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Can We Finally Reverse Aging? Dr. Aubrey de Grey explains a new breakthrough in longevity research using an engineered enzyme that repairs molecular damage once thought permanent. FULL STORY: Aubrey de Grey The LEV Foundation Revel Pharmaceuticals The Scientist #longevity #life #tech #research #aging

Tim Ventura

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27,214 views • 1 month ago •via X (Twitter)

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I interviewed Aubrey de Grey on why neither billionaires nor AI will solve aging. And why a single mouse breakthrough could be the ChatGPT moment for longevity. 0:00 - Longevity Field 20 Years On 08:58 - Are Billionaires Getting It Wrong? 17:13 - Bryan Johnson vs Peter Thiel 23:42 - ChatGPT Moment for Longevity 28:52 - Biological Age vs Lifespan 34:44 - Influencers Will Save Us 39:36 - AI x Science Breakthroughs 48:14 - Sam Altman on Aging 53:39 - Genesis Mission 56:45 - Systems Will Collapse 1:08:55 - GLP-1s & Human Enhancement

I interviewed Aubrey de Grey on why neither billionaires nor AI will solve aging. And why a single mouse breakthrough could be the ChatGPT moment for longevity. 0:00 - Longevity Field 20 Years On 08:58 - Are Billionaires Getting It Wrong? 17:13 - Bryan Johnson vs Peter Thiel 23:42 - ChatGPT Moment for Longevity 28:52 - Biological Age vs Lifespan 34:44 - Influencers Will Save Us 39:36 - AI x Science Breakthroughs 48:14 - Sam Altman on Aging 53:39 - Genesis Mission 56:45 - Systems Will Collapse 1:08:55 - GLP-1s & Human Enhancement

Mgoes (bio/acc 🤖💉)

45,444 views • 7 months ago

IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.

IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.

Yuri Deigin

15,038 views • 1 year ago

Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.

Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.

SciTech Era

17,777 views • 2 months ago

New pod with Aubrey de Grey. Recorded in San Francisco, we discussed the technologies behind life extension and the possibility of curing age... Full interview 👇

New pod with Aubrey de Grey. Recorded in San Francisco, we discussed the technologies behind life extension and the possibility of curing age... Full interview 👇

Peter McCormack 🏴‍☠️🇬🇧🇮🇪

19,742 views • 1 month ago

I love this take. Elon Musk looks at aging like an engineer, not like a mystic. Exactly the same mindset as Aubrey de Grey. Core ideas that really hit: •Aging is not chaos. The whole body degrades in sync, so there must be a central mechanism. •If everything decays together, there is a biological clock or program behind it. •Programs can be rewritten. Aging is not destiny, it is code. •Other species already solved it. Whales reach 200 years, Greenland sharks up to 500. •That means it is not magic. It is biology and engineering. What I truly hope: •That Elon uses his capital, influence, and engineering culture to seriously push aging research. •If not full lifespan extension, then at least curing age related diseases. •Cancer, neurodegeneration, cardiovascular decay should be optional, not inevitable. If aging is engineered, it can be reverse engineered. That idea alone changes everything.

I love this take. Elon Musk looks at aging like an engineer, not like a mystic. Exactly the same mindset as Aubrey de Grey. Core ideas that really hit: •Aging is not chaos. The whole body degrades in sync, so there must be a central mechanism. •If everything decays together, there is a biological clock or program behind it. •Programs can be rewritten. Aging is not destiny, it is code. •Other species already solved it. Whales reach 200 years, Greenland sharks up to 500. •That means it is not magic. It is biology and engineering. What I truly hope: •That Elon uses his capital, influence, and engineering culture to seriously push aging research. •If not full lifespan extension, then at least curing age related diseases. •Cancer, neurodegeneration, cardiovascular decay should be optional, not inevitable. If aging is engineered, it can be reverse engineered. That idea alone changes everything.

VraserX e/acc

391,541 views • 8 months ago

AI REENGINEERS NOBEL-WINNING PROTEINS TO REVERSE CELL AGING OpenAI, working with longevity startup Retro Bio, has developed a specialized model called GPT-4b Micro that redesigned the Nobel Prize–winning Yamanaka factors with stunning efficiency. Unlike the 2012 discovery that reprogrammed less than 0.1% of cells over weeks, the AI-engineered proteins converted more than 30% of cells and showed powerful DNA damage repair. Multiple labs confirmed the results across cell types and delivery methods. The breakthrough signals a leap for regenerative medicine, compressing decades of aging research into mere weeks. Source: rowancheung

AI REENGINEERS NOBEL-WINNING PROTEINS TO REVERSE CELL AGING OpenAI, working with longevity startup Retro Bio, has developed a specialized model called GPT-4b Micro that redesigned the Nobel Prize–winning Yamanaka factors with stunning efficiency. Unlike the 2012 discovery that reprogrammed less than 0.1% of cells over weeks, the AI-engineered proteins converted more than 30% of cells and showed powerful DNA damage repair. Multiple labs confirmed the results across cell types and delivery methods. The breakthrough signals a leap for regenerative medicine, compressing decades of aging research into mere weeks. Source: rowancheung

Mario Nawfal

276,978 views • 1 year ago

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research

Daniel Shur

16,988 views • 5 months ago

Seeing vitalik.eth appreciate our efforts at Eth Bull is highly encouraging! Reflecting back on one of the X Spaces we did to discuss health longevity and anti-aging research with @senstweet and Methuselah Foundation 🧬 Makes me happy to be a part of a journey where we donated $150K to various charitable causes. And it’s exciting to see that $EBULL pumped 2000% in the last hour

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Momin

27,961 views • 1 year ago

Want to live longer? Science says: Keep insulin LOW. Dr. Benjamin Bikman on the clearest signal in aging research: - Animal studies (rodents → insects): Lower insulin = longer life (decades of consistent proof) - Human evidence: Families with exceptional longevity ALL show higher insulin sensitivity (insulin works better → stays lower) - The longer insulin stays low, the longer life tends to be 54-sec clip — one of the strongest longevity levers we have 👇 Who’s actively keeping insulin low for a longer, stronger life? Low-carb, fasting, exercise, berberine, sleep… drop your top insulin hack below

Want to live longer? Science says: Keep insulin LOW. Dr. Benjamin Bikman on the clearest signal in aging research: - Animal studies (rodents → insects): Lower insulin = longer life (decades of consistent proof) - Human evidence: Families with exceptional longevity ALL show higher insulin sensitivity (insulin works better → stays lower) - The longer insulin stays low, the longer life tends to be 54-sec clip — one of the strongest longevity levers we have 👇 Who’s actively keeping insulin low for a longer, stronger life? Low-carb, fasting, exercise, berberine, sleep… drop your top insulin hack below

Camus

27,687 views • 8 months ago

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors E1 Ventures 🇺🇸. Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors E1 Ventures 🇺🇸. Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging

Ashlee Vance

63,172 views • 10 months ago

Everyone wants the fountain of youth. The internet thinks it comes in a peptide vial called Epitalon. It supposedly lengthens telomeres, activates telomerase, improves sleep, and maybe even slows aging itself. But when you actually read the research... The story gets a lot more interesting. We dug through the Cold War origins, the Russian longevity studies, the cancer concerns, the sleep data, and what the evidence really says about one of the most hyped peptides in biohacking. If you've ever wondered whether Epitalon is the closest thing we have to an anti-aging therapy—or just another internet myth—this one's for you. Abud Bakri MD

Everyone wants the fountain of youth. The internet thinks it comes in a peptide vial called Epitalon. It supposedly lengthens telomeres, activates telomerase, improves sleep, and maybe even slows aging itself. But when you actually read the research... The story gets a lot more interesting. We dug through the Cold War origins, the Russian longevity studies, the cancer concerns, the sleep data, and what the evidence really says about one of the most hyped peptides in biohacking. If you've ever wondered whether Epitalon is the closest thing we have to an anti-aging therapy—or just another internet myth—this one's for you. Abud Bakri MD

Dr. Alex Tatem

30,634 views • 3 months ago

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Wall Street Apes

489,664 views • 7 months ago

ARE YOU READY: 🚨 Musk reveals "semi immortality is a solvable problem" and believes that in 10 years the LIFE SPAN will significantly increase, but not quite DOUBLE. Elon Musk recently highlighted aging and human longevity as an "extremely solvable" scientific challenge, sparking fresh discussion about dramatically extended lifespans. In a January 2026 appearance on the Moonshots podcast with Peter Diamandis, Musk described "longevity or semi-immortality" as not particularly hard from a biological perspective. He pointed to the highly synchronized way the human body ages: every part degrades in lockstep, with no one having, for example, an old left arm paired with a young right arm. This suggests an underlying "biological clock" or programmed mechanism that's waiting to be understood and potentially rewritten. "I've long thought that longevity or semi-mortality is an extremely solvable problem. I don't think it's a particularly hard problem... You're pre-programmed to die. And so if you change the program, you will live longer." He added that once scientists identify the root cause of aging, it will likely seem "incredibly obvious" rather than subtle.

ARE YOU READY: 🚨 Musk reveals "semi immortality is a solvable problem" and believes that in 10 years the LIFE SPAN will significantly increase, but not quite DOUBLE. Elon Musk recently highlighted aging and human longevity as an "extremely solvable" scientific challenge, sparking fresh discussion about dramatically extended lifespans. In a January 2026 appearance on the Moonshots podcast with Peter Diamandis, Musk described "longevity or semi-immortality" as not particularly hard from a biological perspective. He pointed to the highly synchronized way the human body ages: every part degrades in lockstep, with no one having, for example, an old left arm paired with a young right arm. This suggests an underlying "biological clock" or programmed mechanism that's waiting to be understood and potentially rewritten. "I've long thought that longevity or semi-mortality is an extremely solvable problem. I don't think it's a particularly hard problem... You're pre-programmed to die. And so if you change the program, you will live longer." He added that once scientists identify the root cause of aging, it will likely seem "incredibly obvious" rather than subtle.

TRENDING ➞ 911

43,736 views • 2 months ago

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

KanekoaTheGreat

1,234,391 views • 1 month ago

Brand-new research (PMID: 42102814) has uncovered a bizarre link between a compound found in aged garlic and longevity. 🧄 It's called: S1PC. Remarkably, it causes fat cells to release tiny vesicles carrying an enzyme that travels to the brain, boosting levels of the energy molecule NAD in just minutes. In animal studies, this reduced frailty and even increased muscle strength through a previously unrecognized brain-to-muscle circuit. In the full deep dive, we unpack the mechanism, the animal data, and what—if anything—it could mean for humans. You won't want to miss this one... unless you're a vampire. 🧄 Deep dive linked below

Nick Norwitz MD PhD

15,234 views • 2 months ago

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”

The All-In Podcast

2,983,249 views • 2 months ago

Theoretical physicist Michio Kaku on why aging is simply an accumulation of errors that AI can now identify: He opens with a bold claim about what artificial intelligence might finally make possible: "Artificial intelligence may give us something that the kings and queens of old could never conquer and that is the aging process." For Dr. Michio Kaku, the science behind why we age is no longer a mystery. It comes down to one thing: errors building up inside our cells over time. "We now know why things age. Things get old and die because they accumulate error. Error in the form of DNA mistakes. Accumulation of errors inside cells." The challenge, until now, has been the sheer scale of the problem. Identifying exactly where and how these errors occur across the human genome has been beyond what conventional research could handle. That's where artificial intelligence changes everything: "But now we have artificial intelligence. We can analyze millions of genomes of old people, compare them to millions of genomes of young people, and identify where aging takes place in the body."

Theoretical physicist Michio Kaku on why aging is simply an accumulation of errors that AI can now identify: He opens with a bold claim about what artificial intelligence might finally make possible: "Artificial intelligence may give us something that the kings and queens of old could never conquer and that is the aging process." For Dr. Michio Kaku, the science behind why we age is no longer a mystery. It comes down to one thing: errors building up inside our cells over time. "We now know why things age. Things get old and die because they accumulate error. Error in the form of DNA mistakes. Accumulation of errors inside cells." The challenge, until now, has been the sheer scale of the problem. Identifying exactly where and how these errors occur across the human genome has been beyond what conventional research could handle. That's where artificial intelligence changes everything: "But now we have artificial intelligence. We can analyze millions of genomes of old people, compare them to millions of genomes of young people, and identify where aging takes place in the body."

Big Brain AI

78,764 views • 3 months ago

$GOOGL has an anti-aging asset nobody is pricing. Friedberg david friedberg walked through a Calico paper that should be on Alphabet holders' radar. Calico is Google's longevity lab. Working with Revel Pharma, it used AlphaFold plus directed evolution to design a novel enzyme that degrades CML, the glycation end-product that stiffens tissue and drives aging. The result is not a slide. Across five recursive design cycles the enzyme degraded 52-97% of CML on human proteins, and on donated skin from patients over 70 it eliminated about 55% of CML - reversing the skin's profile toward that of a 31-year-old. It is AI-designed proteins doing something genuinely new in biology, not a benchmark score. Chamath Chamath Palihapitiya frames the first market as cosmetic: a workable anti-aging cream is a multi-trillion-dollar category. This is the AlphaFold thesis paying out in a product line, and the AlphaFold-to-drugs bridge is exactly what Demis Hassabis Demis Hassabis has argued is the real near-term return on Google's AI - not chatbots, but designed molecules. Same company, same stack, a second revenue engine the market files under "research." Implication: this is deep-optionality inside a name you already hold on search and cloud. It does not move the $GOOGL model this year. But it is a reminder that Alphabet's AI edge shows up in drug and materials design, an option the Street assigns roughly zero value. If a Calico or Isomorphic asset reaches a real market, that is upside no analyst is underwriting. Watch for Calico or Isomorphic Labs to move a designed molecule toward a commercial or clinical path.

Podcast Alpha

124,354 views • 1 month ago