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The reason you age has nothing to do with bad genetics. Evolution literally never NEEDED you to live past 40. And now one lab is overriding millions of years of biological programming. David Sinclair explained the logic: in prehistoric times, most humans died from famine, disease, or war by...

81,851 просмотров • 4 месяцев назад •via X (Twitter)

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.Naval: You have a beautiful definition of knowledge, which most people don’t even try to tackle, about how knowledge perpetuates itself in the environment. You gave some really good examples. One was around genes. Successful, highly adapted genes contain a lot of knowledge and can cause themselves to be replicated because they’re survivors. In the same way, knowledge itself is a survivor, in that if you transmit to me the knowledge of how to build a computer, it’s an incredibly useful thing. I’m going to build more and more computers and that knowledge will be passed on. Your underlying point that you repeated here was if you want to understand the physical universe you have to understand knowledge, because it is the thing that over time takes over and changes more and more the universe—more than almost anything else. You have to understand all the explanations behind it. You can’t just say “particle collisions” because that explains everything, so it explains nothing. It’s not a useful level to operate at. Therefore, the things that create knowledge are uniquely influential in the universe. And as far as we know, there are only two systems that create knowledge. There’s evolution and there are humans. But is there a difference even between these two forms of knowledge creation, between evolution and between humans? David Deutsch: Yes. I have argued that the human way of creating knowledge is the ultimate one, that there aren’t any more powerful ones than that. This is the argument against the supernatural. Assuming that there is a form of knowledge creation that’s more powerful than ours is equivalent to invoking the supernatural, which is therefore a bad explanation—as invoking the supernatural always is. The difference between biological evolution and human creative thought is that biological evolution is inherently limited in its range. That’s because biological evolution has no foresight. It can’t see a problem and conjecture a solution. Whenever biological evolution produces a solution to something, it’s always before natural selection has even begun. This is Charles Darwin’s insight. This is the difference between Charles Darwin’s theory of evolution and the other theories of evolution that had been around for a century or more before that, including Charles Darwin’s grandfather and Lamarck. The thing they didn’t get is that the creation of knowledge in evolution begins before. That means that biological evolution can’t reach places that are not reachable by successive improvements, each of which allows a viable organism to exist. Creationists say that biological evolution has, in fact, reached things that are not reachable by incremental steps, each of which is a viable organism. They’re factually mistaken. The thing which they have in mind is the idea of a creator who can imagine things that don’t exist and who can create an idea that is not the culmination of a whole load of viable things. A thinking being can create something that’s a culmination of a whole load of non-viable things. Explanatory creativity makes humans unique Out of all the billions and billions of species that have ever existed, none of them has ever made a campfire, even though many of them would’ve been helped by having the genetic capacity to make campfires. The reason it didn’t happen in the biosphere is that there is no such thing as making a partially functional campfire; whereas there is, for example, with making hot water. The bombardier beetles squirt boiling water at their enemies. You can easily see that just squirting cold water at your enemies is not totally unhelpful. Then making it a bit hotter and a bit hotter. Squirting boiling water no doubt required many adaptations to make sure the beetle didn’t boil itself while it was making this boiling water. That happened because there was a sequence of steps in between, all of which were useful. But with campfires, it’s very hard to see how that could happen. Humans have explanatory creativity. Once you have that, you can get to the moon. You can cause asteroids which are heading towards the earth to turn around and go away. Perhaps no other planet in the universe has that power, and it has it only because of the presence of explanatory creativity on it.

Deutsch Explains

186,329 просмотров • 1 год назад

.Jacob Kimmel thinks that the functionality to reverse aging already exists in our epigenome. But then why didn't evolution already optimize for longevity? Jacob explains that if you consider evolution as an optimizer, the gradients flow in a really surprising way. Naively, it seems like evolution should want you to live longer (more time to have babies and care for your kin). Jacob explains 3 complications on the naive picture: 1. Baseline mortality was brutal throughout most of history. Even without aging, you'd likely die from infection, predation, or accident before reaching 50. So there's no signal flowing back from 100 to the genome which incentivizes some selective process to make you live longer, even if it was easy to do. 2. There's selection against fixing just one (but not at all) causes of aging). Because then you have some grandpa who's slightly healthier but still a worse use of resources than the next generation from the gene's eye point of view. 3. Evolution is very limited as an optimizer. The step size (number of variants you can test in parallel) is limited by your step size. And through the most of history, this bandwidth was dominated by selective pressures much more urgent than de-aging (for example, building a better immune system to fight infectious diseases). Full episode with Jacob Kimmel out Thursday. So excited about this one. Jacob's simple 3-point list led to more than half an hour of random digressions, from how many antibiotics were naturally evolved, to how hard evolution actually optimized for intelligence, to how we can actually detect the evidence for some deadly ancestor of HIV in our genome.

Dwarkesh Patel

257,862 просмотров • 11 месяцев назад

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

84,263 просмотров • 3 месяцев назад

"[With] the messenger RNA vaccines...[there are] 10 ways that it can induce cancer...the spike protein alone...will bind to the major suppressor genes...[which] means the cancer you would normally get when you were 70 or 80, you are going to get when you're 20, 30, or 40." Angus Dalgleish, a professor of oncology at St George’s, University of London, describes for Senator Malcolm Roberts (Malcolm Roberts 🇦🇺) et al. during a presentation for Australia's Federal (national) parliament two of the 10 ways that the COVID injections induce cancer in the victims who took the shots. While he mentions the DNA-plasmid/SV40 contamination, here he highlights the phenomenon wherein the "the spike protein alone in messenger RNA vaccines will bind to the major [cancer] suppressor genes." Dalgleish notes that this means that "the cancer you would normally get when you were 70 or 80, you are going to get when you're 20, 30, or 40." "By putting this into children, we run the serious risk that they're going to make everybody have the equivalent mutations of these genes, and it's absolutely horrendous," Dalgleish says. "The very fact that that's a possibility and we're using them for an infectious disease that doesn't kill anybody should strike fear into the heart of all of us." --------------Partial transcription of clip--------------- "But the messenger RNA vaccines that, we have with the spike protein, that in those 10 ways that it can induce cancer, I mean, there's two or three which are really frightening. One, which has been widely discussed with the contamination issue, is that there are some oncogene stimulants there, SV40 is in the Pfizer. We know that. "We have a list of people here who have been discussed in the Perth conference recently of all the people who have shown the contamination from McKernan in the US, David Speicher, Kony Grao [?], Phillip Buckhaults, etcetera. And there's another paper just come out from Wurzburg [?] that, not only confirms all this but shows that they will convert cells to cancer. So we know that that's a direct thing. "The second thing, which I really want to emphasize, is the spike protein alone and messenger RNA vaccines will bind to the major suppressor genes. Now the suppressor genes are basically your cancer policeman. If you do get cancer, they will suppress it. P53, BRCA, MSH. MSH is well associated with a thing called Lynch Syndrome in colorectal cancer, which is very relevant to the fact we're getting an explosion of colorectal cancers at the moment. So what happens if you have a mutation in any of those three major suppressor genes, you're just unfortunate to be born with it, it means the cancer you would normally get when you were 70 or 80, you are going to get when you're 20, 30, or 40. "By putting this into children, we run the serious risk that they're going to make everybody have the equivalent of mutations of these genes, and it's absolutely horrendous. The very fact that that's a possibility and we're using them for an infectious disease that doesn't kill anybody should strike fear into the heart of all of us. And I believe leaves no doubt at all that these vaccines must be banned now, and anybody who opposes it, anybody says there's reason for it has to be held to account for what not only has happened, but what is going to happen in the future if we persist with this."

Sense Receptor

33,743 просмотров • 1 год назад

Intelligence was the one thing that never scaled. We scaled everything else. Steel. Energy. Compute. The one resource that built all of it never left the skull. Musk: “People thought defeating Go was either never or 20 years away.” Twelve months later it was over. Musk: “Now that same AlphaGo system can defeat the top 50 players simultaneously with 0% chance of them winning. And that’s one year later.” Fifty lifetimes of mastery against a system that does not know it is playing a game. Zero percent chance. That was not a competition. That was a preview. Musk: “The degrees of freedom to which artificial intelligence is able to apply itself are really increasing by 10 orders of magnitude a year.” Ten billion times. Every twelve months. No brain alive can visualize that number. By design. Every hard problem that ever defeated us did it for the same reason. Not complexity. Scarcity. The only mind capable of solving it was biological and there was never enough of it. Cancer. Fusion. Climate. The physics we cannot even see yet. Not waiting on more data. Waiting on something that can think at a scale biology never allowed. That just arrived. Most people hear this and reduce it to a question about their paycheck. They are watching the single largest expansion of capability in the history of life on this planet and worrying about a job title. For ten thousand years intelligence had one speed. One brain. One lifetime. Every civilization on earth throttled by the same biological ceiling. That ceiling just shattered. We are the only species that ever hit its own limit and built what breaks through it. That is not an ending. That is the point of everything we ever built.

Dustin

24,315 просмотров • 1 месяц назад

"We do it again. We do it again. We do it again. Because, this can't be. The problem is..it be. No matter how skeptical you are, be as skeptical as you'd like, but there it is." ~Bengston (This is what Mick West said he doesn't find interesting and thus, he doesn't want to interview Bengston. The truth? IMO, he's scared shitless to take on Bengston as there's too much data to refute. Psi (or whatever this is) is real and this is one of the more interesting claims in the world. How could you NOT be interested in this? How about you, Michael Shermer?) "We re-injected the mice without any treatment, and the mice were immune to cancer." ~Bengston (It's the 1970s on Long Island. A skeptical Bill Bengston is working as a lifeguard at the town pool and meets a guy, Ben, who claims to be psychic. No matter what tests Bengston comes up with, Ben passes with flying colors. Then Ben starts healing people. But how to know if they were being healed with Ben's psi or something more prosaic? Did they change their diet? Supplements? Conventional medicine? Not everybody came back so it was very hard to know. So Bengston moves to the lab where Ben would try to cure mice of a cancer that has killed every mouse ever injected within 27 days max. At the last minute, Ben drops out and Bengston is forced to be the healer.) ~ Bill Bengston: "If you watch a few hundred healings, at first it's exhilarating, but after a while it's frustrating. Because you don't know what, why, where, when, any of those things that someone interested in serious inquiry might be interested in. You were just looking at people coming in, some benefit occurred. People leaving. Sometimes they didn't come back. Sometimes it took more than one treatment. Sometimes it happened pretty quick. I think I was the fastest ever (Bengston says Ben healed his back after one short treatment). But what did? "So you come in, you have x, it's a famous algebraic disease. You have x, and you leave better. Now maybe it's the multiple treatments, you know, whatever it may be. But you leave better. What did it? Was it time? Because people get better over time. Was it belief? I didn't think it was belief, because I wasn't a believer. I was an experiencer, but not a believer. Was it the food you ate, the food you stopped eating, the grapefruit you had in the morning? I can't...I don't have the head to wrap myself around clinical questions like that. I never know why something happens, because there's too many variables and such. "And so, after watching a couple hundred healings, taking part in a couple hundred healings, I decided to...I gotta go past this. And I ran into another guy who was watching this, somewhat parallel to me. A geologist, pretty well known (David Krinsley ~Joe). And we said, 'What can we do to test this? You know, the phenomenon is seriously interesting. What could we do to really test it so that if healing occurs, there's no viable counter hypothesis.' "And at the time, he was the head of the geology department at City University of New York, and he said, 'I got some favors owed me, let me see what I can find out in the biology department. I'm pretty good friends with the chairman of the biology department there.' "And so he met with the biology chair, and he said, 'Well, let me poke around in my department and see what we can do.' And he said, 'I got the perfect study. There's a mouse model of cancer that has 100% fatality. Never been an extension of life past a month after it's been injected with cancer. There's thousands of journal articles written about this mouse and this cancer. Everybody around the world knows this mouse and this cancer. If you're in oncology, you know this mouse and this cancer, and [there] has never been a cure.' "I said, 'Let's do it. Let's find out what we can do.' "And at the time, I had no idea what to expect. So I was thinking, 'Well, maybe we can extend the life towards a month. Maybe it won't be a normal curve distribution, maybe it'll be a negatively-skewed distribution. And maybe the mouse will live to the end of their lifespan and all that. "We had no idea what to expect. "So we got a cage of mice. I held the cage of mice for an hour at a time in the lab at Queens College, City University, and we watched as the tumors grew. And I was sure this was failing. And incidentally, I'm almost always wrong. I expected, if we got to the mice right after injection and we treated them a couple times, enough, every day - we didn't know - if we treated them every day, they wouldn't develop cancer. I was thinking, you know, it's something like radiation. You know, you go, 'Zzt, zzt,' and you zap the mice and the tumors, or the cancer cells die, or something along those lines. I was thinking conventional oncology. "And so, I put my hands around the cage of mice, treated them every day, the tumors started to grow anyway, and I wanted to call off the experiment. You know, it shows you how much I believe. I got talked into going a couple extra days, and the tumors developed these blackened areas. And I said, 'Let's call it off, didn't work. You know, we tried it. Didn't work.' "Go a couple more days. Tumors started to ulcerate, and so there was this raw part of a tumor. And I said, 'Would you pay attention? It doesn't work!' Couple more days. And then the tumors suddenly imploded, and the mice were cured. They weren't remitted, they were cured. And by that, I mean it wasn't a suppression of symptoms, it wasn't a temporary reduction in symptoms. It was...there was no cancer in the mouse at all. "And it's farther than that. We re-injected the mice without any treatment, and the mice were immune to cancer. Now that's reasonably interesting. "So, first thing you do is, I, as a skeptic, go, 'Umm, this doesn't make any sense (laughs). Let's do it again. But let's not do it with just me, let's do it with some volunteers.' "So I had a couple of faculty volunteers who thought this thing was insane, and they were right. So I had a couple of faculty volunteers, they got a couple of student volunteers. All non-believers, no experience in any of this hocus pocus. Taught 'em the little technique that I had developed. They treated the mice, the exact same pattern: Tumor grows, blackened area, ulceration, implosion, full lifespan cure. "We do it again. We do it again. We do it again. Because, this can't be. The problem is..it be." (Both laugh) "It's just, you know, no matter how skeptical you are, be as skeptical as you'd like, but there it is. You know, I deny this gravity, you know? I don't believe in gravity. There is gravity. I don't believe in this healing. There is healing. "I just finished, recently, my twentieth mouse experiment, I'm a little slow. I've done it in, I think, six medical schools, equal number of other biology labs. And I just finished at Tokyo University, multiple strains of cancer and details you don't care about. "And so, I have done, at this point, twenty mouse experiments, multiple medical schools, many cell experiments. I've done many experiments. That's the really short version. A hundred years truncated into a couple of paragraphs."

Joe Murgia

12,705 просмотров • 1 год назад

RFK Jr. Reveals: Gardasil Vaccine 37x More Lethal Than Cervical Cancer It Prevents "Gardasil is probably the single worst mass vaccine that we've ever seen. Vaccine targets millions of pre-teens and teens, for whom the risk of dying from cervical cancer is zero. Nobody in their right mind would ever take this vaccine if they actually read the clinical literature." "Death rates in the Gardasil trial were 37 times the death rates for cervical cancer. Children who take that vaccine, the Gardasil vaccine, are 37 times more likely to die from the vaccine than they are to die from cervical cancer." "So the problem with Gardasil, like most vaccines, is it was never tested against a true placebo, an inert placebo. And the CDC and HHS say... If you don't test it against a true placebo, it's not science. You have no way of gauging whether the injuries you're seeing from the product are being caused by that product or whether they're just bad, sad coincidences." "The entity that is actually performing the study is, and paying for the study, is Merck. Merck got to decide which injuries were being caused by Gardasil and which were just bad coincidences and because it had that power it just wrote them all off as bad coincidences." "You can do that when there's no placebo because the injuries they were seeing in the control group which where the girls were getting aluminum neurotoxins were identical to the injuries they were getting in the Gardasil group so they said well we don't have to report any of these as vaccine injuries. So they were able to license something that is insanely dangerous."

Camus

1,463,131 просмотров • 1 год назад

🚨Here's what a lot of people misunderstand about cancer treatment, says drpaulmarik: "Cancer is not homogeneous. The somatic mutation theory—which is the current theory in which treatment is based—posits that you have a mutation in a single cell, and that gives rise to a whole population of cells that look the same and have the same mutation. But the Cancer Genome Atlas has shown that that theory is completely wrong. The cancer cells are very heterogeneous, so they're made up of very different populations of cells with different mutations, and one of the populations is the cancer stem cell. It's a sub-population of the cancer. These are generally slow-growing, but they're distinct in that they have the ability to divide indefinitely and grow indefinitely, and can change their characteristics. Basically, if you get rid of the fast-dividing cells, which is the cancer, you're left with the stem cells, which then become the roots, which grow back to form the tumor" sometimes years later. Conventional chemotherapy gets rid of the fast-dividing regular cancer cells but *NOT* the stem cells. So the key question is: how do you get rid of the stem cells? “There are a number of repurposed drugs that do it, and this has been well-established in scientific medical literature. One of the most effective treatments to knock out the stem cell is the famous horse deworming medicine," says drpaulmarik. Yes, ivermectin. Independent Medical Alliance

Jan Jekielek

96,002 просмотров • 1 год назад

David Reich is back. He and collaborator Ali Akbari just published a paper that overturns a long-standing consensus about human evolution — that natural selection has been dormant in our species since the agricultural revolution. By scaling ancient DNA sequencing and developing a new statistical method, they found that selection has actually sped up. Selection went especially bonkers during the Bronze Age (around 3,000 years ago). That's when gene frequencies for everything from immune function to body fat to intelligence were most in flux. Over the last 10,000 years, selection pushed the genetic predictor of cognitive performance up by roughly a full standard deviation — most of it between 4,000 and 2,000 years ago. After we finished recording, David sketched out on a whiteboard his new heretical model about who the Neanderthals really were. Luckily, I took out my iPhone and managed to record it. He thinks the standard story (that Neanderthals are some separate archaic lineage we interbred with a little) just doesn't fit the evidence. Instead, he proposes that Neanderthals are essentially genetically-swamped modern humans. A small population somewhere around the Caucasus invented Middle Stone Age technology roughly 300,000 years ago and expanded outward. The ones that moved into Europe interbred with local archaic humans, got genetically swamped, and became Neanderthals. The same expansion went into Africa, met much more diverged archaic Africans, and that mixture became us. This means Neanderthals and modern humans share the same cultural ancestry — the only difference is which archaic humans they mixed with afterward. David is a brilliant and rigorous scholar. It was a real delight to learn from him again. 0:00:00 – Ancient DNA suggests strong selection over last 10,000 years 0:16:24 – Natural selection intensified during the Bronze Age 0:35:40 – Why didn't evolution max out intelligence? 0:58:00 – Evolution is limited by time, not population size 1:09:40 – Why no farming before the Ice Age? 1:17:52 – The Neanderthal puzzle David can’t stop thinking about 1:54:40 – The methodology behind this breakthrough

Dwarkesh Patel

272,212 просмотров • 2 месяцев назад