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Nick Norwitz MD PhD

@nicknorwitz • 123,564 subscribers

MD, PhD. Harvard, Oxford. Educator. Professional Guinea Pig. StayCurious Metabolism Letter, Top Best-Seller in Science 🔗 https://t.co/YoPdkV719L

Shorts

🥓I Ate 600 Strips of Bacon 🥓 🫀Here’s What Happened to My Cholesterol🫀 1/4) In an N =1 experiment modeled on the #720Eggs Eggperiment, I dropped my LDL by 22% while eating 600 strips of bacon over 20 days. That’s 21,000 Calories from bacon while eating ~300 grams of fat per day, and buckets of saturated fat, and I was able to drop my cholesterol. Here’s what you need to know…

🥓I Ate 600 Strips of Bacon 🥓 🫀Here’s What Happened to My Cholesterol🫀 1/4) In an N =1 experiment modeled on the #720Eggs Eggperiment, I dropped my LDL by 22% while eating 600 strips of bacon over 20 days. That’s 21,000 Calories from bacon while eating ~300 grams of fat per day, and buckets of saturated fat, and I was able to drop my cholesterol. Here’s what you need to know…

476,576 views

700 Cholesterol 0 mm3 Plaque (CCTA + Heartflow) The scan we review in today’s video (🔗 below) is not your average CAC scan. It quantifies both calcified and soft plaque throughout the arteries. And importantly, “he’s young” is not a sufficient explanation. 👉People in their 20s and 30s commonly show measurable plaque on these scans. 👉There are even well-known plant-based influencers in their 30s with a decent amount of plaque 👉Children with homozygous familial hypercholesterolemia as young as a year or two can already demonstrate advanced plaque burden with LDL levels similar to mine. The irrefutable reality is that elevated LDL and ApoB do not translate into identical plaque progression in every individual. That is 100% a fact. Understanding the biological differences that make some people dramatically more or less susceptible than others is absolutely critical to precision medicine. Anyone pretending these individual differences do not matter is ignoring reality. Anyone who protests again asking questions that need to be answered is a problem.

700 Cholesterol 0 mm3 Plaque (CCTA + Heartflow) The scan we review in today’s video (🔗 below) is not your average CAC scan. It quantifies both calcified and soft plaque throughout the arteries. And importantly, “he’s young” is not a sufficient explanation. 👉People in their 20s and 30s commonly show measurable plaque on these scans. 👉There are even well-known plant-based influencers in their 30s with a decent amount of plaque 👉Children with homozygous familial hypercholesterolemia as young as a year or two can already demonstrate advanced plaque burden with LDL levels similar to mine. The irrefutable reality is that elevated LDL and ApoB do not translate into identical plaque progression in every individual. That is 100% a fact. Understanding the biological differences that make some people dramatically more or less susceptible than others is absolutely critical to precision medicine. Anyone pretending these individual differences do not matter is ignoring reality. Anyone who protests again asking questions that need to be answered is a problem.

13,468 views

Working on 6,000 Calorie diet I can maintain for overfeeding n = 1 study Breakfast: 10 eggs cooked in 3 Tbsp Macadamia Oil with 8 Tbsp Macadamia Butter Calories: 1936 - Fat: 178 g (83 %kCal) - Protein: 68 g - Carbs, net: 16 g Plan to finish jar of macadamia butter and eat 2 Ketobricks Robert Sikes | Natural Bodybuilder 💪, which will bring me to 4,792. Then large ribeye and EVOO should break 6,000. Butter vs Celery video: WHY? Want to try to Drop LDL while keto with "excess" fat, i.e. "hypercaloric..." but evidently my body could compensate at 4,300 Cal ( so need to go higher... Goodness doing #CICO "right" is really hard 😜 P.S. Omega-7 video: House of Macadamias Brandon Hiemstra -15% Off All Bundles -10% off any item (non-bundle) with code "NICK10"

Working on 6,000 Calorie diet I can maintain for overfeeding n = 1 study Breakfast: 10 eggs cooked in 3 Tbsp Macadamia Oil with 8 Tbsp Macadamia Butter Calories: 1936 - Fat: 178 g (83 %kCal) - Protein: 68 g - Carbs, net: 16 g Plan to finish jar of macadamia butter and eat 2 Ketobricks Robert Sikes | Natural Bodybuilder 💪, which will bring me to 4,792. Then large ribeye and EVOO should break 6,000. Butter vs Celery video: WHY? Want to try to Drop LDL while keto with "excess" fat, i.e. "hypercaloric..." but evidently my body could compensate at 4,300 Cal ( so need to go higher... Goodness doing #CICO "right" is really hard 😜 P.S. Omega-7 video: House of Macadamias Brandon Hiemstra -15% Off All Bundles -10% off any item (non-bundle) with code "NICK10"

188,082 views

“Definitely Do Not Stop Statins.” — Bryan Johnson “I’m not the best person to make these arguments [about statins].” — also Bryan Johnson Seems inconsistent 🤔 I’d politely suggest you walk back your stance or admit to overstepping on your blunt recommendation. I’d be happy to have a conversation with you or your team on the matter of precision and personal prescription of lipid-modifying medication. I think you’ll find my stance rather moderate & reasonable. 3000 word deep dive here: Cc More Plates More Dates

“Definitely Do Not Stop Statins.” — Bryan Johnson “I’m not the best person to make these arguments [about statins].” — also Bryan Johnson Seems inconsistent 🤔 I’d politely suggest you walk back your stance or admit to overstepping on your blunt recommendation. I’d be happy to have a conversation with you or your team on the matter of precision and personal prescription of lipid-modifying medication. I think you’ll find my stance rather moderate & reasonable. 3000 word deep dive here: Cc More Plates More Dates

31,332 views

The BIG mental health headline of last week comes from a new clinical study published in Translational Psychiatry: a #KetogenicDiet appears to be highly effective in treating depression among college students. 1/6) 🧵This thread will walk you through the major positive findings. And at the end I’ll direct you to content where you can learn more about the mechanisms by which ketones heal the brain, metabolic psychiatry, and new basic science data that will (or should) blow your mind 🔗 To the full breakdown, mechanistic discussion, paper, and more Metabolic Psychiatry content below in 5/6 and 6/6 cc Jan Ellison Baszucki David Baszucki Dave Feldman Chris Palmer, MD Benjamin Bikman Andrew Koutnik, Ph.D. Eric Rodgers Coalition for Metabolic Health

The BIG mental health headline of last week comes from a new clinical study published in Translational Psychiatry: a #KetogenicDiet appears to be highly effective in treating depression among college students. 1/6) 🧵This thread will walk you through the major positive findings. And at the end I’ll direct you to content where you can learn more about the mechanisms by which ketones heal the brain, metabolic psychiatry, and new basic science data that will (or should) blow your mind 🔗 To the full breakdown, mechanistic discussion, paper, and more Metabolic Psychiatry content below in 5/6 and 6/6 cc Jan Ellison Baszucki David Baszucki Dave Feldman Chris Palmer, MD Benjamin Bikman Andrew Koutnik, Ph.D. Eric Rodgers Coalition for Metabolic Health

13,875 views

🔥Inflammation Causes Anxiety: Root Cause and Cure (video link in first reply) What causes anxiety? An underappreciated truth is that behavioral states and emotions — including anxiety — can be the consequence of a metabolic state. New data show how inflammation can act directly on the brain to promote anxiety. In today’s video, we will break down these new findings and provide practical tip and takeaways because “Mental health is Metabolic health, and Metabolic Health is Mental Health.” Treat the body to treat the mind.

🔥Inflammation Causes Anxiety: Root Cause and Cure (video link in first reply) What causes anxiety? An underappreciated truth is that behavioral states and emotions — including anxiety — can be the consequence of a metabolic state. New data show how inflammation can act directly on the brain to promote anxiety. In today’s video, we will break down these new findings and provide practical tip and takeaways because “Mental health is Metabolic health, and Metabolic Health is Mental Health.” Treat the body to treat the mind.

11,745 views

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🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

Nick Norwitz MD PhD

3,217,104 views • 2 years ago

If you have high Lp(a), like me, here are 5 things you need to know to protect your heart: 1. Lp(a) is ~90% genetic. While it can be influenced at the margins (e.g. inflammation), most people have a genetic “floor.” I inherited mine from my father. Do you know yours? 2. Your genes may be fixed—but your jeans aren’t. Specifically, visceral fat matters. People with low waist-to-hip ratios, a proxy for less visceral fat, often show little to no added cardiovascular risk from high Lp(a). Why? Because Lp(a) interacts with the metabolic environment. 3. Medications matter. Statins can increase Lp(a), while PCSK9 inhibitors tend to decrease it. 4. Vitamin C may help reduce the atherogenicity of Lp(a) by working inside the lumen of blood vessels and inside artery walls 5. Ketogenic diets may also reduce Lp(a)-related risk—working inside the artery to lower inflammation, oxidative stress, and depletion of key cofactors caused by Lp(a). This is the Cliff Notes version. For the full deep dives—10,000+ words of nuance, mechanisms, and references—check the comments and stay curious.

If you have high Lp(a), like me, here are 5 things you need to know to protect your heart: 1. Lp(a) is ~90% genetic. While it can be influenced at the margins (e.g. inflammation), most people have a genetic “floor.” I inherited mine from my father. Do you know yours? 2. Your genes may be fixed—but your jeans aren’t. Specifically, visceral fat matters. People with low waist-to-hip ratios, a proxy for less visceral fat, often show little to no added cardiovascular risk from high Lp(a). Why? Because Lp(a) interacts with the metabolic environment. 3. Medications matter. Statins can increase Lp(a), while PCSK9 inhibitors tend to decrease it. 4. Vitamin C may help reduce the atherogenicity of Lp(a) by working inside the lumen of blood vessels and inside artery walls 5. Ketogenic diets may also reduce Lp(a)-related risk—working inside the artery to lower inflammation, oxidative stress, and depletion of key cofactors caused by Lp(a). This is the Cliff Notes version. For the full deep dives—10,000+ words of nuance, mechanisms, and references—check the comments and stay curious.

Nick Norwitz MD PhD

111,286 views • 2 months ago

Video of a guy trying to do 100 push-ups went viral. I'm just a lab nerd, but I thought I give it a whirl. Maybe my form could have been better on a few, but it's been a while. Oh, and wait for the end... cc Pяom Pяom🌚 UGO & The Big Steppers Abud Bakri MD

Video of a guy trying to do 100 push-ups went viral. I'm just a lab nerd, but I thought I give it a whirl. Maybe my form could have been better on a few, but it's been a while. Oh, and wait for the end... cc Pяom Pяom🌚 UGO & The Big Steppers Abud Bakri MD

Nick Norwitz MD PhD

71,888 views • 1 month ago

Gene Editing For LDL Lowering in 5 minutes 👇 I’d appreciate if those interested in the new VERVE-102 / PCSK9 Gene Editing for Cholesterol research take 5 minutes to hear me out on why this is a breakthrough. People are missing key details and the bigger story. Cc Dave Feldman Austin Dudzinski, PharmD, BCACP Abud Bakri MD NEJM Dr. David Ludwig Dr David Unwin Louisa Nicola Hundred Health Darius Sharpe Dr Shawn Baker 🥩 Jan Ellison Baszucki Bret Scher, MD Benjamin Bikman Eric Rodgers

Gene Editing For LDL Lowering in 5 minutes 👇 I’d appreciate if those interested in the new VERVE-102 / PCSK9 Gene Editing for Cholesterol research take 5 minutes to hear me out on why this is a breakthrough. People are missing key details and the bigger story. Cc Dave Feldman Austin Dudzinski, PharmD, BCACP Abud Bakri MD NEJM Dr. David Ludwig Dr David Unwin Louisa Nicola Hundred Health Darius Sharpe Dr Shawn Baker 🥩 Jan Ellison Baszucki Bret Scher, MD Benjamin Bikman Eric Rodgers

Nick Norwitz MD PhD

13,295 views • 8 days ago

Wait?! What if we are wrong? What if we’re hurting millions of people?!? Listen to my rant and let me know when it clicks👇 cc Dave Feldman

Wait?! What if we are wrong? What if we’re hurting millions of people?!? Listen to my rant and let me know when it clicks👇 cc Dave Feldman

Nick Norwitz MD PhD

56,064 views • 1 month ago

Cardiology has become obsessed with the mantra “lower is better.” Lower LDL, lower ApoB, and you're going to be better off. This simple tagline misses the forest for a stupid little cholesterol shrub. It’s well known that intervening to lower LDL and ApoB doesn’t necessarily result in better overall outcomes for the whole person, even in circumstances where cardiovascular risk might be reduced. It's therefore incredibly sad when "certain cardiologist experts" (heavy quotes there) make false claims like: "people with a PCSK9 loss of function mutation have very low LDL-C and live 15-20 years longer than those who don't. And we have meds now that cause that effect." That nonsense I could forgive. What is far more troubling is that there's a general failure to challange problematic (and sometimes outright false) narratives like this provided they align with the status quo, even when the status quo has failed public health miserably. We need to broaden the aperture of the discussion because the "science is not settled." Below is an excerpt from this morning video on the lipid marker linked to longevity (not LDL or ApoB): 🚨Then, of course, watch The Cholesterol Code movie on Amazon and leave a review! #CholesterolCodeMovie Dave Feldman

Cardiology has become obsessed with the mantra “lower is better.” Lower LDL, lower ApoB, and you're going to be better off. This simple tagline misses the forest for a stupid little cholesterol shrub. It’s well known that intervening to lower LDL and ApoB doesn’t necessarily result in better overall outcomes for the whole person, even in circumstances where cardiovascular risk might be reduced. It's therefore incredibly sad when "certain cardiologist experts" (heavy quotes there) make false claims like: "people with a PCSK9 loss of function mutation have very low LDL-C and live 15-20 years longer than those who don't. And we have meds now that cause that effect." That nonsense I could forgive. What is far more troubling is that there's a general failure to challange problematic (and sometimes outright false) narratives like this provided they align with the status quo, even when the status quo has failed public health miserably. We need to broaden the aperture of the discussion because the "science is not settled." Below is an excerpt from this morning video on the lipid marker linked to longevity (not LDL or ApoB): 🚨Then, of course, watch The Cholesterol Code movie on Amazon and leave a review! #CholesterolCodeMovie Dave Feldman

Nick Norwitz MD PhD

55,569 views • 1 month ago

🔥 Why I’m Committed to Making Metabolic Health Mainstream (in 2 min) 🔥 From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose. Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone... I need an army of Metabolic Health Enthusiasts —people who are ready to go beyond investing in their own health to help change the culture, disrupt norms, and provoke hard but necessary discussions Watch this 2-minute video, and if my story resonates with you, I invite you to join me on this journey. ⁉️Ask Hard Questions, Authentically 🫂Support Your Fellow Metabolic Health Enthusiasts 🤔Engage. Give Feedback! 🗣️Share this message and share your story! Together, we can make Metabolic Health a Movement that transforms lives. #MetabolicHealth #StayCurious

🔥 Why I’m Committed to Making Metabolic Health Mainstream (in 2 min) 🔥 From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose. Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone... I need an army of Metabolic Health Enthusiasts —people who are ready to go beyond investing in their own health to help change the culture, disrupt norms, and provoke hard but necessary discussions Watch this 2-minute video, and if my story resonates with you, I invite you to join me on this journey. ⁉️Ask Hard Questions, Authentically 🫂Support Your Fellow Metabolic Health Enthusiasts 🤔Engage. Give Feedback! 🗣️Share this message and share your story! Together, we can make Metabolic Health a Movement that transforms lives. #MetabolicHealth #StayCurious

Nick Norwitz MD PhD

443,000 views • 1 year ago

🚨This is crazy—and you haven’t seen it. A Stanford randomized controlled trial found that high-dose of a specific soluble fiber increased liver injury markers (ALT) in some people. The trial was stopped early for safety in a subset of participants. Let your brain ferment that. For more fiber nuance, check out today's interview with Dr. Andrew Koutnik, Ph.D. ... if you're brain is constipated, he's like heavy dose ex-lax

🚨This is crazy—and you haven’t seen it. A Stanford randomized controlled trial found that high-dose of a specific soluble fiber increased liver injury markers (ALT) in some people. The trial was stopped early for safety in a subset of participants. Let your brain ferment that. For more fiber nuance, check out today's interview with Dr. Andrew Koutnik, Ph.D. ... if you're brain is constipated, he's like heavy dose ex-lax

Nick Norwitz MD PhD

133,024 views • 5 months ago

Ezetimibe cut my LDL by 56%. But that wasn't the point...

Ezetimibe cut my LDL by 56%. But that wasn't the point...

Nick Norwitz MD PhD

38,873 views • 1 month ago

Calories don’t cause obesity any more than an odometer causes driving. The persistence of the CICO mindset isn’t due to rigorous intellectual debate among competing models — it’s due to confusion. CICO isn’t a model of obesity. It’s a circular thinking masquerading as science.

Calories don’t cause obesity any more than an odometer causes driving. The persistence of the CICO mindset isn’t due to rigorous intellectual debate among competing models — it’s due to confusion. CICO isn’t a model of obesity. It’s a circular thinking masquerading as science.

Nick Norwitz MD PhD

138,326 views • 7 months ago

Statins Slash GLP-1: (~10-minute Data Digest for X) Human trial data published in a major journal show that statins cause insulin resistance and deplete GLP-1 levels in humans. This should have been breaking news... But no one talked about it. Why don’t doctors know? Why aren’t patients being informed about the risks? PLEASE really listen to what I’m saying and why I’m upset. It’s more nuanced than scaremongering about medications or economic conspiracy theories. 🔁If you care, share (retweet and tag your favorite, or least favorite, health influencer) 🔗Links to the YouTube video, Substack article, and Instagram posts in first comment. - Cell Metabolism (PMID: 38325336)

Statins Slash GLP-1: (~10-minute Data Digest for X) Human trial data published in a major journal show that statins cause insulin resistance and deplete GLP-1 levels in humans. This should have been breaking news... But no one talked about it. Why don’t doctors know? Why aren’t patients being informed about the risks? PLEASE really listen to what I’m saying and why I’m upset. It’s more nuanced than scaremongering about medications or economic conspiracy theories. 🔁If you care, share (retweet and tag your favorite, or least favorite, health influencer) 🔗Links to the YouTube video, Substack article, and Instagram posts in first comment. - Cell Metabolism (PMID: 38325336)

Nick Norwitz MD PhD

168,388 views • 9 months ago

This is—without a doubt—the longest I’ve ever sat on a video before releasing it. Because once I open this Pandora’s box, there’s no closing it. 🚨Full Video: In this video, I share my personal decision to walk around with an LDL of 574 mg/dl and a total cholesterol over 700. But this isn’t about one biomarker, or one study. Decisions about whether to act, when to act, and how to act aren’t simple math problems. Individual complexity and thoughtful consideration can turn what looks like a straightforward equation into something far more nuanced. 🚨This video isn’t about telling you what to think—it’s about showing you how I think. It’s not about dogma or conspiracy. It’s about authenticity, transparency, and the kind of nuanced conversations we need to have if we’re going to approach this topic responsibly. And I say that without irony. If you watch all the way through—rather than jumping to conclusions—you might be surprised by where I land… and what I’m planning next. We don't need to agree. We do need to be willing to keep our eyes, ears, and hearts open to new data and divergent opinions. cc Dave Feldman Adrian Soto-Mota Bret Scher, MD Dr Aseem Malhotra Jan Ellison Baszucki Metabolic Mind Coalition for Metabolic Health Austin Dudzinski, PharmD, BCACP Eric Rodgers Andrew Koutnik, Ph.D. Peter Attia (I'm sure we'll have a productive and cordial chat one day)

This is—without a doubt—the longest I’ve ever sat on a video before releasing it. Because once I open this Pandora’s box, there’s no closing it. 🚨Full Video: In this video, I share my personal decision to walk around with an LDL of 574 mg/dl and a total cholesterol over 700. But this isn’t about one biomarker, or one study. Decisions about whether to act, when to act, and how to act aren’t simple math problems. Individual complexity and thoughtful consideration can turn what looks like a straightforward equation into something far more nuanced. 🚨This video isn’t about telling you what to think—it’s about showing you how I think. It’s not about dogma or conspiracy. It’s about authenticity, transparency, and the kind of nuanced conversations we need to have if we’re going to approach this topic responsibly. And I say that without irony. If you watch all the way through—rather than jumping to conclusions—you might be surprised by where I land… and what I’m planning next. We don't need to agree. We do need to be willing to keep our eyes, ears, and hearts open to new data and divergent opinions. cc Dave Feldman Adrian Soto-Mota Bret Scher, MD Dr Aseem Malhotra Jan Ellison Baszucki Metabolic Mind Coalition for Metabolic Health Austin Dudzinski, PharmD, BCACP Eric Rodgers Andrew Koutnik, Ph.D. Peter Attia (I'm sure we'll have a productive and cordial chat one day)

Nick Norwitz MD PhD

138,478 views • 7 months ago

Cardiology Has an LDL Obsession. What to Measure Instead... 🔗New video: 👇1 min clip on LDL vs Insulin Resistance The landscape of atherosclerosis is changing. New drugs are lowering LDL, total cholesterol and ApoB lower and lower, while larger risk factors like insulin resistance, obesity, and diabetes persist. If you want a comparison, lipoprotein insulin resistance score (LP-IR). Because 1.0 is risk neutral, insulin resistance score is a more than 14X more powerful predictor of new coronary heart disease than LDL. But we know who gets all the attention. Answer: [See Clip] That’s not proportional medicine Do you agree? For more nuances see the video linked above. cc Benjamin Bikman Dave Feldman

Cardiology Has an LDL Obsession. What to Measure Instead... 🔗New video: 👇1 min clip on LDL vs Insulin Resistance The landscape of atherosclerosis is changing. New drugs are lowering LDL, total cholesterol and ApoB lower and lower, while larger risk factors like insulin resistance, obesity, and diabetes persist. If you want a comparison, lipoprotein insulin resistance score (LP-IR). Because 1.0 is risk neutral, insulin resistance score is a more than 14X more powerful predictor of new coronary heart disease than LDL. But we know who gets all the attention. Answer: [See Clip] That’s not proportional medicine Do you agree? For more nuances see the video linked above. cc Benjamin Bikman Dave Feldman

Nick Norwitz MD PhD

77,831 views • 4 months ago

The Statin Data Peter Attia Deleted I was surprised to find in a commentary on a human study showing Statins Slash GLP-1 levels Petter omitted the key graph When you omit the most important graph, that's not nuance. It's curation. 👉Full video:

The Statin Data Peter Attia Deleted I was surprised to find in a commentary on a human study showing Statins Slash GLP-1 levels Petter omitted the key graph When you omit the most important graph, that's not nuance. It's curation. 👉Full video:

Nick Norwitz MD PhD

71,532 views • 3 months ago

🚀Did your #LDL cholesterol sky-rocket on #keto? 🧈Were you told it' was because of Saturated Fat? 🚨NEW META OF 41 RCTs just busted that MYTH! 3 Main findings 👉 In studies with 'lean' BMI ( 35), LDL-C ⬇️ 💥BOOM, there's a money shot!💥 👉 Inverse association between BMI and LDL-C 👉 BMI dominates over saturated fat, which has comparatively minimal impact; thus, it's more likely having 6-pack abs is a severe risk factor for high LDL-C on #keto, not butter, beef, bacon or cream 🔗PAPER LINK 🔗 - (To share the data love, copy this link to a Quote tweet or original Tweet with your reaction. Please engage!) FULL Video Abstract (7 min): Major props to first-author Adrian Soto-Mota and senior Dr. David Ludwig. These man are humble & kind geniuses that I'm privileged to know and learn under And +100 pts for the #LEM ⚡️ Dave Feldman Of interest to More Plates More Dates Peter Attia @PlantChompers and Walter Willett (if he had a Twitter) Simon Hill MSc, BSc Thomas Dayspring William Cromwell, MD LipoFan Andrew D. Huberman, Ph.D. Dominic D'Agostino Layne Norton, PhD Metabolic Health Summit

🚀Did your #LDL cholesterol sky-rocket on #keto? 🧈Were you told it' was because of Saturated Fat? 🚨NEW META OF 41 RCTs just busted that MYTH! 3 Main findings 👉 In studies with 'lean' BMI ( 35), LDL-C ⬇️ 💥BOOM, there's a money shot!💥 👉 Inverse association between BMI and LDL-C 👉 BMI dominates over saturated fat, which has comparatively minimal impact; thus, it's more likely having 6-pack abs is a severe risk factor for high LDL-C on #keto, not butter, beef, bacon or cream 🔗PAPER LINK 🔗 - (To share the data love, copy this link to a Quote tweet or original Tweet with your reaction. Please engage!) FULL Video Abstract (7 min): Major props to first-author Adrian Soto-Mota and senior Dr. David Ludwig. These man are humble & kind geniuses that I'm privileged to know and learn under And +100 pts for the #LEM ⚡️ Dave Feldman Of interest to More Plates More Dates Peter Attia @PlantChompers and Walter Willett (if he had a Twitter) Simon Hill MSc, BSc Thomas Dayspring William Cromwell, MD LipoFan Andrew D. Huberman, Ph.D. Dominic D'Agostino Layne Norton, PhD Metabolic Health Summit

Nick Norwitz MD PhD

269,263 views • 2 years ago

High-dose Nattokinase may reduce atherosclerosis (61 seconds) 🫀👇 Nattokinase reduces blood pressure, blood clotting, inflammation, and oxidative stress. Link at the end of the associated thread.

High-dose Nattokinase may reduce atherosclerosis (61 seconds) 🫀👇 Nattokinase reduces blood pressure, blood clotting, inflammation, and oxidative stress. Link at the end of the associated thread.

Nick Norwitz MD PhD

55,645 views • 4 months ago

Fiber ≠ fiber. Some fibers (e.g. arabinoxylan) lower cholesterol on average. Others (like inulin) often don’t. And at the individual level? Some people actually see LDL go up with inulin. The question isn’t “Is fiber good or bad?” It’s which fiber, at what dose, in whom. Details + mechanisms in the deep dive linked at the end of the associated thread. #StayCurious

Fiber ≠ fiber. Some fibers (e.g. arabinoxylan) lower cholesterol on average. Others (like inulin) often don’t. And at the individual level? Some people actually see LDL go up with inulin. The question isn’t “Is fiber good or bad?” It’s which fiber, at what dose, in whom. Details + mechanisms in the deep dive linked at the end of the associated thread. #StayCurious

Nick Norwitz MD PhD

60,388 views • 5 months ago

LDL and the Problem of Incomplete Framing 🫀 Here's my mini rant... There is long list of risk factors that carry far greater consequence than LDL alone. Take obesity, type 2 diabetes, insulin resistance, elevated blood pressure, chronic inflammation, smoking history. I could go on, but the point is actually really obvious... When LDL cholesterol monopolizes the spotlight, the problem is that the framing is incomplete. Instead, it becomes actively harmful to patients to pull away attention and clinical urgency from factors that matter more than LDL. The spotlight of medicine directs attention and resources, towards what's easiest to monetize and medicalize: LDL cholesterol, a marker that's easy to smash with a drug that makes money. I am NOT making the argument about bad intentions. I'm describing a clear systemic problem, one that perpetuates the broader metabolic health epidemic we continue to find ourselves in, including cardiovascular disease.

LDL and the Problem of Incomplete Framing 🫀 Here's my mini rant... There is long list of risk factors that carry far greater consequence than LDL alone. Take obesity, type 2 diabetes, insulin resistance, elevated blood pressure, chronic inflammation, smoking history. I could go on, but the point is actually really obvious... When LDL cholesterol monopolizes the spotlight, the problem is that the framing is incomplete. Instead, it becomes actively harmful to patients to pull away attention and clinical urgency from factors that matter more than LDL. The spotlight of medicine directs attention and resources, towards what's easiest to monetize and medicalize: LDL cholesterol, a marker that's easy to smash with a drug that makes money. I am NOT making the argument about bad intentions. I'm describing a clear systemic problem, one that perpetuates the broader metabolic health epidemic we continue to find ourselves in, including cardiovascular disease.

Nick Norwitz MD PhD

45,303 views • 4 months ago

Lower ApoC3 is one of the only lipid biomarkers that truly predicts longevity (not LDL nor ApoB) Ketogenic Diets lower ApoC3 by as much as 50% in 2 weeks. Whet your appetite with this short. Then dip into the deep dive...

Lower ApoC3 is one of the only lipid biomarkers that truly predicts longevity (not LDL nor ApoB) Ketogenic Diets lower ApoC3 by as much as 50% in 2 weeks. Whet your appetite with this short. Then dip into the deep dive...

Nick Norwitz MD PhD

36,507 views • 3 months ago

My Cholesterol Is Over 700... But My Arteries Are Clean If you take literally *64 sec* to watch this short, you’ll realize: this isn’t a flex. It’s a reminder that medicine lives in the gray, and that blindly repeating platitudes like “lower cholesterol is always better” fails real patients. We need more research. More personalization. More curiosity — and less dogma. Do you agree? 👍 👎

My Cholesterol Is Over 700... But My Arteries Are Clean If you take literally 64 sec to watch this short, you’ll realize: this isn’t a flex. It’s a reminder that medicine lives in the gray, and that blindly repeating platitudes like “lower cholesterol is always better” fails real patients. We need more research. More personalization. More curiosity — and less dogma. Do you agree? 👍 👎

Nick Norwitz MD PhD

50,934 views • 6 months ago