John Cumbers
@johncumbers • 18,808 subscribers
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David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
John Cumbers834,012 görüntüleme • 2 ay önce
![The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."](https://image.24vids.com/tw-2032771680482066766/amplify_video_thumb/2032771296023687168/img/5UrqpQ1UbgNbXtCB.jpg)
The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
John Cumbers1,157,028 görüntüleme • 3 ay önce
David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
John Cumbers416,363 görüntüleme • 3 ay önce
When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair
John Cumbers303,981 görüntüleme • 3 ay önce
A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair
John Cumbers231,259 görüntüleme • 2 ay önce
Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.
John Cumbers157,115 görüntüleme • 1 ay önce
A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair
John Cumbers202,930 görüntüleme • 2 ay önce
Dr. David Sinclair was one of the most well-known advocates for drinking red wine. His reason was because red wine contains resveratrol, a molecule linked in longevity. He drank red wine because of it every day. Then he read data that changed his mind. Studies show that people who drink even one glass of alcohol a day tend to have smaller brain size. And the more you drink, the smaller your brain gets. The trend line was clear. Now he just takes resveratrol as a pure supplement. (about a gram mixed with olive oil or yogurt so his body can absorb it) He says since quitting he has mental clarity he has not felt since his 20s. PS. David Sinclair (David Sinclair) is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. You won't want to miss it. Tickets available now:
John Cumbers71,922 görüntüleme • 1 ay önce
David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
John Cumbers84,230 görüntüleme • 2 ay önce
David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.
John Cumbers95,588 görüntüleme • 2 ay önce
1. No screens after 7:30pm. 2. His bedroom stays completely dark and cold. 3. He stops drinking liquids at 4:00pm to avoid bathroom trips. These 3 changes alone improved his sleep score by 28% in 2 weeks. This clip below gives you an even more comprehensive breakdown: ↓
John Cumbers375,841 görüntüleme • 1 yıl önce
David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:
John Cumbers56,025 görüntüleme • 1 ay önce
David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.
John Cumbers55,220 görüntüleme • 2 ay önce
7. Exact food protocol Bryan eats exactly 2,250 calories daily: • 25% protein (141g) • 35% carbs (197g) • 40% fat (100g) "Super Veggie" lunch: lentils, broccoli, cauliflower, mushrooms, garlic, and ginger. His meals are plant-based by choice, not necessity for longevity.
John Cumbers228,225 görüntüleme • 1 yıl önce
David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
John Cumbers21,184 görüntüleme • 2 ay önce
When explaining the fundamental flaw with the current agricultural system, Bruce Friedrich said: "For about 12,000 years we have been raising animals for meat in roughly the same way: we farm them." This is an incredibly inefficient process, where up to 99% of what we feed animals goes toward keeping them alive, leaving 1% in animal meat for us to consume: "It takes about 80 calories to feed a fish, 90 calories into a chicken or 110 calories into a pig to get one calorie back out in the form of that animal's meat." Because such a small percentage of the animal comes back as meat, we have to farm them at a massive scale to compensate. This increases the scale of the end-to-end agricultural operation - growing vast quantities of crops, shipping them to feed mills, operating those mills, shipping the feed to farms, operating the farms, then shipping animals to slaughterhouses and operating those too. Every step in that chain drives up the cost of land, crops, and ultimately the price of the meat when we buy it at the grocery store. Since meat is essential to human health, this has played a major factor in us maintaining our health. "More than three billion people according to the 2025 numbers from the UN Food and Agriculture Organization are unable to afford a nutritious diet. And more than 750 million people are living in nutritional deficit. Which is to say that they're starving." — Bruce Friedrich 🔸
John Cumbers18,693 görüntüleme • 2 ay önce
Daha fazla içerik yok.