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“Technologies like GPS, satellite communications, and global navigation all operate as if Earth is curved. Could any version of a flat earth realistically reproduce those same results? I would say no. I think you’re trying to apply a framework beyond its scope of applicability. It’s emblematic of the fact...

47,161 views • 2 months ago •via X (Twitter)

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Palmer Luckey’s advice for founder-led communications “My advice to people would probably be to recognize that the value of your reputation is very high,” Anduril founder Palmer Luckey begins. “If people do not trust you; if they do not believe in what you’re saying; if they do not think that you’re a person worth listening to, they’re going to have a hard time working with you.” Palmer also argues that founders don’t need to be neutral: “You don’t need to be neutral. You can be a propagandist. You can advocate for a particular point of view . . . In general, people should recognize that if you say something where you caveat it and hedge it and basically end up saying something that most people would agree with, you might as well have said nothing at all.” He continues: “You are not going to build a following of people who say, ‘I just love Palmer’s right-down-the-middle, very-hedged takes that everyone agrees with.’ If you’re just restating common sentiment, it’s not going to get you anywhere . . . So one of the things I tell people is, ‘Make sure that when you’re saying something, you’re SAYING something. Make sure you’re trying to persuade and affect change.’ — maybe not in everybody, but in some people. If you make some people love what you’re saying and some people hate what you’re saying, that’s a lot better than having everybody lukewarm agree with you. Don’t waste your time communicating about the things everyone already agrees with you on. Focus on the things where you need to change their mind.” Source: Lulu Cheng Meservey (Sep 2025)

Startup Archive

78,576 views • 2 months ago

Alex Karp, Palantir: “At a certain level of accomplishment, you’re in an artistic space where it’s very hard to explain why you have your insights.” "There’s one country in the world where you get rewarded for that.. in America, if you deliver, you can be you.” “This is a maximal freedom culture… & that self-expression—because it’s not playbook—creates an environment that is exceedingly hard to compete with & will piss off all the right people.” . . . "I think in the end, to do something important—whether it’s me, or @elianoayounes, or look at all these people here—these are among the best and most talented people in the world. At a certain level of accomplishment, you’re in an artistic space where it’s very hard to explain why you have your insights, and it goes way beyond experiences that have of course also influenced them. But I just have artistic impulses, and they shape my life, and I’ve allowed myself—or I’ve been forced to allow myself—the freedom to live that way. And there’s one country in the world where you get rewarded for that, because in America, if you deliver, you can be you. You’re your own boss, right? You decide who you want to talk to, you decide who you don’t want to talk to. You have ideas of things you’d like to advance on. And I think one of the biggest variables in my life is simply that I live in a culture where if you deliver—in this case economically—and by the way, at 18, for most investors, we were failing for at least 15 years. Many would say 18 years. Honestly, some would say until two years ago. And still, this is a culture where the financials are going to show up. That’s only possible in this culture. I guess maybe because I lived abroad so long, it’s easier for me to accept and rely on that. I think sometimes people who’ve lived here their whole life don’t always exactly understand that this is a maximal freedom culture. It’s the only culture like this in the world, and it allows you to self-express. And if you self-express, that self-expression—because it’s not playbook—creates an environment that is exceedingly hard to compete with and will piss off all the right people."

Molly O’Shea

52,497 views • 6 months ago

$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” ______________________________________ “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _______________________________________ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”

Jack Prescott

27,317 views • 13 days ago

.Naval: You define wealth in a beautiful way. You talk about wealth as a set of physical transformations that we can affect. So as a society it becomes very clear that knowledge leads directly to wealth creation for everybody. A given individual can obviously affect physical transformations proportional to the resources available to them—but much more proportional to the knowledge available to them. Knowledge is a huge force multiplier. You then define resources as the thing that you combine with knowledge to create wealth. New knowledge allows you to use new things as resources and discard old things that maybe we’re running out of. There are lots of examples of how we’ve done that in the past. For example, in energy we’ve gone from wood to coal to oil to nuclear. But then people say, “Now we’re out of ideas. Now we’re caught up. Now we’re done. There aren’t going to be new ideas, and now we have to freeze the frame and conserve what we have.” The counter to that is, “No, we’ll create new knowledge and have new resources. Don’t worry about the old ones.” Well they say, “If you’re going to have new resources, if you can’t think of them now, it’s not real.” This now gets into the realm of people demanding that if you’re going to claim that new knowledge will be created, you have to name that knowledge now. Otherwise it’s not real. But that seems like a Catch-22. David Deutsch: It does, and it’s a bad argument. I don’t want to claim that the knowledge will be created. We’re fallible; we may not create it. We may destroy ourselves. We may miss the solution that’s right under our nose, so that when the snailiens come from another galaxy and look at us, they’ll say, “How can it possibly be that they failed to do so-and-so when it was right in front of them?” That could happen. I can’t prove or argue that it won’t happen. What I always argue, though, is that we have what it takes. We have everything that it takes to achieve that. If we don’t, it’ll be because of bad choices we have made, not because of constraints imposed on us by the planet or the solar system. Naval: It will be by anti-rational memes that restrict the creation of knowledge and the growth of knowledge. David Deutsch: Maybe. Or maybe it’ll be by well-intentioned errors, which nobody could see why they were errors. Again, it doesn’t take malevolence to make mistakes. Mistakes are the normal condition of humans. All we can do is try to find them. Maybe not destroying the means of correcting errors is the heart of morality; because if there is no way of correcting errors, then sooner or later one of those will get us. Naval: Don’t destroy the means of error correction is the base of morality. I love that. I think about places like North Korea where you can’t have elections and a revolution is very difficult because the gang in charge is armed to the teeth and they’ve destroyed the means of political error correction for a long time. That is a case where humanity is trapped in a local minimum, and it’s very hard to climb out of that hole. If too much of the world falls into that mindset, then we as a species may just stagnate because we’ve lost our biggest advantage. We’ve lost our biggest discovery, which was the ability to make new discoveries.

Deutsch Explains

143,949 views • 2 years ago

CHAMATH: STAYING IN CALIFORNIA (DESPITE THE TAXES) “It’s given me everything, so I will not leave and I will keep building companies there and hiring people there. And if there’s taxes that I have to pay, I’ll pay these taxes. But I just think that at some point, we’re better off addressing the core issue of why people believe this form of governance actually makes sense. Is it because they actually think it’s better, or is it that they’re just angry about a bunch of other things? And I think it’s mostly the latter, so we should fix that because there is no sane human being that could look at any of this information and think that we are well run. We are completely, completely out of our mind… You know, there is a period where I definitely thought about [leaving California] and I went around. I looked at different places and I thought: ‘Wait a minute, California is incredible, Palo Alto is incredible, it’s given me everything.’ And I just said: ‘Okay, mentally here’s the number and just allocate it and just let’s move on with our lives and get back to building things that I think are important.’ The reason why people are angry, it’s the same reason they were angry in 1890, it’s the same reason they were angry in Europe in 1930 at the beginning, it’s the same reason after 2008, we’ve had all of this pushback, it’s the same reason. So at some point, we should just fix the core problem that everybody is shouting about, as opposed to allowing these other people to pervert the frustration they have into these dumb ideas and programs that are always about, give me more money and I will solve your problems. It just doesn’t work… The core problem is there is a large number of people that look and believe that the latter has been pulled up above them. Why do they believe that right now? I think very specifically technology has had this profoundly positive impact but very, very few of us participated in it. In the way that we all think that we’ve made it better for everybody, looking at Instagram reels does not make your life better. That’s not true. Being able to have a functional search is useful, but it doesn’t necessarily make your life better. So we have to answer the question, how does this economically benefit more people?” Chamath Palihapitiya via Squawk Box Andrew Ross Sorkin Joe Kernen

Ron Pragides 

44,526 views • 1 month ago