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🧬 Take a look inside a 3D tissue bioprinting lab! NIH postdoctoral fellow Dr. Cristina Antich Acedo demonstrates how cutting-edge bioprinting can recreate human tissue structure. By combining different cell types and biomaterials, researchers can mimic real biological environments with precision. 🔬 This technology helps accelerate the path from...

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NIH

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14,495 görüntüleme • 3 ay önce •via X (Twitter)

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⚡🎉 We are thrilled to introduce VORTEX, an AI-powered computational framework for predicting 3D Spatial Transcriptomics (ST) using 3D tissue images and minimal 2D ST! 🧬 By combining cutting-edge 3D non-destructive tissue imaging with AI, VORTEX imputes the 3D molecular landscape of large tissue samples in a cost-effective and scalable manner. 🧠💡Our approach: By pretraining on diverse 3D morphology–2D transcriptomic pairs from heterogeneous tissue samples, and then fine-tuning on minimal 2D ST data from a volume of interest, VORTEX leverages both generic tissue-specific and sample-specific morphomolecular correlates to predict 3D ST. Congratulations to our superstar co-leads Cristina Almagro Pérez and Andrew H. Song, this was an exciting collaboration with Jonathan Liu Sizun Jiang Ali Bashashati. Preprint: Demo: Read the excellent blog from our superstar grad student Cristina Almagro Pérez: Also see our previous work on 3D Computational Pathology from Andrew H. Song published in Cell last year: Stay tuned for more to come.
0:51

⚡🎉 We are thrilled to introduce VORTEX, an AI-powered computational framework for predicting 3D Spatial Transcriptomics (ST) using 3D tissue images and minimal 2D ST! 🧬 By combining cutting-edge 3D non-destructive tissue imaging with AI, VORTEX imputes the 3D molecular landscape of large tissue samples in a cost-effective and scalable manner. 🧠💡Our approach: By pretraining on diverse 3D morphology–2D transcriptomic pairs from heterogeneous tissue samples, and then fine-tuning on minimal 2D ST data from a volume of interest, VORTEX leverages both generic tissue-specific and sample-specific morphomolecular correlates to predict 3D ST. Congratulations to our superstar co-leads Cristina Almagro Pérez and Andrew H. Song, this was an exciting collaboration with Jonathan Liu Sizun Jiang Ali Bashashati. Preprint: Demo: Read the excellent blog from our superstar grad student Cristina Almagro Pérez: Also see our previous work on 3D Computational Pathology from Andrew H. Song published in Cell last year: Stay tuned for more to come.

Faisal Mahmood

17,991 görüntüleme • 1 yıl önce

.Jay Bhattacharya, MD, PhD and Dr. @NKleinstreuer talk about NIH’s shift toward human-focused research and how NIH will no longer issue NOFOs exclusively for animal models. Watch the latest episode of The Director’s Desk to hear more:
1:29

.Jay Bhattacharya, MD, PhD and Dr. @NKleinstreuer talk about NIH’s shift toward human-focused research and how NIH will no longer issue NOFOs exclusively for animal models. Watch the latest episode of The Director’s Desk to hear more:

NIH

143,695 görüntüleme • 1 yıl önce

NIH researchers are exploring how immature cells called stem cells develop into specialized cells like heart or lung cells. This research on how cells keep their DNA organized during that specialization process could help advance the development of lab grown organs for thousands of people waiting on a transplant. Watch the full video to learn more:
2:14

NIH researchers are exploring how immature cells called stem cells develop into specialized cells like heart or lung cells. This research on how cells keep their DNA organized during that specialization process could help advance the development of lab grown organs for thousands of people waiting on a transplant. Watch the full video to learn more:

NIH

19,895 görüntüleme • 6 ay önce

Looking for more out of your fellowship? Dr. Rachel Strength shares how her favorite part of being a clinical fellow at NIH is the relationships she’s built with mentors and patients. Learn more about how you can get more out of your fellowship experience, build connections, collaborate across disciplines, and grow your career in an environment designed for impact with NIAID Clinical Fellowship Opportunities:
1:20

Looking for more out of your fellowship? Dr. Rachel Strength shares how her favorite part of being a clinical fellow at NIH is the relationships she’s built with mentors and patients. Learn more about how you can get more out of your fellowship experience, build connections, collaborate across disciplines, and grow your career in an environment designed for impact with NIAID Clinical Fellowship Opportunities:

NIH

22,007 görüntüleme • 9 gün önce

How does NIH’s Unified Funding Strategy strengthen scientific stewardship? 🔬 Dr. Nora Volkow, Director of the National Institute on Drug Abuse (NIDA), explains how the new plan allows us to identify research gaps while also identifying areas of redundancy, making it easier to fund the science most likely to bring about new benefits to human health. Hear more from NIH leadership at the upcoming webinar “Understanding NIH’s Unified Funding Strategy: What the Research Community Needs to Know” ➡️
0:39

How does NIH’s Unified Funding Strategy strengthen scientific stewardship? 🔬 Dr. Nora Volkow, Director of the National Institute on Drug Abuse (NIDA), explains how the new plan allows us to identify research gaps while also identifying areas of redundancy, making it easier to fund the science most likely to bring about new benefits to human health. Hear more from NIH leadership at the upcoming webinar “Understanding NIH’s Unified Funding Strategy: What the Research Community Needs to Know” ➡️

NIH

18,171 görüntüleme • 1 ay önce

NEW episode! Drug development has never been more expensive, in terms of output per dollar spent. This trend, called Eroom’s law, is surprising, considering the incredible technological advances in drug discovery, from genome sequencing to engineering to microscopy. On a new episode of the Works in Progress podcast, Ben Southwood and I talk to Ruxandra Teslo 🧬 about why this has happened and what can be done about it. We discuss how: • AI isn’t a magic bullet for drug discovery. Predictive models lack the physical human data, like individual variation and rare side effects, that can only be generated by actually running real-world clinical trials. • As scientists invent more effective drugs, it becomes harder to discover new treatments that can surpass past successes. This is known as the "Better than the Beatles" problem. • Biotech companies are increasingly moving their "first-in-human" trials to Australia because its simpler regulations allow researchers to test drug safety faster and cheaper than in the US. • Clinical trials can be made more efficient with various reforms including: embracing platform trials, allowing researchers to select from independent ethics boards, expanding the funding and validation of surrogate endpoints, increasing transparency by releasing regulatory correspondence from failed companies, and much more. Timestamps: 00:00:00 Eroom’s law and the paradox of drug development 00:08:03 How clinical trials actually work 00:10:23 The power and controversy of surrogate endpoints 00:14:01 How historical patent laws influenced trial timelines 00:22:46 The Australia advantage and regulatory drag 00:29:08 Institutional review boards (IRBs) and bureaucratic drag 00:32:21 Open science and successful reforms 00:41:49 Our wishlist for clinical trial reforms, and which reforms we *don’t* like 00:53:48 Why AI isn’t a magic bullet for drug discovery
56:13

NEW episode! Drug development has never been more expensive, in terms of output per dollar spent. This trend, called Eroom’s law, is surprising, considering the incredible technological advances in drug discovery, from genome sequencing to engineering to microscopy. On a new episode of the Works in Progress podcast, Ben Southwood and I talk to Ruxandra Teslo 🧬 about why this has happened and what can be done about it. We discuss how: • AI isn’t a magic bullet for drug discovery. Predictive models lack the physical human data, like individual variation and rare side effects, that can only be generated by actually running real-world clinical trials. • As scientists invent more effective drugs, it becomes harder to discover new treatments that can surpass past successes. This is known as the "Better than the Beatles" problem. • Biotech companies are increasingly moving their "first-in-human" trials to Australia because its simpler regulations allow researchers to test drug safety faster and cheaper than in the US. • Clinical trials can be made more efficient with various reforms including: embracing platform trials, allowing researchers to select from independent ethics boards, expanding the funding and validation of surrogate endpoints, increasing transparency by releasing regulatory correspondence from failed companies, and much more. Timestamps: 00:00:00 Eroom’s law and the paradox of drug development 00:08:03 How clinical trials actually work 00:10:23 The power and controversy of surrogate endpoints 00:14:01 How historical patent laws influenced trial timelines 00:22:46 The Australia advantage and regulatory drag 00:29:08 Institutional review boards (IRBs) and bureaucratic drag 00:32:21 Open science and successful reforms 00:41:49 Our wishlist for clinical trial reforms, and which reforms we *don’t* like 00:53:48 Why AI isn’t a magic bullet for drug discovery

Saloni

109,256 görüntüleme • 4 ay önce

Ranging in size from as small as a speck of pepper to the size of an apple seed, ticks can be hard to spot and remove, increasing the chance of exposure to tick-borne diseases. NIH researchers are exploring how to trigger a process found in animals, where molecules called cytokines activate the neurons that cause us to itch. This would allow humans to scratch off a tick before it can transmit disease. Watch the full video to learn more:
2:12

Ranging in size from as small as a speck of pepper to the size of an apple seed, ticks can be hard to spot and remove, increasing the chance of exposure to tick-borne diseases. NIH researchers are exploring how to trigger a process found in animals, where molecules called cytokines activate the neurons that cause us to itch. This would allow humans to scratch off a tick before it can transmit disease. Watch the full video to learn more:

NIH

11,519 görüntüleme • 5 ay önce

“Just the idea that 2-meter-long DNA can be wrapped up in a tiny cell is just mind-boggling” – Dr. Peter Park on how NIH-supported research led to key discoveries about DNA organization’s impact on health & disease. Watch the full video:
0:57

“Just the idea that 2-meter-long DNA can be wrapped up in a tiny cell is just mind-boggling” – Dr. Peter Park on how NIH-supported research led to key discoveries about DNA organization’s impact on health & disease. Watch the full video:

NIH

17,824 görüntüleme • 1 yıl önce

Why choose NIH for your clinical fellowship? Dr. Derek MacMath, a Clinical Fellow at the National Institute of Allergy and Infectious Diseases (NIAID), values the close proximity to the NIH Clinical Center and the unique opportunity to conduct translational research. See why NIH is an exceptional place to train, collaborate, and make an impact. Learn more about NIAID Clinical Fellowship opportunities:
1:25

Why choose NIH for your clinical fellowship? Dr. Derek MacMath, a Clinical Fellow at the National Institute of Allergy and Infectious Diseases (NIAID), values the close proximity to the NIH Clinical Center and the unique opportunity to conduct translational research. See why NIH is an exceptional place to train, collaborate, and make an impact. Learn more about NIAID Clinical Fellowship opportunities:

NIH

13,079 görüntüleme • 26 gün önce

🩺 Could our urine reveal more insights into how diabetes harms our kidneys? NIH researchers are studying tiny extracellular vesicles called exosomes found in urine to better understand how diabetes harms the kidneys. 🎥 Watch to learn more:
1:31

🩺 Could our urine reveal more insights into how diabetes harms our kidneys? NIH researchers are studying tiny extracellular vesicles called exosomes found in urine to better understand how diabetes harms the kidneys. 🎥 Watch to learn more:

NIH

26,800 görüntüleme • 22 gün önce

Dr Anthony Fauci authorized over $200 million US taxpayer dollars for transgender animal testing and animal torture “Can you describe what exactly the American people's taxpayer dollars were spent on regarding transgender animal testing?” “Yeah: - In a lot of these cases, they involve mice, rats, monkeys who are being surgically mutilated and subjected to hormone therapies to mimic female to male or male to female gender transitions - Gender affirming hormone therapies, and then looking at the biological, psychological, and physiological effects of the gender transitions - Looking at the effects of taking vaccines after you've transitioned these animals from male to female or female to male - Looking at the size of their genitals changing after you've put them on estrogen or testosterone therapies to transition them - There was a $1.1 million grant to give female lab rats testosterone to mimic transgender male humans and then overdose them with this party drug to see if female animals taking testosterone were more likely to overdose on the sex party drug than animals who are not taking testosterone “Are many of these taxpayer funded animal studies shared with the public or is there a significant oversight of this research?” “You essentially needed a degree in information technology to navigate the federal spending databases to find any of this stuff.” “In our analysis, Dr. Fauci funded about 95% of the change-drender animal experiments” “What we are doing to test human effects is poisoning lab animals - Forcing them to breathe wildfire smoke simulated in a laboratory by burning different types of foliage and pumping into animals cages - Making them obese to simulate what it would be like for obese people to be exposed to wildfire smoke - Shooting off handguns and rifles and forcing animals to breathe the emissions and gun control experiments - and the list goes on and on”
3:14

Dr Anthony Fauci authorized over $200 million US taxpayer dollars for transgender animal testing and animal torture “Can you describe what exactly the American people's taxpayer dollars were spent on regarding transgender animal testing?” “Yeah: - In a lot of these cases, they involve mice, rats, monkeys who are being surgically mutilated and subjected to hormone therapies to mimic female to male or male to female gender transitions - Gender affirming hormone therapies, and then looking at the biological, psychological, and physiological effects of the gender transitions - Looking at the effects of taking vaccines after you've transitioned these animals from male to female or female to male - Looking at the size of their genitals changing after you've put them on estrogen or testosterone therapies to transition them - There was a $1.1 million grant to give female lab rats testosterone to mimic transgender male humans and then overdose them with this party drug to see if female animals taking testosterone were more likely to overdose on the sex party drug than animals who are not taking testosterone “Are many of these taxpayer funded animal studies shared with the public or is there a significant oversight of this research?” “You essentially needed a degree in information technology to navigate the federal spending databases to find any of this stuff.” “In our analysis, Dr. Fauci funded about 95% of the change-drender animal experiments” “What we are doing to test human effects is poisoning lab animals - Forcing them to breathe wildfire smoke simulated in a laboratory by burning different types of foliage and pumping into animals cages - Making them obese to simulate what it would be like for obese people to be exposed to wildfire smoke - Shooting off handguns and rifles and forcing animals to breathe the emissions and gun control experiments - and the list goes on and on”

Wall Street Apes

237,297 görüntüleme • 1 yıl önce

What if scientists knew how to stop or slow the spread of cancer cells to other parts of the body? This process, also known as cancer metastasis, is responsible for the majority of cancer deaths. NIH researchers are studying this process with hopes of preventing it from happening. 🎥 Watch the full video to learn more:
0:55

What if scientists knew how to stop or slow the spread of cancer cells to other parts of the body? This process, also known as cancer metastasis, is responsible for the majority of cancer deaths. NIH researchers are studying this process with hopes of preventing it from happening. 🎥 Watch the full video to learn more:

NIH

12,677 görüntüleme • 2 ay önce

Chronic inflammation plays a role in some of today’s biggest health challenges, including Alzheimer’s, cancer, and heart disease. NIH researchers are developing new medications designed to boost the body’s natural anti-inflammatory responses and potentially help millions of people living with chronic inflammation. Learn more in this video:
2:06

Chronic inflammation plays a role in some of today’s biggest health challenges, including Alzheimer’s, cancer, and heart disease. NIH researchers are developing new medications designed to boost the body’s natural anti-inflammatory responses and potentially help millions of people living with chronic inflammation. Learn more in this video:

NIH

10,407 görüntüleme • 3 ay önce

NIH researchers studied more than 11,000 Americans and found that many people think healthy foods like fruits and vegetables are tasty too. The findings offer new insights into how our attitudes toward food may influence what we eat. 🎥 Watch the video to learn more: #EatRealFood
1:54

NIH researchers studied more than 11,000 Americans and found that many people think healthy foods like fruits and vegetables are tasty too. The findings offer new insights into how our attitudes toward food may influence what we eat. 🎥 Watch the video to learn more: #EatRealFood

NIH

17,508 görüntüleme • 1 ay önce

Every breakthrough begins with curiosity. Every discovery brings us one step closer to better treatments and brighter futures. Learn more about NIH vision science at
0:30

Every breakthrough begins with curiosity. Every discovery brings us one step closer to better treatments and brighter futures. Learn more about NIH vision science at

NIH

20,285 görüntüleme • 28 gün önce

It is because of the gold standard research conducted at NIH that children with rare diseases are provided the opportunity of lifesaving therapies and treatments. We are proud of our friends at U.S. FDA launching a framework for accelerating the development of individualized therapies for ultra rare diseases. Read more about FDA’s plan to accelerate cures here ➡️ HHS
1:58

It is because of the gold standard research conducted at NIH that children with rare diseases are provided the opportunity of lifesaving therapies and treatments. We are proud of our friends at U.S. FDA launching a framework for accelerating the development of individualized therapies for ultra rare diseases. Read more about FDA’s plan to accelerate cures here ➡️ HHS

NIH

22,498 görüntüleme • 6 ay önce

From 1975 to 2020, prevention and screening efforts averted 4.75 million deaths from five cancer types: breast, cervical, colorectal, lung, and prostate. A new NIH study emphasizes just how much prevention and screening contributes to reductions in mortality.
0:49

From 1975 to 2020, prevention and screening efforts averted 4.75 million deaths from five cancer types: breast, cervical, colorectal, lung, and prostate. A new NIH study emphasizes just how much prevention and screening contributes to reductions in mortality.

NIH

11,660 görüntüleme • 1 yıl önce

How many of you actually know how "what you eat" grows? 🤔 I never learned crop science in school. I learned it by walking around our farm with my father, who showed me different crops and explained how they grow. But not everyone has access to a farm, so I built a 3D Crop Science application in Three.js using Claude Opus 5 to make that learning experience more visual and interactive. It is an exploration of different types of seeds where each seed has three different stages. The first stage shows the whole seed. The second stage is a cross section that shows what is inside the seed and how it grows. The third stage shows the germination phase through a 3D model. There are 24 models in total. The original models were 1,349.6 MB, which Claude optimized down to just 11.6 MB in total. All of the 3D models were generated using Tripo 🔜 gamescom. Claude also created visual information for each seed showing details like seed type, storage tissue and germination phase. Each seed also has a YouTube video that shows how it actually grows in the real world. There is also a section showing where each seed is commonly grown using both a 3D globe and a flat map. You can explore different regions and click on specific areas to see more information about where that seed is grown. The entire experience is fully responsive and also includes quizzes that you can take in both normal and 3D formats. I strongly believe education becomes much more effective when you can see, interact, watch and explore instead of relying only on textbooks. Live: Code:
1:14

How many of you actually know how "what you eat" grows? 🤔 I never learned crop science in school. I learned it by walking around our farm with my father, who showed me different crops and explained how they grow. But not everyone has access to a farm, so I built a 3D Crop Science application in Three.js using Claude Opus 5 to make that learning experience more visual and interactive. It is an exploration of different types of seeds where each seed has three different stages. The first stage shows the whole seed. The second stage is a cross section that shows what is inside the seed and how it grows. The third stage shows the germination phase through a 3D model. There are 24 models in total. The original models were 1,349.6 MB, which Claude optimized down to just 11.6 MB in total. All of the 3D models were generated using Tripo 🔜 gamescom. Claude also created visual information for each seed showing details like seed type, storage tissue and germination phase. Each seed also has a YouTube video that shows how it actually grows in the real world. There is also a section showing where each seed is commonly grown using both a 3D globe and a flat map. You can explore different regions and click on specific areas to see more information about where that seed is grown. The entire experience is fully responsive and also includes quizzes that you can take in both normal and 3D formats. I strongly believe education becomes much more effective when you can see, interact, watch and explore instead of relying only on textbooks. Live: Code:

The Bugged Dev

41,496 görüntüleme • 3 gün önce