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This is PSP, right? Neurodegenerative and progressive, right? Wrong. This is autoimmune encephalitis associated with autoantibodies directed against the GABAB receptor. Great teaching case presented by Mustafa, Garg and colleagues Movement Disorders Clinical Practice Key Points: - Progressive recurrent backward falls for 3 months. - Slowness w/ unclear speech,...

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Michael Okun

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13,311 просмотров • 1 год назад •via X (Twitter)

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Комментарии: 8

Фото профиля Abhishek Lenka
Abhishek Lenka1 год назад

@MDCP_Journal Nice case @Divyani_Garg

Фото профиля Elise Oyin
Elise Oyin1 год назад

We don't allow no progesterone antagonist to operate even 0.1% and we ban all anti-progesterone activity, and for there to be no switch of any kind in regards to progesterone from agonists to antagonist in Elise Oyinkromeineifa's body even 0.1% in the name of Jesus Christ u9ges

Фото профиля The Wolf of College Street
The Wolf of College Street1 год назад

@MDCP_Journal I would have thought IgLON5 tbh Interesting case

Фото профиля CorpusGAL"awe"sum
CorpusGAL"awe"sum1 год назад

@MDCP_Journal Which antibodies have you seen commonly associated with this?

Фото профиля Shilpa Chitnis, M.D., Ph.D., FAAN.
Shilpa Chitnis, M.D., Ph.D., FAAN.1 год назад

@MDCP_Journal @natalievitek

Фото профиля Dr. Abu Shuraih Sakhri
Dr. Abu Shuraih Sakhri1 год назад

@MDCP_Journal @DrFarsanaNeuro

Фото профиля Yet Ze
Yet Ze1 год назад

@MDCP_Journal Do you have the case report for free? I can't download it please

Фото профиля ArianeK 💜 #Care4Complex (she/her)
ArianeK 💜 #Care4Complex (she/her)1 год назад

@MDCP_Journal This is also what my case of toxic encephalitis and drug induced Parkinsonism looked like. Onset over a few weeks and then worsened badly over months as the medication reaction was presumed to be autoimmune encephalitis, so I was wrongly kept on the drug causing it (prednisone).

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Dr. Marty Makary: “I think the most exciting part of the announcement... is we are going to approve a drug called leucovorin for the treatment of autism, and it may help 50-60% of kids with autism." “Autism may be an autoimmune disease for some kids.” “The autoimmune reaction blocks the receptor of folate starving the brain of this critical vitamin and folate, and the drug that we are going to approve, bypasses that blocked receptor.” “Studies have shown that up to two-thirds of kids with a folate deficiency will see an improvement in their autistic symptoms.”
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Dr. Marty Makary: “I think the most exciting part of the announcement... is we are going to approve a drug called leucovorin for the treatment of autism, and it may help 50-60% of kids with autism." “Autism may be an autoimmune disease for some kids.” “The autoimmune reaction blocks the receptor of folate starving the brain of this critical vitamin and folate, and the drug that we are going to approve, bypasses that blocked receptor.” “Studies have shown that up to two-thirds of kids with a folate deficiency will see an improvement in their autistic symptoms.”

MAHA Action

18,771 просмотров • 9 месяцев назад

Here is your humbling case of the day that was just published? ' Will you miss this 17 year old who comes in with a year and a half of behavioral change, loss of appetite, weight loss, and folks have suggested he has a functional movement disorder. Did you think PERM? Key Points: - It is actually progressive encephalomyelitis with rigidity and myoclonus (PERM) - Considered part of the large spectrum of stiff-person-syndrome - Think brainstem and autonomic involvement in addition to axial and limb rigidity, CNS hyperexcitability - Autoantibodies against glycine receptor in 70% of PERM cases - Other antibodies include glutamic acid decarboxylase (GAD), dipeptidyl peptidase-like-protein-6 (DPPX), and of course amphiphysin - This case was anti-DPPX-associated PERM My take: One word: humbling....
1:20

Here is your humbling case of the day that was just published? ' Will you miss this 17 year old who comes in with a year and a half of behavioral change, loss of appetite, weight loss, and folks have suggested he has a functional movement disorder. Did you think PERM? Key Points: - It is actually progressive encephalomyelitis with rigidity and myoclonus (PERM) - Considered part of the large spectrum of stiff-person-syndrome - Think brainstem and autonomic involvement in addition to axial and limb rigidity, CNS hyperexcitability - Autoantibodies against glycine receptor in 70% of PERM cases - Other antibodies include glutamic acid decarboxylase (GAD), dipeptidyl peptidase-like-protein-6 (DPPX), and of course amphiphysin - This case was anti-DPPX-associated PERM My take: One word: humbling....

Michael Okun

95,624 просмотров • 2 лет назад

Would you know myorhythmia if you saw it? Would you think paraneoplastic? Myorhythmia is so seldomly seen this is a great opportunity to share. Here are some adjectives to keep in mind: repetitive, rhythmic, slow (1-4 Hz). Locations: tend to be cranial and limb. This cool case by Gurram and colleagues is Anti-IgLON5 related. Slow, rhythmic, synchronous involuntary myorhythmic movements noted in chin, tongue and palate. Do you know the 5 phenotypes for IgLON5? 1- sleep disorder, 2- bulbar syndrome, 3- PSP like and 4- other movement disorders, 5- cognitive impairment possibly w/ chorea and neuromuscular issues. This cool case had facial-lingual-palatal myorhythmia, mild parkinsonism, and fasciculations.
0:45

Would you know myorhythmia if you saw it? Would you think paraneoplastic? Myorhythmia is so seldomly seen this is a great opportunity to share. Here are some adjectives to keep in mind: repetitive, rhythmic, slow (1-4 Hz). Locations: tend to be cranial and limb. This cool case by Gurram and colleagues is Anti-IgLON5 related. Slow, rhythmic, synchronous involuntary myorhythmic movements noted in chin, tongue and palate. Do you know the 5 phenotypes for IgLON5? 1- sleep disorder, 2- bulbar syndrome, 3- PSP like and 4- other movement disorders, 5- cognitive impairment possibly w/ chorea and neuromuscular issues. This cool case had facial-lingual-palatal myorhythmia, mild parkinsonism, and fasciculations.

Michael Okun

53,725 просмотров • 2 лет назад

500% increased risks. Read that again. We’re seeing a massive scale of increased risk for chronic, autoimmune, and neurological disorders. This is the "wake-up call" for all Americans. Are you surprised by these statistics?
1:01

500% increased risks. Read that again. We’re seeing a massive scale of increased risk for chronic, autoimmune, and neurological disorders. This is the "wake-up call" for all Americans. Are you surprised by these statistics?

Mary Talley Bowden MD

37,451 просмотров • 4 месяцев назад

Check out the unusual gait pattern worsened by levodopa in this case of a PARKIN gene related Parkinson's. This is why we call it Parkinson's diseases plural as there are so many different manifestations, with or without known gene mutations. Nice case by Mehta and colleagues in Movement Disorders Clinical Practice. Key Points: - 26 year old Parkin gene-related early-onset Parkinson's. - Paradoxical response to levodopa, dopamine worsened dystonia. - Amantadine seemed to help. - Complaint was tightness of lower limbs when walking. - Had heterozygous PRKN mutations, w/ a 'missense pathogenic mutation in exon 7 (c.850G > C (p. Gly284Arg) and a deletion mutation in exon 3 (241 bp),' - 'Forward walking was characterized by bilateral hip flexion and abduction, flexed knees, ankle inversion and plantar flexion rebound during the stance phase on the left foot and reduced arm swing bilaterally.' My take: Some of these PARKIN and genetic PD cases may respond to anticholinergics or dopamine agonists, however in this case this was not helpful. The improvement w/ amantadine was humbling and unexpected. The authors suggest to us to try amantadine, if dopamine is worsening dystonia or gait in the setting of PARKIN. 'Parkinsons diseases, every day we learn something new.' A close look at the video suggests the amantadine helped however did not resolve the challenge. DBS may be a reasonable next step to consider. #Parkinsons
1:41

Check out the unusual gait pattern worsened by levodopa in this case of a PARKIN gene related Parkinson's. This is why we call it Parkinson's diseases plural as there are so many different manifestations, with or without known gene mutations. Nice case by Mehta and colleagues in Movement Disorders Clinical Practice. Key Points: - 26 year old Parkin gene-related early-onset Parkinson's. - Paradoxical response to levodopa, dopamine worsened dystonia. - Amantadine seemed to help. - Complaint was tightness of lower limbs when walking. - Had heterozygous PRKN mutations, w/ a 'missense pathogenic mutation in exon 7 (c.850G > C (p. Gly284Arg) and a deletion mutation in exon 3 (241 bp),' - 'Forward walking was characterized by bilateral hip flexion and abduction, flexed knees, ankle inversion and plantar flexion rebound during the stance phase on the left foot and reduced arm swing bilaterally.' My take: Some of these PARKIN and genetic PD cases may respond to anticholinergics or dopamine agonists, however in this case this was not helpful. The improvement w/ amantadine was humbling and unexpected. The authors suggest to us to try amantadine, if dopamine is worsening dystonia or gait in the setting of PARKIN. 'Parkinsons diseases, every day we learn something new.' A close look at the video suggests the amantadine helped however did not resolve the challenge. DBS may be a reasonable next step to consider. #Parkinsons

Michael Okun

16,809 просмотров • 2 лет назад

Can you identify 'belly dancer dyskinesia?' Hint: look for undulating or circular abdominal contractions. Nice case by Cho, Hallett and colleagues in Movement Disorders Clinical Practice Key Points: - Spinal cord or basal ganglia lesions. - If spinal cord origin, the movements tend to continue during sleep. - An MRI may be helpful if a structural lesion is present. - Physiological studies can be helpful. My take: This case they present turned out to be a 'functional movement disorder' and the movements disappeared with sleep. There was no exposure to a dopamine blocking medication. There was no history of abdominal surgery. The authors remind us to uncover possible 'suggestibility, entrainability, and distractibility.' Physiologically the BP potential is actually present WITH functional myoclonus. Many propriospinal myoclonus cases have turned out to be functional movement disorders. HUMBLING even for the experts. … #dyskinesia #bellydancer #functionalmovementdisorder
0:30

Can you identify 'belly dancer dyskinesia?' Hint: look for undulating or circular abdominal contractions. Nice case by Cho, Hallett and colleagues in Movement Disorders Clinical Practice Key Points: - Spinal cord or basal ganglia lesions. - If spinal cord origin, the movements tend to continue during sleep. - An MRI may be helpful if a structural lesion is present. - Physiological studies can be helpful. My take: This case they present turned out to be a 'functional movement disorder' and the movements disappeared with sleep. There was no exposure to a dopamine blocking medication. There was no history of abdominal surgery. The authors remind us to uncover possible 'suggestibility, entrainability, and distractibility.' Physiologically the BP potential is actually present WITH functional myoclonus. Many propriospinal myoclonus cases have turned out to be functional movement disorders. HUMBLING even for the experts. … #dyskinesia #bellydancer #functionalmovementdisorder

Michael Okun

12,686 просмотров • 1 год назад

Can you identify an oculogyric crisis? @ChristosGanos and colleagues teach us about the intriguing possibility that the rolling eyes we frequently see after administration of a drug, may be localized to a brain lesion network associated with a brain dopaminergic transcriptomic signature. Read about it in a new paper Brain. Key Points: - Oculogyric crises what are they? Acute episodes sustained, typically upward, conjugate deviation of the eyes. - Common cause? Acute D2-dopamine receptor blockade by a drug. - The authors used data from 14 previously reported cases of lesion-induced oculogyric crises and employed' lesion network mapping' to search for shared connections. - What was the common network? Basal ganglia, thalamic, brainstem nuclei and cerebellum. - A look at the gene expression profiles showed spatial overlap specifically with the gene coding for dopamine receptor type 2 (DRD2). - The very cool part: spatial overlap with DRD2 and DRD3 gene expression seemed to be 'specific to brain lesions associated with oculogyric crises when contrasted to lesions that led to other movement disorders.' My take: I love the use of multiple modalities to chase down a common neural network for oculogyric crises. We should keep in mind that these were cases associated with brain lesions, and as we all contribute by reporting more cases and sharing their MRI scans we will likely further refine our understanding of the network. For clinicians when you see this, look down that medication list for the 'dopamine blocker' as your first step in diagnosis. This video by Elan Louis provides a nice illustration of oculogyric crisis to help you to identify them in your practice. #Parkinsons #oculogyric
0:21

Can you identify an oculogyric crisis? @ChristosGanos and colleagues teach us about the intriguing possibility that the rolling eyes we frequently see after administration of a drug, may be localized to a brain lesion network associated with a brain dopaminergic transcriptomic signature. Read about it in a new paper Brain. Key Points: - Oculogyric crises what are they? Acute episodes sustained, typically upward, conjugate deviation of the eyes. - Common cause? Acute D2-dopamine receptor blockade by a drug. - The authors used data from 14 previously reported cases of lesion-induced oculogyric crises and employed' lesion network mapping' to search for shared connections. - What was the common network? Basal ganglia, thalamic, brainstem nuclei and cerebellum. - A look at the gene expression profiles showed spatial overlap specifically with the gene coding for dopamine receptor type 2 (DRD2). - The very cool part: spatial overlap with DRD2 and DRD3 gene expression seemed to be 'specific to brain lesions associated with oculogyric crises when contrasted to lesions that led to other movement disorders.' My take: I love the use of multiple modalities to chase down a common neural network for oculogyric crises. We should keep in mind that these were cases associated with brain lesions, and as we all contribute by reporting more cases and sharing their MRI scans we will likely further refine our understanding of the network. For clinicians when you see this, look down that medication list for the 'dopamine blocker' as your first step in diagnosis. This video by Elan Louis provides a nice illustration of oculogyric crisis to help you to identify them in your practice. #Parkinsons #oculogyric

Michael Okun

15,398 просмотров • 2 лет назад

The traditional explanation for autoimmune disease is being fundamentally questioned. The idea that the body suddenly attacks itself for no reason is a flawed narrative. The conditions—Crohn's, Sjogren's, Hashimoto's—are real, but the "autoimmune" label may be a medical dead end. By definition, these are idiopathic diseases, meaning their origin is unknown. If we don't know the cause, how can we be certain of the mechanism? This is not a denial of suffering, but a critique of a label that offers management instead of cure. The fact that people can and do heal from these conditions proves the problem isn't an irreversibly broken immune system. The body isn't attacking itself; it's responding to a root cause we have yet to identify. Fibromyalgia and Chronic Fatigue Syndrome share the same story: "No known cause, no known cure." It's time we applied the same critical thinking to the entire autoimmune category. True healing begins when we stop blaming the body and start looking for the trigger.
1:25

The traditional explanation for autoimmune disease is being fundamentally questioned. The idea that the body suddenly attacks itself for no reason is a flawed narrative. The conditions—Crohn's, Sjogren's, Hashimoto's—are real, but the "autoimmune" label may be a medical dead end. By definition, these are idiopathic diseases, meaning their origin is unknown. If we don't know the cause, how can we be certain of the mechanism? This is not a denial of suffering, but a critique of a label that offers management instead of cure. The fact that people can and do heal from these conditions proves the problem isn't an irreversibly broken immune system. The body isn't attacking itself; it's responding to a root cause we have yet to identify. Fibromyalgia and Chronic Fatigue Syndrome share the same story: "No known cause, no known cure." It's time we applied the same critical thinking to the entire autoimmune category. True healing begins when we stop blaming the body and start looking for the trigger.

Camus

52,532 просмотров • 7 месяцев назад

Do you remember the case of the 'frozen addict' from recreational drug use (MPTP). Is there a 'new frozen addict syndrome' caused by methcathione (ephedrone). YES. This psychostimulant leads to release of brain catecholamines. Check out this case and video by Thayler and Gurevitch which responded to amantadine and check out the link to manganese. Key points: - Methcathione (ephedrone) can be used as a recreational drug and use has been documented in Eastern Europe and other world locations. - This chemical is synthesized by oxidation of ephedrine or pseudoephedrine w/potassium permanganate. - It is usually given IV and the 'parkinsonism' is thought to be caused by manganese. - It is unlike the MPTP frozen addict as in this case levodopa does not work to treat. - The authors point out that the syndrome tends to be more symmetrical than in idiopathic PD; the clinician should look for bradykinesia, dystonia, and gait impairment. - Check out this 41 year old case w/ a normal flurodopa PET and an abnormal MRI. - He was treated with a 5-day course of IV amantadine followed by oral amantadine. My take: It is humbling to think about the history of a recreational drug which provided one of our best overall animal models of PD (the MPTP model). Now we are observing another form of recreational drug induced parkinsonism, and this one seems to be related to manganese. It is interesting in this case to observe the response to IV and oral amantadine; which as a therapy has multiple mechanisms of action including on dopamine, acetlycholine and glutamate pathways. In the USA, we have not used IV amantadine so this will be a new trick for us. One important aspect of this case was that the clinicians resisted the urge to 'dismiss the person' as an addict or as functional case. Similar to Bill Langston's experience with the MPTP frozen addict, these authors persisted, made the diagnosis and designed and implemented a treatment. BRAVO. Remember, we will all (one day) come down with a disease or diseases and Fortuna est caeca; Fortune is blind. #Parkinsons #manganese #methcathione #ephedrone
1:07

Do you remember the case of the 'frozen addict' from recreational drug use (MPTP). Is there a 'new frozen addict syndrome' caused by methcathione (ephedrone). YES. This psychostimulant leads to release of brain catecholamines. Check out this case and video by Thayler and Gurevitch which responded to amantadine and check out the link to manganese. Key points: - Methcathione (ephedrone) can be used as a recreational drug and use has been documented in Eastern Europe and other world locations. - This chemical is synthesized by oxidation of ephedrine or pseudoephedrine w/potassium permanganate. - It is usually given IV and the 'parkinsonism' is thought to be caused by manganese. - It is unlike the MPTP frozen addict as in this case levodopa does not work to treat. - The authors point out that the syndrome tends to be more symmetrical than in idiopathic PD; the clinician should look for bradykinesia, dystonia, and gait impairment. - Check out this 41 year old case w/ a normal flurodopa PET and an abnormal MRI. - He was treated with a 5-day course of IV amantadine followed by oral amantadine. My take: It is humbling to think about the history of a recreational drug which provided one of our best overall animal models of PD (the MPTP model). Now we are observing another form of recreational drug induced parkinsonism, and this one seems to be related to manganese. It is interesting in this case to observe the response to IV and oral amantadine; which as a therapy has multiple mechanisms of action including on dopamine, acetlycholine and glutamate pathways. In the USA, we have not used IV amantadine so this will be a new trick for us. One important aspect of this case was that the clinicians resisted the urge to 'dismiss the person' as an addict or as functional case. Similar to Bill Langston's experience with the MPTP frozen addict, these authors persisted, made the diagnosis and designed and implemented a treatment. BRAVO. Remember, we will all (one day) come down with a disease or diseases and Fortuna est caeca; Fortune is blind. #Parkinsons #manganese #methcathione #ephedrone

Michael Okun

12,915 просмотров • 2 лет назад

🚨 Dr. Scott Gottlieb Now Says Autism Could Be Caused by Autoimmune Issues, Particularly in Children With a Genetic Vulnerability GOTTLIEB: “The speculation is that people with autism have autoantibodies against the folate receptors … by giving this metabolically active form, it more easily penetrates the brain. That's why you see symptom improvement.” BECKY: “The MTHFR gene, is that specifically what it's linked to because that's the gene that doesn't take folate?” GOTTLIEB: “There is some speculation, yeah.” What could cause this autoimmune reaction, and why is this just being discussed today??
1:03

🚨 Dr. Scott Gottlieb Now Says Autism Could Be Caused by Autoimmune Issues, Particularly in Children With a Genetic Vulnerability GOTTLIEB: “The speculation is that people with autism have autoantibodies against the folate receptors … by giving this metabolically active form, it more easily penetrates the brain. That's why you see symptom improvement.” BECKY: “The MTHFR gene, is that specifically what it's linked to because that's the gene that doesn't take folate?” GOTTLIEB: “There is some speculation, yeah.” What could cause this autoimmune reaction, and why is this just being discussed today??

Chief Nerd

568,390 просмотров • 9 месяцев назад

This is happening on a daily basis to not just ticket holders and office bearers of PTI but anyone who is a relative or even remotely associated with the party. And this is being done directly on the orders of IG police who is getting instructed by the criminals ruling the country. We will be filing cases against the police and the illegal CMs for damages.
2:20

This is happening on a daily basis to not just ticket holders and office bearers of PTI but anyone who is a relative or even remotely associated with the party. And this is being done directly on the orders of IG police who is getting instructed by the criminals ruling the country. We will be filing cases against the police and the illegal CMs for damages.

Imran Khan

1,059,378 просмотров • 2 лет назад

In modern medicine, the risks associated with receiving the MMR vaccine typically take a backseat to the “benefit” of not contracting measles. BUT what if we have it backward and there’s actually more risk in getting the shot than coming down with a case of measles? As Dr. Ben Edwards (Dr. Ben Edwards, M.D.) makes clear, we SHOULD really be asking questions about the way these vaccines, including MMR, create an “immune imbalance” causing children to present with “autoimmune diseases” and “cancers.”
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In modern medicine, the risks associated with receiving the MMR vaccine typically take a backseat to the “benefit” of not contracting measles. BUT what if we have it backward and there’s actually more risk in getting the shot than coming down with a case of measles? As Dr. Ben Edwards (Dr. Ben Edwards, M.D.) makes clear, we SHOULD really be asking questions about the way these vaccines, including MMR, create an “immune imbalance” causing children to present with “autoimmune diseases” and “cancers.”

Children’s Health Defense

25,444 просмотров • 1 год назад

Long COVID: The Immune & Lymphatic System Long COVID is associated with persistent immune dysregulation. Studies document chronic inflammation, abnormal immune activation, altered T- and B-cell signaling, and the presence of autoantibodies. This immune dysregulation can create a state of vulnerability in the body, which can increase susceptibility to infections, reactivation of latent-viruses as seen with EBV, CMV, HSV... and contribute to the emergence or unmasking of secondary conditions, including autoimmune diseases such as Lupus, neurologic disorders such as multiple sclerosis (MS), and even certain can also impact how your body responds to other infections and illnesses, impact vaccine efficacy and antibody response, and more. Long COVID can reflect a destabilized immune system with systemic consequences that vary by person, severity, and time since infection. We are all #OneInfectionAway Learn more about #LongCOVID and visit our #LongCOVIDAwareness Month page to take action, get involved, and spread the word! Access the video here:
1:12

Long COVID: The Immune & Lymphatic System Long COVID is associated with persistent immune dysregulation. Studies document chronic inflammation, abnormal immune activation, altered T- and B-cell signaling, and the presence of autoantibodies. This immune dysregulation can create a state of vulnerability in the body, which can increase susceptibility to infections, reactivation of latent-viruses as seen with EBV, CMV, HSV... and contribute to the emergence or unmasking of secondary conditions, including autoimmune diseases such as Lupus, neurologic disorders such as multiple sclerosis (MS), and even certain can also impact how your body responds to other infections and illnesses, impact vaccine efficacy and antibody response, and more. Long COVID can reflect a destabilized immune system with systemic consequences that vary by person, severity, and time since infection. We are all #OneInfectionAway Learn more about #LongCOVID and visit our #LongCOVIDAwareness Month page to take action, get involved, and spread the word! Access the video here:

COVID-19 Longhauler Advocacy Project

10,571 просмотров • 3 месяцев назад

"I was living my dream. Everything changed." Abi burton was preparing for the Commonwealth Games when warning signs first appeared. Autoimmune encephalitis would leave her in a coma. This is her story. #Remarkables in partnership with HSBC Sport
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"I was living my dream. Everything changed." Abi burton was preparing for the Commonwealth Games when warning signs first appeared. Autoimmune encephalitis would leave her in a coma. This is her story. #Remarkables in partnership with HSBC Sport

HSBC SVNS

143,929 просмотров • 3 лет назад

ADHD, Autism, Tics, and Epilepsy--Sequelae of Encephalitis or Brain Inflammation after Vaccination Twenty vaccines list encephalitis or brain inflammation in their package inserts as single products. With greater probably, when many vaccines are given in combination, there is a real risk of encephalitis in the baby that results days, weeks, or months later in the development of ADHD, autism, tics, and epilepsy. These are the consequences of excessive vaccination that has occurred since 1986 when vaccine liability protection was given to vaccine manufacturers by law. Dr Peter McCullough,™ who sees patients with these problems in clinical practice, explains to Grant Stinchfield on Stinchfield Tonight, Real America's Voice. Grant Stinchfield Real America's Voice (RAV) McCullough Foundation
1:12

ADHD, Autism, Tics, and Epilepsy--Sequelae of Encephalitis or Brain Inflammation after Vaccination Twenty vaccines list encephalitis or brain inflammation in their package inserts as single products. With greater probably, when many vaccines are given in combination, there is a real risk of encephalitis in the baby that results days, weeks, or months later in the development of ADHD, autism, tics, and epilepsy. These are the consequences of excessive vaccination that has occurred since 1986 when vaccine liability protection was given to vaccine manufacturers by law. Dr Peter McCullough,™ who sees patients with these problems in clinical practice, explains to Grant Stinchfield on Stinchfield Tonight, Real America's Voice. Grant Stinchfield Real America's Voice (RAV) McCullough Foundation

Peter A. McCullough, MD, MPH®

70,590 просмотров • 7 месяцев назад

Guided by Hon’ble PM Shri Narendra Modi Ji’s vision of Affordable, Accessible, Accountable Healthcare for All and under the guidance of Hon’ble Union Minister of Health & Family Welfare Shri Jagat Prakash Nadda Ji, Goa will be the first state in India to launch the Pricing Policy for Innovative Lifesaving Therapies (PPILT). With confidential, outcome-linked pricing, we are ensuring that cutting-edge care for conditions like cancer, genetic disorders & autoimmune diseases can be provided within the public healthcare budget. Fulfilling the spirit of Antyodaya and inspired by One Earth, One Health, this step blends innovation with compassion, strengthens our public health system, and takes us closer to achieving #HealthForAll in Goa. #GoaCare #PPILTGoa
1:11

Guided by Hon’ble PM Shri Narendra Modi Ji’s vision of Affordable, Accessible, Accountable Healthcare for All and under the guidance of Hon’ble Union Minister of Health & Family Welfare Shri Jagat Prakash Nadda Ji, Goa will be the first state in India to launch the Pricing Policy for Innovative Lifesaving Therapies (PPILT). With confidential, outcome-linked pricing, we are ensuring that cutting-edge care for conditions like cancer, genetic disorders & autoimmune diseases can be provided within the public healthcare budget. Fulfilling the spirit of Antyodaya and inspired by One Earth, One Health, this step blends innovation with compassion, strengthens our public health system, and takes us closer to achieving #HealthForAll in Goa. #GoaCare #PPILTGoa

Vishwajit Rane

27,195 просмотров • 10 месяцев назад

Can you pick out who has Parkinson's disease from the video using the 'whistle-smile' reflex? Maybe? Frederic Hanes described this sign in 1943. Giulia Paparella and colleagues revisit the observation in a trial of 34 Parkinson's folks versus 34 healthy controls in Movement Disorders Clinical Practice. Key Points: - When healthy individuals are prompted to whistle during a medical examination, 'they typically comply and subsequently smile.' - In Parkinson's 'they execute the whistle but often fail to produce an immediate smile.' - In their study they showed a sensitivity of 76% and a specificity of 65% for the sign. My take: It is hard to believe that there are only two papers on this sign published since 1943. Behavioral neurologists have long been fascinated by spontaneous smiling versus posed and elicited smiling in Parkinson's disease. Though the sensitivity and specificity are too low to become a biomarker, this is a sign neurologists can keep in their pockets for teaching. Researchers may also consider studying this phenomenon with functional imaging as the limbic-motor newtowrk is fascinating and we have also observed DBS induced smiling. The brain is a fascinating supercomputer and frankly, we do not know what we do not know. Ecce signum – behold the sign of the smile in Parkinson's. #Parkinsons Smiles induced by DBS: Spontaneous and posed smiles in Parkinson: Motor cortex and facial smiling in primates by Morecraft: #Parkinsons #smilefest2024 #smile
0:25

Can you pick out who has Parkinson's disease from the video using the 'whistle-smile' reflex? Maybe? Frederic Hanes described this sign in 1943. Giulia Paparella and colleagues revisit the observation in a trial of 34 Parkinson's folks versus 34 healthy controls in Movement Disorders Clinical Practice. Key Points: - When healthy individuals are prompted to whistle during a medical examination, 'they typically comply and subsequently smile.' - In Parkinson's 'they execute the whistle but often fail to produce an immediate smile.' - In their study they showed a sensitivity of 76% and a specificity of 65% for the sign. My take: It is hard to believe that there are only two papers on this sign published since 1943. Behavioral neurologists have long been fascinated by spontaneous smiling versus posed and elicited smiling in Parkinson's disease. Though the sensitivity and specificity are too low to become a biomarker, this is a sign neurologists can keep in their pockets for teaching. Researchers may also consider studying this phenomenon with functional imaging as the limbic-motor newtowrk is fascinating and we have also observed DBS induced smiling. The brain is a fascinating supercomputer and frankly, we do not know what we do not know. Ecce signum – behold the sign of the smile in Parkinson's. #Parkinsons Smiles induced by DBS: Spontaneous and posed smiles in Parkinson: Motor cortex and facial smiling in primates by Morecraft: #Parkinsons #smilefest2024 #smile

Michael Okun

12,711 просмотров • 1 год назад

.Ben Shapiro on why he thinks AOC is suddenly against betting markets: “Name another aspect of consumption that AOC is dramatically against…like prostitution, drugs, alcohol - name a thing that AOC believes there should not be a market for. The only thing she believes there should not be a market for is a prediction market, and the only reason she's saying that is because, of course, Don Jr. is associated with prediction markets. I think it's that simple.”
1:14

.Ben Shapiro on why he thinks AOC is suddenly against betting markets: “Name another aspect of consumption that AOC is dramatically against…like prostitution, drugs, alcohol - name a thing that AOC believes there should not be a market for. The only thing she believes there should not be a market for is a prediction market, and the only reason she's saying that is because, of course, Don Jr. is associated with prediction markets. I think it's that simple.”

Daily Wire

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