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Nick Norwitz MD PhD

@nicknorwitz • 130,539 subscribers

MD-PhD. Harvard-Oxford. 1.3M YouTube Best-Selling Metabolism Newsletter https://t.co/YoPdkV6tkd Educational content only. Not medical advice.

Shorts

The Lion Diet Experiment (A Primer 🧵👇) 1/7) For a 30 days I ran the strictest version of carnivore: the Lion Diet. No dairy. No eggs. No seafood. No coffee. Just ruminant muscle meat, salt, and water. I didn't do it as an intended permanent lifestyle shift, but as a personal exploration of what remains the most controversial diets of my lifetime, and a "fad" that won't die. Or, maybe it's more than that? ⚠️Trigger warning for later in the thread

The Lion Diet Experiment (A Primer 🧵👇) 1/7) For a 30 days I ran the strictest version of carnivore: the Lion Diet. No dairy. No eggs. No seafood. No coffee. Just ruminant muscle meat, salt, and water. I didn't do it as an intended permanent lifestyle shift, but as a personal exploration of what remains the most controversial diets of my lifetime, and a "fad" that won't die. Or, maybe it's more than that? ⚠️Trigger warning for later in the thread

148,832 görüntüleme

🥓I Ate 600 Strips of Bacon 🥓 🫀Here’s What Happened to My Cholesterol🫀 1/4) In an N =1 experiment modeled on the #720Eggs Eggperiment, I dropped my LDL by 22% while eating 600 strips of bacon over 20 days. That’s 21,000 Calories from bacon while eating ~300 grams of fat per day, and buckets of saturated fat, and I was able to drop my cholesterol. Here’s what you need to know…

🥓I Ate 600 Strips of Bacon 🥓 🫀Here’s What Happened to My Cholesterol🫀 1/4) In an N =1 experiment modeled on the #720Eggs Eggperiment, I dropped my LDL by 22% while eating 600 strips of bacon over 20 days. That’s 21,000 Calories from bacon while eating ~300 grams of fat per day, and buckets of saturated fat, and I was able to drop my cholesterol. Here’s what you need to know…

476,837 görüntüleme

A case of two coronary scans: Nick Norwitz (high-fat, keto 🍳); Simon Hill (plant-based 🌱) First, for context, this post is largely in response to an incredibly nuanced and non-dogmatic podcast conversation between Dave Feldman and Darius Sharpe, one that had me scratching my chin and holding my ribs throughout. I definitely recommend giving it a listen. 12/10 Episode! They spend a substantial amount of time discussing cardiovascular risk and, in particular, the contrast between my coronary CT scan, showing 0 calcified and 0 soft plaque (total plaque 0mm3) despite astronomical LDL levels in the high 500s for seven years vs that of plant-based nutrition influencer Simon Hill, which showed 61.3 mm3 of plaque despite his never having had high LDL and, for the last decade or so, targeting exceptionally low LDL and ApoB, including by taking a PCSK9 inhibitor and eating a low-saturated-fat, plant-forward diet. First and foremost, there’s only so much you can conclude from a comparison of two cases. That’s obvious, so let me state that clearly. However, considering the broader context and expressed public interested, it’s still an interesting thought puzzle: What is “protecting” me from atherosclerosis, or what is leading Simon to develop plaque despite his low LDL and ApoB? I’ll address the common hand-wavy answer up front: “Well, maybe Nick has some special protective genetics.” What I’d say to this is that, although I can’t rule it out definitively since we haven’t annotated the entire human genome, my father had 99% occlusion of his left anterior descending artery at 44, and I also inherited his high Lp(a), which sits between 150 and 200. That is in addition to my historically exceptionally high LDL and a history of inflammatory bowel disease, which should further increase my risk of progression. Yet despite all of that, I have no measurable plaque, even though, as the patient, I can tell you that many cardiologists assured me I would. Additionally, the excuse that “he’s just young” doesn’t fly, since Simon is also young. We’re both in our 30s. And, as a historical comparator, children with homozygous familial hypercholesterolemia can develop plaque within a few years of being born. So, puzzle me this: Why am I not developing plaque if the relationship between LDL/ApoB exposure and plaque progression is so "remarkably consistent?" Hand-wave if you want, but I’d like something more specific please. (And I’d like anybody to tell me why they think I was confident enough to spend seven years on a self-experiment, risking my heart on the bet that this would effectively be the outcome. Was I just cocky and lucky?) That’s mostly what I want to post: a thought question to consider based on two individuals who have chosen to make their data publicly available. However, since this field is so wrapped in controversy, let me elaborate on a few more points that are related. 1. KETO-CTA. To anyone who wants to pivot and try to point the finger at KETO-CTA, I will remind you that, in 4 separate analyses, there was no relationship between LDL or ApoB and plaque progression. That remains true to this day. In fact, it's a result that remains more robust for having had our hands forced to run the additional analyses. With respect to our retraction of the April 7th Cleerly paper, which continues to be misrepresented (at this point, I have to assume willfully) I will remind you: i) we the authors, pushed forward the retraction of the April 7 paper; it was not forced upon us ii) we did so because of the Cleerly anomalies that came to light after publication – nb: Dave and I were blinded to elements of data willfully to protect the integrity of the project (there’s an irony for you) iii) we sought retraction only after company’s refusal to repeat a properly blinded rescan and quality assessment, and subsequent analyses that made the only reasonable interpretation that Cleerly systematically overestimated plaque progression iv) in none of the analyses did ApoB or LDL predict plaque progression, which was the main novel finding and remains robust. 2. Ezetimibe I am now taking ezetimibe. Critics have tried to cast this - incorrectly - as some form of me hedging, but I intentionally did not start it until after my 7-year scan, and I am not withholding any information from or about that scan. The reason I’m taking ezetimibe, which I have very clearly disclosed, including in my newsletter and in a video, is 2024 Aging Biology research suggesting cholesterol-independent effects on neuroprotection, which is something that’s important to me. The fact that I am taking it, I would cast as a testament that I’m not dogmatic on this issue, and I’m not trying to “LDL-maxx” for some aware. Rather, I’m being open, honest and transparent in my journey as a person and patient trying to make the best decision for myself at ever step of the journey. Also, on the topic of ezetimibe, see recent work by Adrian Soto-Mota DoctorTro et al., which adds another layer of nuance to LDL and ApoB management in the context of low-carbohydrate diets. TL;DR, if someone sees their LDL and ApoB rise on a low-carbohydrate / ketogenic diet, ezetimibe is likely to punch above its weight for LDL and ApoB reduction. Setting aside dogma, understanding individual biology and how to manipulate it can often be very useful in a clinical setting. I will always put data first. Acknowledging this fact is not contradictory to anything I’ve said, but completely consistent with it. It is all about individual context. Now, everyone should go listen to episode 43 of TFP_ with Dave Feldman and Darius Sharpe (Spotify, Apple and YouTube). It’s stupendous! P.S. I want to thank Dave for sharing on the podcast that, before each of my cardiac scans, I said a priori that I would release the results, whatever they were. You all know Dave to be impeccably honest. That is not in dispute, and it has always been my intent to share my data openly, as I have.

A case of two coronary scans: Nick Norwitz (high-fat, keto 🍳); Simon Hill (plant-based 🌱) First, for context, this post is largely in response to an incredibly nuanced and non-dogmatic podcast conversation between Dave Feldman and Darius Sharpe, one that had me scratching my chin and holding my ribs throughout. I definitely recommend giving it a listen. 12/10 Episode! They spend a substantial amount of time discussing cardiovascular risk and, in particular, the contrast between my coronary CT scan, showing 0 calcified and 0 soft plaque (total plaque 0mm3) despite astronomical LDL levels in the high 500s for seven years vs that of plant-based nutrition influencer Simon Hill, which showed 61.3 mm3 of plaque despite his never having had high LDL and, for the last decade or so, targeting exceptionally low LDL and ApoB, including by taking a PCSK9 inhibitor and eating a low-saturated-fat, plant-forward diet. First and foremost, there’s only so much you can conclude from a comparison of two cases. That’s obvious, so let me state that clearly. However, considering the broader context and expressed public interested, it’s still an interesting thought puzzle: What is “protecting” me from atherosclerosis, or what is leading Simon to develop plaque despite his low LDL and ApoB? I’ll address the common hand-wavy answer up front: “Well, maybe Nick has some special protective genetics.” What I’d say to this is that, although I can’t rule it out definitively since we haven’t annotated the entire human genome, my father had 99% occlusion of his left anterior descending artery at 44, and I also inherited his high Lp(a), which sits between 150 and 200. That is in addition to my historically exceptionally high LDL and a history of inflammatory bowel disease, which should further increase my risk of progression. Yet despite all of that, I have no measurable plaque, even though, as the patient, I can tell you that many cardiologists assured me I would. Additionally, the excuse that “he’s just young” doesn’t fly, since Simon is also young. We’re both in our 30s. And, as a historical comparator, children with homozygous familial hypercholesterolemia can develop plaque within a few years of being born. So, puzzle me this: Why am I not developing plaque if the relationship between LDL/ApoB exposure and plaque progression is so "remarkably consistent?" Hand-wave if you want, but I’d like something more specific please. (And I’d like anybody to tell me why they think I was confident enough to spend seven years on a self-experiment, risking my heart on the bet that this would effectively be the outcome. Was I just cocky and lucky?) That’s mostly what I want to post: a thought question to consider based on two individuals who have chosen to make their data publicly available. However, since this field is so wrapped in controversy, let me elaborate on a few more points that are related. 1. KETO-CTA. To anyone who wants to pivot and try to point the finger at KETO-CTA, I will remind you that, in 4 separate analyses, there was no relationship between LDL or ApoB and plaque progression. That remains true to this day. In fact, it's a result that remains more robust for having had our hands forced to run the additional analyses. With respect to our retraction of the April 7th Cleerly paper, which continues to be misrepresented (at this point, I have to assume willfully) I will remind you: i) we the authors, pushed forward the retraction of the April 7 paper; it was not forced upon us ii) we did so because of the Cleerly anomalies that came to light after publication – nb: Dave and I were blinded to elements of data willfully to protect the integrity of the project (there’s an irony for you) iii) we sought retraction only after company’s refusal to repeat a properly blinded rescan and quality assessment, and subsequent analyses that made the only reasonable interpretation that Cleerly systematically overestimated plaque progression iv) in none of the analyses did ApoB or LDL predict plaque progression, which was the main novel finding and remains robust. 2. Ezetimibe I am now taking ezetimibe. Critics have tried to cast this - incorrectly - as some form of me hedging, but I intentionally did not start it until after my 7-year scan, and I am not withholding any information from or about that scan. The reason I’m taking ezetimibe, which I have very clearly disclosed, including in my newsletter and in a video, is 2024 Aging Biology research suggesting cholesterol-independent effects on neuroprotection, which is something that’s important to me. The fact that I am taking it, I would cast as a testament that I’m not dogmatic on this issue, and I’m not trying to “LDL-maxx” for some aware. Rather, I’m being open, honest and transparent in my journey as a person and patient trying to make the best decision for myself at ever step of the journey. Also, on the topic of ezetimibe, see recent work by Adrian Soto-Mota DoctorTro et al., which adds another layer of nuance to LDL and ApoB management in the context of low-carbohydrate diets. TL;DR, if someone sees their LDL and ApoB rise on a low-carbohydrate / ketogenic diet, ezetimibe is likely to punch above its weight for LDL and ApoB reduction. Setting aside dogma, understanding individual biology and how to manipulate it can often be very useful in a clinical setting. I will always put data first. Acknowledging this fact is not contradictory to anything I’ve said, but completely consistent with it. It is all about individual context. Now, everyone should go listen to episode 43 of TFP_ with Dave Feldman and Darius Sharpe (Spotify, Apple and YouTube). It’s stupendous! P.S. I want to thank Dave for sharing on the podcast that, before each of my cardiac scans, I said a priori that I would release the results, whatever they were. You all know Dave to be impeccably honest. That is not in dispute, and it has always been my intent to share my data openly, as I have.

22,617 görüntüleme

“Definitely Do Not Stop Statins.” — Bryan Johnson “I’m not the best person to make these arguments [about statins].” — also Bryan Johnson Seems inconsistent 🤔 I’d politely suggest you walk back your stance or admit to overstepping on your blunt recommendation. I’d be happy to have a conversation with you or your team on the matter of precision and personal prescription of lipid-modifying medication. I think you’ll find my stance rather moderate & reasonable. 3000 word deep dive here: Cc More Plates More Dates

“Definitely Do Not Stop Statins.” — Bryan Johnson “I’m not the best person to make these arguments [about statins].” — also Bryan Johnson Seems inconsistent 🤔 I’d politely suggest you walk back your stance or admit to overstepping on your blunt recommendation. I’d be happy to have a conversation with you or your team on the matter of precision and personal prescription of lipid-modifying medication. I think you’ll find my stance rather moderate & reasonable. 3000 word deep dive here: Cc More Plates More Dates

31,332 görüntüleme

700 Cholesterol 0 mm3 Plaque (CCTA + Heartflow) The scan we review in today’s video (🔗 below) is not your average CAC scan. It quantifies both calcified and soft plaque throughout the arteries. And importantly, “he’s young” is not a sufficient explanation. 👉People in their 20s and 30s commonly show measurable plaque on these scans. 👉There are even well-known plant-based influencers in their 30s with a decent amount of plaque 👉Children with homozygous familial hypercholesterolemia as young as a year or two can already demonstrate advanced plaque burden with LDL levels similar to mine. The irrefutable reality is that elevated LDL and ApoB do not translate into identical plaque progression in every individual. That is 100% a fact. Understanding the biological differences that make some people dramatically more or less susceptible than others is absolutely critical to precision medicine. Anyone pretending these individual differences do not matter is ignoring reality. Anyone who protests again asking questions that need to be answered is a problem.

700 Cholesterol 0 mm3 Plaque (CCTA + Heartflow) The scan we review in today’s video (🔗 below) is not your average CAC scan. It quantifies both calcified and soft plaque throughout the arteries. And importantly, “he’s young” is not a sufficient explanation. 👉People in their 20s and 30s commonly show measurable plaque on these scans. 👉There are even well-known plant-based influencers in their 30s with a decent amount of plaque 👉Children with homozygous familial hypercholesterolemia as young as a year or two can already demonstrate advanced plaque burden with LDL levels similar to mine. The irrefutable reality is that elevated LDL and ApoB do not translate into identical plaque progression in every individual. That is 100% a fact. Understanding the biological differences that make some people dramatically more or less susceptible than others is absolutely critical to precision medicine. Anyone pretending these individual differences do not matter is ignoring reality. Anyone who protests again asking questions that need to be answered is a problem.

14,145 görüntüleme

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It’s hard for some people to understand why I did an MD at Harvard and a PhD at Oxford, then chose not to become a conventional doctor. Here’s my why. And if you or someone you know feels lonely or underserved by conventional medicine, these 10 min might be worth your time. 🙏

It’s hard for some people to understand why I did an MD at Harvard and a PhD at Oxford, then chose not to become a conventional doctor. Here’s my why. And if you or someone you know feels lonely or underserved by conventional medicine, these 10 min might be worth your time. 🙏

Nick Norwitz MD PhD

282,831 görüntüleme • 1 ay önce

🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

Nick Norwitz MD PhD

3,218,416 görüntüleme • 2 yıl önce

If you understand what I say in the next 90 seconds, you'll understand insulin resistance better than most doctors👇

If you understand what I say in the next 90 seconds, you'll understand insulin resistance better than most doctors👇

Nick Norwitz MD PhD

109,874 görüntüleme • 1 ay önce

The Strange Science of Eating Only Meat (New video) The video linked above is a 20-minute breakdown of my experience with the lion diet and, more importantly, the literature and social movement surrounding the carnivore diet. Here’s a 1 min trailer and primer👇 The carnivore diet has had a fascinating trajectory over the past decade, and people are now questioning whether it’s dying off, the inevitable fate of any fad diet. My thesis is that the story is more nuanced. Carnivore, like any dietary pattern, does not need to be a religion. It can be a therapeutic intervention. Some people may need it for long periods of time, others just for chapters. In this way, it’s analogous to a medicine. If you take the time to watch the video, or even if you don’t, I’d just ask you to consider that maybe what we need here is a little less arrogance and derision, and a bit more curiosity and compassion.

The Strange Science of Eating Only Meat (New video) The video linked above is a 20-minute breakdown of my experience with the lion diet and, more importantly, the literature and social movement surrounding the carnivore diet. Here’s a 1 min trailer and primer👇 The carnivore diet has had a fascinating trajectory over the past decade, and people are now questioning whether it’s dying off, the inevitable fate of any fad diet. My thesis is that the story is more nuanced. Carnivore, like any dietary pattern, does not need to be a religion. It can be a therapeutic intervention. Some people may need it for long periods of time, others just for chapters. In this way, it’s analogous to a medicine. If you take the time to watch the video, or even if you don’t, I’d just ask you to consider that maybe what we need here is a little less arrogance and derision, and a bit more curiosity and compassion.

Nick Norwitz MD PhD

89,703 görüntüleme • 1 ay önce

There’s a gross double standard when it comes to how academia discusses and covers LDL & ApoB. (Nerd rant 👇)

There’s a gross double standard when it comes to how academia discusses and covers LDL & ApoB. (Nerd rant 👇)

Nick Norwitz MD PhD

13,299 görüntüleme • 7 gün önce

I explain the Copper Peptide (GHK-Cu) in 2 minutes

I explain the Copper Peptide (GHK-Cu) in 2 minutes

Nick Norwitz MD PhD

120,796 görüntüleme • 3 ay önce

Could bacon and eggs be better breakfast for your heart than oatmeal? 6-month RCT in patients with obesity says...

Could bacon and eggs be better breakfast for your heart than oatmeal? 6-month RCT in patients with obesity says...

Nick Norwitz MD PhD

50,164 görüntüleme • 1 ay önce

Yes the keto diet “won” over the Mediterranean diet and plant-based diet. Here’s a mini-rant on the context & why it matters, if you can spare 4 min👇

Yes the keto diet “won” over the Mediterranean diet and plant-based diet. Here’s a mini-rant on the context & why it matters, if you can spare 4 min👇

Nick Norwitz MD PhD

48,833 görüntüleme • 1 ay önce

🔥 Why I’m Committed to Making Metabolic Health Mainstream (in 2 min) 🔥 From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose. Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone... I need an army of Metabolic Health Enthusiasts —people who are ready to go beyond investing in their own health to help change the culture, disrupt norms, and provoke hard but necessary discussions Watch this 2-minute video, and if my story resonates with you, I invite you to join me on this journey. ⁉️Ask Hard Questions, Authentically 🫂Support Your Fellow Metabolic Health Enthusiasts 🤔Engage. Give Feedback! 🗣️Share this message and share your story! Together, we can make Metabolic Health a Movement that transforms lives. #MetabolicHealth #StayCurious

🔥 Why I’m Committed to Making Metabolic Health Mainstream (in 2 min) 🔥 From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory bowel disease and finding remission through a metabolic health intervention, I knew I had found my purpose. Now, I'm on a mission to inspire change, spark conversation, and shift the way we think about health at its core. But I can’t do it alone... I need an army of Metabolic Health Enthusiasts —people who are ready to go beyond investing in their own health to help change the culture, disrupt norms, and provoke hard but necessary discussions Watch this 2-minute video, and if my story resonates with you, I invite you to join me on this journey. ⁉️Ask Hard Questions, Authentically 🫂Support Your Fellow Metabolic Health Enthusiasts 🤔Engage. Give Feedback! 🗣️Share this message and share your story! Together, we can make Metabolic Health a Movement that transforms lives. #MetabolicHealth #StayCurious

Nick Norwitz MD PhD

443,107 görüntüleme • 2 yıl önce

Here’s my Problem with Evidence-Based Medicine👇

Here’s my Problem with Evidence-Based Medicine👇

Nick Norwitz MD PhD

14,903 görüntüleme • 17 gün önce

Tesamorelin might be one of the most interesting and underappreciated peptides, with the potential not only to reduce visceral fat and promote muscle growth, but also to improve deep sleep and perhaps even longevity—if used smartly. (PMID: 18057338, PMID: 41851466, more below)

Tesamorelin might be one of the most interesting and underappreciated peptides, with the potential not only to reduce visceral fat and promote muscle growth, but also to improve deep sleep and perhaps even longevity—if used smartly. (PMID: 18057338, PMID: 41851466, more below)

Nick Norwitz MD PhD

68,711 görüntüleme • 3 ay önce

If you have high Lp(a), like me, here are 5 things you need to know to protect your heart: 1. Lp(a) is ~90% genetic. While it can be influenced at the margins (e.g. inflammation), most people have a genetic “floor.” I inherited mine from my father. Do you know yours? 2. Your genes may be fixed—but your jeans aren’t. Specifically, visceral fat matters. People with low waist-to-hip ratios, a proxy for less visceral fat, often show little to no added cardiovascular risk from high Lp(a). Why? Because Lp(a) interacts with the metabolic environment. 3. Medications matter. Statins can increase Lp(a), while PCSK9 inhibitors tend to decrease it. 4. Vitamin C may help reduce the atherogenicity of Lp(a) by working inside the lumen of blood vessels and inside artery walls 5. Ketogenic diets may also reduce Lp(a)-related risk—working inside the artery to lower inflammation, oxidative stress, and depletion of key cofactors caused by Lp(a). This is the Cliff Notes version. For the full deep dives—10,000+ words of nuance, mechanisms, and references—check the comments and stay curious.

If you have high Lp(a), like me, here are 5 things you need to know to protect your heart: 1. Lp(a) is ~90% genetic. While it can be influenced at the margins (e.g. inflammation), most people have a genetic “floor.” I inherited mine from my father. Do you know yours? 2. Your genes may be fixed—but your jeans aren’t. Specifically, visceral fat matters. People with low waist-to-hip ratios, a proxy for less visceral fat, often show little to no added cardiovascular risk from high Lp(a). Why? Because Lp(a) interacts with the metabolic environment. 3. Medications matter. Statins can increase Lp(a), while PCSK9 inhibitors tend to decrease it. 4. Vitamin C may help reduce the atherogenicity of Lp(a) by working inside the lumen of blood vessels and inside artery walls 5. Ketogenic diets may also reduce Lp(a)-related risk—working inside the artery to lower inflammation, oxidative stress, and depletion of key cofactors caused by Lp(a). This is the Cliff Notes version. For the full deep dives—10,000+ words of nuance, mechanisms, and references—check the comments and stay curious.

Nick Norwitz MD PhD

111,704 görüntüleme • 6 ay önce

🚨This is crazy—and you haven’t seen it. A Stanford randomized controlled trial found that high-dose of a specific soluble fiber increased liver injury markers (ALT) in some people. The trial was stopped early for safety in a subset of participants. Let your brain ferment that. For more fiber nuance, check out today's interview with Dr. Andrew Koutnik, Ph.D. ... if you're brain is constipated, he's like heavy dose ex-lax

🚨This is crazy—and you haven’t seen it. A Stanford randomized controlled trial found that high-dose of a specific soluble fiber increased liver injury markers (ALT) in some people. The trial was stopped early for safety in a subset of participants. Let your brain ferment that. For more fiber nuance, check out today's interview with Dr. Andrew Koutnik, Ph.D. ... if you're brain is constipated, he's like heavy dose ex-lax

Nick Norwitz MD PhD

133,092 görüntüleme • 10 ay önce

Statins Slash GLP-1: (~10-minute Data Digest for X) Human trial data published in a major journal show that statins cause insulin resistance and deplete GLP-1 levels in humans. This should have been breaking news... But no one talked about it. Why don’t doctors know? Why aren’t patients being informed about the risks? PLEASE really listen to what I’m saying and why I’m upset. It’s more nuanced than scaremongering about medications or economic conspiracy theories. 🔁If you care, share (retweet and tag your favorite, or least favorite, health influencer) 🔗Links to the YouTube video, Substack article, and Instagram posts in first comment. - Cell Metabolism (PMID: 38325336)

Statins Slash GLP-1: (~10-minute Data Digest for X) Human trial data published in a major journal show that statins cause insulin resistance and deplete GLP-1 levels in humans. This should have been breaking news... But no one talked about it. Why don’t doctors know? Why aren’t patients being informed about the risks? PLEASE really listen to what I’m saying and why I’m upset. It’s more nuanced than scaremongering about medications or economic conspiracy theories. 🔁If you care, share (retweet and tag your favorite, or least favorite, health influencer) 🔗Links to the YouTube video, Substack article, and Instagram posts in first comment. - Cell Metabolism (PMID: 38325336)

Nick Norwitz MD PhD

169,198 görüntüleme • 1 yıl önce

Why did a keto diet with > 5X the saturated fat and 50X the cholesterol of a plant-based diet lower LDL and ApoB?

Why did a keto diet with > 5X the saturated fat and 50X the cholesterol of a plant-based diet lower LDL and ApoB?

Nick Norwitz MD PhD

23,143 görüntüleme • 1 ay önce

Do carbs cause insulin resistance? (<90 sec)

Do carbs cause insulin resistance? (<90 sec)

Nick Norwitz MD PhD

18,703 görüntüleme • 1 ay önce

It's seems counterintuitive to use a restrictive carnivore-keto diet to help heal eating disorders (anorexia)... unless you consider that mental health disorders might be metabolic brain disorders. In which case 👇

It's seems counterintuitive to use a restrictive carnivore-keto diet to help heal eating disorders (anorexia)... unless you consider that mental health disorders might be metabolic brain disorders. In which case 👇

Nick Norwitz MD PhD

15,558 görüntüleme • 26 gün önce

Calories don’t cause obesity any more than an odometer causes driving. The persistence of the CICO mindset isn’t due to rigorous intellectual debate among competing models — it’s due to confusion. CICO isn’t a model of obesity. It’s a circular thinking masquerading as science.

Calories don’t cause obesity any more than an odometer causes driving. The persistence of the CICO mindset isn’t due to rigorous intellectual debate among competing models — it’s due to confusion. CICO isn’t a model of obesity. It’s a circular thinking masquerading as science.

Nick Norwitz MD PhD

138,326 görüntüleme • 1 yıl önce

This is—without a doubt—the longest I’ve ever sat on a video before releasing it. Because once I open this Pandora’s box, there’s no closing it. 🚨Full Video: In this video, I share my personal decision to walk around with an LDL of 574 mg/dl and a total cholesterol over 700. But this isn’t about one biomarker, or one study. Decisions about whether to act, when to act, and how to act aren’t simple math problems. Individual complexity and thoughtful consideration can turn what looks like a straightforward equation into something far more nuanced. 🚨This video isn’t about telling you what to think—it’s about showing you how I think. It’s not about dogma or conspiracy. It’s about authenticity, transparency, and the kind of nuanced conversations we need to have if we’re going to approach this topic responsibly. And I say that without irony. If you watch all the way through—rather than jumping to conclusions—you might be surprised by where I land… and what I’m planning next. We don't need to agree. We do need to be willing to keep our eyes, ears, and hearts open to new data and divergent opinions. cc Dave Feldman Adrian Soto-Mota Bret Scher, MD Dr Aseem Malhotra Jan Ellison Baszucki Metabolic Mind Coalition for Metabolic Health Austin Dudzinski, PharmD, BCACP Eric Rodgers Andrew Koutnik, Ph.D. Peter Attia (I'm sure we'll have a productive and cordial chat one day)

This is—without a doubt—the longest I’ve ever sat on a video before releasing it. Because once I open this Pandora’s box, there’s no closing it. 🚨Full Video: In this video, I share my personal decision to walk around with an LDL of 574 mg/dl and a total cholesterol over 700. But this isn’t about one biomarker, or one study. Decisions about whether to act, when to act, and how to act aren’t simple math problems. Individual complexity and thoughtful consideration can turn what looks like a straightforward equation into something far more nuanced. 🚨This video isn’t about telling you what to think—it’s about showing you how I think. It’s not about dogma or conspiracy. It’s about authenticity, transparency, and the kind of nuanced conversations we need to have if we’re going to approach this topic responsibly. And I say that without irony. If you watch all the way through—rather than jumping to conclusions—you might be surprised by where I land… and what I’m planning next. We don't need to agree. We do need to be willing to keep our eyes, ears, and hearts open to new data and divergent opinions. cc Dave Feldman Adrian Soto-Mota Bret Scher, MD Dr Aseem Malhotra Jan Ellison Baszucki Metabolic Mind Coalition for Metabolic Health Austin Dudzinski, PharmD, BCACP Eric Rodgers Andrew Koutnik, Ph.D. Peter Attia (I'm sure we'll have a productive and cordial chat one day)

Nick Norwitz MD PhD

138,564 görüntüleme • 1 yıl önce

Video of a guy trying to do 100 push-ups went viral. I'm just a lab nerd, but I thought I give it a whirl. Maybe my form could have been better on a few, but it's been a while. Oh, and wait for the end... cc Pяom Pяom🌚 UGO & The Big Steppers Abud Bakri MD

Video of a guy trying to do 100 push-ups went viral. I'm just a lab nerd, but I thought I give it a whirl. Maybe my form could have been better on a few, but it's been a while. Oh, and wait for the end... cc Pяom Pяom🌚 UGO & The Big Steppers Abud Bakri MD

Nick Norwitz MD PhD

72,597 görüntüleme • 6 ay önce