One protein, two opposing roles: This ‘compelling’ study shows... how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.show more

PML retraction resulting in eccentric MR. A good example... from Oung Savly MD FACC FASE FESC FAAP FEACVI 🇰🇭 nicely demonstrating that the eccentricity can be caused either by hypermobility of one leaflet or hypomobility of the other one #echofirst Same MR jet direction, different causesshow more

Two times, the autotranslated subs identify them as boyfriends.... I don't know French, but they're saying "copain", and from what I can tell from web searches, it can mean either friend or boyfriend, depending on context.show more

Just 8 besties sharing dancing brain cells🧠🕺 This or... That w/ ALPHA DRIVE ONE premieres in ONE hour! 🔗 #ThisorThat_ALPHADRIVEONE #ALPHADRIVEONE #ALD1 #hello82show more

This footage shows a jaguar and a puma using... the same trail, but not at the same time. These two big cats were filmed days apart in the Osa Peninsula, Costa Rica, and their movements were combined into one video to highlight how they navigate the same environmentshow more

You’re gonna remember this one!! This is a case... w/either the most crazy or most predictable ending—depending on how you look at it! It’s in the “I’ve never seen that in my 15 year career” column Patient who had a mesenchymal stem implantation for a remote spinal cord injury. Can you see what happened? Did something go wrong or go right? Watch to the end to find out!!!show more

Dhalia also has a new Break Trigger: Briar Rose.... Dhalia fires two shots and depending on your input, you can cause the second shot to explode either on contact or after a set amount of time passes. #indiegame #indiedev #fightinggames #FGC #animation #gamedevshow more

Sculpture of the Ras protein (G12C) bound to GDP... and the drug Sotorasib (AMG510). The protein is half bronze and half steel with a copper seam between the two metals. Represents how the drug locks the protein in a unique conformation that blocks its function and cancer growth.show more

Treat me like this, it's either one of two... things, either we fuck, or I fall in love #Fortaleza #gayboy #Daddy_Son #ruivoshow more

This magnified view of a Tradescantia spathacea plant shows... the opening of its stomata, pores that allow the plant to take in CO2 and release O2 while minimising water loss. New research has identified a two-protein system that regulates this mechanism:show more

Calcium and bicarbonate signalling pathways have pivotal, resonating roles... in matching ATP production to demand.show more

A single E. coli cell, placed on a dish,... will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.show more

#Mizzou commit Braylon Ellison put two defenders on the... ground in one play this weekend 🥞 Ellison will graduate early and join #mizzoufootball this spring. Until then, opposing teams beware Boonville in the playoffs 🫣show more

Pranks can build trust or break it, depending on... the punchline.show more

🇦🇪 TOKEN2049: A thousand people are seated in the... main hall waiting for @CZ_binance. The doors are closed, and no one else can get in. But at the same time, no one can leave either.show more

THE DIFFERENCE BETWEEN JINKOOK AND JINMIN DURING THE WATER... SPLASH IN SO WHAT,HOW YOU CAN SEE THEIR DYNAMICS BY THIS GESTURE😭😭show more

It's remarkable that BLACKPINK sold out Wembley Stadium TWICE... without debuting on national TV or promoting on major UK shows, unlike other artists that headline the same venue before not to mention its the same set from their 3 shows in 2023 Hate train isn’t working and that’s why they madshow more

One move in one spot and we can drop... a Jean size or two.🔥show more

🐟: "Isn't this my own belt?" 🎬: "Is it... your belt?" 🐟: "This is the one I usually wear" 🍋: "Isn't that also the the one I usually wear, don't we wear the same one?" 🎬: "How can you two wear the same belt?!?!?" Film production so poor they can only afford one belt??? 😅🤣show more

Nearly 14,000 containers heading out of Los Angeles 🚢... This video shows just how massive one container ship can be and how much cargo moves through L.A., one of the busiest ports in the world.show more

Top 5 advances in medicine this week (🧵) 1.... The first-in-human use of stem cells to repair the heart The video shows how the engineered heart muscle contracts - in a dish This approach requires surgery and immunosuppression, and with only one patient so far, so it's not perfect: larger trials are underway!show more