#fluorescencefriday

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A Sticky Dance Between a Cell and a Neuron. #neuroscience #science #mysterious #HiddenWorld #cell #FluorescenceFriday ➡️A Schwann cell precursor interacting with sensory axons 🔬🧫

A Sticky Dance Between a Cell and a Neuron. #neuroscience #science #mysterious #HiddenWorld #cell #FluorescenceFriday ➡️A Schwann cell precursor interacting with sensory axons 🔬🧫

Alexandre Dumoulin @axonsalex.bsky.social

30,374 görüntüleme • 4 ay önce

In a recent overnight imaging session, I made a startling discovery... COS7 throw midnight dance parties. Who knew? These party animals are dressed in Vimentin-TagGFP (orange) and the ER marker SnapTag-Sec61b (blue) #FluorescenceFriday

In a recent overnight imaging session, I made a startling discovery... COS7 throw midnight dance parties. Who knew? These party animals are dressed in Vimentin-TagGFP (orange) and the ER marker SnapTag-Sec61b (blue) #FluorescenceFriday

135,876 görüntüleme • 3 yıl önce

*The uninvited guest* (sound on) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

The uninvited guest (sound on) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

Danielle Beckman

24,148 görüntüleme • 8 ay önce

This is a direct immunostaining using the frontal lobe of a patient with Alzheimer. Why is there so little high-resolution microscopy being performed in human tissue? There is so much data we can extract..and in 3D! (Dream Theater sounds appropriate this time) #FluorescenceFriday

This is a direct immunostaining using the frontal lobe of a patient with Alzheimer. Why is there so little high-resolution microscopy being performed in human tissue? There is so much data we can extract..and in 3D! (Dream Theater sounds appropriate this time) #FluorescenceFriday

Danielle Beckman

26,000 görüntüleme • 10 ay önce

#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.

#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.

41,977 görüntüleme • 2 yıl önce

'Life of a Neuron', the exhibit that turned our microscopy images to life, is finally coming back! In Houston, TX this time 🤩! Happy #FluorescenceFriday 🔬

'Life of a Neuron', the exhibit that turned our microscopy images to life, is finally coming back! In Houston, TX this time 🤩! Happy #FluorescenceFriday 🔬

Danielle Beckman

34,007 görüntüleme • 1 yıl önce

#FluorescenceFriday #cellbiology #bioart A neutrophilic cell migrating through a 3D collagen mesh at 1.3 sec intervals for 5.5 min, as seen by lattice light sheet microscopy.

#FluorescenceFriday #cellbiology #bioart A neutrophilic cell migrating through a 3D collagen mesh at 1.3 sec intervals for 5.5 min, as seen by lattice light sheet microscopy.

37,597 görüntüleme • 2 yıl önce

#FluorescenceFriday #zebrafish #bioart To see cells as they really are, it's necessary to see them in the native multicellular environment in which they evolved. However, the deeper we peer into living tissue, the more our view is obscured by optical aberrations. Here, take a trip as we dive 200 um down from the optic tectum to the hindbrain in a living zebrafish, turning on adaptive optics to correct these aberrations as we go, to see oligodendrocytes (orange) and neural nuclei (green).

#FluorescenceFriday #zebrafish #bioart To see cells as they really are, it's necessary to see them in the native multicellular environment in which they evolved. However, the deeper we peer into living tissue, the more our view is obscured by optical aberrations. Here, take a trip as we dive 200 um down from the optic tectum to the hindbrain in a living zebrafish, turning on adaptive optics to correct these aberrations as we go, to see oligodendrocytes (orange) and neural nuclei (green).

26,318 görüntüleme • 2 yıl önce

#FluorescenceFriday #cellbiology #bioart Three examples of mitochondrial remodeling by lysosomes/late endosomes actively transported along microtubules, as seen by grazing incidence structured illumination microscopy at 1-2 frames/sec.

#FluorescenceFriday #cellbiology #bioart Three examples of mitochondrial remodeling by lysosomes/late endosomes actively transported along microtubules, as seen by grazing incidence structured illumination microscopy at 1-2 frames/sec.

23,083 görüntüleme • 2 yıl önce

Time-lapse recording of floorplate cytonemes (green) interacting with axons (magenta). 1 image taken every second for 10 min (played at 30 fps). Cytonemes love interacting with axons! 💚#FluorescenceFriday

Time-lapse recording of floorplate cytonemes (green) interacting with axons (magenta). 1 image taken every second for 10 min (played at 30 fps). Cytonemes love interacting with axons! 💚#FluorescenceFriday

Alexandre Dumoulin @axonsalex.bsky.social

17,994 görüntüleme • 1 yıl önce

#FluorescenceFriday #neuroscience #bioart A minute sliver of some of the most complex matter in the known universe: a small subset of neurons (yellow) and pre- (blue) and post- (magenta) synaptic markers over 75 x 100 x 125 um in layers IV-V of the mouse primary somatosensory cortex, as seen by combined expansion and lattice light sheet microscopy (ExLLSM): The first six seconds show all pre/post synaptic pairs, the remainder shows only those pairs associated with the small subset of labeled dendritic spines. An insanely complicated computational machine.

#FluorescenceFriday #neuroscience #bioart A minute sliver of some of the most complex matter in the known universe: a small subset of neurons (yellow) and pre- (blue) and post- (magenta) synaptic markers over 75 x 100 x 125 um in layers IV-V of the mouse primary somatosensory cortex, as seen by combined expansion and lattice light sheet microscopy (ExLLSM): The first six seconds show all pre/post synaptic pairs, the remainder shows only those pairs associated with the small subset of labeled dendritic spines. An insanely complicated computational machine.

17,465 görüntüleme • 2 yıl önce

An Evans Blue labeled heart for this #FluorescenceFriday courtesy of recently minted PhD Sam Honeycutt. And if you’re interested in how to perform this cost efficient labeling method check out

An Evans Blue labeled heart for this #FluorescenceFriday courtesy of recently minted PhD Sam Honeycutt. And if you’re interested in how to perform this cost efficient labeling method check out

20,121 görüntüleme • 2 yıl önce