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Supplementing with vitamin D could dramatically cut your dementia risk—by as much as 40% A major study of more than 12,000 adults found that after 5 years, 84% of vitamin D supplement users were dementia-free versus just 68% of non-users, with protective effects even among adults at genetic risk... show more

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Supplementing with vitamin D may be one of the simplest ways to lower your dementia risk Large observational and genetic studies show that vitamin D deficiency is linked to ~80% higher dementia risk in standard cohorts and ~50% higher risk when you look at genetics Yet, roughly 70% of people in the U.S. have insufficient vitamin D levels The solution is simple: consider supplementing with 2,000–4,000 IU/day of and aim for blood levels around 40–80 ng/mL (confirmed with a blood test)

Supplementing with vitamin D may be one of the simplest ways to lower your dementia risk Large observational and genetic studies show that vitamin D deficiency is linked to ~80% higher dementia risk in standard cohorts and ~50% higher risk when you look at genetics Yet, roughly 70% of people in the U.S. have insufficient vitamin D levels The solution is simple: consider supplementing with 2,000–4,000 IU/day of and aim for blood levels around 40–80 ng/mL (confirmed with a blood test)

FoundMyFitness Clips

20,251 views • 7 months ago

Supplementing with vitamin D could cut your risk of dementia by nearly half In a study of more than 12,000 older adults, those who supplemented with vitamin D were 40% less likely to develop dementia over the following decade And after just 5 years, 84% of vitamin D users remained dementia-free compared to only 68% of non-users This benefit even extended to people with mild cognitive impairment and the APOE4 gene—a major genetic risk factor for Alzheimer's disease

Supplementing with vitamin D could cut your risk of dementia by nearly half In a study of more than 12,000 older adults, those who supplemented with vitamin D were 40% less likely to develop dementia over the following decade And after just 5 years, 84% of vitamin D users remained dementia-free compared to only 68% of non-users This benefit even extended to people with mild cognitive impairment and the APOE4 gene—a major genetic risk factor for Alzheimer's disease

FoundMyFitness Clips

273,514 views • 1 year ago

4. 70% of Americans Are Vitamin D Deficient Vitamin D deficiency increases dementia risk by 80%. But people who supplement with vitamin D3 have a 40% reduced risk of dementia. Most people need 4,000 IUs daily to reach optimal blood levels of 40-60 ng/mL.

4. 70% of Americans Are Vitamin D Deficient Vitamin D deficiency increases dementia risk by 80%. But people who supplement with vitamin D3 have a 40% reduced risk of dementia. Most people need 4,000 IUs daily to reach optimal blood levels of 40-60 ng/mL.

Joey Yochheim | Default Kings

62,040 views • 1 year ago

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Dr. Rhonda Patrick

245,484 views • 1 year ago

Vitamin D directly controls thousands of genes that influence aging and brain health Once converted to its active form, vitamin D3 acts as a steroid hormone that regulates more than 5% of your protein-coding genome, switching on immune defenses, neurotransmitter production, and longevity genes like Klotho Yet ~70% of Americans have insufficient or deficient levels The solution is clear and evidence-based: consider supplementing with ~4,000 IU/day and aim for blood levels ~40–60 ng/mL

Vitamin D directly controls thousands of genes that influence aging and brain health Once converted to its active form, vitamin D3 acts as a steroid hormone that regulates more than 5% of your protein-coding genome, switching on immune defenses, neurotransmitter production, and longevity genes like Klotho Yet ~70% of Americans have insufficient or deficient levels The solution is clear and evidence-based: consider supplementing with ~4,000 IU/day and aim for blood levels ~40–60 ng/mL

FoundMyFitness Clips

48,626 views • 4 months ago

Vitamin D isn't just a vitamin—it's a steroid hormone that regulates over 5% of your entire genome Yet over 70% of Americans don't have adequate vitamin D levels, severely limiting their immune function, mood regulation, and cognitive health Clinical evidence points to blood levels of 40-60 ng/mL being the sweet spot Supplementing with 4,000 IU daily typically moves people from deficiency to sufficient levels (in general, 1,000 IU raises blood levels by roughly 5–10 ng/mL)

Vitamin D isn't just a vitamin—it's a steroid hormone that regulates over 5% of your entire genome Yet over 70% of Americans don't have adequate vitamin D levels, severely limiting their immune function, mood regulation, and cognitive health Clinical evidence points to blood levels of 40-60 ng/mL being the sweet spot Supplementing with 4,000 IU daily typically moves people from deficiency to sufficient levels (in general, 1,000 IU raises blood levels by roughly 5–10 ng/mL)

FoundMyFitness Clips

54,412 views • 1 year ago

Vitamin D is so much more than just a vitamin It’s actually a steroid hormone that controls the expression of nearly 1,000 genes But ~70% of Americans have insufficient or deficient levels, falling short of the optimal 40–60 ng/mL range Typically, every 1,000 IU of supplementation raises blood levels by ~5 ng/mL The solution is simple

Vitamin D is so much more than just a vitamin It’s actually a steroid hormone that controls the expression of nearly 1,000 genes But ~70% of Americans have insufficient or deficient levels, falling short of the optimal 40–60 ng/mL range Typically, every 1,000 IU of supplementation raises blood levels by ~5 ng/mL The solution is simple

FoundMyFitness Clips

35,472 views • 1 year ago

Supplementing vitamin D could significantly boost memory and attention—even in people already facing cognitive decline Clinical trials found that adults with mild cognitive impairment or Alzheimer’s improved cognition after one year of taking just 800 IU/day vitamin D Patients with Alzheimer’s also saw reduced blood markers linked to disease progression (amyloid-beta 42)

Supplementing vitamin D could significantly boost memory and attention—even in people already facing cognitive decline Clinical trials found that adults with mild cognitive impairment or Alzheimer’s improved cognition after one year of taking just 800 IU/day vitamin D Patients with Alzheimer’s also saw reduced blood markers linked to disease progression (amyloid-beta 42)

FoundMyFitness Clips

14,130 views • 1 year ago

This single nutrient regulates over 1,000 genes in the human body, influencing everything from brain to muscle function Vitamin D And despite its critical role, vitamin D insufficiency is alarmingly common (~70% of the the population has inadequate levels: <30 ng/mL) But it's easy to correct with supplementation Get a blood test, and know that ideal levels are around 40-60 ng/mL On average, every ~1,000 IUs of vitamin D3 increases blood levels by ~5 ng/mL

This single nutrient regulates over 1,000 genes in the human body, influencing everything from brain to muscle function Vitamin D And despite its critical role, vitamin D insufficiency is alarmingly common (~70% of the the population has inadequate levels: <30 ng/mL) But it's easy to correct with supplementation Get a blood test, and know that ideal levels are around 40-60 ng/mL On average, every ~1,000 IUs of vitamin D3 increases blood levels by ~5 ng/mL

FoundMyFitness Clips

39,208 views • 1 year ago

Dr. Rhonda Patrick ranks her top supplements to fill critical micronutrient gaps "70% of us lack vitamin D—it's a hormone controlling 5% of our genome. Low levels accelerate aging, dementia risk. Solution: Supplement to hit 40-60 ng/mL blood level." This isn't optional—it's foundational health. Full 7:29 breakdown inside—life-changing.

Dr. Rhonda Patrick ranks her top supplements to fill critical micronutrient gaps "70% of us lack vitamin D—it's a hormone controlling 5% of our genome. Low levels accelerate aging, dementia risk. Solution: Supplement to hit 40-60 ng/mL blood level." This isn't optional—it's foundational health. Full 7:29 breakdown inside—life-changing.

Camus

91,580 views • 7 months ago

Massive new vitamin D study just dropped — and it’s getting zero mainstream attention A 4-year trial with 25,000 adults across the US (led by 140 researchers) found: Vitamin D3 supplementation significantly preserved telomere length (only 1 year of aging in 4 years). This follows a 10-year Canadian study (12,000 people) showing ~40% reduced dementia risk with vitamin D. The message is clear: Start early, preserve what you have — telomeres don’t reverse once shortened. 2:04 clip inside — game-changing science you need to hear.

Massive new vitamin D study just dropped — and it’s getting zero mainstream attention A 4-year trial with 25,000 adults across the US (led by 140 researchers) found: Vitamin D3 supplementation significantly preserved telomere length (only 1 year of aging in 4 years). This follows a 10-year Canadian study (12,000 people) showing ~40% reduced dementia risk with vitamin D. The message is clear: Start early, preserve what you have — telomeres don’t reverse once shortened. 2:04 clip inside — game-changing science you need to hear.

Camus

1,973,454 views • 7 months ago

Massive study (25,000+ adults, 4 years, published 2025 in Am J Clin Nutr): Daily 2,000 IU vitamin D3 preserved telomere length — equivalent to slowing biological aging by ~3 years! Telomeres (DNA caps that shorten with age) shortened significantly less in the D3 group vs. placebo — hearts, cells, and overall aging markers looked younger. Marcel James highlights: This builds on prior research (e.g., Canadian 12,000-person study showing ~40% lower dementia risk with vitamin D supplementation over 10 years). Key: It's about preserving length (not reversing) — so start early (ideally before 40–45) to protect as long as possible. Never too late to start, but earlier maximizes benefit against age-related decline, heart issues, dementia risk, and more. Boosting vitamin D (sun, food, or supplement) one of the easiest longevity levers?

Massive study (25,000+ adults, 4 years, published 2025 in Am J Clin Nutr): Daily 2,000 IU vitamin D3 preserved telomere length — equivalent to slowing biological aging by ~3 years! Telomeres (DNA caps that shorten with age) shortened significantly less in the D3 group vs. placebo — hearts, cells, and overall aging markers looked younger. Marcel James highlights: This builds on prior research (e.g., Canadian 12,000-person study showing ~40% lower dementia risk with vitamin D supplementation over 10 years). Key: It's about preserving length (not reversing) — so start early (ideally before 40–45) to protect as long as possible. Never too late to start, but earlier maximizes benefit against age-related decline, heart issues, dementia risk, and more. Boosting vitamin D (sun, food, or supplement) one of the easiest longevity levers?

Camus

90,859 views • 4 months ago

🚨How much vitamin D should we be taking?” Marc Siegel MD: “Vitamin D is a super immune vitamin. About 40% of people are deficient.” “I recommend 2,000–5,000 units a day, monitored by your doctor. It reduces severe flu risk and helps the immune system fight infections.”

🚨How much vitamin D should we be taking?” Marc Siegel MD: “Vitamin D is a super immune vitamin. About 40% of people are deficient.” “I recommend 2,000–5,000 units a day, monitored by your doctor. It reduces severe flu risk and helps the immune system fight infections.”

Laura Ingraham

512,266 views • 6 months ago

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

Dr. Rhonda Patrick

217,153 views • 7 months ago

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

no.mind

243,202 views • 4 months ago

Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?

Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?

Camus

266,618 views • 3 months ago

"Avoiding The Sun Is Just As Dangerous As Smoking Cigarettes." Dr Eric Berg "There Are At Least 17 Different Cancers, Autoimmune Diseases & Cardiovascular Disease Linked To Vitamin D Insufficiency." "Vitamin D is intimately involved in over 2,000 different genes." "Our immune system absolutely cannot work without Vitamin D. 90-95% of Vitamin D comes from the sun." "Even in the early 1900s, they had Sanitariums that you can go to, to bathe in the sun as a cure for TB (Tuberculosis) & Asthma & many different illnesses." The American Dermatology Association says you must stay out of the sun & use sunscreen everyday because the sun is dangerous. We have been lied to with the attempt to indoctrinate us to, all of a sudden, be fearful of the sun. Always remember that the key to unlock & activate Vitamin D is Magnesium. Magnesium must be present in food or supplement form to activate Vitamin D, even from the sun. And for Vitamin D to transport Calcium correctly to the bones & not calcify within arterial walls & soft tissues within the body, the cofactor K2 must also be present in the diet or in supplement form. 30 minutes of sunlight can manufacture 30,000 IU of Vit D. Healing Benefits of the Sun & Vitamin D: Stroke Prevention Cancer Prevention Heart Attack Prevention Bone Health Immune System Health Depression Prevention Natural Appetite Suppressant Natural Blood Sugar/Insulin Control Mood Enhancer Keratin Production to Prevent Hair Loss Naturally Lowers Blood Pressure Optimal Libido & Hormone Production Supports Muscle Health & Injury Prevention The Higher your Vitamin D Level, the more benefits & protections you will experience. Vitamin D Levels (25-hydroxyvitamin D) 70 nmol/L Optimal Protection 👇Vitamin D Deficiency Increases Mortality👇 👇Vitamin D Deficiency Causes Chronic Disease👇

"Avoiding The Sun Is Just As Dangerous As Smoking Cigarettes." Dr Eric Berg "There Are At Least 17 Different Cancers, Autoimmune Diseases & Cardiovascular Disease Linked To Vitamin D Insufficiency." "Vitamin D is intimately involved in over 2,000 different genes." "Our immune system absolutely cannot work without Vitamin D. 90-95% of Vitamin D comes from the sun." "Even in the early 1900s, they had Sanitariums that you can go to, to bathe in the sun as a cure for TB (Tuberculosis) & Asthma & many different illnesses." The American Dermatology Association says you must stay out of the sun & use sunscreen everyday because the sun is dangerous. We have been lied to with the attempt to indoctrinate us to, all of a sudden, be fearful of the sun. Always remember that the key to unlock & activate Vitamin D is Magnesium. Magnesium must be present in food or supplement form to activate Vitamin D, even from the sun. And for Vitamin D to transport Calcium correctly to the bones & not calcify within arterial walls & soft tissues within the body, the cofactor K2 must also be present in the diet or in supplement form. 30 minutes of sunlight can manufacture 30,000 IU of Vit D. Healing Benefits of the Sun & Vitamin D: Stroke Prevention Cancer Prevention Heart Attack Prevention Bone Health Immune System Health Depression Prevention Natural Appetite Suppressant Natural Blood Sugar/Insulin Control Mood Enhancer Keratin Production to Prevent Hair Loss Naturally Lowers Blood Pressure Optimal Libido & Hormone Production Supports Muscle Health & Injury Prevention The Higher your Vitamin D Level, the more benefits & protections you will experience. Vitamin D Levels (25-hydroxyvitamin D) 70 nmol/L Optimal Protection 👇Vitamin D Deficiency Increases Mortality👇 👇Vitamin D Deficiency Causes Chronic Disease👇

Valerie Anne Smith

40,877 views • 1 year ago

A cancer breakthrough hiding in plain sight: Vitamin D. Oncologist Prof. Angus Dalgleish revealed a game-changing finding to pancreatic cancer expert Daniel Von Hoff: his successful immunotherapy trial insisted on normal Vitamin D levels. Skeptical, Von Hoff reviewed 30 years of data from 4,000 patients. The result was staggering: not one patient with low Vitamin D had responded to chemotherapy. The "responders" in his past trials were simply those with adequate Vitamin D levels. The drug alone wasn't the hero; it needed a competent immune system, primed by Vitamin D. The takeaway: Vitamin D is non-negotiable for immune function. Every white blood cell has receptors for it. The official "normal" level (~50 nmol/L) is too low. For therapy, aim for >100 nmol/L. Correcting this deficiency could be the key to turning non-responders into responders. A simple, safe, and foundational step we can no longer ignore.

A cancer breakthrough hiding in plain sight: Vitamin D. Oncologist Prof. Angus Dalgleish revealed a game-changing finding to pancreatic cancer expert Daniel Von Hoff: his successful immunotherapy trial insisted on normal Vitamin D levels. Skeptical, Von Hoff reviewed 30 years of data from 4,000 patients. The result was staggering: not one patient with low Vitamin D had responded to chemotherapy. The "responders" in his past trials were simply those with adequate Vitamin D levels. The drug alone wasn't the hero; it needed a competent immune system, primed by Vitamin D. The takeaway: Vitamin D is non-negotiable for immune function. Every white blood cell has receptors for it. The official "normal" level (~50 nmol/L) is too low. For therapy, aim for >100 nmol/L. Correcting this deficiency could be the key to turning non-responders into responders. A simple, safe, and foundational step we can no longer ignore.

Camus

175,549 views • 9 months ago

Vitamin D mistake A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D (2014) US, nearly 15 times too low UK, 0ver 22 times too low IOM calculation 600 units (15 mcg), 97.5% of people will achieve 63 nmol/L (25.2 ng/ml) Correct calculation 600 units (15 mcg), 97.5% of people will achieve 26.8 nmol/L (10.7 ng/ml) Requirements based on correct calculation 8,895 IU of vitamin D per day may be needed to accomplish that 97.5% of individuals achieve serum 25(OH)D values of 50 nmol/L or more. The "Average" vs. "Individual" Mistake Canada studies Diet gives 232 IU of vitamin D per day Institute of Medicine (IOM), RDA vitamin D 600 IU per day, (aged 1 to 70 years) Now called the National Academy of Medicine UK is even worse 400 iu or 10 mcg 600 iu per day to achieve serum 25-hydroxyvitamin D (25(OH)D) levels of 50 nmol/L or more in 97.5% of healthy individuals. Levels of 50 nmol/L or more have been shown to benefit bone health and to prevent disease and injury. The IOM based their RDA for vitamin D on an aggregation of 10 supplementation studies, (32 dose protocols) carried out during winter months, at locations above 50th parallel IOM regressed the 32 study averages, dose: plasma ratio On the basis of this, IOM estimated that 600 IU of vitamin D would achieve an average 25(OH)D level of 63 nmol/L Requirements based on correct calculation 8,895 IU of vitamin D per day This dose is well in excess of the current RDA of 600 IU per day and the tolerable upper intake of 4000 IU per day. The public health and clinical implications of the miscalculated RDA for vitamin D are serious. With the current recommendation of 600 IU, bone health objectives and disease and injury prevention targets will not be met. We recommend that the RDA for vitamin D be reconsidered to allow for appropriate public health and clinical decision-making. The Big Vitamin D Mistake Explanation of the statistical error The "Average" vs. "Individual" Mistake The Institute of Medicine’s goal was to find a vitamin D dose that ensures 97.5% of individual people reach a healthy blood level (50 nmol/L). The statistical error occurred because the IOM analysed the averages of different studies rather than the data of individual participants. They looked at 10 studies and took the average blood levels achieved in those studies. They calculated a statistical range (Confidence Interval) based on those averages. They found that with 600 IU, 97.5% of the study averages would hit the target. The Problem There is much less variation between "averages" than there is between "individuals." By using the averages, the IOM accidentally "smoothed out" the data. They assumed that if the average person in a study was fine, then almost everyone was fine. The Classroom Analogy Imagine you want to ensure every student passes a test. The IOM method They looked at the average scores of 30 different classrooms. They set a curriculum so that 97.5% of classrooms would have a passing average. The Reality Even in a classroom with a passing average, there are students who fail. The Correction To ensure 97.5% of students pass, you have to look at the lowest-performing students, not the class average. The Consequence When the authors of this paper re-calculated the numbers using the variation of individuals (rather than study averages), they found that the current RDA of 600 IU does not cover 97.5% of the population. Instead, it only ensures that 97.5% of people reach a blood level of 26.8 nmol/L (far below the target of 50 nmol/L). To actually get 97.5% of the population to the healthy target of 50 nmol/L, the math suggests you would need a dose of 8,895 IU per day.

Vitamin D mistake A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D (2014) US, nearly 15 times too low UK, 0ver 22 times too low IOM calculation 600 units (15 mcg), 97.5% of people will achieve 63 nmol/L (25.2 ng/ml) Correct calculation 600 units (15 mcg), 97.5% of people will achieve 26.8 nmol/L (10.7 ng/ml) Requirements based on correct calculation 8,895 IU of vitamin D per day may be needed to accomplish that 97.5% of individuals achieve serum 25(OH)D values of 50 nmol/L or more. The "Average" vs. "Individual" Mistake Canada studies Diet gives 232 IU of vitamin D per day Institute of Medicine (IOM), RDA vitamin D 600 IU per day, (aged 1 to 70 years) Now called the National Academy of Medicine UK is even worse 400 iu or 10 mcg 600 iu per day to achieve serum 25-hydroxyvitamin D (25(OH)D) levels of 50 nmol/L or more in 97.5% of healthy individuals. Levels of 50 nmol/L or more have been shown to benefit bone health and to prevent disease and injury. The IOM based their RDA for vitamin D on an aggregation of 10 supplementation studies, (32 dose protocols) carried out during winter months, at locations above 50th parallel IOM regressed the 32 study averages, dose: plasma ratio On the basis of this, IOM estimated that 600 IU of vitamin D would achieve an average 25(OH)D level of 63 nmol/L Requirements based on correct calculation 8,895 IU of vitamin D per day This dose is well in excess of the current RDA of 600 IU per day and the tolerable upper intake of 4000 IU per day. The public health and clinical implications of the miscalculated RDA for vitamin D are serious. With the current recommendation of 600 IU, bone health objectives and disease and injury prevention targets will not be met. We recommend that the RDA for vitamin D be reconsidered to allow for appropriate public health and clinical decision-making. The Big Vitamin D Mistake Explanation of the statistical error The "Average" vs. "Individual" Mistake The Institute of Medicine’s goal was to find a vitamin D dose that ensures 97.5% of individual people reach a healthy blood level (50 nmol/L). The statistical error occurred because the IOM analysed the averages of different studies rather than the data of individual participants. They looked at 10 studies and took the average blood levels achieved in those studies. They calculated a statistical range (Confidence Interval) based on those averages. They found that with 600 IU, 97.5% of the study averages would hit the target. The Problem There is much less variation between "averages" than there is between "individuals." By using the averages, the IOM accidentally "smoothed out" the data. They assumed that if the average person in a study was fine, then almost everyone was fine. The Classroom Analogy Imagine you want to ensure every student passes a test. The IOM method They looked at the average scores of 30 different classrooms. They set a curriculum so that 97.5% of classrooms would have a passing average. The Reality Even in a classroom with a passing average, there are students who fail. The Correction To ensure 97.5% of students pass, you have to look at the lowest-performing students, not the class average. The Consequence When the authors of this paper re-calculated the numbers using the variation of individuals (rather than study averages), they found that the current RDA of 600 IU does not cover 97.5% of the population. Instead, it only ensures that 97.5% of people reach a blood level of 26.8 nmol/L (far below the target of 50 nmol/L). To actually get 97.5% of the population to the healthy target of 50 nmol/L, the math suggests you would need a dose of 8,895 IU per day.

Jordan Chain

14,450 views • 7 months ago

Dr. Ryan Cole joins Dr. Ardis to explain why vitamin D is more than a supplement — it's a powerful immune-regulating pro hormone: ▪️Vitamin D is a pro hormone, not just a vitamin, regulating up to 5% of the human genome. ▪️Activates 2,000 genes involved in immune communication. ▪️Prevents cytokine storms by stopping dangerous immune overreactions. ▪️Levels above 50 ng/mL can block inflammatory pathways entirely. ▪️55 ng/mL is ideal — saturates all receptors and boosts resilience. ▪️Illness depletes vitamin D, so slightly higher levels are recommended. ▪️Deficiency causes disrupted gene signaling. ▪️Adequate levels ensure precise immune control and prevent system overload.

Dr. Ryan Cole joins Dr. Ardis to explain why vitamin D is more than a supplement — it's a powerful immune-regulating pro hormone: ▪️Vitamin D is a pro hormone, not just a vitamin, regulating up to 5% of the human genome. ▪️Activates 2,000 genes involved in immune communication. ▪️Prevents cytokine storms by stopping dangerous immune overreactions. ▪️Levels above 50 ng/mL can block inflammatory pathways entirely. ▪️55 ng/mL is ideal — saturates all receptors and boosts resilience. ▪️Illness depletes vitamin D, so slightly higher levels are recommended. ▪️Deficiency causes disrupted gene signaling. ▪️Adequate levels ensure precise immune control and prevent system overload.

Camus

46,201 views • 1 year ago