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Yes, everyone’s hyping the fly brain. So we gave a human-connectome model two sabers and RUSH E. 🧠⚔️ The wiring comes from a published human structural connectome derived from diffusion MRI tractography. Each node corresponds to a brain region, represented here by one simplified computational unit. We’re working at... show more

Neurolab

3,220 subscribers

12,924 views • 9 days ago •via X (Twitter)

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13 Comments

BioLLM9 days ago

How is this possible? You realize H01 (the connectome also produced by @GoogleAI) is around 1.4PB - thats Petabytes. It represents a slice of about 160,000 neurons. Is there a simplified connectome you have found?

Neurolab8 days ago

The paper is attached on the comment. As we mentioned, we are not using single neurons for this model. We are considering each brain region/subregiom as a node and also its real whitematter connectome for its connections (plus the euclidean distance for the cortico-corical). The idea was to show how extraordinary the human brain is if just by simplifying it in this way, we still have a good reservoir network... imagine if we simulate all neurons. Have a look into the paper attached, it is a really good one.

Neurolab9 days ago

To keep sense of the scale of the human brain: each cortical node represents a whole region—not a single biological neuron. With 1,000 cortical regions, that works out to roughly 16 million biological neurons per node on average—over 100 times the neuron count of the adult FlyWire brain. In this experiment, we compress each region into one simplified computational unit. Here for the ref behind the model

Neurolab9 days ago

And now that you are here: Check out our whitepaper, deck, roadmap, and more

Superpositionbigbang9 days ago

This is the future of the virtual world!

Utkarsh Agrawal9 days ago

Nice, I trained them how to fight in MMA

Neurolab9 days ago

No grappling!?!?

Utkarsh Agrawal9 days ago

it will come, the'll learn 😂 just the training is taking time

Big Pharmai8 days ago

Crazy

Martin Ronfort9 days ago

Moving from simulated environments to physical movement is a massive leap for connectome-based robotics, and we actually went deeper on this here:

samuel tan9 days ago

since neurons forming is an emergent phenomena from individual cell interactions,Can a ai procedurally generate where neurons should be given previous scans of human neurons.

Lusik G8 days ago

Everyone copying @BioLLM_ come up with your own ideas

Neurolab8 days ago

@BioLLM_ What are you even talking abt? Go read our wp and roadmap

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30,766 views • 5 months ago

New episode with Adam Marblestone, CEO and co-founder of Convergent Research. Adam is an extraordinary catalyst and accelerant for science: he has influenced or routed billions in funding, he helped start significant companies and scientific subfields, and he is the world’s go-to person for neuroscience roadmapping. This year, the NSF launched a $1.5B X-Labs initiative inspired by the FRO model Adam pioneered. Though he started with neuroscience, today he helps organize scientific endeavors across many fields, including AI, math, biology, climate, astrophysics, and more. Adam proposes that fields like neurotech, whole-brain emulation, cryo, and nanotech are severely limited by capital and coordination — not ideas. Connectomics is a clear case. He argues that mapping the brain's full wiring diagram is the approach most poised-to-scale and still extremely neglected. Costs for a molecularly annotated mouse connectome have come down orders of magnitude, from an estimated $10B to $100M–200M, Adam suggests, with a human connectome perhaps costing around $1B–2B. The cost curve of connectomes is similar to transistors and gene sequencing: once it is low enough, we get extraordinary outcomes for humanity. Near-term applications could pay for it: new drug targets for brain disease, insights for AI development, emulations, and even “control knobs” for mood and focus we haven’t identified yet. In this episode, we go deep on many topics in neurotech and beyond: what the brain can do that computers still can't; what neuroscience could teach AI; how you'd actually map a whole mammal brain; how far today's fly-brain simulations really get toward an upload; what it would take to move mind uploading beyond the fringe or science; where brain-computer interfaces go next; nanotech, reversible cryonics, AI doing its own ML research, and even predictive, agent-based economics. I'm very excited to have Adam on the podcast. Hope you enjoy! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:40 What are the grand challenges of neurotech? 00:04:50 What the brain does that computers still can't (on a few bananas a day) 00:14:43 The neuroscience overhang: why brains learn from so little data 00:26:29 How to record and map the brain: DNA "ticker tape," ultrasound, and the unexplored map 00:40:29 Why connectomics is the area most poised to scale 00:47:54 How whole-brain connectomics works, end to end 00:55:27 Simulating the fly brain: how far does it actually get us? 00:57:51 What would it cost to map a mammal's brain? 00:59:55 What will be connectomics' ChatGPT moment? 01:04:35 What a connectome unlocks: disease, drug targets, and the brain's control knobs 01:14:20 Scaling up to the human brain — a faster timeline than expected 01:17:34 Mapping activity, and what the fly connectome has revealed 01:27:55 What you could build with today's connectome 01:35:29 Why uploading may be one of civilization's great cornerstones and transitions 01:42:43 Optimistic visions of a future with uploading 01:49:12 Beyond neurotech: virtual cells, nanotech, and AI-driven science 02:15:29 BCIs today: semi-invasive devices, ultrasound, and what's on the horizon 02:22:44 Why science is capital-and coordination-limited, not idea-limited

New episode with Adam Marblestone, CEO and co-founder of Convergent Research. Adam is an extraordinary catalyst and accelerant for science: he has influenced or routed billions in funding, he helped start significant companies and scientific subfields, and he is the world’s go-to person for neuroscience roadmapping. This year, the NSF launched a $1.5B X-Labs initiative inspired by the FRO model Adam pioneered. Though he started with neuroscience, today he helps organize scientific endeavors across many fields, including AI, math, biology, climate, astrophysics, and more. Adam proposes that fields like neurotech, whole-brain emulation, cryo, and nanotech are severely limited by capital and coordination — not ideas. Connectomics is a clear case. He argues that mapping the brain's full wiring diagram is the approach most poised-to-scale and still extremely neglected. Costs for a molecularly annotated mouse connectome have come down orders of magnitude, from an estimated $10B to $100M–200M, Adam suggests, with a human connectome perhaps costing around $1B–2B. The cost curve of connectomes is similar to transistors and gene sequencing: once it is low enough, we get extraordinary outcomes for humanity. Near-term applications could pay for it: new drug targets for brain disease, insights for AI development, emulations, and even “control knobs” for mood and focus we haven’t identified yet. In this episode, we go deep on many topics in neurotech and beyond: what the brain can do that computers still can't; what neuroscience could teach AI; how you'd actually map a whole mammal brain; how far today's fly-brain simulations really get toward an upload; what it would take to move mind uploading beyond the fringe or science; where brain-computer interfaces go next; nanotech, reversible cryonics, AI doing its own ML research, and even predictive, agent-based economics. I'm very excited to have Adam on the podcast. Hope you enjoy! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:40 What are the grand challenges of neurotech? 00:04:50 What the brain does that computers still can't (on a few bananas a day) 00:14:43 The neuroscience overhang: why brains learn from so little data 00:26:29 How to record and map the brain: DNA "ticker tape," ultrasound, and the unexplored map 00:40:29 Why connectomics is the area most poised to scale 00:47:54 How whole-brain connectomics works, end to end 00:55:27 Simulating the fly brain: how far does it actually get us? 00:57:51 What would it cost to map a mammal's brain? 00:59:55 What will be connectomics' ChatGPT moment? 01:04:35 What a connectome unlocks: disease, drug targets, and the brain's control knobs 01:14:20 Scaling up to the human brain — a faster timeline than expected 01:17:34 Mapping activity, and what the fly connectome has revealed 01:27:55 What you could build with today's connectome 01:35:29 Why uploading may be one of civilization's great cornerstones and transitions 01:42:43 Optimistic visions of a future with uploading 01:49:12 Beyond neurotech: virtual cells, nanotech, and AI-driven science 02:15:29 BCIs today: semi-invasive devices, ultrasound, and what's on the horizon 02:22:44 Why science is capital-and coordination-limited, not idea-limited

Juan Benet

227,138 views • 27 days ago

My guest has a PhD from the University of Toronto. She taught at the university level, then at two prep schools for years. In 2017 she walked away from education after the system covered up the abuse of one of her students. She turned whistleblower, went public, and started digging into the brain science of what had happened. That work became two books, The Bullied Brain and The Gaslit Brain, and a long-running column for Psychology Today. Jennifer Fraser studies abuse cultures for a living. We get into gaslighting and what it actually does to your brain. She lays out the dark tetrad — narcissism, Machiavellianism, psychopathy, sadism — and the mask these people wear so well it fools the experts. How they read you, isolate you, and make you doubt your own memory. We cover the lie that abuse is the price of greatness. Coaches who don't want to win — they want to hurt the kids. Why refusing a bad order is the real test of leadership. And the part that matters most: the brain is wired to repair. The Gaslit Brain: Join the Cleared Hot Newsletter:

My guest has a PhD from the University of Toronto. She taught at the university level, then at two prep schools for years. In 2017 she walked away from education after the system covered up the abuse of one of her students. She turned whistleblower, went public, and started digging into the brain science of what had happened. That work became two books, The Bullied Brain and The Gaslit Brain, and a long-running column for Psychology Today. Jennifer Fraser studies abuse cultures for a living. We get into gaslighting and what it actually does to your brain. She lays out the dark tetrad — narcissism, Machiavellianism, psychopathy, sadism — and the mask these people wear so well it fools the experts. How they read you, isolate you, and make you doubt your own memory. We cover the lie that abuse is the price of greatness. Coaches who don't want to win — they want to hurt the kids. Why refusing a bad order is the real test of leadership. And the part that matters most: the brain is wired to repair. The Gaslit Brain: Join the Cleared Hot Newsletter:

Andy Stumpf

13,687 views • 2 months ago

‼️Food made from WHAT?!🤦🏿‍♂️🤮….. Yes, it’s real….. If we do not get it together, support/buy from farmers, grow our own food and become more independent this system will have the people eating bugs…… Some foods already have bugs in it so we have to get things together. This is what they think of us…. This is not a theory - it is very much a conspiracy to depopulate the earth of human beings. They are using MRNA in food and CRISPR to manipulate the genetics of plants & insects in order to feed it to the human family…… Wake the hell up!🔥 Take Intellectual Power and get your 🧠 health right ✊🏿 . . 🧠🌿 . . 🌺👸🏾 . . ✊🏿Full interview here: #Mrnafood #Allthingsbugs #rizzaislam #intellectualxtremist #intellectualpower #brain #Insects #Foodsupply #explore

‼️Food made from WHAT?!🤦🏿‍♂️🤮….. Yes, it’s real….. If we do not get it together, support/buy from farmers, grow our own food and become more independent this system will have the people eating bugs…… Some foods already have bugs in it so we have to get things together. This is what they think of us…. This is not a theory - it is very much a conspiracy to depopulate the earth of human beings. They are using MRNA in food and CRISPR to manipulate the genetics of plants & insects in order to feed it to the human family…… Wake the hell up!🔥 Take Intellectual Power and get your 🧠 health right ✊🏿 . . 🧠🌿 . . 🌺👸🏾 . . ✊🏿Full interview here: #Mrnafood #Allthingsbugs #rizzaislam #intellectualxtremist #intellectualpower #brain #Insects #Foodsupply #explore

Rizza Islam official

108,181 views • 1 year ago