Nick Norwitz MD PhD
@nicknorwitz • 125,704 subscribers
MD, PhD. Harvard, Oxford. Educator. Professional Guinea Pig. StayCurious Metabolism Letter, Top Best-Seller in Science 🔗 https://t.co/YoPdkV719L
Shorts
![“Definitely Do Not Stop Statins.” — Bryan Johnson “I’m not the best person to make these arguments [about statins].” — also Bryan Johnson Seems inconsistent 🤔 I’d politely suggest you walk back your stance or admit to overstepping on your blunt recommendation. I’d be happy to have a conversation with you or your team on the matter of precision and personal prescription of lipid-modifying medication. I think you’ll find my stance rather moderate & reasonable. 3000 word deep dive here: Cc More Plates More Dates](https://image.24vids.com/tw-2010703895073317110/amplify_video_thumb/2010703838672556032/img/jFruNvWeE1AiBddM.jpg)
Videos
Tesamorelin might be one of the most interesting and underappreciated peptides, with the potential not only to reduce visceral fat and promote muscle growth, but also to improve deep sleep and perhaps even longevity—if used smartly. (PMID: 18057338, PMID: 41851466, more below)
Nick Norwitz MD PhD62,476 Aufrufe • vor 8 Tagen
🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔
Nick Norwitz MD PhD3,217,473 Aufrufe • vor 2 Jahren
If you take supplements, we'd love your help with something. (NOT a sales pitch 👀) Stanford University's Professor Michael Snyder—probably the world's leading metabolism researchers (see below)—is building a resource to help you choose the best supplements. Here's the problem. Right now, supplement information is scattered across podcasts, marketing websites, and social media. It's incredibly difficult to separate genuine science from hype. I know. I myself spend hours trying to source the best products… and it can be difficult to follow the breadcrumb trail. So, Michael Snyder (Michael Snyder, PhD) and the Stanford Snyder Lab are trying to build something better: A living database where anyone can quickly see what the science says, learn from the experiences of thousands of other people, and ultimately make more informed decisions. 🚨HERE: 👉This is NOT a sales pitch to buy anything. 👉This is an altruistic project to help you. 👉And – ultimately – help spinoff into robust human studies around this information. There are so many unanswered questions: 🤔How well does pinealon actually help REM sleep? 🤔Will 5-amino-1MQ fundamentally change energy metabolism in aging humans? I could go on… 🤔Would tadalafil + taurine really boost cardiovascular health or athletic performance? 🤔What's the real effect of melatonin-maxxing? Abud Bakri MD 🤔What supplements would help with autoimmune disease? Bryan Johnson But here's the thing: this only works if people contribute. If you've ever taken a supplement—even something as simple as creatine, magnesium, vitamin D, fish oil, or berberine—you can help. Add what you've taken. Share your experience. It only takes a couple of minutes (click the link 🔗 above), and every contribution makes the database more useful for everyone else. This is YOUR chance to get your questions answered. Also, let’s be clear: I’m NOT being compensated to share this message. I’m doing it because it’s a project I want to support. If you want to support it too, just give this a re-post and spread the word. Maybe repost with a supplement you want more deeply investigated? This is Citizen Science meeting one of the top science labs in the world. Take the opportunity! Post-Script... A bit more about Michael Snyder (in my own words) 😊 And a note, I'm not being hyperbolic when I say Michael Snyder is one of the world's leading biomedical and metabolism researchers. By almost any academic metric, he's in rare company: an h-index of 228, an i10-index of 872, and more than 266,000 scientific citations—including over 100,000 citations in the past five years alone. His work spans virtually every premier scientific journal, including Science, Cell, Nature, and many others. But what impresses me even more than his scientific accomplishments is who he is as a person. Despite a career that has made him an academic legend, he's remained remarkably humble, genuinely curious, and deeply kind. Everyone I've spoken to who knows Michael (including Andrew D. Huberman, Ph.D., who had him on the podcast) says the same thing: he's simply a good human being. Do a good thing - and help yourself in the process.
Nick Norwitz MD PhD43,695 Aufrufe • vor 13 Tagen
This is what a ketogenic diet does to mitochondria (ft Benjamin Bikman)
Nick Norwitz MD PhD24,973 Aufrufe • vor 7 Tagen
If you have high Lp(a), like me, here are 5 things you need to know to protect your heart: 1. Lp(a) is ~90% genetic. While it can be influenced at the margins (e.g. inflammation), most people have a genetic “floor.” I inherited mine from my father. Do you know yours? 2. Your genes may be fixed—but your jeans aren’t. Specifically, visceral fat matters. People with low waist-to-hip ratios, a proxy for less visceral fat, often show little to no added cardiovascular risk from high Lp(a). Why? Because Lp(a) interacts with the metabolic environment. 3. Medications matter. Statins can increase Lp(a), while PCSK9 inhibitors tend to decrease it. 4. Vitamin C may help reduce the atherogenicity of Lp(a) by working inside the lumen of blood vessels and inside artery walls 5. Ketogenic diets may also reduce Lp(a)-related risk—working inside the artery to lower inflammation, oxidative stress, and depletion of key cofactors caused by Lp(a). This is the Cliff Notes version. For the full deep dives—10,000+ words of nuance, mechanisms, and references—check the comments and stay curious.
Nick Norwitz MD PhD111,704 Aufrufe • vor 3 Monaten
🔥 Why I’m Committed to Making Metabolic Health Mainstream (in 2 min) 🔥 From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose. Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone... I need an army of Metabolic Health Enthusiasts —people who are ready to go beyond investing in their own health to help change the culture, disrupt norms, and provoke hard but necessary discussions Watch this 2-minute video, and if my story resonates with you, I invite you to join me on this journey. ⁉️Ask Hard Questions, Authentically 🫂Support Your Fellow Metabolic Health Enthusiasts 🤔Engage. Give Feedback! 🗣️Share this message and share your story! Together, we can make Metabolic Health a Movement that transforms lives. #MetabolicHealth #StayCurious
Nick Norwitz MD PhD443,020 Aufrufe • vor 1 Jahr
Video of a guy trying to do 100 push-ups went viral. I'm just a lab nerd, but I thought I give it a whirl. Maybe my form could have been better on a few, but it's been a while. Oh, and wait for the end... cc Pяom Pяom🌚 UGO & The Big Steppers Abud Bakri MD
Nick Norwitz MD PhD72,597 Aufrufe • vor 3 Monaten
🚨This is crazy—and you haven’t seen it. A Stanford randomized controlled trial found that high-dose of a specific soluble fiber increased liver injury markers (ALT) in some people. The trial was stopped early for safety in a subset of participants. Let your brain ferment that. For more fiber nuance, check out today's interview with Dr. Andrew Koutnik, Ph.D. ... if you're brain is constipated, he's like heavy dose ex-lax
Nick Norwitz MD PhD133,092 Aufrufe • vor 7 Monaten
Brand-new research (PMID: 42102814) has uncovered a bizarre link between a compound found in aged garlic and longevity. 🧄 It's called: S1PC. Remarkably, it causes fat cells to release tiny vesicles carrying an enzyme that travels to the brain, boosting levels of the energy molecule NAD in just minutes. In animal studies, this reduced frailty and even increased muscle strength through a previously unrecognized brain-to-muscle circuit. In the full deep dive, we unpack the mechanism, the animal data, and what—if anything—it could mean for humans. You won't want to miss this one... unless you're a vampire. 🧄 Deep dive linked below
Nick Norwitz MD PhD15,234 Aufrufe • vor 17 Tagen
Statins Slash GLP-1: (~10-minute Data Digest for X) Human trial data published in a major journal show that statins cause insulin resistance and deplete GLP-1 levels in humans. This should have been breaking news... But no one talked about it. Why don’t doctors know? Why aren’t patients being informed about the risks? PLEASE really listen to what I’m saying and why I’m upset. It’s more nuanced than scaremongering about medications or economic conspiracy theories. 🔁If you care, share (retweet and tag your favorite, or least favorite, health influencer) 🔗Links to the YouTube video, Substack article, and Instagram posts in first comment. - Cell Metabolism (PMID: 38325336)
Nick Norwitz MD PhD168,567 Aufrufe • vor 11 Monaten
Calories don’t cause obesity any more than an odometer causes driving. The persistence of the CICO mindset isn’t due to rigorous intellectual debate among competing models — it’s due to confusion. CICO isn’t a model of obesity. It’s a circular thinking masquerading as science.
Nick Norwitz MD PhD138,326 Aufrufe • vor 9 Monaten
Cardiology has become obsessed with the mantra “lower is better.” Lower LDL, lower ApoB, and you're going to be better off. This simple tagline misses the forest for a stupid little cholesterol shrub. It’s well known that intervening to lower LDL and ApoB doesn’t necessarily result in better overall outcomes for the whole person, even in circumstances where cardiovascular risk might be reduced. It's therefore incredibly sad when "certain cardiologist experts" (heavy quotes there) make false claims like: "people with a PCSK9 loss of function mutation have very low LDL-C and live 15-20 years longer than those who don't. And we have meds now that cause that effect." That nonsense I could forgive. What is far more troubling is that there's a general failure to challange problematic (and sometimes outright false) narratives like this provided they align with the status quo, even when the status quo has failed public health miserably. We need to broaden the aperture of the discussion because the "science is not settled." Below is an excerpt from this morning video on the lipid marker linked to longevity (not LDL or ApoB): 🚨Then, of course, watch The Cholesterol Code movie on Amazon and leave a review! #CholesterolCodeMovie Dave Feldman
Nick Norwitz MD PhD56,203 Aufrufe • vor 3 Monaten
This is—without a doubt—the longest I’ve ever sat on a video before releasing it. Because once I open this Pandora’s box, there’s no closing it. 🚨Full Video: In this video, I share my personal decision to walk around with an LDL of 574 mg/dl and a total cholesterol over 700. But this isn’t about one biomarker, or one study. Decisions about whether to act, when to act, and how to act aren’t simple math problems. Individual complexity and thoughtful consideration can turn what looks like a straightforward equation into something far more nuanced. 🚨This video isn’t about telling you what to think—it’s about showing you how I think. It’s not about dogma or conspiracy. It’s about authenticity, transparency, and the kind of nuanced conversations we need to have if we’re going to approach this topic responsibly. And I say that without irony. If you watch all the way through—rather than jumping to conclusions—you might be surprised by where I land… and what I’m planning next. We don't need to agree. We do need to be willing to keep our eyes, ears, and hearts open to new data and divergent opinions. cc Dave Feldman Adrian Soto-Mota Bret Scher, MD Dr Aseem Malhotra Jan Ellison Baszucki Metabolic Mind Coalition for Metabolic Health Austin Dudzinski, PharmD, BCACP Eric Rodgers Andrew Koutnik, Ph.D. Peter Attia (I'm sure we'll have a productive and cordial chat one day)
Nick Norwitz MD PhD138,523 Aufrufe • vor 9 Monaten
![Cardiology Has an LDL Obsession. What to Measure Instead... 🔗New video: 👇1 min clip on LDL vs Insulin Resistance The landscape of atherosclerosis is changing. New drugs are lowering LDL, total cholesterol and ApoB lower and lower, while larger risk factors like insulin resistance, obesity, and diabetes persist. If you want a comparison, lipoprotein insulin resistance score (LP-IR). Because 1.0 is risk neutral, insulin resistance score is a more than 14X more powerful predictor of new coronary heart disease than LDL. But we know who gets all the attention. Answer: [See Clip] That’s not proportional medicine Do you agree? For more nuances see the video linked above. cc Benjamin Bikman Dave Feldman](https://image.24vids.com/tw-2018299690681286688/amplify_video_thumb/2018298809382514688/img/bQXfdKFsJiD5wh3_.jpg)
Cardiology Has an LDL Obsession. What to Measure Instead... 🔗New video: 👇1 min clip on LDL vs Insulin Resistance The landscape of atherosclerosis is changing. New drugs are lowering LDL, total cholesterol and ApoB lower and lower, while larger risk factors like insulin resistance, obesity, and diabetes persist. If you want a comparison, lipoprotein insulin resistance score (LP-IR). Because 1.0 is risk neutral, insulin resistance score is a more than 14X more powerful predictor of new coronary heart disease than LDL. But we know who gets all the attention. Answer: [See Clip] That’s not proportional medicine Do you agree? For more nuances see the video linked above. cc Benjamin Bikman Dave Feldman
Nick Norwitz MD PhD77,831 Aufrufe • vor 5 Monaten
🚀Did your #LDL cholesterol sky-rocket on #keto? 🧈Were you told it' was because of Saturated Fat? 🚨NEW META OF 41 RCTs just busted that MYTH! 3 Main findings 👉 In studies with 'lean' BMI ( 35), LDL-C ⬇️ 💥BOOM, there's a money shot!💥 👉 Inverse association between BMI and LDL-C 👉 BMI dominates over saturated fat, which has comparatively minimal impact; thus, it's more likely having 6-pack abs is a severe risk factor for high LDL-C on #keto, not butter, beef, bacon or cream 🔗PAPER LINK 🔗 - (To share the data love, copy this link to a Quote tweet or original Tweet with your reaction. Please engage!) FULL Video Abstract (7 min): Major props to first-author Adrian Soto-Mota and senior Dr. David Ludwig. These man are humble & kind geniuses that I'm privileged to know and learn under And +100 pts for the #LEM ⚡️ Dave Feldman Of interest to More Plates More Dates Peter Attia @PlantChompers and Walter Willett (if he had a Twitter) Simon Hill MSc, BSc Thomas Dayspring William Cromwell, MD LipoFan Andrew D. Huberman, Ph.D. Dominic D'Agostino Layne Norton, PhD Metabolic Health Summit
Nick Norwitz MD PhD269,263 Aufrufe • vor 2 Jahren
Ezetimibe cut my LDL by 56%. But that wasn't the point...
Nick Norwitz MD PhD38,970 Aufrufe • vor 3 Monaten