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Biologists use specialized open-source models for tasks like modeling the structure of molecular systems, designing drug-like molecules, and predicting the effects of genetic mutations. But these models are often expensive to run, potentially limiting their impact. In our latest Science Blog, we share how Claude was able to optimize...

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Anthropic

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636,748 views • 1 month ago •via X (Twitter)

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We are excited to launch our two models Pharia-1-LLM-7B-control and Pharia-1-LLM-7B-control-aligned. Both models and the code used to train them are now publicly available and open-sourced for non-commercial research and educational use. Read our model blog post here: Learn more about our open-source codebase Scaling: #writtenbyalephalpha
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We are excited to launch our two models Pharia-1-LLM-7B-control and Pharia-1-LLM-7B-control-aligned. Both models and the code used to train them are now publicly available and open-sourced for non-commercial research and educational use. Read our model blog post here: Learn more about our open-source codebase Scaling: #writtenbyalephalpha

Aleph Alpha

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We are open-sourcing RISE, our red-teaming algorithm that breaks the safeguards of the latest image models from OpenAI, DeepMind, and others. RISE uses readily available models like Qwen and Gemini Flash under the hood, with no additional training required. Read more:
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We are open-sourcing RISE, our red-teaming algorithm that breaks the safeguards of the latest image models from OpenAI, DeepMind, and others. RISE uses readily available models like Qwen and Gemini Flash under the hood, with no additional training required. Read more:

White Circle

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Microsoft killed the GPU mafia 🤯 They finally open-sourced their 1-bit LLM inference framework called bitnet.cpp. It lets you run 100B parameter models on your local CPU without GPUs. - 6.17x faster inference - 82.2% less energy on CPUs 100% Open Source.
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Microsoft killed the GPU mafia 🤯 They finally open-sourced their 1-bit LLM inference framework called bitnet.cpp. It lets you run 100B parameter models on your local CPU without GPUs. - 6.17x faster inference - 82.2% less energy on CPUs 100% Open Source.

Oliver

1,632,505 views • 9 months ago

Microsoft just changed the game 🤯 They've open-sourced bitnet.cpp, a 1-bit LLM inference framework. It let's you run 100B parameter models on your local CPU without GPUs. - 6.17x faster inference - 82.2% less energy on CPUs 100% Open Source.
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Microsoft just changed the game 🤯 They've open-sourced bitnet.cpp, a 1-bit LLM inference framework. It let's you run 100B parameter models on your local CPU without GPUs. - 6.17x faster inference - 82.2% less energy on CPUs 100% Open Source.

Oliver

116,002 views • 26 days ago

Cline Desktop just launched. An open-source workspace for open-weight models 🤯 > Import tasks from other coding agents > Run agents in parallel > Schedule tasks to run on their own Free models built in: DeepSeek V4 Flash, GLM 5.3 Flash, Laguna S 2.1. I had early access and I can assure you it feels incredible. Pick your model and provider, and run it. 100% open source.
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Cline Desktop just launched. An open-source workspace for open-weight models 🤯 > Import tasks from other coding agents > Run agents in parallel > Schedule tasks to run on their own Free models built in: DeepSeek V4 Flash, GLM 5.3 Flash, Laguna S 2.1. I had early access and I can assure you it feels incredible. Pick your model and provider, and run it. 100% open source.

Alvaro Cintas

15,934 views • 1 month ago

ESMFold2 and the ESM-C family, now available for use! We’ve partnered with biohub (the ESM team’s new home), to provide day 1 access to their newly open-sourced series of models. The family of models show best-in-class results for structure prediction, de novo design, and protein-language model tasks.
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ESMFold2 and the ESM-C family, now available for use! We’ve partnered with biohub (the ESM team’s new home), to provide day 1 access to their newly open-sourced series of models. The family of models show best-in-class results for structure prediction, de novo design, and protein-language model tasks.

Deniz Kavi

15,772 views • 5 months ago

We are continuing to advance open-source AI. Just announced -- new tools for speech, safety, and autonomous driving. Learn about the open models, datasets, and research we’re releasing at #NeurIPS2025:
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We are continuing to advance open-source AI. Just announced -- new tools for speech, safety, and autonomous driving. Learn about the open models, datasets, and research we’re releasing at #NeurIPS2025:

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Something just launched that makes VS Code feel ancient. And im all in for it: Cline Desktop app, an open-source app for open-weight models (and you know how much i love open source) brings its coding agent into a standalone Cline Desktop app for Mac + Windows. Just open a project and tell it what you want to change. No need to open VS Code first. In Cline's demo, it adds priority filters to a task board, works through the code and runs the build. Glad to see the model choice stays open, too. You can bring your own API keys, use supported open-weight models and even switch models halfway through a project!
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Something just launched that makes VS Code feel ancient. And im all in for it: Cline Desktop app, an open-source app for open-weight models (and you know how much i love open source) brings its coding agent into a standalone Cline Desktop app for Mac + Windows. Just open a project and tell it what you want to change. No need to open VS Code first. In Cline's demo, it adds priority filters to a task board, works through the code and runs the build. Glad to see the model choice stays open, too. You can bring your own API keys, use supported open-weight models and even switch models halfway through a project!

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40,292 views • 1 month ago

Introducing $JTVO Staking Stake JTVO to fund GPUs that run open-source models for you: automatically, and fully private. Every other model is still one key away on the Jatevo gateway. live on this end of the week
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Introducing $JTVO Staking Stake JTVO to fund GPUs that run open-source models for you: automatically, and fully private. Every other model is still one key away on the Jatevo gateway. live on this end of the week

Jatevo

12,337 views • 1 month ago

Excited to annouce that @askvenice is now integrated as our sole LLM inference provider for bunnyCompute. We love the product and recommend it for any LLM use case. Open-source models, no data retention, no censorship - that's why we chose them.
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Excited to annouce that @askvenice is now integrated as our sole LLM inference provider for bunnyCompute. We love the product and recommend it for any LLM use case. Open-source models, no data retention, no censorship - that's why we chose them.

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Cline Desktop launches today! The Cline team gave us early access, so we’ve had some time to explore what they’re building. Cline Desktop is an open-source app built for open-weight models, bringing Cline into a dedicated desktop workspace with parallel agent sessions, scheduled tasks, flexible model and provider choice, a built-in Marketplace, and support for importing existing workflows from tools like Claude Code and Codex. It’s a meaningful step toward making open-weight models more practical for everyday agentic workflows!
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Cline Desktop launches today! The Cline team gave us early access, so we’ve had some time to explore what they’re building. Cline Desktop is an open-source app built for open-weight models, bringing Cline into a dedicated desktop workspace with parallel agent sessions, scheduled tasks, flexible model and provider choice, a built-in Marketplace, and support for importing existing workflows from tools like Claude Code and Codex. It’s a meaningful step toward making open-weight models more practical for everyday agentic workflows!

Documenting AGI

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I’ve been building Dexter for 2 months now. It’s like Claude Code, but for finance. What Dexter can do: • find undervalued stocks • analyze them in detail • build investment thesis All of the code is open source. Bonus: Dexter can also run on local LLMs.
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I’ve been building Dexter for 2 months now. It’s like Claude Code, but for finance. What Dexter can do: • find undervalued stocks • analyze them in detail • build investment thesis All of the code is open source. Bonus: Dexter can also run on local LLMs.

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We now have an easy overview of all open-source models supported in our API You can find pricing, context limits, supported features, and more
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We now have an easy overview of all open-source models supported in our API You can find pricing, context limits, supported features, and more

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No more excuses to not help fund the open source software that powers your code Just type /tribute in Claude Code
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No more excuses to not help fund the open source software that powers your code Just type /tribute in Claude Code

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Aider is an open source AI coding assistant for the terminal, offering repo-aware edits, git-native workflows, and support for a wide range of models. Explore more:
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Aider is an open source AI coding assistant for the terminal, offering repo-aware edits, git-native workflows, and support for a wide range of models. Explore more:

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As a supporter of the open weights ecosystem, we're proud to be a post-training partner for NVIDIA Nemotron. We post-train Nemotron models for customer use cases, de-risk mainline RL runs on our AC2 platform and training stack, and contribute aggregate workload statistics for inference benchmarking. This is how open models get better, and we're excited to keep working closely with NVIDIA AI.
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As a supporter of the open weights ecosystem, we're proud to be a post-training partner for NVIDIA Nemotron. We post-train Nemotron models for customer use cases, de-risk mainline RL runs on our AC2 platform and training stack, and contribute aggregate workload statistics for inference benchmarking. This is how open models get better, and we're excited to keep working closely with NVIDIA AI.

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Krea 2 is back and this time the weights are OPEN. This open source release ships with two models designed to work together — Krea 2 RAW and Krea 2 Turbo. RAW is for training, Turbo is for inference.
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Krea 2 is back and this time the weights are OPEN. This open source release ships with two models designed to work together — Krea 2 RAW and Krea 2 Turbo. RAW is for training, Turbo is for inference.

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A few of you asked for the code for these SwiftUI prototypes, I just added them to my open source repo, link in the replies
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A few of you asked for the code for these SwiftUI prototypes, I just added them to my open source repo, link in the replies

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I've nearly ditched closed source models for image generation (in creative workflows). For most tasks, the cost/speed ratio doesn't justify closed models anymore. Open models have caught up on quality and I can try 15 new images in 1-2 sec. Iteration speed matters. Sharing the few models I currently use ⬇️
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I've nearly ditched closed source models for image generation (in creative workflows). For most tasks, the cost/speed ratio doesn't justify closed models anymore. Open models have caught up on quality and I can try 15 new images in 1-2 sec. Iteration speed matters. Sharing the few models I currently use ⬇️

Victor M

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We are open-sourcing TTSKit! Run state-of-the-art text-to-speech models on your Mac and iPhone. The launch version supports Qwen Qwen3-TTS and generates audio faster than real-time playback with sub-200 ms time-to-first-byte. Voice cloning and advanced speed optimizations will be in the next version. Link to the GitHub repo and models on Hugging Face in comments.
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We are open-sourcing TTSKit! Run state-of-the-art text-to-speech models on your Mac and iPhone. The launch version supports Qwen Qwen3-TTS and generates audio faster than real-time playback with sub-200 ms time-to-first-byte. Voice cloning and advanced speed optimizations will be in the next version. Link to the GitHub repo and models on Hugging Face in comments.

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