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The Difference between Play and "Play"~ // Sonic The Hedgehog Comic Dub Gadget 🎙️: DoodleHouseVA🔞MINORS DNI Lanolin 🎙️: VickiFox🔞(Voice Comms Open) 🎨: 🎶QUAVERNSFW🎶 COMMISSIONS CLOSED (10/10) SFX: OpenNSFW 🟣 Available Now #SonicTheHedeghog #lanolinthesheep

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DoodleHouseVA🔞MINORS DNI

34,871 subscribers

134,257 次观看 • 11 个月前 •via X (Twitter)

NSFW#SonicTheHedeghog#lanolinthesheep
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Kali tried on a pair of Blake' clothes and unsurprisingly they couldn't handle her much THICKER body!!! 🎨 = Owl_pie (commissions CLOSED) 🎙️ = Tigress Dee 🔞 (Kali Belladonna) 🎵 = HentAudio 🇺🇦 🟢COMMS OPEN🟢, LewdSound V2🔞🔊(COMMISSIONS OPEN) & OpenNSFW 🟣 Available Now
0:41

Kali tried on a pair of Blake' clothes and unsurprisingly they couldn't handle her much THICKER body!!! 🎨 = Owl_pie (commissions CLOSED) 🎙️ = Tigress Dee 🔞 (Kali Belladonna) 🎵 = HentAudio 🇺🇦 🟢COMMS OPEN🟢, LewdSound V2🔞🔊(COMMISSIONS OPEN) & OpenNSFW 🟣 Available Now

Crimson Crow VA (Commissions Open) 🔞

14,827 次观看 • 17 天前

🍒Breeding your slippery lil slut Calico!🍒 ˚⟡ ꒰ა♡໒꒱ ⟡ ˚ 🖌️ Animator: TrevoButEvil🔞(Comms CLOSED) 🎙️ VA: HunnieVA 🍯👻 (me!) 🎙️🎧 Editing + VA: ArkihamAfterDark🔞 🔊 SFX Pack: OpenNSFW 🟣 Available Now
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🍒Breeding your slippery lil slut Calico!🍒 ˚⟡ ꒰ა♡໒꒱ ⟡ ˚ 🖌️ Animator: TrevoButEvil🔞(Comms CLOSED) 🎙️ VA: HunnieVA 🍯👻 (me!) 🎙️🎧 Editing + VA: ArkihamAfterDark🔞 🔊 SFX Pack: OpenNSFW 🟣 Available Now

HunnieVA 🍯👻

93,618 次观看 • 9 个月前

Tsu' ass is so BIG even Miruko is shocked at it's MASSIVE size!!! 🎨 = 🔞: EvilZoultan (YCH COMMISSIONS!) 🎙️ = Starlie Skye🌟 🔞 | Comms OPEN + Voice pack! (Tsu) & ⛧♱ Coco Kymmie ⛧♱ (Miruko) 🎵 = PlumEnjoyer (Comms Closed) (using HentAudio 🇺🇦 🟢COMMS OPEN🟢, Lewd K. & OpenNSFW SFX packs)
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Tsu' ass is so BIG even Miruko is shocked at it's MASSIVE size!!! 🎨 = 🔞: EvilZoultan (YCH COMMISSIONS!) 🎙️ = Starlie Skye🌟 🔞 | Comms OPEN + Voice pack! (Tsu) & ⛧♱ Coco Kymmie ⛧♱ (Miruko) 🎵 = PlumEnjoyer (Comms Closed) (using HentAudio 🇺🇦 🟢COMMS OPEN🟢, Lewd K. & OpenNSFW SFX packs)

Crimson Crow VA (Commissions Open) 🔞

84,442 次观看 • 1 年前

Helen is FURIOUS that Violet would ever claim their asses are equal, so she get Tony to be the deciding voter on who has the bigger ass! (Violet is 18+) 🎨 = Jay Marvel - 18+ ADULT Art 🔞 🎙️ = ☁️💫Chloe Angel💫☁️ (Helen) & Marina 🔞🩵 (Violet) 🎵 = PlumEnjoyerSFX (Using HentAudio 🇺🇦 🟢COMMS OPEN🟢, LewdSound V2🔞🔊(COMMISSIONS OPEN) & OpenNSFW 🟣 Available Now SFX packs
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Helen is FURIOUS that Violet would ever claim their asses are equal, so she get Tony to be the deciding voter on who has the bigger ass! (Violet is 18+) 🎨 = Jay Marvel - 18+ ADULT Art 🔞 🎙️ = ☁️💫Chloe Angel💫☁️ (Helen) & Marina 🔞🩵 (Violet) 🎵 = PlumEnjoyerSFX (Using HentAudio 🇺🇦 🟢COMMS OPEN🟢, LewdSound V2🔞🔊(COMMISSIONS OPEN) & OpenNSFW 🟣 Available Now SFX packs

Crimson Crow VA (Commissions Open) 🔞

122,787 次观看 • 1 个月前

Before Alastor joined this is how they paid for everything for the hotel! 🎨 = 🔞 Mei Lewds 🔞 - CLOSED COMMS 🎙️ = 🔞Twinkle Park (Commissions open: 1/5) 🔞 (Angle Dust) & DarkHalfling (Vaggi)
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Before Alastor joined this is how they paid for everything for the hotel! 🎨 = 🔞 Mei Lewds 🔞 - CLOSED COMMS 🎙️ = 🔞Twinkle Park (Commissions open: 1/5) 🔞 (Angle Dust) & DarkHalfling (Vaggi)

Crimson Crow VA (Commissions Open) 🔞

35,974 次观看 • 8 个月前

My first time ever doing Sfx edit project. Might need some practice, but I hoped you enjoyed it😊. Art by мoonιԍ VA by 💞 MeruraVa🎙️ (COMMS OPEN! 💞🔞) SFX pack by OpenNSFW 🟣 Available Now
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My first time ever doing Sfx edit project. Might need some practice, but I hoped you enjoyed it😊. Art by мoonιԍ VA by 💞 MeruraVa🎙️ (COMMS OPEN! 💞🔞) SFX pack by OpenNSFW 🟣 Available Now

Both name

162,156 次观看 • 7 个月前

Helen is FURIOUS that Violet would ever claim their asses are equal, so she get Tony to be the deciding voter on who has the bigger ass! *3D RENDER VERSION* (Violet is 18+) 🎨 = Prevence🔞 (Happy Birthday!!!) 🎙️= ☁️💫Chloe Angel💫☁️ (Helen) & Marina 🔞🩵 (Violet) 🎵 = PlumEnjoyerSFX (Using HentAudio 🇺🇦 🟢COMMS OPEN🟢, LewdSound V2🔞🔊(COMMISSIONS OPEN) & OpenNSFW 🟣 Available Now SFX packs)
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Helen is FURIOUS that Violet would ever claim their asses are equal, so she get Tony to be the deciding voter on who has the bigger ass! *3D RENDER VERSION* (Violet is 18+) 🎨 = Prevence🔞 (Happy Birthday!!!) 🎙️= ☁️💫Chloe Angel💫☁️ (Helen) & Marina 🔞🩵 (Violet) 🎵 = PlumEnjoyerSFX (Using HentAudio 🇺🇦 🟢COMMS OPEN🟢, LewdSound V2🔞🔊(COMMISSIONS OPEN) & OpenNSFW 🟣 Available Now SFX packs)

Crimson Crow VA (Commissions Open) 🔞

69,997 次观看 • 1 个月前

Okay okay, here's the actually video (2/2) 🎙️VA: 🔞PhosphorusVA | NSFW Voice Actor | DM For Booking 🎨Art: 🔞XStupid_FurryX🔞 (OPEN COMMS) 🔊SFX Pack: HentAudio 🇺🇦 🟢COMMS OPEN🟢 💵Commissioned: Nice and Grey 💻Edit: Take a guess #NSFW #Furry #Yaoi
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Okay okay, here's the actually video (2/2) 🎙️VA: 🔞PhosphorusVA | NSFW Voice Actor | DM For Booking 🎨Art: 🔞XStupid_FurryX🔞 (OPEN COMMS) 🔊SFX Pack: HentAudio 🇺🇦 🟢COMMS OPEN🟢 💵Commissioned: Nice and Grey 💻Edit: Take a guess #NSFW #Furry #Yaoi

Fumio Bukita

69,530 次观看 • 2 年前

Yang spots you staring at her and she can't help but tease you with her HUMONGOUS boobs and phat ass!!! 🎨 = Tap🔞(comms closed) 🎙️ = ☁️💫Chloe Angel💫☁️ (Yang) 🎵 = PlumEnjoyer (Comms OPEN - 1/4) (Using HentAudio 🇺🇦 🟢COMMS OPEN🟢, Lewd K. & OpenNSFW SFX pack)
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Yang spots you staring at her and she can't help but tease you with her HUMONGOUS boobs and phat ass!!! 🎨 = Tap🔞(comms closed) 🎙️ = ☁️💫Chloe Angel💫☁️ (Yang) 🎵 = PlumEnjoyer (Comms OPEN - 1/4) (Using HentAudio 🇺🇦 🟢COMMS OPEN🟢, Lewd K. & OpenNSFW SFX pack)

Crimson Crow VA (Commissions Open) 🔞

52,287 次观看 • 9 个月前

10k followers!! as i promised here's the dub of this comic ❤ thank you for @mieramommy for voicing Neru and Mephisto Jones (🎙️🔞 ) ( Comms / Collabs Open! ) as anon-san!!
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10k followers!! as i promised here's the dub of this comic ❤ thank you for @mieramommy for voicing Neru and Mephisto Jones (🎙️🔞 ) ( Comms / Collabs Open! ) as anon-san!!

akira (comm closed)

37,120 次观看 • 1 年前

Game: Conkers Bad Fur Day Cog: Leo Greystone🔞🎙️ Conker: 🔞Twinkle Park (Commissions Open) (3/5)🔞 (ME!) So, Sparks... What happens when two voice actors with 30 years of experience between the two of them collaborate for the first time? They fuck around. A special thanks to the lovely Leo *Sentual inhale* Greystone for taking time out of his busy day of being the best to play with me. #Nintendo #rareware #voiceover #conkersbadfurday
1:01

Game: Conkers Bad Fur Day Cog: Leo Greystone🔞🎙️ Conker: 🔞Twinkle Park (Commissions Open) (3/5)🔞 (ME!) So, Sparks... What happens when two voice actors with 30 years of experience between the two of them collaborate for the first time? They fuck around. A special thanks to the lovely Leo *Sentual inhale* Greystone for taking time out of his busy day of being the best to play with me. #Nintendo #rareware #voiceover #conkersbadfurday

🔞Twinkle Park (Commissions Open) (3/5)🔞

30,111 次观看 • 1 年前

I put together a compilation of all the 'I Think We're Gonna Have To Kill This Guy' Steven Universe memes we voiced! Which one was your favorite? 🎨 Artists Featured: ✨seasaltcosmos✨OPEN FOR WORK! ʙᴇᴄᴋʏ🔞 Fab (COMMISSIONS OPEN) rad 💜🏹 shop open! @Thatbirdguy_ ııdouǝɯǝlƎ (Commissions Closed) Dae 💫✨ @DessyDreamer 💜💛 DJ_Drawsome 💛💜 | Back to the Art Stuff 🖌️ ⋆˙✦ Robby💫. ݁₊ kiwii 𝓻𝓲𝓼𝓾𝓴𝓸 🍓🎀 Jun Kurosu ilu Brandon Santiago @tokenblckfrnd Sam @/purplepipp Nati on VGen @hugs4toh MarlineAnimates🌱 💀burger water💀 ColorBrews(.bsky) 🎙️ VAs Featured: Kevin Paculan Meggie-Elise | Voice Actor 🎙️🌸✨ 🎙Juan🌌 Voice Actor Josh Portillo 🎙 D. Tyler Fultz Dray/Lüstaire Liv Smith 🏳️‍⚧️🇮🇪 Pax ➡️ DFW SJ Harris | Voice Actress Diana Helen Kennedy, Voice Actor HyperVoiceActing Max Lindsey Voice Over DietDrKelpVA @/someactingguy Jacie Wiley Malcolm Ray ✌🏿 BigBenVA Josie O' Lantern - VA🏳️‍⚧️🌈🐢 @/RaymonVillaVO GM Hakim 🎙️ Voice Actor ColorBrews(.bsky)
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I put together a compilation of all the 'I Think We're Gonna Have To Kill This Guy' Steven Universe memes we voiced! Which one was your favorite? 🎨 Artists Featured: ✨seasaltcosmos✨OPEN FOR WORK! ʙᴇᴄᴋʏ🔞 Fab (COMMISSIONS OPEN) rad 💜🏹 shop open! @Thatbirdguy_ ııdouǝɯǝlƎ (Commissions Closed) Dae 💫✨ @DessyDreamer 💜💛 DJ_Drawsome 💛💜 | Back to the Art Stuff 🖌️ ⋆˙✦ Robby💫. ݁₊ kiwii 𝓻𝓲𝓼𝓾𝓴𝓸 🍓🎀 Jun Kurosu ilu Brandon Santiago @tokenblckfrnd Sam @/purplepipp Nati on VGen @hugs4toh MarlineAnimates🌱 💀burger water💀 ColorBrews(.bsky) 🎙️ VAs Featured: Kevin Paculan Meggie-Elise | Voice Actor 🎙️🌸✨ 🎙Juan🌌 Voice Actor Josh Portillo 🎙 D. Tyler Fultz Dray/Lüstaire Liv Smith 🏳️‍⚧️🇮🇪 Pax ➡️ DFW SJ Harris | Voice Actress Diana Helen Kennedy, Voice Actor HyperVoiceActing Max Lindsey Voice Over DietDrKelpVA @/someactingguy Jacie Wiley Malcolm Ray ✌🏿 BigBenVA Josie O' Lantern - VA🏳️‍⚧️🌈🐢 @/RaymonVillaVO GM Hakim 🎙️ Voice Actor ColorBrews(.bsky)

Meggie-Elise | Voice Actor 🎙️🌸✨

15,295 次观看 • 1 年前

Kuya, pa-tugtog ka naman daw! 😅🎶 Don’t miss the latest #GMAPBBCollab updates! Catch them on weekdays at 10:57 AM, before TiktoClock, and at 5:40 PM, before Family Feud, on GMA! Watch the full episodes of your favorite GMA shows on the new GMA Play app. Download now on Google Play and App Store. Also available on and Android TVs! For PBB All-Access Livestream, visit:
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Kuya, pa-tugtog ka naman daw! 😅🎶 Don’t miss the latest #GMAPBBCollab updates! Catch them on weekdays at 10:57 AM, before TiktoClock, and at 5:40 PM, before Family Feud, on GMA! Watch the full episodes of your favorite GMA shows on the new GMA Play app. Download now on Google Play and App Store. Also available on and Android TVs! For PBB All-Access Livestream, visit:

GMA Network

11,475 次观看 • 6 个月前

🚀 Meet the new Qwen3-TTS lineup: VoiceDesign & VoiceClone! Create, control, and clone voices—faster and more expressive than ever. ⚡ VoiceDesign-VD-Flash • Fully controllable speech via free-form text instructions — tone, rhythm, emotion, persona • No preset voices. Design your own unique vocal identity • Outperforms GPT-4o-mini-tts & Gemini-2.5-pro on role-play benchmarks ⚡ VoiceClone-VC-Flash • Clone any voice from just 3 seconds of audio • Generate speech in 10 languages (CN / EN / JP / ES + more) • 15% lower WER vs. ElevenLabs & GPT-4o-Audio in multilingual tests • Context-aware cadence for more natural delivery 🎙️ Try it now • Qwen Chat: • Blog:
3:21

🚀 Meet the new Qwen3-TTS lineup: VoiceDesign & VoiceClone! Create, control, and clone voices—faster and more expressive than ever. ⚡ VoiceDesign-VD-Flash • Fully controllable speech via free-form text instructions — tone, rhythm, emotion, persona • No preset voices. Design your own unique vocal identity • Outperforms GPT-4o-mini-tts & Gemini-2.5-pro on role-play benchmarks ⚡ VoiceClone-VC-Flash • Clone any voice from just 3 seconds of audio • Generate speech in 10 languages (CN / EN / JP / ES + more) • 15% lower WER vs. ElevenLabs & GPT-4o-Audio in multilingual tests • Context-aware cadence for more natural delivery 🎙️ Try it now • Qwen Chat: • Blog:

Qwen

180,928 次观看 • 8 个月前

🚨 IMPORTANT THREAD: PLEASE READ 🚨 Hey everyone, My husband and I are still going through an incredibly difficult time financially. Right now, we have less than $200 in our bank account, and we’re struggling to find steady work despite actively searching. Money has been especially tight these past few months, and we’re doing everything we can to stay afloat. 🫠 While donations through Ko-fi or PayPal would mean the world to us, I hate asking for money outright. That’s why I’m reopening my voiceover commissions and offering something special for Valentine’s Day! 💝 Valentine’s Day Special 💝 Looking for the perfect gift? I’m offering personalized voice-over commissions! 🎙️ Whether it’s: 💌 A heartfelt custom message 🎭 An impression of your favorite character 🎤 A unique voice for your OC I’d love to bring it to life! Personalized messages are just $10 each (up to 50 words), and this offer is available until EOD February 15th CST. 🎙️ Other Voiceover Services 🎙️ I also offer a variety of voiceover work, including narration, character voices, and more. A few notes: ❌ I do not accept NSFW work. 🚫 None of my voiceover work is permitted for AI usage. Additionally, my husband specializes in video editing and sound design. If you need those services, feel free to DM us for rates and details! If you’re not in need of these services but still want to help, here’s how: ☕ Ko-fi: 📧 PayPal/Contact: meggieelise17@gmail.com Even if you can’t commission or donate, simply sharing or RTing this post would mean so much to us. We truly appreciate anything you can do. Thank you for your kindness and support. 🫶
1:35

🚨 IMPORTANT THREAD: PLEASE READ 🚨 Hey everyone, My husband and I are still going through an incredibly difficult time financially. Right now, we have less than $200 in our bank account, and we’re struggling to find steady work despite actively searching. Money has been especially tight these past few months, and we’re doing everything we can to stay afloat. 🫠 While donations through Ko-fi or PayPal would mean the world to us, I hate asking for money outright. That’s why I’m reopening my voiceover commissions and offering something special for Valentine’s Day! 💝 Valentine’s Day Special 💝 Looking for the perfect gift? I’m offering personalized voice-over commissions! 🎙️ Whether it’s: 💌 A heartfelt custom message 🎭 An impression of your favorite character 🎤 A unique voice for your OC I’d love to bring it to life! Personalized messages are just $10 each (up to 50 words), and this offer is available until EOD February 15th CST. 🎙️ Other Voiceover Services 🎙️ I also offer a variety of voiceover work, including narration, character voices, and more. A few notes: ❌ I do not accept NSFW work. 🚫 None of my voiceover work is permitted for AI usage. Additionally, my husband specializes in video editing and sound design. If you need those services, feel free to DM us for rates and details! If you’re not in need of these services but still want to help, here’s how: ☕ Ko-fi: 📧 PayPal/Contact: [email protected] Even if you can’t commission or donate, simply sharing or RTing this post would mean so much to us. We truly appreciate anything you can do. Thank you for your kindness and support. 🫶

Meggie-Elise | Voice Actor 🎙️🌸✨

36,807 次观看 • 1 年前

📢 AIRDROP 333 $BANMAO 🎁 ​👉​Like ❤️ + Repost 🔁 + Follow 🐱 banmao 🐱🍌 👉​Comment your XLayer wallet address 👇 ​🚀 BANMAO RPS - The FIRST GameFi & Childhood Rock-Paper-Scissors Triumphs on X Layer! ✊🖐✌️ 💬​Dear Gamers, ​We are thrilled to announce the official launch of BANMAO RPS – a GameFi version of the timeless, beloved classic, Rock-Paper-Scissors, now available on the X Layer network! 🎉 BANMAO RPS is proud to be the FIRST GameFi project on X Layer! ​🌟 What Makes BANMAO RPS SPECIAL? ​Simple & Easy to Play: 🎮 No complex learning curve, just pick Rock, Paper, or Scissors. Easy to approach, endless fun! ​Ultra-Low Cost on X Layer: 💰 Enjoy a near-free transaction experience thanks to the optimization of the X Layer network. Let's unlock the flow of X Layer together! 🌊 ​Multi-Language Support: The current website supports 7 languages. ​Eye-Catching Interface: 🎨 Modern, intuitive game design that offers a delightful visual experience. ​Completely Decentralized & Transparent: 🔗 ​Open Source Smart Contract. ​No backdoors or abusive Admin privileges. 🛡️ ​Everything is Community-Driven: Game results are determined in a decentralized manner; no one can interfere or cheat. ⚖️ ​📜 Contract Address & Verification ​Transparency is our top priority! You can verify the source code and game logic here: ​BANMAO RPS Contract: ​🤝 Join the Community & Develop Together! ​Let's put the past aside, respect differences, and look towards the future with $BANMAO. Become part of a growing community where fun and decentralization meet! 🌍✨ ​Download OKX Wallet 📲 and search for " in the dApp section. ​Or visit the website directly: 🌐 ​🙏 Big Thanks to DOREMON (ＤＯＲＥＭＯＮ)! ​We extend our sincerest gratitude to DOREMON (ＤＯＲＥＭＯＮ) for developing this amazing game. All suggestions and feedback to help make $BANMAO RPS even better, including translation contributions, can be sent to his mailbox. ✉️ ​Play now, Win big, and Discover the power of decentralized GameFi on X Layer! 🚀🏆 🔑 CA: 0x16d91d1615fc55b76d5f92365bd60c069b46ef78 💰 1$ → 10$ → 100$ → 1000$ 🚀🌕 🎶 Faith & dreams will overcome greed & fear 🎶 ✨ 信念和梦想将战胜人性中的贪婪与恐惧 ✨ 🔥 Together we rise, united as one community! 🔥 一起崛起，团结就是力量！ X Layer OKX OKXchinese OKX Wallet 中文 OKX Wallet Star_OKX 📌 #banmao #okx #xlayer #memecoin #community #btc #eth #okb #bananacat #香蕉猫 #memeking #Airdrop #GameFi
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📢 AIRDROP 333 $BANMAO 🎁 ​👉​Like ❤️ + Repost 🔁 + Follow 🐱 banmao 🐱🍌 👉​Comment your XLayer wallet address 👇 ​🚀 BANMAO RPS - The FIRST GameFi & Childhood Rock-Paper-Scissors Triumphs on X Layer! ✊🖐✌️ 💬​Dear Gamers, ​We are thrilled to announce the official launch of BANMAO RPS – a GameFi version of the timeless, beloved classic, Rock-Paper-Scissors, now available on the X Layer network! 🎉 BANMAO RPS is proud to be the FIRST GameFi project on X Layer! ​🌟 What Makes BANMAO RPS SPECIAL? ​Simple & Easy to Play: 🎮 No complex learning curve, just pick Rock, Paper, or Scissors. Easy to approach, endless fun! ​Ultra-Low Cost on X Layer: 💰 Enjoy a near-free transaction experience thanks to the optimization of the X Layer network. Let's unlock the flow of X Layer together! 🌊 ​Multi-Language Support: The current website supports 7 languages. ​Eye-Catching Interface: 🎨 Modern, intuitive game design that offers a delightful visual experience. ​Completely Decentralized & Transparent: 🔗 ​Open Source Smart Contract. ​No backdoors or abusive Admin privileges. 🛡️ ​Everything is Community-Driven: Game results are determined in a decentralized manner; no one can interfere or cheat. ⚖️ ​📜 Contract Address & Verification ​Transparency is our top priority! You can verify the source code and game logic here: ​BANMAO RPS Contract: ​🤝 Join the Community & Develop Together! ​Let's put the past aside, respect differences, and look towards the future with $BANMAO. Become part of a growing community where fun and decentralization meet! 🌍✨ ​Download OKX Wallet 📲 and search for " in the dApp section. ​Or visit the website directly: 🌐 ​🙏 Big Thanks to DOREMON (ＤＯＲＥＭＯＮ)! ​We extend our sincerest gratitude to DOREMON (ＤＯＲＥＭＯＮ) for developing this amazing game. All suggestions and feedback to help make $BANMAO RPS even better, including translation contributions, can be sent to his mailbox. ✉️ ​Play now, Win big, and Discover the power of decentralized GameFi on X Layer! 🚀🏆 🔑 CA: 0x16d91d1615fc55b76d5f92365bd60c069b46ef78 💰 1$ → 10$ → 100$ → 1000$ 🚀🌕 🎶 Faith & dreams will overcome greed & fear 🎶 ✨ 信念和梦想将战胜人性中的贪婪与恐惧 ✨ 🔥 Together we rise, united as one community! 🔥 一起崛起，团结就是力量！ X Layer OKX OKXchinese OKX Wallet 中文 OKX Wallet Star_OKX 📌 #banmao #okx #xlayer #memecoin #community #btc #eth #okb #bananacat #香蕉猫 #memeking #Airdrop #GameFi

banmao 🐱🍌

22,674 次观看 • 9 个月前

What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan
0:33

What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan

Markus J. Buehler

47,242 次观看 • 2 年前

MrBeast: "If you knew what I knew, you could get 10 million subscribers in six months" "Your videos suck. You think your videos are good, but they suck. They just do. And the sooner you learn how to make good, great videos that people actually want to watch, the sooner you'll get views." MrBeast shares his early reality: "When I was 14, I thought my videos were the best in the world. They weren't, they were terrible. To be successful, you kind of have to have a little bit of that ego where you think your content's great. But also, if you have sub-1,000 subscribers, there's a good probability your videos just suck. They just do." He explains what to do about it: "You need to make hundreds of videos. Improve something every time. And just get to the point where they don't suck. When you make good content, you'll blow up. It's not the algorithm. It's not anything. Most people who are in my position just made terrible videos, and that's okay. Because you've got to make a bunch of videos and improve over time to be great." MrBeast uses an analogy: "You don't just pick up a baseball and become an MLB-level athlete within a year. It takes many, many, many years. YouTube's kind of the same way." On analysis paralysis: "A lot of people get analysis paralysis. They'll sit there and plan their first video for three months. If you have zero videos on your channel, your first video is not gonna get views. Period. Your first 10 are not gonna get views. I can very confidently say that. So stop sitting there and thinking for months and months on end. Just get to work and start uploading." He gives the formula: "All you need to do is make 100 videos and improve something every time. Do that, and then on your 101st video, we'll start talking. Maybe you can get some views. But your first 100 are gonna suck." How to improve something each time: "The second video: put more effort into the script. The third one: learn a new editing trick. The fourth one: figure out a way to have better inflections in your voice. The fifth one: study a new thumbnail tip and implement it. The sixth one: figure out a new title. There's infinite ways. The coloring, the frame rate, the editing, the filming, the production, the jokes, the pacing, every little thing can be improved. There's literally no such thing as a perfect video." On the algorithm: "What YouTube wants is for people to click on a video and watch it. That's what it is at its core. By studying the algorithm, you'll learn that you're more studying human psychology. What do humans want to watch?" MrBeast shares a simple reframe: "Anytime you say the word 'algorithm,' just replace it with 'audience' and it works perfectly. 'The algorithm didn't like that video?' No, the audience didn't like that video. Literally, that's it. If people are clicking and watching, it gets promoted more. The algorithm just reflects what the people want." On titles: "Short, simple, and just so freaking interesting that you have to click. If someone reads it, are they like, do they have to watch it? Is it just so intrinsically interesting that it's gonna haunt them if they don't click?" He adds nuance: "Keep it below 50 characters. Above 50 characters, on certain devices it goes dot, dot, dot, and that's the worst thing because then people don't even know what they're clicking on." MrBeast shares the extremity principle: "The more extreme the opinion, typically the higher the click-through rate. 'Fiji water sucks', that'd do fine. But 'Fiji water is the worst water I've ever drank in my life', way more extreme, would do way better. But then you have to deliver. The more extreme you are, the more extreme you have to be in the video." On the first 5 seconds: "Before you film a video, what is the thumbnail? What is the title? Then what's the first 5 seconds? Then what's the first 30 seconds?" He explains why autoplay changed everything: "On YouTube now, videos automatically play. So many people don't even see the thumbnail because it autoplays so quickly. The thumbnail is irrelevant for them. I have to visually convince you to click on the video in the first 5 seconds. Before, the hook was important because you had to convince people to watch. Now you have to convince people to click and watch at the same time, with the first 5 seconds." On matching expectations: "Your title and thumbnail set expectations. At the very beginning of the video, to minimize drop-off, you want to assure them that those expectations are being met. If you click on a video called 'Tether is a scam' and at the very beginning, he starts talking about literally anything else, you're like, 'Oh, this is BS. This isn't what I clicked on.' But if at the very start you go, 'Tether is a scam and I'm gonna teach you why,' then it's like, okay, you match the expectations. Then you want to exceed them." He emphasizes the importance: "The thing people undervalue the most is literally the first 10 seconds of the video. That 15% difference in viewership between losing 35% of viewers in the first 30 seconds versus losing 20%, that really does make the difference between 2 million views and 10 million views. You just had a more strategic intro that hooked them." On removing dull moments: "You basically want to remove every dull moment. Find the 10 most critical people you know, make them watch the video, and just roast it. If I talk to a camera for 10 seconds without a cut, a lot of people will get bored. Having a B-cam and C-cam three seconds in, cutting to a different angle, now it's more interesting even though it's essentially the same thing." On keeping viewers watching: "Give them why they clicked. Tell them why they should watch. Then just stick on topic. That right there isn't even super complex, but I would already put you in the upper echelon of YouTube. A lot of people drag it out. It's like, 'I'm going to eat $100 ice cream, but first...' and then it's them birthday shopping for their mom. That's not why I came here." On quality over quantity: "It's much easier to get 5 million views on one video than 50,000 views on 100 videos. A lot of small YouTubers just post videos that aren't bad but aren't great, and none of them ever pop off, so they never get an audience. It might be better to upload half or a third or even a fifth of the videos, but make the videos you upload so freaking good that the algorithm has to promote it." He warns against the consistency trap: "When you set a consistent schedule and you're constantly having to upload videos that aren't as good as you'd like because you gotta hit 'Oh, this Monday I said I'd upload', that's a dangerous trap. The viewers notice the quality isn't as good and it makes them less likely to watch. I think it hurts your longevity." On the real metric that matters: "A big thing that everyone underestimates, what was your experience with your last video? If people loved the last video of yours that they watched, they're more likely to watch your next one. When people watch your video, you don't want them to go, 'Okay, that was good, but that's enough of you for the day.' What you want is them to go, 'Holy crap, that was crazy! Oh my god, what's that?' and they watch 10 videos. That's how you get high view counts. People watch 10 videos, not one." On thumbnails: "You want it to be simple. When they're scrolling, you want them to instantly understand what you're conveying and feel some type of emotion. Make it so interesting, or spike their curiosity so much, that if they don't click it, they'll wonder before they go to bed what happened?" He gives an example: "If you uploaded 'I rode a skateboard with 1,000 other people on it', and people are falling off the side, it's about to go off a big ramp if you don't click that, you're gonna be so curious. Later in the day, when you're daydreaming, you'll think, 'What happened to those 1,000 people on that skateboard?' That's the mindset you should have when making thumbnails." On knowledge being the only barrier: "It's all knowledge. It really is. I could start a new channel tomorrow without using my face or my voice, without ever promoting it, and in six months have 20 million subscribers. I just could. It's purely knowledge. If you knew what I knew, you could get 10 million subscribers no matter where you are right now within six months." He addresses the skeptics: "90% of the people watching don't agree with that. Everyone has excuses. 'Nah, YouTube just doesn't work like that, Jimmy.' But I mentor a lot of people. I see it all the time. It is possible. It is simply knowledge. The second you accept that it is knowledge and you start your journey of learning figuring out what makes a good video, what does my audience want, how can I elevate and then you take that knowledge and just assume 'I will never understand what the perfect video is' and every single day be devoted to learning and improving as much as possible there you go." On money not being the barrier: "There are tons of viral ideas that don't require money. It does not require money to go viral. One of my most-viewed videos was spending 24 hours in a desert, we just grabbed a tent and some stuff and went to the desert. It got 60-70 million views. People say, 'I could be MrBeast if I had money.' A, I didn't start off with money; I was poor, I had no money. It took me seven years just to buy a camera saving up from YouTube. And B, some of our most-viewed videos literally anyone can do." On why no one will outwork him: "No one's ever gonna do what I do better than me. It's just not humanly possible. I reinvest every penny I make. I work every hour I'm awake. I devote every atom in my brain to solving this. I hire the best people on the planet. I've been doing this for 14 years. And I think in decades, not years. I'm gonna be doing this for another 20-30 years. If I thought someone was doing better than me, I'd just start sleeping less so I could work even more." But he doesn't recommend it: "I don't have a life. I don't have work-life balance. My personality, my soul, my being is making the best videos possible. That is why I exist on this planet. And I don't recommend it. You should have work-life balance. You should not devote your entire life to this one thing. I have a mental breakdown every other week because I push myself so hard. I don't recommend it." The only question that matters: "Subscribers don't matter. Views don't matter. I mean, they do. But everything you want as a creator comes from making the best videos possible and thumbnails. The video part's the hard part. Ask: 'How can I make my videos better?' Do that every single day for years. And then you'll probably get views."
18:41

MrBeast: "If you knew what I knew, you could get 10 million subscribers in six months" "Your videos suck. You think your videos are good, but they suck. They just do. And the sooner you learn how to make good, great videos that people actually want to watch, the sooner you'll get views." MrBeast shares his early reality: "When I was 14, I thought my videos were the best in the world. They weren't, they were terrible. To be successful, you kind of have to have a little bit of that ego where you think your content's great. But also, if you have sub-1,000 subscribers, there's a good probability your videos just suck. They just do." He explains what to do about it: "You need to make hundreds of videos. Improve something every time. And just get to the point where they don't suck. When you make good content, you'll blow up. It's not the algorithm. It's not anything. Most people who are in my position just made terrible videos, and that's okay. Because you've got to make a bunch of videos and improve over time to be great." MrBeast uses an analogy: "You don't just pick up a baseball and become an MLB-level athlete within a year. It takes many, many, many years. YouTube's kind of the same way." On analysis paralysis: "A lot of people get analysis paralysis. They'll sit there and plan their first video for three months. If you have zero videos on your channel, your first video is not gonna get views. Period. Your first 10 are not gonna get views. I can very confidently say that. So stop sitting there and thinking for months and months on end. Just get to work and start uploading." He gives the formula: "All you need to do is make 100 videos and improve something every time. Do that, and then on your 101st video, we'll start talking. Maybe you can get some views. But your first 100 are gonna suck." How to improve something each time: "The second video: put more effort into the script. The third one: learn a new editing trick. The fourth one: figure out a way to have better inflections in your voice. The fifth one: study a new thumbnail tip and implement it. The sixth one: figure out a new title. There's infinite ways. The coloring, the frame rate, the editing, the filming, the production, the jokes, the pacing, every little thing can be improved. There's literally no such thing as a perfect video." On the algorithm: "What YouTube wants is for people to click on a video and watch it. That's what it is at its core. By studying the algorithm, you'll learn that you're more studying human psychology. What do humans want to watch?" MrBeast shares a simple reframe: "Anytime you say the word 'algorithm,' just replace it with 'audience' and it works perfectly. 'The algorithm didn't like that video?' No, the audience didn't like that video. Literally, that's it. If people are clicking and watching, it gets promoted more. The algorithm just reflects what the people want." On titles: "Short, simple, and just so freaking interesting that you have to click. If someone reads it, are they like, do they have to watch it? Is it just so intrinsically interesting that it's gonna haunt them if they don't click?" He adds nuance: "Keep it below 50 characters. Above 50 characters, on certain devices it goes dot, dot, dot, and that's the worst thing because then people don't even know what they're clicking on." MrBeast shares the extremity principle: "The more extreme the opinion, typically the higher the click-through rate. 'Fiji water sucks', that'd do fine. But 'Fiji water is the worst water I've ever drank in my life', way more extreme, would do way better. But then you have to deliver. The more extreme you are, the more extreme you have to be in the video." On the first 5 seconds: "Before you film a video, what is the thumbnail? What is the title? Then what's the first 5 seconds? Then what's the first 30 seconds?" He explains why autoplay changed everything: "On YouTube now, videos automatically play. So many people don't even see the thumbnail because it autoplays so quickly. The thumbnail is irrelevant for them. I have to visually convince you to click on the video in the first 5 seconds. Before, the hook was important because you had to convince people to watch. Now you have to convince people to click and watch at the same time, with the first 5 seconds." On matching expectations: "Your title and thumbnail set expectations. At the very beginning of the video, to minimize drop-off, you want to assure them that those expectations are being met. If you click on a video called 'Tether is a scam' and at the very beginning, he starts talking about literally anything else, you're like, 'Oh, this is BS. This isn't what I clicked on.' But if at the very start you go, 'Tether is a scam and I'm gonna teach you why,' then it's like, okay, you match the expectations. Then you want to exceed them." He emphasizes the importance: "The thing people undervalue the most is literally the first 10 seconds of the video. That 15% difference in viewership between losing 35% of viewers in the first 30 seconds versus losing 20%, that really does make the difference between 2 million views and 10 million views. You just had a more strategic intro that hooked them." On removing dull moments: "You basically want to remove every dull moment. Find the 10 most critical people you know, make them watch the video, and just roast it. If I talk to a camera for 10 seconds without a cut, a lot of people will get bored. Having a B-cam and C-cam three seconds in, cutting to a different angle, now it's more interesting even though it's essentially the same thing." On keeping viewers watching: "Give them why they clicked. Tell them why they should watch. Then just stick on topic. That right there isn't even super complex, but I would already put you in the upper echelon of YouTube. A lot of people drag it out. It's like, 'I'm going to eat $100 ice cream, but first...' and then it's them birthday shopping for their mom. That's not why I came here." On quality over quantity: "It's much easier to get 5 million views on one video than 50,000 views on 100 videos. A lot of small YouTubers just post videos that aren't bad but aren't great, and none of them ever pop off, so they never get an audience. It might be better to upload half or a third or even a fifth of the videos, but make the videos you upload so freaking good that the algorithm has to promote it." He warns against the consistency trap: "When you set a consistent schedule and you're constantly having to upload videos that aren't as good as you'd like because you gotta hit 'Oh, this Monday I said I'd upload', that's a dangerous trap. The viewers notice the quality isn't as good and it makes them less likely to watch. I think it hurts your longevity." On the real metric that matters: "A big thing that everyone underestimates, what was your experience with your last video? If people loved the last video of yours that they watched, they're more likely to watch your next one. When people watch your video, you don't want them to go, 'Okay, that was good, but that's enough of you for the day.' What you want is them to go, 'Holy crap, that was crazy! Oh my god, what's that?' and they watch 10 videos. That's how you get high view counts. People watch 10 videos, not one." On thumbnails: "You want it to be simple. When they're scrolling, you want them to instantly understand what you're conveying and feel some type of emotion. Make it so interesting, or spike their curiosity so much, that if they don't click it, they'll wonder before they go to bed what happened?" He gives an example: "If you uploaded 'I rode a skateboard with 1,000 other people on it', and people are falling off the side, it's about to go off a big ramp if you don't click that, you're gonna be so curious. Later in the day, when you're daydreaming, you'll think, 'What happened to those 1,000 people on that skateboard?' That's the mindset you should have when making thumbnails." On knowledge being the only barrier: "It's all knowledge. It really is. I could start a new channel tomorrow without using my face or my voice, without ever promoting it, and in six months have 20 million subscribers. I just could. It's purely knowledge. If you knew what I knew, you could get 10 million subscribers no matter where you are right now within six months." He addresses the skeptics: "90% of the people watching don't agree with that. Everyone has excuses. 'Nah, YouTube just doesn't work like that, Jimmy.' But I mentor a lot of people. I see it all the time. It is possible. It is simply knowledge. The second you accept that it is knowledge and you start your journey of learning figuring out what makes a good video, what does my audience want, how can I elevate and then you take that knowledge and just assume 'I will never understand what the perfect video is' and every single day be devoted to learning and improving as much as possible there you go." On money not being the barrier: "There are tons of viral ideas that don't require money. It does not require money to go viral. One of my most-viewed videos was spending 24 hours in a desert, we just grabbed a tent and some stuff and went to the desert. It got 60-70 million views. People say, 'I could be MrBeast if I had money.' A, I didn't start off with money; I was poor, I had no money. It took me seven years just to buy a camera saving up from YouTube. And B, some of our most-viewed videos literally anyone can do." On why no one will outwork him: "No one's ever gonna do what I do better than me. It's just not humanly possible. I reinvest every penny I make. I work every hour I'm awake. I devote every atom in my brain to solving this. I hire the best people on the planet. I've been doing this for 14 years. And I think in decades, not years. I'm gonna be doing this for another 20-30 years. If I thought someone was doing better than me, I'd just start sleeping less so I could work even more." But he doesn't recommend it: "I don't have a life. I don't have work-life balance. My personality, my soul, my being is making the best videos possible. That is why I exist on this planet. And I don't recommend it. You should have work-life balance. You should not devote your entire life to this one thing. I have a mental breakdown every other week because I push myself so hard. I don't recommend it." The only question that matters: "Subscribers don't matter. Views don't matter. I mean, they do. But everything you want as a creator comes from making the best videos possible and thumbnails. The video part's the hard part. Ask: 'How can I make my videos better?' Do that every single day for years. And then you'll probably get views."

Jaynit

125,413 次观看 • 2 个月前