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Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in collaboration with the Marius Pachitariu lab at HHMI |... show more

Sergiu P. Pasca

14,406 subscribers

27,410 次观看 • 1 年前 •via X (Twitter)

健康养生科学技术 #assembloids

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10 条评论

Sergiu P. Pasca 的头像

Sergiu P. Pasca1 年前

Preprint here:

Prof Peter Hotez MD PhD 的头像

Prof Peter Hotez MD PhD1 年前

Extraordinary work, really impressive!

Sergiu P. Pasca 的头像

Sergiu P. Pasca1 年前

Thank you, Peter!

Maria Robles 的头像

Maria Robles1 年前

This is incredible. Congratulations ...the implications here are mindblowing !

Maria Robles 的头像

Maria Robles1 年前

We at Robles BioCeutics are big fans of your work !

Carolyn Bertozzi 的头像

Carolyn Bertozzi1 年前

Amazing ! 🤯

Sergiu P. Pasca 的头像

Sergiu P. Pasca1 年前

Thank you 🙏

Ella Marushchenko 的头像

Ella Marushchenko1 年前

Impressive work! Congratulations, Prof. Pasca!

Sergiu P. Pasca 的头像

Sergiu P. Pasca1 年前

Thank you

Julio Aguado 的头像

Julio Aguado1 年前

wow, exciting work indeed! 🤯

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Our latest work is out today in Science Magazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by Massimo Onesto with Neal Amin

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