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A GRAVE statistical error has kept vitamin D recommendations DANGEROUSLY LOW for DECADES. A peer-reviewed study found 8,895 IU/day is needed for 97.5% of people to reach ≥50 nmol/L — NOT a mere 600 IU/day. The Institute of Medicine "misread" its own analysis, using values meant for group averages... show more

Nicolas Hulscher, MPH

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Vitamin D mistake A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D (2014) US, nearly 15 times too low UK, 0ver 22 times too low IOM calculation 600 units (15 mcg), 97.5% of people will achieve 63 nmol/L (25.2 ng/ml) Correct calculation 600 units (15 mcg), 97.5% of people will achieve 26.8 nmol/L (10.7 ng/ml) Requirements based on correct calculation 8,895 IU of vitamin D per day may be needed to accomplish that 97.5% of individuals achieve serum 25(OH)D values of 50 nmol/L or more. The "Average" vs. "Individual" Mistake Canada studies Diet gives 232 IU of vitamin D per day Institute of Medicine (IOM), RDA vitamin D 600 IU per day, (aged 1 to 70 years) Now called the National Academy of Medicine UK is even worse 400 iu or 10 mcg 600 iu per day to achieve serum 25-hydroxyvitamin D (25(OH)D) levels of 50 nmol/L or more in 97.5% of healthy individuals. Levels of 50 nmol/L or more have been shown to benefit bone health and to prevent disease and injury. The IOM based their RDA for vitamin D on an aggregation of 10 supplementation studies, (32 dose protocols) carried out during winter months, at locations above 50th parallel IOM regressed the 32 study averages, dose: plasma ratio On the basis of this, IOM estimated that 600 IU of vitamin D would achieve an average 25(OH)D level of 63 nmol/L Requirements based on correct calculation 8,895 IU of vitamin D per day This dose is well in excess of the current RDA of 600 IU per day and the tolerable upper intake of 4000 IU per day. The public health and clinical implications of the miscalculated RDA for vitamin D are serious. With the current recommendation of 600 IU, bone health objectives and disease and injury prevention targets will not be met. We recommend that the RDA for vitamin D be reconsidered to allow for appropriate public health and clinical decision-making. The Big Vitamin D Mistake Explanation of the statistical error The "Average" vs. "Individual" Mistake The Institute of Medicine’s goal was to find a vitamin D dose that ensures 97.5% of individual people reach a healthy blood level (50 nmol/L). The statistical error occurred because the IOM analysed the averages of different studies rather than the data of individual participants. They looked at 10 studies and took the average blood levels achieved in those studies. They calculated a statistical range (Confidence Interval) based on those averages. They found that with 600 IU, 97.5% of the study averages would hit the target. The Problem There is much less variation between "averages" than there is between "individuals." By using the averages, the IOM accidentally "smoothed out" the data. They assumed that if the average person in a study was fine, then almost everyone was fine. The Classroom Analogy Imagine you want to ensure every student passes a test. The IOM method They looked at the average scores of 30 different classrooms. They set a curriculum so that 97.5% of classrooms would have a passing average. The Reality Even in a classroom with a passing average, there are students who fail. The Correction To ensure 97.5% of students pass, you have to look at the lowest-performing students, not the class average. The Consequence When the authors of this paper re-calculated the numbers using the variation of individuals (rather than study averages), they found that the current RDA of 600 IU does not cover 97.5% of the population. Instead, it only ensures that 97.5% of people reach a blood level of 26.8 nmol/L (far below the target of 50 nmol/L). To actually get 97.5% of the population to the healthy target of 50 nmol/L, the math suggests you would need a dose of 8,895 IU per day.

Vitamin D mistake A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D (2014) US, nearly 15 times too low UK, 0ver 22 times too low IOM calculation 600 units (15 mcg), 97.5% of people will achieve 63 nmol/L (25.2 ng/ml) Correct calculation 600 units (15 mcg), 97.5% of people will achieve 26.8 nmol/L (10.7 ng/ml) Requirements based on correct calculation 8,895 IU of vitamin D per day may be needed to accomplish that 97.5% of individuals achieve serum 25(OH)D values of 50 nmol/L or more. The "Average" vs. "Individual" Mistake Canada studies Diet gives 232 IU of vitamin D per day Institute of Medicine (IOM), RDA vitamin D 600 IU per day, (aged 1 to 70 years) Now called the National Academy of Medicine UK is even worse 400 iu or 10 mcg 600 iu per day to achieve serum 25-hydroxyvitamin D (25(OH)D) levels of 50 nmol/L or more in 97.5% of healthy individuals. Levels of 50 nmol/L or more have been shown to benefit bone health and to prevent disease and injury. The IOM based their RDA for vitamin D on an aggregation of 10 supplementation studies, (32 dose protocols) carried out during winter months, at locations above 50th parallel IOM regressed the 32 study averages, dose: plasma ratio On the basis of this, IOM estimated that 600 IU of vitamin D would achieve an average 25(OH)D level of 63 nmol/L Requirements based on correct calculation 8,895 IU of vitamin D per day This dose is well in excess of the current RDA of 600 IU per day and the tolerable upper intake of 4000 IU per day. The public health and clinical implications of the miscalculated RDA for vitamin D are serious. With the current recommendation of 600 IU, bone health objectives and disease and injury prevention targets will not be met. We recommend that the RDA for vitamin D be reconsidered to allow for appropriate public health and clinical decision-making. The Big Vitamin D Mistake Explanation of the statistical error The "Average" vs. "Individual" Mistake The Institute of Medicine’s goal was to find a vitamin D dose that ensures 97.5% of individual people reach a healthy blood level (50 nmol/L). The statistical error occurred because the IOM analysed the averages of different studies rather than the data of individual participants. They looked at 10 studies and took the average blood levels achieved in those studies. They calculated a statistical range (Confidence Interval) based on those averages. They found that with 600 IU, 97.5% of the study averages would hit the target. The Problem There is much less variation between "averages" than there is between "individuals." By using the averages, the IOM accidentally "smoothed out" the data. They assumed that if the average person in a study was fine, then almost everyone was fine. The Classroom Analogy Imagine you want to ensure every student passes a test. The IOM method They looked at the average scores of 30 different classrooms. They set a curriculum so that 97.5% of classrooms would have a passing average. The Reality Even in a classroom with a passing average, there are students who fail. The Correction To ensure 97.5% of students pass, you have to look at the lowest-performing students, not the class average. The Consequence When the authors of this paper re-calculated the numbers using the variation of individuals (rather than study averages), they found that the current RDA of 600 IU does not cover 97.5% of the population. Instead, it only ensures that 97.5% of people reach a blood level of 26.8 nmol/L (far below the target of 50 nmol/L). To actually get 97.5% of the population to the healthy target of 50 nmol/L, the math suggests you would need a dose of 8,895 IU per day.

Jordan Chain

14,450 görüntüleme • 8 ay önce

Your doctor says your vitamin D level of 22 is "normal" — but what if that cutoff was based on a statistical error? A peer-reviewed study found the IOM miscalculated the RDA by 15x: it should be ~8,800 IU/day, not 600. And vitamin D isn't even a vitamin — it's a steroid hormone that regulates 200+ genes. Here's what the science actually shows.

Your doctor says your vitamin D level of 22 is "normal" — but what if that cutoff was based on a statistical error? A peer-reviewed study found the IOM miscalculated the RDA by 15x: it should be ~8,800 IU/day, not 600. And vitamin D isn't even a vitamin — it's a steroid hormone that regulates 200+ genes. Here's what the science actually shows.

Robert Lufkin MD

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Just Stop Oil has organized a banquet for its activists. A group of people decided to let them taste their own medicine

Just Stop Oil has organized a banquet for its activists. A group of people decided to let them taste their own medicine

Visegrád 24

452,421 görüntüleme • 3 yıl önce

The "Swedish Study" is often cited to justify anti trans rhetoric however the author of the study itself has since come out to explain why people are misinterpreting its findings. If you look at meta-analysis of peer reviewed studies they find a less than 1-5% regret rate

The "Swedish Study" is often cited to justify anti trans rhetoric however the author of the study itself has since come out to explain why people are misinterpreting its findings. If you look at meta-analysis of peer reviewed studies they find a less than 1-5% regret rate

The Serfs (youtube.com/theserftimes)

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“I have never set foot in my country. I have never walked its streets or touched its soil.” Noor Pahlavi, daughter of Reza Pahlavi, was born in exile. Like millions of Iranians, she has only known a homeland kept out of reach by a regime that has denied its people freedom for 47 years. This is not a fight for a throne. It is a fight for the right of a people to live free in their own country.

“I have never set foot in my country. I have never walked its streets or touched its soil.” Noor Pahlavi, daughter of Reza Pahlavi, was born in exile. Like millions of Iranians, she has only known a homeland kept out of reach by a regime that has denied its people freedom for 47 years. This is not a fight for a throne. It is a fight for the right of a people to live free in their own country.

Hananya Naftali

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A cancer breakthrough hiding in plain sight: Vitamin D. Oncologist Prof. Angus Dalgleish revealed a game-changing finding to pancreatic cancer expert Daniel Von Hoff: his successful immunotherapy trial insisted on normal Vitamin D levels. Skeptical, Von Hoff reviewed 30 years of data from 4,000 patients. The result was staggering: not one patient with low Vitamin D had responded to chemotherapy. The "responders" in his past trials were simply those with adequate Vitamin D levels. The drug alone wasn't the hero; it needed a competent immune system, primed by Vitamin D. The takeaway: Vitamin D is non-negotiable for immune function. Every white blood cell has receptors for it. The official "normal" level (~50 nmol/L) is too low. For therapy, aim for >100 nmol/L. Correcting this deficiency could be the key to turning non-responders into responders. A simple, safe, and foundational step we can no longer ignore.

A cancer breakthrough hiding in plain sight: Vitamin D. Oncologist Prof. Angus Dalgleish revealed a game-changing finding to pancreatic cancer expert Daniel Von Hoff: his successful immunotherapy trial insisted on normal Vitamin D levels. Skeptical, Von Hoff reviewed 30 years of data from 4,000 patients. The result was staggering: not one patient with low Vitamin D had responded to chemotherapy. The "responders" in his past trials were simply those with adequate Vitamin D levels. The drug alone wasn't the hero; it needed a competent immune system, primed by Vitamin D. The takeaway: Vitamin D is non-negotiable for immune function. Every white blood cell has receptors for it. The official "normal" level (~50 nmol/L) is too low. For therapy, aim for >100 nmol/L. Correcting this deficiency could be the key to turning non-responders into responders. A simple, safe, and foundational step we can no longer ignore.

Camus

175,549 görüntüleme • 10 ay önce

🎞️ At a moment when movies are at the forefront of everyone’s minds, the Institute for Advanced Study is delighted to present a 90-second film of its own: a new anthem video showcasing IAS and its mission of enabling foundational discovery.

🎞️ At a moment when movies are at the forefront of everyone’s minds, the Institute for Advanced Study is delighted to present a 90-second film of its own: a new anthem video showcasing IAS and its mission of enabling foundational discovery.

Institute for Advanced Study (IAS)

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Dr. Pierre Kory: Big Pharma is ‘TERRIFIED’ of Vitamin D Why? Because “It threatens the DISEASE MODEL.” A new meta-analysis out of Italy, published in the journal, Nutrients, has unearthed some shocking data about Vitamin D. Looking at data from 16 different studies and 1.26 million individuals, the meta-analysis revealed: • Vitamin D showed about a 60% effectiveness against the incidence of COVID-19 in randomized control trials. • Vitamin D showed about 40-50% effectiveness in reducing the incidence of COVID-19 in observational studies. • For preventing severe COVID-19 cases requiring ICU care, vitamin D supplementation was about 70% effective. So, we didn’t need to lock ourselves inside for years, be afraid, and vilify our neighbors for not wearing a mask. All we needed to do was to go outside, get sunshine, and increase our vitamin D levels, and everything would have been fine.

Dr. Pierre Kory: Big Pharma is ‘TERRIFIED’ of Vitamin D Why? Because “It threatens the DISEASE MODEL.” A new meta-analysis out of Italy, published in the journal, Nutrients, has unearthed some shocking data about Vitamin D. Looking at data from 16 different studies and 1.26 million individuals, the meta-analysis revealed: • Vitamin D showed about a 60% effectiveness against the incidence of COVID-19 in randomized control trials. • Vitamin D showed about 40-50% effectiveness in reducing the incidence of COVID-19 in observational studies. • For preventing severe COVID-19 cases requiring ICU care, vitamin D supplementation was about 70% effective. So, we didn’t need to lock ourselves inside for years, be afraid, and vilify our neighbors for not wearing a mask. All we needed to do was to go outside, get sunshine, and increase our vitamin D levels, and everything would have been fine.

The Vigilant Fox 🦊

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High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

no.mind

243,202 görüntüleme • 4 ay önce

Meet the Institute for the Study of War researchers who say the Ukraine war has entered a new phase to Ukraine’s advantage and that now is the time for its allies to provide crucial help.

Meet the Institute for the Study of War researchers who say the Ukraine war has entered a new phase to Ukraine’s advantage and that now is the time for its allies to provide crucial help.

Jim Sciutto

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Dr. Eric Berg shows us a historical 1970's pharmacology book revealing a "Maintenance" dose of Vitamin D above 50,000 IU. And a 2014 re-analysis covered recently by Dr John Campbell revealed we might need around 8,895 IU's. For decades the WHO (World Health Organization) has been recommending around 200 IU a day.

Dr. Eric Berg shows us a historical 1970's pharmacology book revealing a "Maintenance" dose of Vitamin D above 50,000 IU. And a 2014 re-analysis covered recently by Dr John Campbell revealed we might need around 8,895 IU's. For decades the WHO (World Health Organization) has been recommending around 200 IU a day.

Humanspective

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Emancipation Day is as a powerful reminder of the dehumanizing history of slavery. Its also a day for celebrating the resilience and fortitude of all the abolitionists, especially the Black individuals and communities, who worked tirelessly to abolish this heinous institution.

Emancipation Day is as a powerful reminder of the dehumanizing history of slavery. Its also a day for celebrating the resilience and fortitude of all the abolitionists, especially the Black individuals and communities, who worked tirelessly to abolish this heinous institution.

Mayor Olivia Chow 🇨🇦

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Supplementing with vitamin D could dramatically cut your dementia risk—by as much as 40% A major study of more than 12,000 adults found that after 5 years, 84% of vitamin D supplement users were dementia-free versus just 68% of non-users, with protective effects even among adults at genetic risk (APOE e4 carriers saw a 33% risk reduction) ~70% of people in the U.S. have insufficient vitamin D levels The solution is simple: Consider supplementing with 2,000–4,000 IU/day, and aim for optimal blood levels of 40–80 ng/mL (check with a blood test)

Supplementing with vitamin D could dramatically cut your dementia risk—by as much as 40% A major study of more than 12,000 adults found that after 5 years, 84% of vitamin D supplement users were dementia-free versus just 68% of non-users, with protective effects even among adults at genetic risk (APOE e4 carriers saw a 33% risk reduction) ~70% of people in the U.S. have insufficient vitamin D levels The solution is simple: Consider supplementing with 2,000–4,000 IU/day, and aim for optimal blood levels of 40–80 ng/mL (check with a blood test)

FoundMyFitness Clips

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$BTC Statistical Study using Claude - A Beginner's Workflow Here's an example of a z-score study on $BTC - still tinkering so don't take this as overtly useful information but the creation of a dashboard for the visualization of statistical data is phenomenal. my current workflow: > import $BTC time data - .csv file (can get this information from multiple venues - Binance is where I got mine) > creating bins - if you have a larger data set - you can use recent data to prevent overt bias in the long direction or filter consolidation and trending regime data into separate bins for statistical analysis - however, you will have to define thresholds and determine what that entails. > defining metrics in Claude that you want to use for statistical analysis e.g. for z-score what is it based on and what type of calculation? make sure you understand the calculations being performed for any metrics that you are doing a study for and modify them accordingly. > prompting Claude to do a statistical analysis with specific instructions and then tell it to create visualization for this. I've been messing around with this and I'm seriously impressed by the output.

Stoic

19,757 görüntüleme • 1 yıl önce

June 25 marks the day a nation born out of fighting for its own freedom was shackled by its own rulers. Bharat Mata — the mother of democracy — was handcuffed, chained, and arrested. The Constitution wasn’t sidelined — it was slaughtered. In a ruthless lust for power, Congress crippled democracy. The nation remembers this grave day, etched in betrayal. A day when India and its freedom was taken hostage. #SamvidhanHatyaDiwas

June 25 marks the day a nation born out of fighting for its own freedom was shackled by its own rulers. Bharat Mata — the mother of democracy — was handcuffed, chained, and arrested. The Constitution wasn’t sidelined — it was slaughtered. In a ruthless lust for power, Congress crippled democracy. The nation remembers this grave day, etched in betrayal. A day when India and its freedom was taken hostage. #SamvidhanHatyaDiwas

BJP

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Instead of providing for the Iranian people, the regime has been investing its resources in Pickaxe Mountain, a heavily fortified underground nuclear facility. Victoria Coates is Vice President of Heritage’s Kathryn and Shelby Cullom Davis Institute for National Security and Foreign Policy.

Instead of providing for the Iranian people, the regime has been investing its resources in Pickaxe Mountain, a heavily fortified underground nuclear facility. Victoria Coates is Vice President of Heritage’s Kathryn and Shelby Cullom Davis Institute for National Security and Foreign Policy.

Heritage Foundation

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