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Caffeine doses above 250 mg can interfere with creatine’s effectiveness at the muscle-cell level Higher caffeine intake directly opposes creatine’s cellular effects, disrupting calcium handling in muscles and potentially limiting muscle performance While occasional combined use is likely fine, regular mixing of high-dose caffeine and creatine can blunt benefits

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Here's the timestamp from our latest episode with @darrencandow where this is discussed in depth:

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Did you know? 75% of Americans are chronically dehydrated, yet just a 2% drop in hydration can affect your mood, energy, and mental performance. 💧 Track your intake easily with our app.

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For the love of god, can you just let me live

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What the hell!?! @hubermanlab says drinking coffee early can block adenosine receptors before adenosine clears and thereby disrupt cortisol rhythms. It’s impossible to deconflict all this stuff and I feel like even those of us who try to pay attention end up with an arbitrary assortment of health practices.

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if you drink coffee in morning and creatine at night, most of the caffeine should be metabolized at that point

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What about 250mg of caffeine.. in morning That’s roughly 2 shots of espresso- perfect to jump start a day And creatine mid day and later in the day? So 4+ hours apart?

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Download our free "How to Train According to the Experts" guide Distilling nearly 100 episodes of the FoundMyFitness podcast and its expert insights, this guide provides actionable, evidence-based principles to optimize training outcomes Available now Get it here:

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Ggrrreat lol good to know 🙏🏼🙏🏼

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Good info

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Does the same effect take place if you space them out several hours? Like if I have creatine in the morning say 7:00 a.m. am I safe to have my caffeine at 12:00 p.m. without affecting creatine levels?

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Is it ok to combine creatine with caffeine? They are generally not a problem together unless your caffeine dose is very high. The interference seems to show up around ~350 mg of caffeine pre-workout (about 3.5 cups of coffee), where caffeine may blunt some of creatine’s performance benefit because they have opposite effects on muscle relaxation. So yes, you can put creatine in your coffee (I do). Just don’t mega-dose caffeine before training if you want the full ergogenic effect. Even then, the effect is probably minor enough to not stress about.

Is it ok to combine creatine with caffeine? They are generally not a problem together unless your caffeine dose is very high. The interference seems to show up around ~350 mg of caffeine pre-workout (about 3.5 cups of coffee), where caffeine may blunt some of creatine’s performance benefit because they have opposite effects on muscle relaxation. So yes, you can put creatine in your coffee (I do). Just don’t mega-dose caffeine before training if you want the full ergogenic effect. Even then, the effect is probably minor enough to not stress about.

Dr. Rhonda Patrick

97,603 görüntüleme • 1 ay önce

Why I upped my creatine dose to 10 grams per day. I used to take 5 grams of creatine daily, which provides solid benefits for muscle strength and performance (when combined with resistance training). Recently, I increased my dose to 10 grams, and here’s why I made the switch. Research suggests that 10 grams of creatine per day may offer additional advantages, particularly for brain health. Studies show that this higher dose increases creatine levels in areas like the grey matter, white matter, and thalamus more effectively than lower doses, such as 4 grams, over an 8-week period. This is likely due to a "spillover effect", where excess creatine benefits the brain once muscles are fully saturated. While 5 grams is effective for physical performance, 10 grams seems to provide a broader range of benefits, including potential cognitive support and bone health. If you’re considering creatine supplementation and want to maximize its effects, a 10-gram daily dose could be worth exploring.

Why I upped my creatine dose to 10 grams per day. I used to take 5 grams of creatine daily, which provides solid benefits for muscle strength and performance (when combined with resistance training). Recently, I increased my dose to 10 grams, and here’s why I made the switch. Research suggests that 10 grams of creatine per day may offer additional advantages, particularly for brain health. Studies show that this higher dose increases creatine levels in areas like the grey matter, white matter, and thalamus more effectively than lower doses, such as 4 grams, over an 8-week period. This is likely due to a "spillover effect", where excess creatine benefits the brain once muscles are fully saturated. While 5 grams is effective for physical performance, 10 grams seems to provide a broader range of benefits, including potential cognitive support and bone health. If you’re considering creatine supplementation and want to maximize its effects, a 10-gram daily dose could be worth exploring.

Dr. Rhonda Patrick

331,381 görüntüleme • 11 ay önce

“I have very high caffeine tolerance.” Andrew D. Huberman, Ph.D. breaks down caffeine intake, which includes 4–6 cans of Mateína yerba mate per day, and occasionally a couple double espressos: “Caffeine's great. It's definitely a performance enhancer - so much so that the people who regulate this stuff in sports set an upper limit on the milligrams of caffeine that you can ingest.” “I cut off my caffeine intake at about 2 pm, but I also drink caffeine first thing in the morning if I'm going to work out in the first two hours of the day. I do that about three or four days a week.” “Other times, I wait a little while. I love yerba. I also drink coffee. I'll have a couple of double espressos. I love it.” “By 8:00 or 9:00, if you cut caffeine out earlier, you're going to crash on a steep cliff - and it feels great because you fall asleep easily.”

“I have very high caffeine tolerance.” Andrew D. Huberman, Ph.D. breaks down caffeine intake, which includes 4–6 cans of Mateína yerba mate per day, and occasionally a couple double espressos: “Caffeine's great. It's definitely a performance enhancer - so much so that the people who regulate this stuff in sports set an upper limit on the milligrams of caffeine that you can ingest.” “I cut off my caffeine intake at about 2 pm, but I also drink caffeine first thing in the morning if I'm going to work out in the first two hours of the day. I do that about three or four days a week.” “Other times, I wait a little while. I love yerba. I also drink coffee. I'll have a couple of double espressos. I love it.” “By 8:00 or 9:00, if you cut caffeine out earlier, you're going to crash on a steep cliff - and it feels great because you fall asleep easily.”

TBPN

53,138 görüntüleme • 5 ay önce

The combination of coffee and L-theanine is a proven way to enhance alertness while reducing the "jitteriness" some people get from high doses of caffeine. Multiple studies show that together they can boost focus, attention, and reduce distractibility during cognitively demanding tasks. Some people refer to the feeling as a "calm yet focused" state. The combination works because L-theanine alters the pharmacological profile of coffee—balancing caffeine-induced stimulation by increasing the activity of alpha brain waves and calming neurotransmitters like GABA and serotonin. For the best results, pair 100–200 mg of L-theanine with 100–150 mg of caffeine;. Take them at the same time due to their similar absorption kinetics. Importantly L-theanine doesn't influence the metabolism (half-life) of caffeine—you still need to be cautious about not drinking coffee too close to bedtime.

Dr. Rhonda Patrick

473,328 görüntüleme • 1 yıl önce

If you’re only taking 5 grams of creatine, your brain might be missing out Research comparing doses shows that 10 grams daily doubles brain creatine content compared to lower amounts—especially in critical brain regions linked to memory and cognition While 5 grams may be sufficient for muscle benefits, it's likely inadequate for fully unlocking creatine’s brain-boosting potential During periods of stress—like sleep deprivation, jet lag, or intense mental demands—upping your dose to 10 grams (or even higher) ensures your brain gets the support it needs most

If you’re only taking 5 grams of creatine, your brain might be missing out Research comparing doses shows that 10 grams daily doubles brain creatine content compared to lower amounts—especially in critical brain regions linked to memory and cognition While 5 grams may be sufficient for muscle benefits, it's likely inadequate for fully unlocking creatine’s brain-boosting potential During periods of stress—like sleep deprivation, jet lag, or intense mental demands—upping your dose to 10 grams (or even higher) ensures your brain gets the support it needs most

FoundMyFitness Clips

1,259,405 görüntüleme • 1 yıl önce

It’s not 100% certain, but the evidence points in one direction: Exogenous DHT usually works best at low, physiological doses (around 4–5 mg) and isn’t meant for continuous, high-dose use. Very high DHT levels can lose their anti-estrogenic/prolactin-lowering effects and may even show ERβ-like or estrogen-like activity, based mostly on animal and in-vitro data. Many people also report better gyno reduction at low doses, while higher amounts can cause paradoxical effects (possibly because impurities only become physiologically relevant at larger doses).

It’s not 100% certain, but the evidence points in one direction: Exogenous DHT usually works best at low, physiological doses (around 4–5 mg) and isn’t meant for continuous, high-dose use. Very high DHT levels can lose their anti-estrogenic/prolactin-lowering effects and may even show ERβ-like or estrogen-like activity, based mostly on animal and in-vitro data. Many people also report better gyno reduction at low doses, while higher amounts can cause paradoxical effects (possibly because impurities only become physiologically relevant at larger doses).

Jamal Dinkoui

15,506 görüntüleme • 7 ay önce

Rhonda Patrick now takes 10 grams of creatine per day — double the standard dose. Why? Once your muscles are saturated at 5g, the extra starts reaching your brain. German research showed 10g meaningfully raises brain creatine levels. Even more striking: 20–30g can completely erase the cognitive damage from 21 hours of sleep deprivation — and in some cases, people performed better than when fully rested. Rhonda uses the higher dose on jet-lagged or high-demand days and says she no longer gets the usual mid-afternoon crash. Many of her vegan friends report more energy and needing less sleep after starting. Creatine is quietly shifting from “muscle supplement” to powerful brain performance tool. Have you tried higher-dose creatine (above 5g)? Did you notice changes in energy, focus, or sleep needs?

Rhonda Patrick now takes 10 grams of creatine per day — double the standard dose. Why? Once your muscles are saturated at 5g, the extra starts reaching your brain. German research showed 10g meaningfully raises brain creatine levels. Even more striking: 20–30g can completely erase the cognitive damage from 21 hours of sleep deprivation — and in some cases, people performed better than when fully rested. Rhonda uses the higher dose on jet-lagged or high-demand days and says she no longer gets the usual mid-afternoon crash. Many of her vegan friends report more energy and needing less sleep after starting. Creatine is quietly shifting from “muscle supplement” to powerful brain performance tool. Have you tried higher-dose creatine (above 5g)? Did you notice changes in energy, focus, or sleep needs?

Camus

281,612 görüntüleme • 2 ay önce

Supplementing with protein during strength training can increase gains in muscle size by approximately 27%, even when baseline protein intake is already considered adequate. The current RDA for protein, 0.8 grams per kilogram of body weight per day, is meant to prevent deficiency, not to optimize muscle growth or performance. Increasing intake to 1.5x the RDA leads to greater improvements in both muscle size and strength when combined with resistance exercise. Doubling the RDA is even better. Meta-analyses suggest that around 1.6 g/kg/day of protein is sufficient to maximize gains in muscle strength and fat-free mass, with potential (though smaller) benefits observed at higher intakes up to 2.2 g/kg/day for those aiming to fully optimize muscle growth and recovery (like athletes). This highlights how conservative the RDA truly is and why higher protein intakes are important, particularly for individuals engaging in regular strength training or other forms of physical activity.

Supplementing with protein during strength training can increase gains in muscle size by approximately 27%, even when baseline protein intake is already considered adequate. The current RDA for protein, 0.8 grams per kilogram of body weight per day, is meant to prevent deficiency, not to optimize muscle growth or performance. Increasing intake to 1.5x the RDA leads to greater improvements in both muscle size and strength when combined with resistance exercise. Doubling the RDA is even better. Meta-analyses suggest that around 1.6 g/kg/day of protein is sufficient to maximize gains in muscle strength and fat-free mass, with potential (though smaller) benefits observed at higher intakes up to 2.2 g/kg/day for those aiming to fully optimize muscle growth and recovery (like athletes). This highlights how conservative the RDA truly is and why higher protein intakes are important, particularly for individuals engaging in regular strength training or other forms of physical activity.

Dr. Rhonda Patrick

92,392 görüntüleme • 8 ay önce

Magnesium plays a vital role in helping the heart and nervous system remain calm and relaxed. It is involved in hundreds of processes in the body, including muscle relaxation and proper nerve function. When levels are adequate, the body is better able to maintain balance and respond to stress. It’s also important to recognize that frequent intake of caffeine and refined sugar may contribute to mineral depletion over time. This can influence how the body regulates calcium and magnesium balance. Supporting mineral status through nourishing, whole foods and wise lifestyle choices can make a noticeable difference for many people — helping the body feel calmer, steadier, and more resilient. 🌿

Magnesium plays a vital role in helping the heart and nervous system remain calm and relaxed. It is involved in hundreds of processes in the body, including muscle relaxation and proper nerve function. When levels are adequate, the body is better able to maintain balance and respond to stress. It’s also important to recognize that frequent intake of caffeine and refined sugar may contribute to mineral depletion over time. This can influence how the body regulates calcium and magnesium balance. Supporting mineral status through nourishing, whole foods and wise lifestyle choices can make a noticeable difference for many people — helping the body feel calmer, steadier, and more resilient. 🌿

Barbara Oneill

25,786 görüntüleme • 4 ay önce

Be careful about stacking stimulants and exercise. Energy drinks, caffeine, and nicotine can improve motivation and performance, but they also cause high-amplitude dopamine release with minimal to zero effort. When you use a stimulant, you might feel more motivated to workout. But in the absence of the stimulant, your motivation levels are likely to plummet. If you need a stimulant for every workout, you’re creating a pattern of behavior that won’t serve you well in the long run. Listen as Dr. Andrew Huberman (Andrew D. Huberman, Ph.D.) describes how he uses caffeine to enhance his workout quality while preventing it from becoming a crutch. Check out the post below for a link to the full episode!

Be careful about stacking stimulants and exercise. Energy drinks, caffeine, and nicotine can improve motivation and performance, but they also cause high-amplitude dopamine release with minimal to zero effort. When you use a stimulant, you might feel more motivated to workout. But in the absence of the stimulant, your motivation levels are likely to plummet. If you need a stimulant for every workout, you’re creating a pattern of behavior that won’t serve you well in the long run. Listen as Dr. Andrew Huberman (Andrew D. Huberman, Ph.D.) describes how he uses caffeine to enhance his workout quality while preventing it from becoming a crutch. Check out the post below for a link to the full episode!

Dr. Rhonda Patrick

554,523 görüntüleme • 2 yıl önce

Why building muscle now protects you later in life | Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick) This clip is from episode # 369 of The Drive which was released on 10/20/25. In the full episode, we cover: -How protein requirements evolve with age, activity, and goals, and why building muscle early is critical for long-term health -The connection between protein intake, mTOR, and longevity, and why fears around activation are largely misplaced -Why creatine’s cognitive effects may be as important as its role in physical performance -How regular heat exposure supports recovery, enhances mood, and may help protect against neurodegenerative disease Listen (Ep. # 369) to the full episode on my website ( or your favorite podcast player.

Why building muscle now protects you later in life | Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick) This clip is from episode # 369 of The Drive which was released on 10/20/25. In the full episode, we cover: -How protein requirements evolve with age, activity, and goals, and why building muscle early is critical for long-term health -The connection between protein intake, mTOR, and longevity, and why fears around activation are largely misplaced -Why creatine’s cognitive effects may be as important as its role in physical performance -How regular heat exposure supports recovery, enhances mood, and may help protect against neurodegenerative disease Listen (Ep. # 369) to the full episode on my website ( or your favorite podcast player.

Peter Attia

45,295 görüntüleme • 6 ay önce

Creatine dose, benefits & safety from Dr. Rhonda Patrick: - Standard muscle dose is 5 g/day of creatine monohydrate - the most well-researched form - but muscles are "very greedy" and consume most of it before it reaches the brain. - Getting creatine into the brain requires higher doses: one German study found that at 10 g/day, MRI scans showed creatine levels rising in key brain regions above what the brain produces on its own. - Creatine shines under brain stress - sleep deprivation, intense cognitive work, travel fatigue. One study gave sleep-deprived subjects 0.35 g per kg bodyweight (roughly 20-25 g) and they performed not just at baseline but above it. - The phosphocreatine system has a frontal bias - the brain areas most associated with strategic planning and working memory rely on it most heavily. "It's one of the most well-studied supplements out there. If it was unsafe, we really would know." Dr. Rhonda Patrick on Andrew D. Huberman, Ph.D.

Creatine dose, benefits & safety from Dr. Rhonda Patrick: - Standard muscle dose is 5 g/day of creatine monohydrate - the most well-researched form - but muscles are "very greedy" and consume most of it before it reaches the brain. - Getting creatine into the brain requires higher doses: one German study found that at 10 g/day, MRI scans showed creatine levels rising in key brain regions above what the brain produces on its own. - Creatine shines under brain stress - sleep deprivation, intense cognitive work, travel fatigue. One study gave sleep-deprived subjects 0.35 g per kg bodyweight (roughly 20-25 g) and they performed not just at baseline but above it. - The phosphocreatine system has a frontal bias - the brain areas most associated with strategic planning and working memory rely on it most heavily. "It's one of the most well-studied supplements out there. If it was unsafe, we really would know." Dr. Rhonda Patrick on Andrew D. Huberman, Ph.D.

Huberman Lab Clips

15,566 görüntüleme • 1 ay önce

Beta-alanine is one of the most effective performance supplements almost no one outside of hardcore fitness circles talks about Unlike caffeine, it doesn’t hype you up—but it does let you push harder and longer by buffering the burn that shuts your muscles down It works by increasing your levels of carnosine, a natural compound that regulates acidity in your muscle cells If you're doing anything high-intensity (like CrossFit or HIIT ), beta-alanine is worth experimenting with

Beta-alanine is one of the most effective performance supplements almost no one outside of hardcore fitness circles talks about Unlike caffeine, it doesn’t hype you up—but it does let you push harder and longer by buffering the burn that shuts your muscles down It works by increasing your levels of carnosine, a natural compound that regulates acidity in your muscle cells If you're doing anything high-intensity (like CrossFit or HIIT ), beta-alanine is worth experimenting with

FoundMyFitness Clips

27,663 görüntüleme • 1 yıl önce

$On average, most people lose 1% of their muscle mass per year and 3% of their strength per year after age 50. It's even worse if you're inactive—strength drops by 4% annually in people who don't engage in resistance exercise! Strength training and a high protein intake can slow or mitigate age-related declines in muscle, and this is important. More muscle enhances metabolism, improves insulin sensitivity, and protects against diabetes. But muscle also safeguards against falls and fractures, which can be a literal death sentence for older adults— up to 58% of older adults who experience a hip fracture die within 12 months of the injury. The evidence is clear: more muscle lowers mortality risk, while less muscle and a higher fat mass increases it. And while resistance exercise is the most important factor for building and maintaining muscle, optimizing protein intake is a proven strategy to increase healthspan at every age. Discover the optimal protein intake tailored to your age, physical activity, and goals in my new episode, The Science of Protein (Episode 97), now available on all major platforms. Watch now:$

On average, most people lose 1% of their muscle mass per year and 3% of their strength per year after age 50. It's even worse if you're inactive—strength drops by 4% annually in people who don't engage in resistance exercise! Strength training and a high protein intake can slow or mitigate age-related declines in muscle, and this is important. More muscle enhances metabolism, improves insulin sensitivity, and protects against diabetes. But muscle also safeguards against falls and fractures, which can be a literal death sentence for older adults— up to 58% of older adults who experience a hip fracture die within 12 months of the injury. The evidence is clear: more muscle lowers mortality risk, while less muscle and a higher fat mass increases it. And while resistance exercise is the most important factor for building and maintaining muscle, optimizing protein intake is a proven strategy to increase healthspan at every age. Discover the optimal protein intake tailored to your age, physical activity, and goals in my new episode, The Science of Protein (Episode 97), now available on all major platforms. Watch now:

Dr. Rhonda Patrick

124,002 görüntüleme • 1 yıl önce

The pre-workout industry has lost its mind. 500 milligrams of caffeine is normal now. Stacked with yohimbe, exotic stimulants, more heat, more tingles, more chaos. That is not energy, that is stimulation. And if you train after 5PM, it forces a choice. Have a great workout and ruin your sleep, or protect your sleep and settle for less. We decided to eliminate that tradeoff completely. This is the launch of a new category: evening-friendly training that actually gives you real energy. Cleanform Nutrition Birds of Prey is not another stim-heavy pre-workout. It is built on cellular energy, not nervous system stimulation. With 5 grams of goBHB®, you are fueling ATP production directly at the mitochondrial level, giving your body steady, usable energy without the crash, without anxiety, and without destroying your sleep. This is not borrowed energy. This is real energy. Train hard at night. Sleep deep. Recover stronger. Every scoop is built for performance: -8 grams L-Citrulline for pumps and blood flow -Setria Glutathione to extend nitric oxide -5 grams goBHB for sustained cellular energy -5 grams Pürest Creatine for strength output -HydroPrime for hydration and endurance -Betaine for power production -AstraGin for absorption No stimulants. No crash. No compromise. And it is DELICIOUS. Available in Strawberry Lemonade and Watermelon Lemonade. If you want caffeine, add it yourself. Coffee, espresso, No Doz. Your call. We built the foundation so you stay in control. This is the future of performance. All the energy. None of the caffeine.

The pre-workout industry has lost its mind. 500 milligrams of caffeine is normal now. Stacked with yohimbe, exotic stimulants, more heat, more tingles, more chaos. That is not energy, that is stimulation. And if you train after 5PM, it forces a choice. Have a great workout and ruin your sleep, or protect your sleep and settle for less. We decided to eliminate that tradeoff completely. This is the launch of a new category: evening-friendly training that actually gives you real energy. Cleanform Nutrition Birds of Prey is not another stim-heavy pre-workout. It is built on cellular energy, not nervous system stimulation. With 5 grams of goBHB®, you are fueling ATP production directly at the mitochondrial level, giving your body steady, usable energy without the crash, without anxiety, and without destroying your sleep. This is not borrowed energy. This is real energy. Train hard at night. Sleep deep. Recover stronger. Every scoop is built for performance: -8 grams L-Citrulline for pumps and blood flow -Setria Glutathione to extend nitric oxide -5 grams goBHB for sustained cellular energy -5 grams Pürest Creatine for strength output -HydroPrime for hydration and endurance -Betaine for power production -AstraGin for absorption No stimulants. No crash. No compromise. And it is DELICIOUS. Available in Strawberry Lemonade and Watermelon Lemonade. If you want caffeine, add it yourself. Coffee, espresso, No Doz. Your call. We built the foundation so you stay in control. This is the future of performance. All the energy. None of the caffeine.

Marc Lobliner - IFBB Pro

75,297 görüntüleme • 3 ay önce

Creatine is for Brain Power, not Just Muscle Power A New RCT just dropped looking at creatine hydrochloride (HCl) and creatine ethyl ester (CEE) on cognitive outcomes (PMID: 40854087). Researchers gave perimenopausal women 8 weeks of either low-dose creatine HCl (750 mg or 1.5 g / day), a blend of HCl + CEE, or placebo. 👉 The 1.5 g HCl group showed small but significant improvements in reaction time and even a ~16% increase in frontal brain creatine levels on MRS scans. The HCl + CEE combo didn’t outperform HCl alone. All forms were well-tolerated and there were no serious side effects. The results add to growing evidence that creatine supports cognition—not just strength, hypertrophy, and power—but let’s keep perspective: ⚠️ Creatine ethyl ester has consistently underperformed in bioavailability studies. Multiple head-to-head trials show it’s rapidly degraded to creatinine in the gut and fails to meaningfully raise muscle creatine compared to creatine monohydrate (PMID:19228401). Creatine HCl seems to dissolve better in water and some anecdotal reports claim it’s easier on digestion for some people, but so far there’s no solid evidence it improves muscle or brain creatine stores beyond what you get with monohydrate. Bottom line: this study is promising for the cognitive benefits of creatine overall, but it doesn’t change the main recommendation Creatine monohydrate is still the gold standard. It’s the form used in hundreds of human RCTs, proven to raise muscle and brain creatine, and it’s cheap. Until stronger data show otherwise, save your money and stick with monohydrate.

Creatine is for Brain Power, not Just Muscle Power A New RCT just dropped looking at creatine hydrochloride (HCl) and creatine ethyl ester (CEE) on cognitive outcomes (PMID: 40854087). Researchers gave perimenopausal women 8 weeks of either low-dose creatine HCl (750 mg or 1.5 g / day), a blend of HCl + CEE, or placebo. 👉 The 1.5 g HCl group showed small but significant improvements in reaction time and even a ~16% increase in frontal brain creatine levels on MRS scans. The HCl + CEE combo didn’t outperform HCl alone. All forms were well-tolerated and there were no serious side effects. The results add to growing evidence that creatine supports cognition—not just strength, hypertrophy, and power—but let’s keep perspective: ⚠️ Creatine ethyl ester has consistently underperformed in bioavailability studies. Multiple head-to-head trials show it’s rapidly degraded to creatinine in the gut and fails to meaningfully raise muscle creatine compared to creatine monohydrate (PMID:19228401). Creatine HCl seems to dissolve better in water and some anecdotal reports claim it’s easier on digestion for some people, but so far there’s no solid evidence it improves muscle or brain creatine stores beyond what you get with monohydrate. Bottom line: this study is promising for the cognitive benefits of creatine overall, but it doesn’t change the main recommendation Creatine monohydrate is still the gold standard. It’s the form used in hundreds of human RCTs, proven to raise muscle and brain creatine, and it’s cheap. Until stronger data show otherwise, save your money and stick with monohydrate.

Layne Norton, PhD

16,253 görüntüleme • 8 ay önce

Your edge just got easier to take. CreGAAtine® is now in capsules. The most advanced creatine innovation, combining creatine monohydrate with guanidinoacetic acid (GAA) now in a convenient capsule form. Why settle for ordinary when you can unlock: 🔥 Up to 16.9% greater muscle creatine saturation, over 800% higher than creatine alone 🔥 4 absorption pathways for superior bioavailability and no transport backlog. 🔥 3.9x higher brain creatine levels for focus and recovery. 🔥 No bloating. No GI distress. No compromises. All the proven benefits of our original powder, just easier to use, anywhere. Capsules. Same science. Same unmatched results. #unmatchedsupps #cregaatine #creatinecapsule #innovation

Your edge just got easier to take. CreGAAtine® is now in capsules. The most advanced creatine innovation, combining creatine monohydrate with guanidinoacetic acid (GAA) now in a convenient capsule form. Why settle for ordinary when you can unlock: 🔥 Up to 16.9% greater muscle creatine saturation, over 800% higher than creatine alone 🔥 4 absorption pathways for superior bioavailability and no transport backlog. 🔥 3.9x higher brain creatine levels for focus and recovery. 🔥 No bloating. No GI distress. No compromises. All the proven benefits of our original powder, just easier to use, anywhere. Capsules. Same science. Same unmatched results. #unmatchedsupps #cregaatine #creatinecapsule #innovation

Bodybuilding.com

12,796 görüntüleme • 4 ay önce

$Creatine isn’t just for athletes. A growing body of scientific evidence now shows creatine helps preserve muscle during aging, maintains bone density, improves cognition (especially during stress), and speeds muscle recovery after intense exercise. To explore the mechanisms, optimal dosing strategies, and practical considerations, and more, I invited a leading creatine researcher Dr. Darren Candow (Darren Candow, PhD, CSEP-CEP, FISSN) onto the podcast. Even if you’re not an athlete—or you’ve dismissed creatine as a muscle supplement—you need to listen to this episode. Links to YouTube, Apple Podcasts, and Spotify in the comments. Timestamps: 0:00 - Introduction 0:56 - What makes creatine effective for exercise performance? 4:23 - The loss of explosive power with aging 5:59 - How creatine speeds up recovery between sets 8:36 - Two ways creatine boosts muscle strength 10:34 - Why creatine might not speed typical weight-training recovery 13:01 - Anti-catabolic effects 13:38 - Why do men and women respond differently? 15:12 - Dietary creatine vs. supplementation 15:59 - Is creatine supplementation necessary—or optional? 17:27 - Why plant-based may benefit most 18:38 - Should creatine dosage change with age? 19:23 - Loading vs. daily dosing 22:20 - Why 5 grams might not be enough—other tissues 24:11 - Can creatine prevent bone loss—even without weight training? 24:32 - How creatine supports osteoblast activity 26:13 - Preventing hip fractures with creatine 28:55 - Creatine vs. bisphosphonates 32:43 - Why creatine isn’t just for weightlifters 35:14 - Why stressed brains benefit most 37:19 - Why brain aging accelerates demand 40:16 - Why 10g per day might be the optimal dose 42:07 - Why creatine counteracts sleep deprivation 45:16 - Before vs. after concussion 47:39 - Should dosage be adjusted by weight? 49:01 - Does creatine improve sleep on training days? 51:56 - Creatine for Alzheimer’s and Parkinson’s 53:29 - Can creatine help with depression and anxiety? 56:46 - Creatine and glutamine for preventing respiratory illness 59:02 - Why creatine may enhance endothelial health and circulation 1:00:26 - Creatine’s role in cardiometabolic health 1:02:07 - When does loading actually make sense? 1:03:12 - Preserving muscle and enhancing recovery after injury 1:06:07 - Is creatine effective without exercise? 1:08:23 - Why creatine might improve male fertility 1:10:19 - Is it safe for children? 1:13:43 - Creatine supplementation during pregnancy 1:15:15 - Could creatine boost motor skills in kids? 1:15:55 - Creatine monohydrate vs. the rest 1:20:37 - How to avoid digestive issues with creatine supplementation 1:23:18 - Does timing matter—and should you cycle it? 1:24:54 - Should you take creatine every day—or only workout days? 1:25:39 - Why caffeine might blunt the effects 1:28:43 - Does creatine increase body fat—or is that a myth? 1:29:30 - Preventing cramps (the hydration myth) 1:30:55 - Why creatine won’t damage your kidneys 1:33:21 - Why creatine is linked (wrongly?) to baldness 1:36:44 - Debunking myths—sleep, cancer, urination 1:40:01 - How creatine affects homocysteine levels 1:42:54 - Creatine and protein—the ideal post-workout pair? 1:45:48 - How to pick the best creatine supplement 1:48:08 - What to know about micronized creatine$

Creatine isn’t just for athletes. A growing body of scientific evidence now shows creatine helps preserve muscle during aging, maintains bone density, improves cognition (especially during stress), and speeds muscle recovery after intense exercise. To explore the mechanisms, optimal dosing strategies, and practical considerations, and more, I invited a leading creatine researcher Dr. Darren Candow (Darren Candow, PhD, CSEP-CEP, FISSN) onto the podcast. Even if you’re not an athlete—or you’ve dismissed creatine as a muscle supplement—you need to listen to this episode. Links to YouTube, Apple Podcasts, and Spotify in the comments. Timestamps: 0:00 - Introduction 0:56 - What makes creatine effective for exercise performance? 4:23 - The loss of explosive power with aging 5:59 - How creatine speeds up recovery between sets 8:36 - Two ways creatine boosts muscle strength 10:34 - Why creatine might not speed typical weight-training recovery 13:01 - Anti-catabolic effects 13:38 - Why do men and women respond differently? 15:12 - Dietary creatine vs. supplementation 15:59 - Is creatine supplementation necessary—or optional? 17:27 - Why plant-based may benefit most 18:38 - Should creatine dosage change with age? 19:23 - Loading vs. daily dosing 22:20 - Why 5 grams might not be enough—other tissues 24:11 - Can creatine prevent bone loss—even without weight training? 24:32 - How creatine supports osteoblast activity 26:13 - Preventing hip fractures with creatine 28:55 - Creatine vs. bisphosphonates 32:43 - Why creatine isn’t just for weightlifters 35:14 - Why stressed brains benefit most 37:19 - Why brain aging accelerates demand 40:16 - Why 10g per day might be the optimal dose 42:07 - Why creatine counteracts sleep deprivation 45:16 - Before vs. after concussion 47:39 - Should dosage be adjusted by weight? 49:01 - Does creatine improve sleep on training days? 51:56 - Creatine for Alzheimer’s and Parkinson’s 53:29 - Can creatine help with depression and anxiety? 56:46 - Creatine and glutamine for preventing respiratory illness 59:02 - Why creatine may enhance endothelial health and circulation 1:00:26 - Creatine’s role in cardiometabolic health 1:02:07 - When does loading actually make sense? 1:03:12 - Preserving muscle and enhancing recovery after injury 1:06:07 - Is creatine effective without exercise? 1:08:23 - Why creatine might improve male fertility 1:10:19 - Is it safe for children? 1:13:43 - Creatine supplementation during pregnancy 1:15:15 - Could creatine boost motor skills in kids? 1:15:55 - Creatine monohydrate vs. the rest 1:20:37 - How to avoid digestive issues with creatine supplementation 1:23:18 - Does timing matter—and should you cycle it? 1:24:54 - Should you take creatine every day—or only workout days? 1:25:39 - Why caffeine might blunt the effects 1:28:43 - Does creatine increase body fat—or is that a myth? 1:29:30 - Preventing cramps (the hydration myth) 1:30:55 - Why creatine won’t damage your kidneys 1:33:21 - Why creatine is linked (wrongly?) to baldness 1:36:44 - Debunking myths—sleep, cancer, urination 1:40:01 - How creatine affects homocysteine levels 1:42:54 - Creatine and protein—the ideal post-workout pair? 1:45:48 - How to pick the best creatine supplement 1:48:08 - What to know about micronized creatine

Dr. Rhonda Patrick

463,757 görüntüleme • 1 yıl önce

Devastating us in old age, a short stint in the hospital can cause just enough atrophy that we may not be able to perform the basic activities of daily living - progressing us catastrophically towards early mortality. In my recent interview with Dr. Chris McGlory, Chris highlights the surprising effects of high-dose omega-3, dramatically reducing muscle loss from immobilization and sensitizing muscles to respond anabolically to protein intake. Watch the full interview with Chris on Apple Podcasts, Spotify, YouTube. Show notes for this episode here:

Devastating us in old age, a short stint in the hospital can cause just enough atrophy that we may not be able to perform the basic activities of daily living - progressing us catastrophically towards early mortality. In my recent interview with Dr. Chris McGlory, Chris highlights the surprising effects of high-dose omega-3, dramatically reducing muscle loss from immobilization and sensitizing muscles to respond anabolically to protein intake. Watch the full interview with Chris on Apple Podcasts, Spotify, YouTube. Show notes for this episode here:

Dr. Rhonda Patrick

125,027 görüntüleme • 3 yıl önce

Most people think of Botox as a cosmetic treatment, but it's interesting to learn that muscles and bones are more connected than they appear. When a muscle is temporarily paralyzed, it no longer places its usual stress on the surrounding bone, which can affect bone density in that specific area. What stands out to me is that the risk seems to depend heavily on the location and dose. Typical cosmetic injections are generally not associated with significant bone loss, while higher-dose treatments in larger muscles, such as the jaw, have raised more concern among researchers. The encouraging part is that Botox's effects are temporary. The body is constantly adapting, and once normal muscle activity returns, the bone can often recover as well. It's a fascinating example of the "use it or lose it" principle at work inside the human body. Video credit; Rby, motherrrrnature, 05-23-2026, https//www.tiktok.com/t/ZP8seDHEJ/

Most people think of Botox as a cosmetic treatment, but it's interesting to learn that muscles and bones are more connected than they appear. When a muscle is temporarily paralyzed, it no longer places its usual stress on the surrounding bone, which can affect bone density in that specific area. What stands out to me is that the risk seems to depend heavily on the location and dose. Typical cosmetic injections are generally not associated with significant bone loss, while higher-dose treatments in larger muscles, such as the jaw, have raised more concern among researchers. The encouraging part is that Botox's effects are temporary. The body is constantly adapting, and once normal muscle activity returns, the bone can often recover as well. It's a fascinating example of the "use it or lose it" principle at work inside the human body. Video credit; Rby, motherrrrnature, 05-23-2026, https//www.tiktok.com/t/ZP8seDHEJ/

Dr. CZ

30,565 görüntüleme • 1 ay önce