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Julia Bauman

@JuliaBauman2 • 10,399 subscribers

PhD student at @Stanford Genetics in @LarsMSteinmetz lab Explaining cool biotech to the world here and @ 60_SecondScience on TikTok

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A new paper shows that personalized pancreatic cancer vaccines can keep patients cancer-free for YEARS - an incredible outcome for a cancer with only a 7% 5-year survival rate.

A new paper shows that personalized pancreatic cancer vaccines can keep patients cancer-free for YEARS - an incredible outcome for a cancer with only a 7% 5-year survival rate.

222,954 Aufrufe • vor 1 Jahr

I’ve been super into the idea of intracellular molecular recording to measure cell dynamics, but this tech offers an interesting alternative: make the cells give you a sample!

I’ve been super into the idea of intracellular molecular recording to measure cell dynamics, but this tech offers an interesting alternative: make the cells give you a sample!

171,832 Aufrufe • vor 2 Jahren

The most beautiful molecular recorder 😍 GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo! From Dingchang Lin's lab in nature

The most beautiful molecular recorder 😍 GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo! From Dingchang Lin's lab in nature

18,427 Aufrufe • vor 2 Monaten

You’ve probably all seen the see-through mouse by now. Here’s a little more detail on how this optical trick works! Amazing work from HongLab in Science Magazine

You’ve probably all seen the see-through mouse by now. Here’s a little more detail on how this optical trick works! Amazing work from HongLab in Science Magazine

111,157 Aufrufe • vor 1 Jahr

Hoping to majorly scale up some single-cell experiments using this tech!

Hoping to majorly scale up some single-cell experiments using this tech!

160,903 Aufrufe • vor 3 Jahren

What good is a science communication channel if you don't get to talk about your own papers on it occasionally, right?😊 We developed a method to simultaneously sequence single-cell DNA and RNA targets, enabling association of genomic variants (including non-coding!) with gene expression changes. Out today in Nature Methods, from Lars Steinmetz lab led by Dominik Lindenhofer! Link below⬇️

What good is a science communication channel if you don't get to talk about your own papers on it occasionally, right?😊 We developed a method to simultaneously sequence single-cell DNA and RNA targets, enabling association of genomic variants (including non-coding!) with gene expression changes. Out today in Nature Methods, from Lars Steinmetz lab led by Dominik Lindenhofer! Link below⬇️

46,976 Aufrufe • vor 9 Monaten

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

45,500 Aufrufe • vor 10 Monaten

As promised, an overview of Roche 's new sequencing tech. Comparable to Illumina NGS in accuracy & read length, but FAST - 5B reads in an hour!

As promised, an overview of Roche 's new sequencing tech. Comparable to Illumina NGS in accuracy & read length, but FAST - 5B reads in an hour!

56,322 Aufrufe • vor 1 Jahr

Discovery of a new class of antibiotic using AI, shown to be effective against MRSA in mice! Incredibly cool work from Jim Collins’s lab at Massachusetts Institute of Technology (MIT) in nature

Discovery of a new class of antibiotic using AI, shown to be effective against MRSA in mice! Incredibly cool work from Jim Collins’s lab at Massachusetts Institute of Technology (MIT) in nature

93,429 Aufrufe • vor 2 Jahren

"Reverse translation" for protein sequencing: turning Edman degradation products into DNA sequence! I definitely do not envy anyone who has to manually do this protocol, but am impressed that it was made to work!

"Reverse translation" for protein sequencing: turning Edman degradation products into DNA sequence! I definitely do not envy anyone who has to manually do this protocol, but am impressed that it was made to work!

76,007 Aufrufe • vor 2 Jahren

Calling of all 20 amino acids by nanopore! An exciting step toward nanopore protein sequencing Beautiful work from Shuo Huang’s group at Nanjing University

Calling of all 20 amino acids by nanopore! An exciting step toward nanopore protein sequencing Beautiful work from Shuo Huang’s group at Nanjing University

91,898 Aufrufe • vor 2 Jahren

Really exciting to see ML tackle protein interactions with increasing success. A breakdown of the latest paper from Bruno Correia‘s lab:

Really exciting to see ML tackle protein interactions with increasing success. A breakdown of the latest paper from Bruno Correia‘s lab:

97,755 Aufrufe • vor 3 Jahren

Really enjoyed this paper! A very cool way to explore the protein sequence landscape.

Really enjoyed this paper! A very cool way to explore the protein sequence landscape.

95,765 Aufrufe • vor 3 Jahren

I've been waiting for the day I could make this video! Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too. Awesome work from Jonathan Gootenberg Omar Abudayyeh Chris Fell Lukas Villiger in nature

I've been waiting for the day I could make this video! Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too. Awesome work from Jonathan Gootenberg Omar Abudayyeh Chris Fell Lukas Villiger in nature

41,304 Aufrufe • vor 1 Jahr

Making CAR T cells in vivo (& with a TRAC knockout) using a new cell type-specific delivery vehicle! Cool study from @doudna_lab in Nature Biotechnology

Making CAR T cells in vivo (& with a TRAC knockout) using a new cell type-specific delivery vehicle! Cool study from @doudna_lab in Nature Biotechnology

68,087 Aufrufe • vor 2 Jahren

The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine

The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine

30,119 Aufrufe • vor 9 Monaten

CAR T cells to reverse - and even prevent - aging phenotypes! The CAR Ts target uPAR, which is upregulated in senescent cells. Treated mice see metabolic improvements & better exercise capacity, & this can work prophylactically, too: treat young mice, and the have better glucose regulation into old age!

CAR T cells to reverse - and even prevent - aging phenotypes! The CAR Ts target uPAR, which is upregulated in senescent cells. Treated mice see metabolic improvements & better exercise capacity, & this can work prophylactically, too: treat young mice, and the have better glucose regulation into old age!

59,821 Aufrufe • vor 2 Jahren

How many proteins could be degraded by molecular glues? New paper from the team at Monte Rosa Therapeutics, Inc suggests it's more than previously thought! Study led by Georg Petzold Pablo Gainza-Cirauqui John Castle & others

How many proteins could be degraded by molecular glues? New paper from the team at Monte Rosa Therapeutics, Inc suggests it's more than previously thought! Study led by Georg Petzold Pablo Gainza-Cirauqui John Castle & others

43,516 Aufrufe • vor 1 Jahr

Evo: a foundation model for genomics! Using a well suited architecture, Evo learns from billions of bp of genomic sequence and performs well on several zero-shot prediction tasks on RNA, DNA and protein. Beautiful paper from Brian Hie & Patrick Hsu at Arc Institute

Evo: a foundation model for genomics! Using a well suited architecture, Evo learns from billions of bp of genomic sequence and performs well on several zero-shot prediction tasks on RNA, DNA and protein. Beautiful paper from Brian Hie & Patrick Hsu at Arc Institute

52,245 Aufrufe • vor 2 Jahren

ecDNA biology is one of those weird, fascinating corners of bio that hook me every time there's a new result. So I loved reading about this one from Howard Chang & Paul Mischel's labs in nature. Very interesting implications for design of non-diluting, non-integrating gene therapy vectors! Great work Venkat & King L Hung 😀

ecDNA biology is one of those weird, fascinating corners of bio that hook me every time there's a new result. So I loved reading about this one from Howard Chang & Paul Mischel's labs in nature. Very interesting implications for design of non-diluting, non-integrating gene therapy vectors! Great work Venkat & King L Hung 😀

17,247 Aufrufe • vor 6 Monaten