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Julia Bauman

@JuliaBauman2 • 10,453 subscribers

PhD student at @Stanford Genetics in @LarsMSteinmetz lab Explaining cool biotech to the world here and @ 60_SecondScience on TikTok

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A new paper shows that personalized pancreatic cancer vaccines can keep patients cancer-free for YEARS - an incredible outcome for a cancer with only a 7% 5-year survival rate.

A new paper shows that personalized pancreatic cancer vaccines can keep patients cancer-free for YEARS - an incredible outcome for a cancer with only a 7% 5-year survival rate.

223,051 görüntüleme • 1 yıl önce

A nanobody PD-L1 inhibitor that covalently inhibits PD-L1, resulting in improved tumor suppression in mice And a nice screening platform for generating more such covalent drugs! Check out the paper in Science Magazine ⬇️

A nanobody PD-L1 inhibitor that covalently inhibits PD-L1, resulting in improved tumor suppression in mice And a nice screening platform for generating more such covalent drugs! Check out the paper in Science Magazine ⬇️

54,174 görüntüleme • 4 ay önce

I’ve been super into the idea of intracellular molecular recording to measure cell dynamics, but this tech offers an interesting alternative: make the cells give you a sample!

I’ve been super into the idea of intracellular molecular recording to measure cell dynamics, but this tech offers an interesting alternative: make the cells give you a sample!

171,896 görüntüleme • 3 yıl önce

You’ve probably all seen the see-through mouse by now. Here’s a little more detail on how this optical trick works! Amazing work from HongLab in Science Magazine

You’ve probably all seen the see-through mouse by now. Here’s a little more detail on how this optical trick works! Amazing work from HongLab in Science Magazine

111,276 görüntüleme • 2 yıl önce

Hoping to majorly scale up some single-cell experiments using this tech!

Hoping to majorly scale up some single-cell experiments using this tech!

160,924 görüntüleme • 3 yıl önce

Discovery of a new class of antibiotic using AI, shown to be effective against MRSA in mice! Incredibly cool work from Jim Collins’s lab at Massachusetts Institute of Technology (MIT) in nature

Discovery of a new class of antibiotic using AI, shown to be effective against MRSA in mice! Incredibly cool work from Jim Collins’s lab at Massachusetts Institute of Technology (MIT) in nature

93,453 görüntüleme • 2 yıl önce

What good is a science communication channel if you don't get to talk about your own papers on it occasionally, right?😊 We developed a method to simultaneously sequence single-cell DNA and RNA targets, enabling association of genomic variants (including non-coding!) with gene expression changes. Out today in Nature Methods, from Lars Steinmetz lab led by Dominik Lindenhofer! Link below⬇️

What good is a science communication channel if you don't get to talk about your own papers on it occasionally, right?😊 We developed a method to simultaneously sequence single-cell DNA and RNA targets, enabling association of genomic variants (including non-coding!) with gene expression changes. Out today in Nature Methods, from Lars Steinmetz lab led by Dominik Lindenhofer! Link below⬇️

47,351 görüntüleme • 1 yıl önce

"Reverse translation" for protein sequencing: turning Edman degradation products into DNA sequence! I definitely do not envy anyone who has to manually do this protocol, but am impressed that it was made to work!

"Reverse translation" for protein sequencing: turning Edman degradation products into DNA sequence! I definitely do not envy anyone who has to manually do this protocol, but am impressed that it was made to work!

76,027 görüntüleme • 2 yıl önce

Calling of all 20 amino acids by nanopore! An exciting step toward nanopore protein sequencing Beautiful work from Shuo Huang’s group at Nanjing University

Calling of all 20 amino acids by nanopore! An exciting step toward nanopore protein sequencing Beautiful work from Shuo Huang’s group at Nanjing University

91,907 görüntüleme • 3 yıl önce

As promised, an overview of Roche 's new sequencing tech. Comparable to Illumina NGS in accuracy & read length, but FAST - 5B reads in an hour!

As promised, an overview of Roche 's new sequencing tech. Comparable to Illumina NGS in accuracy & read length, but FAST - 5B reads in an hour!

56,494 görüntüleme • 1 yıl önce

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

45,595 görüntüleme • 1 yıl önce

Really exciting to see ML tackle protein interactions with increasing success. A breakdown of the latest paper from Bruno Correia‘s lab:

Really exciting to see ML tackle protein interactions with increasing success. A breakdown of the latest paper from Bruno Correia‘s lab:

97,761 görüntüleme • 3 yıl önce

Really enjoyed this paper! A very cool way to explore the protein sequence landscape.

Really enjoyed this paper! A very cool way to explore the protein sequence landscape.

95,771 görüntüleme • 3 yıl önce

Making CAR T cells in vivo (& with a TRAC knockout) using a new cell type-specific delivery vehicle! Cool study from @doudna_lab in Nature Biotechnology

Making CAR T cells in vivo (& with a TRAC knockout) using a new cell type-specific delivery vehicle! Cool study from @doudna_lab in Nature Biotechnology

68,133 görüntüleme • 2 yıl önce

I've been waiting for the day I could make this video! Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too. Awesome work from Jonathan Gootenberg Omar Abudayyeh Chris Fell Lukas Villiger in nature

I've been waiting for the day I could make this video! Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too. Awesome work from Jonathan Gootenberg Omar Abudayyeh Chris Fell Lukas Villiger in nature

41,361 görüntüleme • 1 yıl önce

CAR T cells to reverse - and even prevent - aging phenotypes! The CAR Ts target uPAR, which is upregulated in senescent cells. Treated mice see metabolic improvements & better exercise capacity, & this can work prophylactically, too: treat young mice, and the have better glucose regulation into old age!

CAR T cells to reverse - and even prevent - aging phenotypes! The CAR Ts target uPAR, which is upregulated in senescent cells. Treated mice see metabolic improvements & better exercise capacity, & this can work prophylactically, too: treat young mice, and the have better glucose regulation into old age!

59,914 görüntüleme • 2 yıl önce

The most beautiful molecular recorder 😍 GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo! From Dingchang Lin's lab in nature

The most beautiful molecular recorder 😍 GEMINI is a self-assembling protein system that records cellular events as physical layers, readable via imaging. Achieves down to 15 min resolution and works nicely in vivo! From Dingchang Lin's lab in nature

18,765 görüntüleme • 6 ay önce

How many proteins could be degraded by molecular glues? New paper from the team at Monte Rosa Therapeutics, Inc suggests it's more than previously thought! Study led by Georg Petzold Pablo Gainza-Cirauqui John Castle & others

How many proteins could be degraded by molecular glues? New paper from the team at Monte Rosa Therapeutics, Inc suggests it's more than previously thought! Study led by Georg Petzold Pablo Gainza-Cirauqui John Castle & others

44,101 görüntüleme • 1 yıl önce

The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine

The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine

30,194 görüntüleme • 1 yıl önce

Evo: a foundation model for genomics! Using a well suited architecture, Evo learns from billions of bp of genomic sequence and performs well on several zero-shot prediction tasks on RNA, DNA and protein. Beautiful paper from Brian Hie & Patrick Hsu at Arc Institute

Evo: a foundation model for genomics! Using a well suited architecture, Evo learns from billions of bp of genomic sequence and performs well on several zero-shot prediction tasks on RNA, DNA and protein. Beautiful paper from Brian Hie & Patrick Hsu at Arc Institute

52,395 görüntüleme • 2 yıl önce