正在加载视频...

视频加载失败

加载此视频时出现问题。这可能是由于临时网络问题，或视频可能不可用。

A cell dividing into two daughter cells videoed through a microscope. Chromosomes are labeled in pink. Technique: differential interference microscopy (DIC) and fluorescence. #CellBiology

Dylan Burnette

33,447 subscribers

79,078 次观看 • 5 个月前 •via X (Twitter)

健康养生科学技术 #CellBiology

Anya Rossi• Live Now

Private livecam show

0 条评论

暂无评论

原始帖子的评论将显示在这里

相关视频

A cell videoed through a microscope. DNA in the nucleus (green) and mitochondria (purple) are shown. #CellBiology

A cell videoed through a microscope. DNA in the nucleus (green) and mitochondria (purple) are shown. #CellBiology

Dylan Burnette

52,603 次观看 • 2 年前

A cell videoed through a microscope. DNA (cyan), mitochondria (yellow), and VASP (magenta) are shown. #CellBiology

A cell videoed through a microscope. DNA (cyan), mitochondria (yellow), and VASP (magenta) are shown. #CellBiology

Dylan Burnette

119,329 次观看 • 3 年前

A cell videoed through a microscope. DNA in the nucleus (green) and the powerhouses/overlords of the cell, mitochondria (purple), are shown. #CellBiology

A cell videoed through a microscope. DNA in the nucleus (green) and the powerhouses/overlords of the cell, mitochondria (purple), are shown. #CellBiology

Dylan Burnette

100,561 次观看 • 1 年前

A melanoma cancer cell videoed through a microscope. DNA in the nucleus (yellow), mitochondria (cyan), and VASP (magenta) are shown. #CellBiology

A melanoma cancer cell videoed through a microscope. DNA in the nucleus (yellow), mitochondria (cyan), and VASP (magenta) are shown. #CellBiology

Dylan Burnette

23,480 次观看 • 2 年前

A Golgi apparatus protein in a cell videoed through a microscope. The Golgi is saturated to show the vesicles trafficking around the cell. #CellBiology

A Golgi apparatus protein in a cell videoed through a microscope. The Golgi is saturated to show the vesicles trafficking around the cell. #CellBiology

Dylan Burnette

60,887 次观看 • 3 年前

A cancer cell videoed through a microscope. It has 3 nuclei (magenta). The powerhouse/overlords of the cell, mitochondria, are also shown (green). #CellBiology

A cancer cell videoed through a microscope. It has 3 nuclei (magenta). The powerhouse/overlords of the cell, mitochondria, are also shown (green). #CellBiology

Dylan Burnette

16,897 次观看 • 3 个月前

Mitosis is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Such a division gives rise to genetically identical cells in which the total number of chromosomes is maintained [source:

Mitosis is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Such a division gives rise to genetically identical cells in which the total number of chromosomes is maintained [source:

Massimo

505,583 次观看 • 2 年前

#FluorescenceFriday #cellbiology #bioart The actin cytoskeleton at 60 nm resolution and 3 frames/min, and its association with early endosomes (Rab5a, green), as seen in a COS-7 cell by photoactivated nonlinear structured illumination microscopy

#FluorescenceFriday #cellbiology #bioart The actin cytoskeleton at 60 nm resolution and 3 frames/min, and its association with early endosomes (Rab5a, green), as seen in a COS-7 cell by photoactivated nonlinear structured illumination microscopy

Eric Betzig

25,848 次观看 • 2 年前

We present oblique plane microscopy with adaptive optics (AO): One deformable mirror corrects both the light-sheet and the fluorescence detection. Movie shows cancer cells in a zebrafish xenograft model, before and after application of AO.

We present oblique plane microscopy with adaptive optics (AO): One deformable mirror corrects both the light-sheet and the fluorescence detection. Movie shows cancer cells in a zebrafish xenograft model, before and after application of AO.

Reto Fiolka

13,452 次观看 • 2 年前

Why not show real data instead of a 2D cartoon? Left diagonal: computationally separated 3D volume-rendered movies at 15 sec intervals for 19 minutes of chromosomes, mitochondria, and the ER in the same field of dividing pig kidney cells. Middle diagonal: overlapped color channels computationally sliced in slabs through the volume to reveal internal structure and interactions throughout mitosis. Upper right: zoomed in view in one slab, showing organelle rearrangements in the left cell from metaphase through telophase.

Why not show real data instead of a 2D cartoon? Left diagonal: computationally separated 3D volume-rendered movies at 15 sec intervals for 19 minutes of chromosomes, mitochondria, and the ER in the same field of dividing pig kidney cells. Middle diagonal: overlapped color channels computationally sliced in slabs through the volume to reveal internal structure and interactions throughout mitosis. Upper right: zoomed in view in one slab, showing organelle rearrangements in the left cell from metaphase through telophase.

Eric Betzig

19,923 次观看 • 2 个月前

The head of a bearded dragon embryo (50 days old), imaged with light sheet fluorescence microscopy 🦎🔬

The head of a bearded dragon embryo (50 days old), imaged with light sheet fluorescence microscopy 🦎🔬

Rory Cooper

19,410 次观看 • 1 年前

A white blood cell navigates through red blood cells, scanning for threats

A white blood cell navigates through red blood cells, scanning for threats

HOW THINGS WORK

52,359 次观看 • 11 个月前

Nice example of actin retrograde flow in a gigantic lamellipodium. #cytoskeleton, #actin, #microscopy, #cell-motility, #science

Nice example of actin retrograde flow in a gigantic lamellipodium. #cytoskeleton, #actin, #microscopy, #cell-motility, #science

Jeffrey van Haren

20,435 次观看 • 2 年前

A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

Niko McCarty.

57,948 次观看 • 9 个月前

Mitochondria in a cell. What is going on? Make a guess. Test the guess. Find joy in being wrong. Guess again......... #Science #CellBiology #FindJoyInBeingWrong

Mitochondria in a cell. What is going on? Make a guess. Test the guess. Find joy in being wrong. Guess again......... #Science #CellBiology #FindJoyInBeingWrong

Dylan Burnette

63,438 次观看 • 3 年前

#cellbiology #bioart The actin #cytoskeleton (green) is linked to a variety of transmembrane proteins through alpha-actinin (magenta), with such linkages being particularly dense in membrane ruffles and filopodia. As seen at 3 frames/min for 8 min by linear and non-linear structured illumination microscopy (97 and 60 nm resolution, respectively).

#cellbiology #bioart The actin #cytoskeleton (green) is linked to a variety of transmembrane proteins through alpha-actinin (magenta), with such linkages being particularly dense in membrane ruffles and filopodia. As seen at 3 frames/min for 8 min by linear and non-linear structured illumination microscopy (97 and 60 nm resolution, respectively).

Eric Betzig

25,403 次观看 • 1 年前

Check out this bearded dragon embryo (~30 days old) imaged with light sheet fluorescence microscopy 🦎🔬

Check out this bearded dragon embryo (~30 days old) imaged with light sheet fluorescence microscopy 🦎🔬

Rory Cooper

38,914 次观看 • 1 年前

Bacteria glowing with green fluorescence move inside a fungal cell. In this video, the bacteria seem like an infection, but in successive generations, the two organisms will adapt to each other until they find endosymbiotic balance.

Bacteria glowing with green fluorescence move inside a fungal cell. In this video, the bacteria seem like an infection, but in successive generations, the two organisms will adapt to each other until they find endosymbiotic balance.

Quanta Magazine

18,609 次观看 • 6 个月前

If you have Cancer, this is your visualization. That is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.

If you have Cancer, this is your visualization. That is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.

Brian Roemmele

191,436 次观看 • 6 个月前

Excited to share our new preprint with Bhuvan | புவனசுந்தர் and Vladimir Gelfand! 🎉 Using a sparse vimentin SunTag labeling strategy and 3D FIB-SEM reconstructions, we do a deep dive on vimentin IF dynamics and nanoscale organization in cells. #CellBiology

Excited to share our new preprint with Bhuvan | புவனசுந்தர் and Vladimir Gelfand! 🎉 Using a sparse vimentin SunTag labeling strategy and 3D FIB-SEM reconstructions, we do a deep dive on vimentin IF dynamics and nanoscale organization in cells. #CellBiology

Andy Moore

15,512 次观看 • 2 年前