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David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same... show more

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416,363 views • 5 months ago •via X (Twitter)

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David Sinclair says we’ll find out this year whether aging is reversible. His lab reversed biological age in animals by 75% in six weeks. The FDA has cleared the first human trial. Aging may be information loss. Information can be restored.

David Sinclair says we’ll find out this year whether aging is reversible. His lab reversed biological age in animals by 75% in six weeks. The FDA has cleared the first human trial. Aging may be information loss. Information can be restored.

vitrupo

1,644,359 views • 5 months ago

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

John Cumbers

1,161,731 views • 5 months ago

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”

Fan Commentary: Joe Rogan Recaps

24,517 views • 7 days ago

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

KanekoaTheGreat

1,226,343 views • 7 days ago

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

John Cumbers

157,553 views • 3 months ago

🚨BREAKING: Scientists Just Reversed Aging by UP TO 75% in Animals in ONLY 6 WEEKS... and Humans Are NEXT MONTH! Harvard genius Dr. David Sinclair's lab turned old animals YOUNG again, like hitting Ctrl+Z on biology. He calls your body a glitchy computer that can be FULLY REBOOTED. FDA just gave the green light for the first human trial... starting NEXT MONTH. Immortality just got a launch date? You aging backwards soon? #AgeReversal #Longevity #Immortality

🚨BREAKING: Scientists Just Reversed Aging by UP TO 75% in Animals in ONLY 6 WEEKS... and Humans Are NEXT MONTH! Harvard genius Dr. David Sinclair's lab turned old animals YOUNG again, like hitting Ctrl+Z on biology. He calls your body a glitchy computer that can be FULLY REBOOTED. FDA just gave the green light for the first human trial... starting NEXT MONTH. Immortality just got a launch date? You aging backwards soon? #AgeReversal #Longevity #Immortality

ᙢinus ᙡells

83,868 views • 5 months ago

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair

John Cumbers

305,874 views • 5 months ago

We asked Max Marchione: what happens after we solve obesity? "We still have all of the things that cause aging." "We haven't really been able to slow aging. Aging is very systemic." "Even if you take the Bryan Johnson approach to aging, you maybe only add an extra 10 years to life, which is not an awful amount." "I think the kind of 10-year plus primary therapeutic modality is likely going to be genomic medicine." "If you can modify the genome, you can actually modify how DNA encodes for RNA, which produces proteins and peptides. So you can actually change the proteins and peptides your body produces by modifying DNA."

We asked Max Marchione: what happens after we solve obesity? "We still have all of the things that cause aging." "We haven't really been able to slow aging. Aging is very systemic." "Even if you take the Bryan Johnson approach to aging, you maybe only add an extra 10 years to life, which is not an awful amount." "I think the kind of 10-year plus primary therapeutic modality is likely going to be genomic medicine." "If you can modify the genome, you can actually modify how DNA encodes for RNA, which produces proteins and peptides. So you can actually change the proteins and peptides your body produces by modifying DNA."

MTS

71,587 views • 2 months ago

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.

John Cumbers

55,280 views • 4 months ago

Dr. David Sinclair was one of the most well-known advocates for drinking red wine. His reason was because red wine contains resveratrol, a molecule linked in longevity. He drank red wine because of it every day. Then he read data that changed his mind. Studies show that people who drink even one glass of alcohol a day tend to have smaller brain size. And the more you drink, the smaller your brain gets. The trend line was clear. Now he just takes resveratrol as a pure supplement. (about a gram mixed with olive oil or yogurt so his body can absorb it) He says since quitting he has mental clarity he has not felt since his 20s. PS. David Sinclair (David Sinclair) is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. You won't want to miss it. Tickets available now:

Dr. David Sinclair was one of the most well-known advocates for drinking red wine. His reason was because red wine contains resveratrol, a molecule linked in longevity. He drank red wine because of it every day. Then he read data that changed his mind. Studies show that people who drink even one glass of alcohol a day tend to have smaller brain size. And the more you drink, the smaller your brain gets. The trend line was clear. Now he just takes resveratrol as a pure supplement. (about a gram mixed with olive oil or yogurt so his body can absorb it) He says since quitting he has mental clarity he has not felt since his 20s. PS. David Sinclair (David Sinclair) is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. You won't want to miss it. Tickets available now:

John Cumbers

71,922 views • 3 months ago

David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

John Cumbers

56,136 views • 3 months ago

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Wall Street Apes

489,664 views • 6 months ago

This doctor reversed type 2 diabetes in 157 patients and discovered how the modern diet keeps you sick, hungry & aging faster. Here are 9 lessons he shared in his latest interview that everyone needs to hear: 1. You can reverse type 2 diabetes without drugs.

This doctor reversed type 2 diabetes in 157 patients and discovered how the modern diet keeps you sick, hungry & aging faster. Here are 9 lessons he shared in his latest interview that everyone needs to hear: 1. You can reverse type 2 diabetes without drugs.

LongevityLab

243,378 views • 2 months ago

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

21,184 views • 4 months ago

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

84,263 views • 4 months ago

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

David Sinclair

1,523,188 views • 3 years ago

Hayes: If you have someone who’s already fairly advanced in years and they’re aging quickly, it can have a real effect. It’s weird that everyone just stopped applying those two obvious truths to the situation we’re in now, where they elected who also is on an accelerated aging schedule. I mean, his nickname for Biden was “Sleepy Joe.” He literally fell asleep at a White House event the other day.

Hayes: If you have someone who’s already fairly advanced in years and they’re aging quickly, it can have a real effect. It’s weird that everyone just stopped applying those two obvious truths to the situation we’re in now, where they elected who also is on an accelerated aging schedule. I mean, his nickname for Biden was “Sleepy Joe.” He literally fell asleep at a White House event the other day.

Acyn

147,197 views • 9 months ago

The reason you age has nothing to do with bad genetics. Evolution literally never NEEDED you to live past 40. And now one lab is overriding millions of years of biological programming. David Sinclair explained the logic: in prehistoric times, most humans died from famine, disease, or war by age 30 to 40. If you were born with a mutation that let you live to 90, it was useless. You'd be killed by a predator or a neighboring tribe long before it mattered. So evolution optimized for one thing: breed fast, die young. But here's the proof this can change: Species with no predators evolved dramatically longer lifespans. Bowhead whales live for hundreds of years. Bristlecone pine trees have been alive since the pyramids were built. The reason? Nothing eats them. So evolution gave them stable epigenetic systems. Their cells don't lose identity. They barely get cancer. Humans never got that biological upgrade because we never survived long enough for evolution to select for it. Sinclair's lab proved this by engineering mice with accelerated DNA breaks. No cancer. No mutations. Just broken chromosomes that got repaired imperfectly. Within 10 months, those mice aged 50% faster than their identical twins. Gray hair. Frailty. Every disease of aging. All triggered by the same mechanism his theory predicted. Then they reversed it. Evolution built us to reproduce and die. Science is rewriting that code in real time. — David Sinclair

The reason you age has nothing to do with bad genetics. Evolution literally never NEEDED you to live past 40. And now one lab is overriding millions of years of biological programming. David Sinclair explained the logic: in prehistoric times, most humans died from famine, disease, or war by age 30 to 40. If you were born with a mutation that let you live to 90, it was useless. You'd be killed by a predator or a neighboring tribe long before it mattered. So evolution optimized for one thing: breed fast, die young. But here's the proof this can change: Species with no predators evolved dramatically longer lifespans. Bowhead whales live for hundreds of years. Bristlecone pine trees have been alive since the pyramids were built. The reason? Nothing eats them. So evolution gave them stable epigenetic systems. Their cells don't lose identity. They barely get cancer. Humans never got that biological upgrade because we never survived long enough for evolution to select for it. Sinclair's lab proved this by engineering mice with accelerated DNA breaks. No cancer. No mutations. Just broken chromosomes that got repaired imperfectly. Within 10 months, those mice aged 50% faster than their identical twins. Gray hair. Frailty. Every disease of aging. All triggered by the same mechanism his theory predicted. Then they reversed it. Evolution built us to reproduce and die. Science is rewriting that code in real time. — David Sinclair

Goku

81,851 views • 4 months ago

$David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.$

David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

840,736 views • 4 months ago

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair

John Cumbers

203,147 views • 4 months ago