Video wird geladen...

Video konnte nicht geladen werden

Zur Startseite

The most beautiful molecular recorder 😍 GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo! From Dingchang Lin's lab in nature

JuliaBauman2's profile picture

Julia Bauman

10,454 subscribers

18,818 Aufrufe • vor 7 Monaten •via X (Twitter)

LIVE

Anya Rossi• Live Now

Private livecam show

11 Kommentare

Profilbild von Julia Bauman
Julia Baumanvor 7 Monaten

Link to the paper:

Profilbild von Julia Bauman
Julia Baumanvor 7 Monaten

and the tweetorial:

Profilbild von Julia Bauman
Julia Baumanvor 7 Monaten

@Nature Also, I'm excited that @episteme is now supporting my science communication work! This doesn't change the topics I cover or how I cover them - besides that I may expand into some non-bio topics👀

Profilbild von Sebastian S. Cocioba🪄🌷
Sebastian S. Cocioba🪄🌷vor 7 Monaten

@batmanv10 @DingchangLin @Nature Excellent per usual.

Profilbild von Luis Toledo
Luis Toledovor 7 Monaten

@DingchangLin @Nature

Profilbild von YANYuqing 严宇清
YANYuqing 严宇清vor 7 Monaten

@DingchangLin @Nature Many thanks for reviewing! 🥰

Profilbild von Lukas Süss
Lukas Süssvor 7 Monaten

@bioinfojoe @DingchangLin @Nature 3D protein crystals 🤩 Though my interest here would be: Could this be changed to make the binding site-specific (beyond 4 directions of a unit & including caps) while keeping binding distances mostly equal. Then sequential flush-by selfassembly to make programmably shaped parts?

Profilbild von Jimit Shah 🐌
Jimit Shah 🐌vor 7 Monaten

@DingchangLin @Nature Amazing

Profilbild von John Allen Berger
John Allen Bergervor 7 Monaten

@anshulkundaje @DingchangLin @Nature Too bad 2 dimensional Llms cannot simulate 3 dimensional organic organisms, proteins or genes through text analysis. Fatal flaw just like EVO2. Don’t trust vibe coders with anything scientific

Profilbild von Julia Bauman
Julia Baumanvor 7 Monaten

@anshulkundaje @DingchangLin @Nature I don’t think David Baker is a vibe coder

Profilbild von John Allen Berger
John Allen Bergervor 7 Monaten

@anshulkundaje @DingchangLin @Nature But you don’t know. That is my point we cannot tell vibes coders from the expert software engineers, using AI tools with few guard rails which are easily traversed

Ähnliche Videos

PHOTON COUNTING CT is NOT a better CT It is a NEW imaging modality Photon Counting CT (PCCT) represents a transformative leap in medical imaging, not only as a molecular imaging modality but also as a technology offering ultra-high resolution and functional imaging capabilities. It is fundamentally more than just an enhanced version of traditional CT—PCCT introduces new ways of seeing and understanding the human body, providing critical insights at the molecular, structural, and functional levels. This positions PCCT as a unique imaging modality that requires a fresh approach to technical implementation, operational workflows, and financial planning. Despite the larger upfront investment, PCCT’s ability to drastically reduce downstream healthcare costs makes it a highly valuable investment in the long run. 1. Technical Innovations • Molecular Imaging and Energy Discrimination: Unlike traditional CT, which simply measures the total absorbed energy, PCCT counts individual X-ray photons and differentiates their energy levels. This allows for precise molecular imaging, revealing the composition of tissues and materials at a biochemical level. By distinguishing between different tissue types and contrast agents, PCCT opens up new diagnostic possibilities, such as identifying molecular biomarkers in tumors or distinguishing between stable and unstable plaque in coronary arteries. This capability shifts the focus of imaging from purely anatomical to both anatomical and molecular, offering more comprehensive diagnostic information. • Ultra-High Spatial Resolution: PCCT features significantly smaller detector elements compared to conventional CT scanners, allowing for ultra-high resolution imaging. This means clinicians can visualize fine structures such as microcalcifications in arteries, small lesions in soft tissues, or the intricate architecture of bones. This level of detail was previously unattainable with traditional CT. When combined with molecular imaging, this ultra-high resolution allows for the precise localization and characterization of disease at very early stages, which is essential for early diagnosis and intervention. • Functional Imaging Capabilities: PCCT also excels as a functional imaging modality. By capturing energy-resolved information, PCCT can provide insights into tissue functionality and dynamic physiological processes. For instance, it can detect changes in blood flow, tissue perfusion, and oxygenation without the need for additional contrast agents or scans. This functionality allows for real-time assessment of physiological processes, making it particularly valuable in cardiology, oncology, and neurology for evaluating organ function and monitoring disease progression. • Reduced Noise and Artifact Reduction: Photon-counting technology dramatically reduces electronic noise and imaging artifacts, such as beam hardening, resulting in clearer and more accurate images. The ability to deliver ultra-high resolution images with minimal artifacts improves diagnostic accuracy, reducing the need for repeat scans and ensuring that even subtle abnormalities are detected. 2. Operational Considerations • New Workflow for Molecular, High-Resolution, and Functional Imaging: The integration of molecular, ultra-high resolution, and functional imaging into routine clinical workflows introduces complexity that requires adaptation. Radiologists and technicians need specialized training to interpret and analyze multi-energy datasets that include molecular and functional information. PCCT produces a vast amount of detailed data, requiring clinicians to adopt new imaging protocols and refine their diagnostic approaches to fully leverage its capabilities. • Post-Processing and Data Management: PCCT generates richer, more complex datasets, which necessitates advanced post-processing tools and data management systems. Existing PACS and imaging software may not be equipped to handle such large volumes of data or to process functional and molecular information effectively. This means healthcare institutions must invest in robust IT infrastructure, including upgraded software and storage solutions, as well as provide additional training for staff on new imaging analysis techniques. • Revised Clinical Protocols: The molecular, functional, and ultra-high resolution imaging capabilities of PCCT will likely prompt changes in clinical protocols. For instance, the need for contrast agents may be reduced, simplifying patient preparation and decreasing the risk of adverse reactions. Additionally, the ability to monitor physiological functions in real-time through functional imaging could lead to more dynamic diagnostic procedures, such as assessing the effectiveness of interventions or treatments in real-time. 3. Financial Impact • Higher Initial Investment: PCCT systems are more expensive than traditional CT scanners due to their advanced technology, which includes photon-counting detectors and the computational power required for high-resolution, molecular, and functional imaging. While this upfront cost is significant, it is crucial to view it in the broader context of the downstream benefits and cost reductions that PCCT offers. • Downstream Cost Reductions: Although the initial capital investment is higher, PCCT’s ability to combine molecular, functional, and ultra-high resolution imaging leads to substantial reductions in downstream healthcare costs. Its superior diagnostic accuracy minimizes the need for follow-up tests, repeat scans, or invasive diagnostic procedures, such as diagnostic coronary angiographies. For example, in cardiology, PCCT can precisely differentiate between types of coronary plaque, reducing the need for invasive procedures to assess risk. • Lower Overall Healthcare Expenditures: By enabling earlier, more accurate diagnoses, PCCT can reduce the overall cost of patient care. Early detection of disease, particularly through its molecular and functional imaging capabilities, allows for more targeted treatments, potentially preventing the need for more aggressive and expensive interventions down the line. For instance, early-stage tumor detection via molecular imaging could lead to less invasive treatments, reducing hospital stays and improving patient outcomes, ultimately driving down healthcare costs. • Increased ROI Through Enhanced Patient Outcomes: Over time, the combination of molecular, functional, and ultra-high resolution imaging enhances diagnostic precision, which translates into better patient outcomes. Improved diagnostic accuracy reduces the incidence of unnecessary procedures, minimizes treatment delays, and results in more personalized and effective care. This leads to increased patient satisfaction, better healthcare outcomes, and greater patient throughput—all factors that improve the institution’s return on investment (ROI). • Competitive Advantage and New Revenue Streams: By adopting PCCT, healthcare institutions position themselves at the forefront of advanced imaging technologies. The ability to offer molecular, functional, and ultra-high resolution imaging creates a competitive advantage, attracting more complex and high-value cases. This can boost the institution’s reputation for excellence in diagnostics, leading to increased referrals, new patient populations, and expanded revenue opportunities. Summary Photon Counting CT (PCCT) is not just an evolution of existing CT technology—it is a molecular, ultra-high resolution, and functional imaging modality that fundamentally transforms the diagnostic landscape. Its ability to capture detailed molecular data, visualize minute anatomical structures with ultra-high resolution, and provide real-time functional imaging opens new possibilities for earlier and more precise diagnoses. While the financial investment in PCCT is larger, the reduction in downstream healthcare costs through improved diagnostic accuracy, fewer unnecessary interventions, and earlier disease detection far outweighs the initial expense. For institutions committed to advancing patient care and improving long-term financial outcomes, PCCT is an essential investment in the future of medical imaging. The video attached shows a patient accessing the Hospital for ACS. PCCT can provide ALL the imaging information of the concurrent imaging modalities (CXR, CAG, Echo, CMR) that you see around it... that's a lot! #PhotonCountingCT #MolecularImaging #UltraHighResolution #FunctionalImaging #FutureOfImaging #AdvancedMedicalImaging #EarlyDiseaseDetection #InnovativeCT #CuttingEdgeHealthcare #PrecisionDiagnostics #HealthcareInnovation #MedicalTechnology #CostEffectiveImaging #NextGenCT #PatientCareRevolution
1:10

PHOTON COUNTING CT is NOT a better CT It is a NEW imaging modality Photon Counting CT (PCCT) represents a transformative leap in medical imaging, not only as a molecular imaging modality but also as a technology offering ultra-high resolution and functional imaging capabilities. It is fundamentally more than just an enhanced version of traditional CT—PCCT introduces new ways of seeing and understanding the human body, providing critical insights at the molecular, structural, and functional levels. This positions PCCT as a unique imaging modality that requires a fresh approach to technical implementation, operational workflows, and financial planning. Despite the larger upfront investment, PCCT’s ability to drastically reduce downstream healthcare costs makes it a highly valuable investment in the long run. 1. Technical Innovations • Molecular Imaging and Energy Discrimination: Unlike traditional CT, which simply measures the total absorbed energy, PCCT counts individual X-ray photons and differentiates their energy levels. This allows for precise molecular imaging, revealing the composition of tissues and materials at a biochemical level. By distinguishing between different tissue types and contrast agents, PCCT opens up new diagnostic possibilities, such as identifying molecular biomarkers in tumors or distinguishing between stable and unstable plaque in coronary arteries. This capability shifts the focus of imaging from purely anatomical to both anatomical and molecular, offering more comprehensive diagnostic information. • Ultra-High Spatial Resolution: PCCT features significantly smaller detector elements compared to conventional CT scanners, allowing for ultra-high resolution imaging. This means clinicians can visualize fine structures such as microcalcifications in arteries, small lesions in soft tissues, or the intricate architecture of bones. This level of detail was previously unattainable with traditional CT. When combined with molecular imaging, this ultra-high resolution allows for the precise localization and characterization of disease at very early stages, which is essential for early diagnosis and intervention. • Functional Imaging Capabilities: PCCT also excels as a functional imaging modality. By capturing energy-resolved information, PCCT can provide insights into tissue functionality and dynamic physiological processes. For instance, it can detect changes in blood flow, tissue perfusion, and oxygenation without the need for additional contrast agents or scans. This functionality allows for real-time assessment of physiological processes, making it particularly valuable in cardiology, oncology, and neurology for evaluating organ function and monitoring disease progression. • Reduced Noise and Artifact Reduction: Photon-counting technology dramatically reduces electronic noise and imaging artifacts, such as beam hardening, resulting in clearer and more accurate images. The ability to deliver ultra-high resolution images with minimal artifacts improves diagnostic accuracy, reducing the need for repeat scans and ensuring that even subtle abnormalities are detected. 2. Operational Considerations • New Workflow for Molecular, High-Resolution, and Functional Imaging: The integration of molecular, ultra-high resolution, and functional imaging into routine clinical workflows introduces complexity that requires adaptation. Radiologists and technicians need specialized training to interpret and analyze multi-energy datasets that include molecular and functional information. PCCT produces a vast amount of detailed data, requiring clinicians to adopt new imaging protocols and refine their diagnostic approaches to fully leverage its capabilities. • Post-Processing and Data Management: PCCT generates richer, more complex datasets, which necessitates advanced post-processing tools and data management systems. Existing PACS and imaging software may not be equipped to handle such large volumes of data or to process functional and molecular information effectively. This means healthcare institutions must invest in robust IT infrastructure, including upgraded software and storage solutions, as well as provide additional training for staff on new imaging analysis techniques. • Revised Clinical Protocols: The molecular, functional, and ultra-high resolution imaging capabilities of PCCT will likely prompt changes in clinical protocols. For instance, the need for contrast agents may be reduced, simplifying patient preparation and decreasing the risk of adverse reactions. Additionally, the ability to monitor physiological functions in real-time through functional imaging could lead to more dynamic diagnostic procedures, such as assessing the effectiveness of interventions or treatments in real-time. 3. Financial Impact • Higher Initial Investment: PCCT systems are more expensive than traditional CT scanners due to their advanced technology, which includes photon-counting detectors and the computational power required for high-resolution, molecular, and functional imaging. While this upfront cost is significant, it is crucial to view it in the broader context of the downstream benefits and cost reductions that PCCT offers. • Downstream Cost Reductions: Although the initial capital investment is higher, PCCT’s ability to combine molecular, functional, and ultra-high resolution imaging leads to substantial reductions in downstream healthcare costs. Its superior diagnostic accuracy minimizes the need for follow-up tests, repeat scans, or invasive diagnostic procedures, such as diagnostic coronary angiographies. For example, in cardiology, PCCT can precisely differentiate between types of coronary plaque, reducing the need for invasive procedures to assess risk. • Lower Overall Healthcare Expenditures: By enabling earlier, more accurate diagnoses, PCCT can reduce the overall cost of patient care. Early detection of disease, particularly through its molecular and functional imaging capabilities, allows for more targeted treatments, potentially preventing the need for more aggressive and expensive interventions down the line. For instance, early-stage tumor detection via molecular imaging could lead to less invasive treatments, reducing hospital stays and improving patient outcomes, ultimately driving down healthcare costs. • Increased ROI Through Enhanced Patient Outcomes: Over time, the combination of molecular, functional, and ultra-high resolution imaging enhances diagnostic precision, which translates into better patient outcomes. Improved diagnostic accuracy reduces the incidence of unnecessary procedures, minimizes treatment delays, and results in more personalized and effective care. This leads to increased patient satisfaction, better healthcare outcomes, and greater patient throughput—all factors that improve the institution’s return on investment (ROI). • Competitive Advantage and New Revenue Streams: By adopting PCCT, healthcare institutions position themselves at the forefront of advanced imaging technologies. The ability to offer molecular, functional, and ultra-high resolution imaging creates a competitive advantage, attracting more complex and high-value cases. This can boost the institution’s reputation for excellence in diagnostics, leading to increased referrals, new patient populations, and expanded revenue opportunities. Summary Photon Counting CT (PCCT) is not just an evolution of existing CT technology—it is a molecular, ultra-high resolution, and functional imaging modality that fundamentally transforms the diagnostic landscape. Its ability to capture detailed molecular data, visualize minute anatomical structures with ultra-high resolution, and provide real-time functional imaging opens new possibilities for earlier and more precise diagnoses. While the financial investment in PCCT is larger, the reduction in downstream healthcare costs through improved diagnostic accuracy, fewer unnecessary interventions, and earlier disease detection far outweighs the initial expense. For institutions committed to advancing patient care and improving long-term financial outcomes, PCCT is an essential investment in the future of medical imaging. The video attached shows a patient accessing the Hospital for ACS. PCCT can provide ALL the imaging information of the concurrent imaging modalities (CXR, CAG, Echo, CMR) that you see around it... that's a lot! #PhotonCountingCT #MolecularImaging #UltraHighResolution #FunctionalImaging #FutureOfImaging #AdvancedMedicalImaging #EarlyDiseaseDetection #InnovativeCT #CuttingEdgeHealthcare #PrecisionDiagnostics #HealthcareInnovation #MedicalTechnology #CostEffectiveImaging #NextGenCT #PatientCareRevolution

Dr. Filippo Cademartiri

11,849 Aufrufe • vor 2 Jahren

A new Nature paper from Johns Hopkins (by Prof. Lin Dingchang Lin ) just solved one of the hardest problems in biology: how do you record what every cell in a tissue experienced over time, not just what it looks like right now? The answer: GEMINI — Granularly Expanding Memory for Intracellular Narrative Integration. It works exactly like tree rings. Cells are genetically engineered to express a computationally designed protein assembly. As the assembly grows inside the cell, it captures cellular activity as fluorescent ring patterns — each ring a timestamp, each ring's properties encoding signal intensity. Look at a cross-section under a microscope and you can read the cell's history backward, with ~15-minute resolution. The key: cells build the recorder themselves. GEMINI doesn't interfere with normal function — it just quietly writes. What they demonstrated: In a full tumor xenograft, GEMINI captured every cancer cell's activity history across the entire tumor while it continued to grow normally. For the first time, researchers can look back and see how different regions of the same tumor responded differently to therapy over time — not snapshots, but film. In a mouse brain, GEMINI recorded neural activity dynamics without disrupting behavior, coordination, or memory. It could temporally resolve the history of a brain seizure. Why this matters: Every tool we have in biology gives you state — what the cell looks like now. Sequencing, imaging, proteomics — all snapshots. GEMINI gives you trajectory. It's the difference between a photograph and a video, applied to every cell in an organ simultaneously. The team is explicit that AI-based decoding tools will be central to reading GEMINI's output at whole-brain scale. This is the data layer that makes temporal single-cell atlases possible. Paper: Congratulations Dingchang Lin
1:51

A new Nature paper from Johns Hopkins (by Prof. Lin Dingchang Lin ) just solved one of the hardest problems in biology: how do you record what every cell in a tissue experienced over time, not just what it looks like right now? The answer: GEMINI — Granularly Expanding Memory for Intracellular Narrative Integration. It works exactly like tree rings. Cells are genetically engineered to express a computationally designed protein assembly. As the assembly grows inside the cell, it captures cellular activity as fluorescent ring patterns — each ring a timestamp, each ring's properties encoding signal intensity. Look at a cross-section under a microscope and you can read the cell's history backward, with ~15-minute resolution. The key: cells build the recorder themselves. GEMINI doesn't interfere with normal function — it just quietly writes. What they demonstrated: In a full tumor xenograft, GEMINI captured every cancer cell's activity history across the entire tumor while it continued to grow normally. For the first time, researchers can look back and see how different regions of the same tumor responded differently to therapy over time — not snapshots, but film. In a mouse brain, GEMINI recorded neural activity dynamics without disrupting behavior, coordination, or memory. It could temporally resolve the history of a brain seizure. Why this matters: Every tool we have in biology gives you state — what the cell looks like now. Sequencing, imaging, proteomics — all snapshots. GEMINI gives you trajectory. It's the difference between a photograph and a video, applied to every cell in an organ simultaneously. The team is explicit that AI-based decoding tools will be central to reading GEMINI's output at whole-brain scale. This is the data layer that makes temporal single-cell atlases possible. Paper: Congratulations Dingchang Lin

Bo Wang

85,321 Aufrufe • vor 8 Monaten

Dude records one of the most beautiful spots in nature
0:34

Dude records one of the most beautiful spots in nature

Dudes Posting Their W’s

107,187 Aufrufe • vor 9 Monaten

Our last challenge in the Anthropic x Adaptyv Protein Design Competition is about immunotherapy, one of the most important ways of treating cancer. Immunotherapy helps the immune system attack cancer cells, but distinguishing them from healthy cells isn't always easy. In some cancers, the difference can be as subtle as a single amino acid in a small protein fragment. That's the case with KRAS, a protein that works like a growth switch in our cells. In many cancers, a mutation leaves the switch stuck on, and the cell keeps multiplying itself and grows into a tumor. In Challenge 5, you need to design a binder that sticks to the mutated piece of KRAS, but not to the healthy version, so that the immune system can find and attack the cancer cells. The deadline to submit protein designs for this challenge is November 8. Then, we'll pick the best designs and test them in our lab.
0:58

Our last challenge in the Anthropic x Adaptyv Protein Design Competition is about immunotherapy, one of the most important ways of treating cancer. Immunotherapy helps the immune system attack cancer cells, but distinguishing them from healthy cells isn't always easy. In some cancers, the difference can be as subtle as a single amino acid in a small protein fragment. That's the case with KRAS, a protein that works like a growth switch in our cells. In many cancers, a mutation leaves the switch stuck on, and the cell keeps multiplying itself and grows into a tumor. In Challenge 5, you need to design a binder that sticks to the mutated piece of KRAS, but not to the healthy version, so that the immune system can find and attack the cancer cells. The deadline to submit protein designs for this challenge is November 8. Then, we'll pick the best designs and test them in our lab.

Adaptyv Bio

17,717 Aufrufe • vor 14 Tagen

In the lab assembling the most Japanese fighter possible
0:37

In the lab assembling the most Japanese fighter possible

Jack Slack

56,807 Aufrufe • vor 9 Monaten

The people of Mwihoko in Kiambu County made away with the black box of the AMREF plane that crashed yesterday. For starters, the black box is the most survivable part of the aircraft, which investigators use to reconstruct the events that lead up to a plane crash. The black box is made up of the cockpit voice recorder and the flight data recorder. The cockpit voice recorder collects radio transmissions and sounds such as the pilot’s voices and engine noises, as well as listens to conversations between the pilots and crew and communications with air traffic control. While the flight data recorder monitors a plane’s altitude, airspeed and heading
1:00

The people of Mwihoko in Kiambu County made away with the black box of the AMREF plane that crashed yesterday. For starters, the black box is the most survivable part of the aircraft, which investigators use to reconstruct the events that lead up to a plane crash. The black box is made up of the cockpit voice recorder and the flight data recorder. The cockpit voice recorder collects radio transmissions and sounds such as the pilot’s voices and engine noises, as well as listens to conversations between the pilots and crew and communications with air traffic control. While the flight data recorder monitors a plane’s altitude, airspeed and heading

Bianca™

87,135 Aufrufe • vor 1 Jahr

Together with UC Berkeley we are announcing the laser phase plate - a breakthrough in atomic resolution imaging. This is the brightest continuous wave laser in the world, 100 million times the intensity of the surface of the sun. Phase contrast plays an important role in microscopy, but it was thought close to impossible for electron microscopy, where it would require interfering with an electron beam. Holger Mueller and Robert Glaeser proposed exactly this using a standing wave laser. It has taken over 15 years to make this a reality. Biohub partnered with UC Berkeley and Mueller to support this work and to engineer and build the technology. Contrast has been the critical barrier to achieving atomic resolution imaging of the cell. In cryo-electron tomography, a cellular imaging technology that uses electron microscopy, the low contrast makes it impossible to resolve anything but the largest proteins within their cellular context. The laser phase plate removes that barrier. With advances in AI this breakthrough in contrast will start to open up a new frontier in structural biology, that will allow us to see the molecular machines of the cell, and how they assemble into far more complex and dynamic systems, and understand how they work.
0:46

Together with UC Berkeley we are announcing the laser phase plate - a breakthrough in atomic resolution imaging. This is the brightest continuous wave laser in the world, 100 million times the intensity of the surface of the sun. Phase contrast plays an important role in microscopy, but it was thought close to impossible for electron microscopy, where it would require interfering with an electron beam. Holger Mueller and Robert Glaeser proposed exactly this using a standing wave laser. It has taken over 15 years to make this a reality. Biohub partnered with UC Berkeley and Mueller to support this work and to engineer and build the technology. Contrast has been the critical barrier to achieving atomic resolution imaging of the cell. In cryo-electron tomography, a cellular imaging technology that uses electron microscopy, the low contrast makes it impossible to resolve anything but the largest proteins within their cellular context. The laser phase plate removes that barrier. With advances in AI this breakthrough in contrast will start to open up a new frontier in structural biology, that will allow us to see the molecular machines of the cell, and how they assemble into far more complex and dynamic systems, and understand how they work.

Alex Rives

664,015 Aufrufe • vor 5 Monaten

🔬🤖Excited to share permittivity tensor imaging (PTI), a label-free computational imaging module for high-resolution 3D imaging of dry mass and 3D orientation of organelles, cells, and tissues! 🧬🧫 Just published in Nature Methods Shout out to Li-Hao Yeh , Talon Chandler, Ivan Ivanov, Janie Byrum, Bryant , Syuan-Ming Guo, Cameron Foltz at Chan Zuckerberg Biohub Network, Peter Kazansky lab ORC Southampton, BruceConklin lab at Gladstone Institutes, and May Han lab at Stanford Medicine. 🧵1/n
0:48

🔬🤖Excited to share permittivity tensor imaging (PTI), a label-free computational imaging module for high-resolution 3D imaging of dry mass and 3D orientation of organelles, cells, and tissues! 🧬🧫 Just published in Nature Methods Shout out to Li-Hao Yeh , Talon Chandler, Ivan Ivanov, Janie Byrum, Bryant , Syuan-Ming Guo, Cameron Foltz at Chan Zuckerberg Biohub Network, Peter Kazansky lab ORC Southampton, BruceConklin lab at Gladstone Institutes, and May Han lab at Stanford Medicine. 🧵1/n

Shalin Mehta

16,624 Aufrufe • vor 2 Jahren

GEMINI JUST BECAME AN AI OPERATING SYSTEM Google is shifting Gemini from a chatbot into an agent platform that works across Gmail, Docs, Sheets, and more
8:08

GEMINI JUST BECAME AN AI OPERATING SYSTEM Google is shifting Gemini from a chatbot into an agent platform that works across Gmail, Docs, Sheets, and more

0xMarioNawfal

53,453 Aufrufe • vor 5 Monaten

Dr. Robert Redfield, the former CDC Director, talks about three suspicious events that took place at the Wuhan lab in September 2019: "In Sept. 2019, three things happened in that lab. One is they deleted the sequences. Highly irregular, researchers don't like to do that. The second thing is they changed the command and control from civilian to military. Highly unusual. The third, which is very telling, is they let a contractor redo the ventilation system in that laboratory. Clearly, there was strong evidence that a significant event happened in that laboratory in September."
0:48

Dr. Robert Redfield, the former CDC Director, talks about three suspicious events that took place at the Wuhan lab in September 2019: "In Sept. 2019, three things happened in that lab. One is they deleted the sequences. Highly irregular, researchers don't like to do that. The second thing is they changed the command and control from civilian to military. Highly unusual. The third, which is very telling, is they let a contractor redo the ventilation system in that laboratory. Clearly, there was strong evidence that a significant event happened in that laboratory in September."

KanekoaTheGreat

4,109,536 Aufrufe • vor 3 Jahren

1.Stem cells reside in specialized microenvironments that precisely regulate their behavior. For this reason they are best studied in their in vivo context. A new paper from our lab describes a method for long-term imaging & quantitative analysis of hematopoiesis in vivo in flies
2:08

1.Stem cells reside in specialized microenvironments that precisely regulate their behavior. For this reason they are best studied in their in vivo context. A new paper from our lab describes a method for long-term imaging & quantitative analysis of hematopoiesis in vivo in flies

Tanentzapf Lab

27,033 Aufrufe • vor 3 Jahren

Excited to share Genie 4 today our most realistic and interactive world model: - steer dynamic environments in real time, shaping events, camera angles, and actions - generate native audio matched to the world, from realistic background sounds to characters who can converse in real time! - simulate photorealistic scenes and real-world physics - create more coherent multi-step events through reasoning from Gemini We've started to roll out as a research preview to trusted testers. Coming soon to Google AI Ultra subscribers in Project Genie and early access partners via the Gemini API and AI Studio.
0:50

Excited to share Genie 4 today our most realistic and interactive world model: - steer dynamic environments in real time, shaping events, camera angles, and actions - generate native audio matched to the world, from realistic background sounds to characters who can converse in real time! - simulate photorealistic scenes and real-world physics - create more coherent multi-step events through reasoning from Gemini We've started to roll out as a research preview to trusted testers. Coming soon to Google AI Ultra subscribers in Project Genie and early access partners via the Gemini API and AI Studio.

Sundar Pichai

1,884,798 Aufrufe • vor 14 Tagen

TimeVault preserves the transcriptomic history of a cell, enabling connections between past cellular events and present states from a single sample. Exciting work from Fei Chen Lab @kevin921 !
1:47

TimeVault preserves the transcriptomic history of a cell, enabling connections between past cellular events and present states from a single sample. Exciting work from Fei Chen Lab @kevin921 !

Julia Bauman

12,499 Aufrufe • vor 9 Monaten

Biology is by far the most advanced technology on the planet, self-assembling nanobots that can unpack a single cell into a space-faring civilization in a few billion years.
0:24

Biology is by far the most advanced technology on the planet, self-assembling nanobots that can unpack a single cell into a space-faring civilization in a few billion years.

Andrew Côté

323,485 Aufrufe • vor 1 Jahr

🧬A new imaging technique developed by the Liu Lab uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples, providing a full picture of how these structures are organized inside tissues.
0:33

🧬A new imaging technique developed by the Liu Lab uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples, providing a full picture of how these structures are organized inside tissues.

HHMI | Janelia

79,670 Aufrufe • vor 1 Jahr

Spaceflight is known to induce molecular, cellular, and physiological shifts in astronauts and poses various biomedical challenges to the human body. As more people venture into space, understanding the health risks associated with space exploration is key for the preparation
1:11

Spaceflight is known to induce molecular, cellular, and physiological shifts in astronauts and poses various biomedical challenges to the human body. As more people venture into space, understanding the health risks associated with space exploration is key for the preparation

Springer Nature

31,271 Aufrufe • vor 2 Jahren

We posted a preprint on all-to-all functional mapping of a cortical microcircuit in vivo. Yitong Qi developed molecular tools, optics, and protocols for massively parallel optogenetic stimulation and voltage imaging during animal behavior.
6:33

We posted a preprint on all-to-all functional mapping of a cortical microcircuit in vivo. Yitong Qi developed molecular tools, optics, and protocols for massively parallel optogenetic stimulation and voltage imaging during animal behavior.

Adam Cohen

12,252 Aufrufe • vor 27 Tagen

If you're serious about detoxing at the cellular level, hydrogen water should be in your daily routine. Hydrogen is the smallest, most abundant element in the universe, and it works as a selective antioxidant, neutralizing the dangerous oxidative stress that accelerates aging and disease without disrupting your body’s natural healing processes. I use H2Tab daily. Less than $1 a day for a biohack that goes straight to work where it matters most, your mitochondria and cellular health. Get yours here:
0:32

If you're serious about detoxing at the cellular level, hydrogen water should be in your daily routine. Hydrogen is the smallest, most abundant element in the universe, and it works as a selective antioxidant, neutralizing the dangerous oxidative stress that accelerates aging and disease without disrupting your body’s natural healing processes. I use H2Tab daily. Less than $1 a day for a biohack that goes straight to work where it matters most, your mitochondria and cellular health. Get yours here:

Gary Brecka

51,060 Aufrufe • vor 1 Jahr

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint
0:21

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

eLife - the journal

38,061 Aufrufe • vor 2 Jahren