We have developed MouseMapper AI, a deep learning ensemble... for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. MouseMapper uncovered obesity-induced whole-neuronal changes, most notably, a loss of trigeminal nerve endings linked to impaired whisker sensitivity, as well as tissue-specific macrophage clustering across the body. Kaltenecker, Horvath, Al-Maskari, Kolabas, Chen… Ertürk, bioRxiv (2024)show more

Our recent work in nature, MouseMapper uses foundation-model AI,... mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. next come>show more

So Meghan now suffers from all sorts of disorders... according to the sugars Connective tissue disease Obesity Anterior placenta Pre eclampsia Had to be induced So they are scrambling to explain thisshow more

🚨🇺🇸 MEET DR. JESSICA GLUCK: PUSHING THE BOUNDARIES OF... HEART REGENERATION Dr. Jessica Gluck, assistant professor at TECS, is advancing tissue engineering with her work on creating hearts from a patient’s own cells. Using induced pluripotent stem cells (reprogrammed skin cells), her research aims to regenerate organs and reduce the need for organ donations. Gluck focuses on developing nanofibrous scaffolds that mimic the body’s environment, helping grow functional tissue like heart cells. She’s specifically working to regenerate pacemaker cells, vital for regulating the heart’s rhythm. With her background in biomedical textiles from NC State and UCLA, Gluck aims to tackle major challenges in tissue engineering, including vascularization, and hopes to make organ regeneration a reality. Source: Wilson College Communications, Jessica M. Gluck, PhD, Massimoshow more

Vein viewers use near-infrared light, which is absorbed by... veins and reflected by surrounding tissue, to map veins up to 15mm deep and project the results onto the skin.show more

Using vDISCO tissue clearing, and a new ultrabright chemical... labeling strategy, this Neuron paper introduces LINCS, a powerful method for rapid 3D connectivity mapping in large tissue samples, from whole brains to whole bodies. A very nice advance for scalable circuit mapping, especially by combining strong, uniform labeling with sparse single-neuron reconstruction. Outstanding work by the Rui Lin lab. Full paper: #TissueClearing #LightSheetMicroscopy #Neuroscience #BrainMapping #Connectomics #3DImagingshow more

For easier placement and minimizing tissue dissection, EnCompass provides... a magnetic guide, parallel closure, and uniform tissue pressure – while harnessing the technology we know works well.show more

An unbiased study of whole biological systems is key... to deciphering complexity. Our new paper describes the steps & applications of vDISCO whole mouse imaging in Nature Protocols work by Ruiyao Marika Cai, Ilgın Kolabas et al. #vDISCO #clearing 🧵👇1/nshow more

Jim Caviezel, best known for portraying Jesus in The... Passion of the Christ, visited the Eucharistic Miracle of Lanciano in Italy. In the 8th century, during the celebration of the Catholic Mass, the consecrated Host was said to become Flesh and the Wine became Blood. Both have reportedly remained preserved to this day. Scientific examinations identified the Flesh as human heart tissue and the Blood as type AB, with findings described by some researchers as consistent with tissue from a heart under suffering. 💬 Why do so many people doubt Eucharistic miracles even with scientific evidence?show more

cinema employees seeing a bunch of people bring in... lotion and tissue to the screening instead of popcornshow more

A sneak peak of a complex and technically challenging... experiment that my lab developed: Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple rounds of sequential #HCR and 3D imaging in zebrafish larvae to reveal spatial expression of numerous mRNAs in the same specimen. Data from these imaging data sets are then computationally analyzed for spatial cell groups, spatially variable genes, and differentially expressed genes along 3D. We are leveraging this systems-level SGA to uncover unappreciated mechanistic insight at the cell and tissue levels into #ENS construction. Stay tuned for our work that exploits this pipeline within various mutant and perturbation conditions. Reach out if you are interested in trying this! #fruitypebblesshow more

Back in the civilized world, actual toilet tissue makes... its 3D debut to relieve yourself on the move. As crafting starts to make more sense, you can even turn school books into tissue (although I don't recommend it in real life!): 🧻show more

Vance: We have reinstated a ban on the use... of fetal tissue in research. That's another big oneshow more

🚨 REALITY UPDATE Humans may already have hidden regenerative... abilities. Scientists are now discovering that the body’s inability to regrow tissue may not come from missing biological machinery… but from repair systems being “switched” into scar mode instead of regeneration mode. That changes the entire question. Because for decades scientists assumed mammals simply lost regenerative capability entirely. But new research suggests the regenerative programs may still exist underneath normal healing processes. Researchers studying tissue regeneration found they could partially redirect mammalian healing away from scarring and toward structural regrowth using specific signaling pathways. In experiments, scientists regenerated: • bone • ligaments • joint structures • connective tissue inside injured mammalian tissue. The deeper shift: Human biology may contain dormant regenerative instructions that are normally suppressed. That means the future of medicine may not be: “adding artificial replacement parts”… but: reactivating biological repair programs already hidden inside the body. And this is not isolated anymore. Researchers are now uncovering regeneration-related mechanisms across: • skin healing • heart tissue • stem cell systems • cartilage repair • aging biology The line between healing and regeneration is beginning to blur. If this scales: • scar-free healing may become possible • organ repair could accelerate • regenerative medicine may fundamentally change surgery • aging research could shift dramatically • future medicine may focus on “unlocking” dormant repair pathways The deeper implication: Humans may not lack regenerative power. We may simply lack the signals that activate it fully. Question to audience: If dormant regeneration pathways already exist inside the human body… how much hidden biological capability are we still unaware of? Follow if you want to watch the future forming in real time. #RealityUpdate #FutureOfReality #TheNewPhysicsshow more

A 3D map of mRNA transcripts in a zebrafish... embryo. This video was not made using a microscope. Researchers tag nucleotides with barcodes, which then "link" together in the tissue. Sequencing those links can then be used to computationally infer the 3D positions of genes.show more

🔥🚨JUST IN: These two people stood back-to-back, connected through... their nervous systems and energetic fields, while a doctor applies gentle techniques to the abdomen and chest. As the body's bioelectrical and fascial networks respond, both begin to move in soft, synchronized waves. These movements are a sign of the nervous system releasing stored tension and reorganizing itself, allowing energy to flow more freely. The result is not only physical fluidity, but also a deep sense of pleasure, joy, and emotional well-being as the body returns to balance.show more

The best and most elegant tissue box design.

🚨 SCIENTISTS MAY HAVE FOUND A NEW WAY TO... KILL DRUG-RESISTANT BACTERIA. And it doesn't rely on traditional antibiotics. Researchers repurposed a ruthenium-based anticancer drug and activated it using ultrasound deep inside infected tissue. Why this matters: • Antibiotic resistance is one of the fastest-growing threats to global health • Drug-resistant infections could kill more people than cancer by 2050 • Many antibiotics are losing effectiveness • Deep-tissue infections are difficult to target safely • Bacteria continue evolving resistance to conventional treatments The breakthrough: Scientists used a compound called TLD1433, originally developed for cancer therapy. By itself, the drug is largely inactive. But when exposed to focused ultrasound... it generates highly reactive oxygen molecules that attack bacterial DNA and destroy protective biofilms. Unlike antibiotics, the treatment doesn't target a single bacterial pathway. Instead, it creates widespread oxidative damage that bacteria struggle to evolve resistance against. The results were remarkable: • Outperformed conventional antibiotics in laboratory tests • Reduced survival of pneumonia-causing bacteria to just 14% • Broke down oxygen-starved bacterial biofilms • In animal studies, every treated mouse survived • Only 25% of untreated controls survived The deeper implication is enormous: For decades we've searched for new antibiotics. But the future may not be finding stronger drugs. It may be activating existing drugs only where they're needed. By combining chemistry with precisely targeted ultrasound... scientists could attack dangerous infections deep inside the body while minimizing damage to healthy tissue. The real question is: Could sound become one of medicine's most powerful weapons against antibiotic resistance? Follow for more frontier science and technology discoveries.show more

The future is now: new paper where we developed... & validated the first commercially available wearable to predict tissue loading at three common running injury locations using machine learning Full-text Free formatted full-textshow more