt vitamin D absorption. • Many people have vitamin D resistance, so they can’t absorb it efficiently.

Dr. Eric Berg DC

89,280 views • 1 year ago

4. 70% of Americans Are Vitamin D Deficient Vitamin D deficiency increases dementia risk by 80%. But people who supplement with vitamin D3 have a 40% reduced risk of dementia. Most people need 4,000 IUs daily to reach optimal blood levels of 40-60 ng/mL.

4. 70% of Americans Are Vitamin D Deficient Vitamin D deficiency increases dementia risk by 80%. But people who supplement with vitamin D3 have a 40% reduced risk of dementia. Most people need 4,000 IUs daily to reach optimal blood levels of 40-60 ng/mL.

Joey Yochheim | Default Kings

62,040 views • 11 months ago

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

no.mind

240,565 views • 3 months ago

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

Dr. Rhonda Patrick

216,396 views • 6 months ago