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David Sinclair's lab is using AI to build a pill that reverses aging for $100. Right now, their gene therapy costs roughly $10 million to manufacture. It requires a direct injection into the target organ. That's not going to work for 8 billion people. So Sinclair's team made a...

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43 Kommentare

Profilbild von Juancho
Juanchovor 6 Monaten

@YourDocGoku In case anyone wants all the details in a text format:

Profilbild von Longevity
Longevityvor 6 Monaten

This is pretty cool.

Profilbild von Jason R. Williams, MD, DABR
Jason R. Williams, MD, DABRvor 6 Monaten

@YourDocGoku David and I have been exchanging ideas on this for a while. What his lab calls reprogramming, we see in the clinic every day. When you make a patient's cells younger, they fight cancer better. Period.

Profilbild von Longevity
Longevityvor 6 Monaten

When do you think this'll happen? In 5-10 years?

Profilbild von Toby Cunningham
Toby Cunninghamvor 6 Monaten

@YourDocGoku There will never be a "magic pill". You need the right diet, you need to work out, you need detox protocols like EBO2/TPE/Inuspheresis, Peptides, MUSE Stem Cells, HBOT(hard shell) Red Light Therapy etc... I am doing most of these right now. There is NO Magic Bullet here.

Profilbild von Hamish Ogilvy
Hamish Ogilvyvor 6 Monaten

@YourDocGoku @davidasinclair Let’s get Michael Jordan loaded up and back into his prime!

Profilbild von Longevity
Longevityvor 6 Monaten

@davidasinclair I second this.

Profilbild von Adam ∣ Building to $10K/mo live
Adam ∣ Building to $10K/mo livevor 6 Monaten

@YourDocGoku We have cured aging in mice dozens of times in the last 20 years. The translation to human biology is where 99% of these chemical breakthroughs die. Call me when the human trials actually show systemic markers shifting in a controlled group.

Profilbild von NadelParis
NadelParisvor 6 Monaten

@YourDocGoku @GeniusGTX I want to visit the "Willy Wonka's chocolate factory". I’d like that pill please, and some dark chocolate. 🍫 Okay, just the pill is fine.

Profilbild von Kevin
Kevinvor 6 Monaten

@YourDocGoku @davidasinclair This is the same guy that sold the drug to GSK and got sued for it

Profilbild von Kevin A. Scott, PhD
Kevin A. Scott, PhDvor 6 Monaten

@YourDocGoku to build a pill huh

Profilbild von Longevity
Longevityvor 6 Monaten

Sounds crazy. Your thoughts on this?

Profilbild von AlphaHealth
AlphaHealthvor 6 Monaten

@YourDocGoku why are we trying to prevent aging? It's natural. Humans don't live as long as they should (120) because of poor diet, environmental toxins etc. Maybe spending money on addressing those would be more beneficial?

Profilbild von inthezone
inthezonevor 6 Monaten

So if people live far longer, albeit healthier then more people will exist on planet earth. Pensions will be unaffordable so you will have to continue working for decades more. But maybe AI has replaced your job. Physical jobs probably won’t be viable for those in their 70’s/80’s. Young people will be frustrated with waiting far longer for an inheritance. Live long enough to see relatives younger than you die, god forbid your children. Mental health will be an issue. Mad dictators and sickos will live decades more to terrorise people. I get it! It’s a negative take on living longer. But reality should be faced. I like the idea of living into my 80’s or even 90’s while healthy and mobile. But current life isn’t designed for such a change. Especially when it comes to pensions and financial black holes many countries find themselves in.

Profilbild von Noodles MacIntosh
Noodles MacIntoshvor 6 Monaten

@YourDocGoku So does he still believe in all the supplements he is selling? NMN and all the other ones.

Profilbild von Ben
Benvor 6 Monaten

@YourDocGoku Grifter. Scammer. Both of them.

Profilbild von David Diwei Xia
David Diwei Xiavor 6 Monaten

This is actually the brilliance of @davidasinclair and why his small molecule method must be the path to longevity. Gene therapies are potent and possibly very effective means of age reversal, but they are not affordable. As a society, we cannot have a situation where only the richest, most powerful, and most sadistic have access to longevity. Longevity should be available to everyone or no one.

Profilbild von Anteriojay
Anteriojayvor 6 Monaten

@YourDocGoku Yea sure sure…the earth is overpopulated and we want the population to be 500 million but at the same time want people to live forever 🫠

Profilbild von Jeffrey T Miller
Jeffrey T Millervor 6 Monaten

@YourDocGoku What will you do with all the extra time? Will you alter your path and embrace joy?

Profilbild von Katherine Tidman
Katherine Tidmanvor 6 Monaten

@YourDocGoku Drug companies sit on the sidelines of the supplement world because they can’t patent natural substances. But David Sinclair could bridge this. He could take over-the-counter ingredients and "pharmaceuticalize" them at scale and make them available to everyone inexpensively! 🤩

Profilbild von Absurdist1988
Absurdist1988vor 6 Monaten

@YourDocGoku Sinclair is a grifter.

Profilbild von Cyril Gupta
Cyril Guptavor 6 Monaten

@YourDocGoku David Sinclair’s lab is using AI to turn $10M gene therapies into a $100 pill that could reverse aging, screening billions of molecules to make age-reversal accessible to everyone.

Profilbild von Longevity
Longevityvor 6 Monaten

Yes, that's what I just said.

Profilbild von Clipsleuth.com
Clipsleuth.comvor 6 Monaten

@YourDocGoku The Diary Of A CEO with Steven Bartlett Episode: "David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells..." Mar 23, 2026 · Clip Starts at 15:50 Full episode ↓

Profilbild von surdog007
surdog007vor 6 Monaten

@YourDocGoku Stay alive till 2030

Profilbild von Akuyuki
Akuyukivor 6 Monaten

@YourDocGoku If it was real he would be silenced long ago.

Profilbild von Longevity
Longevityvor 6 Monaten

He does mention how the government did try to silence him so foreign countries couldn't get access to it in the interview. The fact that he's bringing this up now probably means it's been solved 5-10 years ago imo

Profilbild von Roberto Vallarino
Roberto Vallarinovor 6 Monaten

@YourDocGoku What a crock of shit.

Profilbild von Longevity
Longevityvor 6 Monaten

What makes you say this?

Profilbild von Roberto Vallarino
Roberto Vallarinovor 6 Monaten

@YourDocGoku Overhyped promises on all fields.

Profilbild von Real Health Freedom
Real Health Freedomvor 6 Monaten

@YourDocGoku Skip the gene therapy and chemical shortcuts. Real food, daily movement, and solid sleep are the safest ways to feel great and actually enjoy a long life. What’s one simple habit that’s helped you feel younger and stronger? #RealHealthFreedom

Profilbild von Notions
Notionsvor 6 Monaten

@YourDocGoku @davidasinclair If he wants to make serious bank then just charge everyone a percentage of their net worth or a percentage of their last years earnings but keep it low enough so people on the breadline can still afford it?

Profilbild von H PII
H PIIvor 6 Monaten

@YourDocGoku @StevenBartlett Theranos, and Elizabeth Holmes, revisited

Profilbild von Most interesting man on X ☦️
Most interesting man on X ☦️vor 6 Monaten

@YourDocGoku Faster please!

Profilbild von SerenityBuff
SerenityBuffvor 6 Monaten

@YourDocGoku Im sure a lot of people are willing to pay any amount for it, which would give fuel to achieve the pill sooner

Profilbild von stüsentrieb
stüsentriebvor 6 Monaten

@YourDocGoku "They should know within a year or two if the molecules work" OMG GREAT NEWS "in mice." oh.

Profilbild von J.S. Pancione 🇺🇸
J.S. Pancione 🇺🇸vor 6 Monaten

@YourDocGoku Okay, but understand that it will not just be the good honorable contributing kind considerate people who get to live longer...

Profilbild von Chris McAulay
Chris McAulayvor 6 Monaten

@YourDocGoku @LivingForever8 We aren't going to get a pill that reverses aging. Sounds like hype

Profilbild von Longevity
Longevityvor 6 Monaten

@LivingForever8 What makes you say this? Always open to hearing other's opinions. It doesn't sound too good to be true - which is why I believe in the interview he said in 5-10 years, it will happen

Profilbild von Chris McAulay
Chris McAulayvor 6 Monaten

@YourDocGoku @LivingForever8 One pill isn't going to address all of the types of damage that are the hallmarks of ageing. It may have broad systemic effects and it may be more effective in younger people but even then it's a highly dubious assertion.

Profilbild von Turb0Kat
Turb0Katvor 6 Monaten

@YourDocGoku Is he suicidal? Hope he doesnt shoot himself in the back with a rifle.

Profilbild von Matthew2529🇺🇸
Matthew2529🇺🇸vor 6 Monaten

@YourDocGoku @davidasinclair Are we entering Benjamin button territory

Profilbild von Clair Hu
Clair Huvor 6 Monaten

@YourDocGoku @greek_scientist

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David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:
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David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

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🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair
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🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

KanekoaTheGreat

500,515 Aufrufe • vor 1 Monat

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair
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🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

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Harvard Medical School's #1 longevity researcher named one of TIME's 100 most influential people in the world says he can reverse a 92-year-old's skin cells back to age 20: "We've been using mostly artificial intelligence to screen billions of molecules in silico." "We know OSK works, the gene therapy works and we're looking for molecules that do that." "We already have a proof of concept, a cocktail of molecules that we hope to put into a clinical trial into humans within the next couple of months." PS. If you found value in this post make sure to like and repost the first tweet + follow Uncover AI to stay updated with the latest AI news. See you in the next one:
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Harvard Medical School's #1 longevity researcher named one of TIME's 100 most influential people in the world says he can reverse a 92-year-old's skin cells back to age 20: "We've been using mostly artificial intelligence to screen billions of molecules in silico." "We know OSK works, the gene therapy works and we're looking for molecules that do that." "We already have a proof of concept, a cocktail of molecules that we hope to put into a clinical trial into humans within the next couple of months." PS. If you found value in this post make sure to like and repost the first tweet + follow Uncover AI to stay updated with the latest AI news. See you in the next one:

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The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
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The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

John Cumbers

1,163,043 Aufrufe • vor 6 Monaten

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.
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David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.

John Cumbers

55,280 Aufrufe • vor 5 Monaten

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair
1:45

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair

John Cumbers

203,250 Aufrufe • vor 6 Monaten

🚨RUBIO: USAID rife with “rank insubordination” — “we had no choice but to take dramatic steps to bring this thing under control." "They have basically evolved into an agency that believes that they're not even a U.S. government agency...they're completely unresponsive. They just don't consider that they work for the US." "They just think they're a global entity and that their master is the globe and not the United States. And that's not sustainable." “The goal was to reform it. But now we have rank insubordination. Their basic attitude is we don't work for anyone. We work for ourselves. No agency of government can tell us what to do." ."There are things that are happening at USAID that we should not be involved in funding and or that we have a lot of questions about, but they're completely uncooperative. So we had no choice but to take dramatic steps to bring this thing under control."
1:46

🚨RUBIO: USAID rife with “rank insubordination” — “we had no choice but to take dramatic steps to bring this thing under control." "They have basically evolved into an agency that believes that they're not even a U.S. government agency...they're completely unresponsive. They just don't consider that they work for the US." "They just think they're a global entity and that their master is the globe and not the United States. And that's not sustainable." “The goal was to reform it. But now we have rank insubordination. Their basic attitude is we don't work for anyone. We work for ourselves. No agency of government can tell us what to do." ."There are things that are happening at USAID that we should not be involved in funding and or that we have a lot of questions about, but they're completely uncooperative. So we had no choice but to take dramatic steps to bring this thing under control."

Western Lensman

1,689,350 Aufrufe • vor 1 Jahr

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.
1:24

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

John Cumbers

157,742 Aufrufe • vor 5 Monaten

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”
6:19

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”

Fan Commentary: Joe Rogan Recaps

24,517 Aufrufe • vor 1 Monat

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:04

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

84,263 Aufrufe • vor 5 Monaten

Edible Vaccines: They Don't Want You To Know mRNA Gene Therapy Is Going into Your Food Missouri HB 1169, a two-page transparency and disclosure bill for gene therapy products, is getting big-time backlash in deep-red Missouri. You have every right to know if a food product is a gene therapy product — so we have to ask why Missouri legislators would be against this. And they've known how to make edible vaccines for a "very, very long time," going back to the year 2000, attested attorney Tom Renz. "And now they're doing it; now they're going to do it."
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Edible Vaccines: They Don't Want You To Know mRNA Gene Therapy Is Going into Your Food Missouri HB 1169, a two-page transparency and disclosure bill for gene therapy products, is getting big-time backlash in deep-red Missouri. You have every right to know if a food product is a gene therapy product — so we have to ask why Missouri legislators would be against this. And they've known how to make edible vaccines for a "very, very long time," going back to the year 2000, attested attorney Tom Renz. "And now they're doing it; now they're going to do it."

The Vigilant Fox 🦊

762,357 Aufrufe • vor 3 Jahren

Former medical coder and whistleblower Zowe Smith explains how the Covid PCR "tests" were likely used to collect people's DNA and send said DNA to gene banks. This DNA, Smith hypothesizes, can now be used by Larry Ellison's Stargate program to create genome-tailored "vaccines." This clip of Smith (Zowe Smith), who is also the author of The Covid Code: My Life in the Thrill Kill Medical Cult, is taken from a conversation with Charlie Robinson (Macroaggressions Podcast with Charlie Robinson) posted to the Macroaggressions Rumble channel on December 3, 2025. ---------------Partial transcription of clip---------------- "Genetics is, you know, all basically eugenics. And so fast forward to 2020 when I started realizing, oh, there's these false positives with the test. And I knew that you didn't even need to have a test to be diagnosed with it. The doctors had to look at you and say, oh, I think you have Covid. So that's so smart that you were thinking, oh, it's gotta be a genetic screen. "Because at some point down the line, I've actually found documentation from the CDC that ordered every CLIA certified lab to send genetics, sequences to one of two different gene banks. G I S A I— G I S A I D. So GI SAID, or NCBI, one of those two gene banks. And it did say in the fine print, like, oh, these sequences for Covid. "But I asked David Rasnick, who I did an interview with, and he actually knew Kary Mullis and worked with Kary Mullis at one point, who invented PCR. And I asked him this specifically. I said, so obviously the PCR can run an entire DNA sequence. And here's this instruction. I showed him the document. I said, okay, they're sending these sequences and people are trolling me. You know, the Internet masses are commenting back saying, oh, no, that was just the sequence for Covid, for the variant of COVID because they had like six of them listed out. "And I asked him, do you think they're actually, like, after they run the PCR test and they get this sequence and then they have to send it to the gene bank, do you think they're actually spending the time to edit it and cut out just that section? Or do you think they're just sending the whole thing and then the gene bank can decide which section they want to take as their sequence? And he goes, they don't have the time to go in and edit all of that. I mean, they could, but most likely, no. Most likely they're just sending the whole thing. "Then the gene bank that, that they send it to, and he's shown evidence of how much DNA has been sent to these gene banks. They're tracking all of it carefully. So, yeah, that's absolutely what they're doing. Well, NCBI and GISAID, I haven't looked into who owns them, but there's another one that was creating PCR tests. And I believe that all of the PCR tests were doing the same thing, sending, genetic information back to some, some hive mind, whether that's NCBI or, you know, some other gene bank. "So it's generally the testing places that are, you know, having it send back. So there is the Human Genome Project in China, which is now, I forget the name, it's, it changed its name, but it's the biggest biotech company in China now. And they made PCR test kits, PCR and the IgG, which is the antibody test, and they send it to America. And who do you think is getting those results back? "So our DNA is going to some Chinese database. And even our own American military has flagged that gene bank as being a problem because they have all our individual information. And when you go to that gene bank and the other ones are really similar when you look at like why they exist and what they think they're doing with our DNA. Because I was really interested in why are they collecting all of this? They're obviously going to use it against us in some way. "So what is that? How do we get ahead of that or how do we stop it? And it says on the the one in China anyway. And the other ones basically say it and not in so clear terms that they are collecting our DNA because they need this massive amount population genomics so they can create vaccines and therapeutics or drugs, biologics tailored to our individual genome. "And then we have Larry Ellison come out with Donald Trump on day two of the administration saying exactly that. We're going to use AI to analyze your blood, which is how they get the DNA gene sequences. It's AI that creates the DNA gene sequences, that sends it to the gene banks. That's why it's electronic and they can send it, because it's using AI. It's not like, you know, a sample that they're sending. Physically, it's a digital code. It all comes together."
4:34

Former medical coder and whistleblower Zowe Smith explains how the Covid PCR "tests" were likely used to collect people's DNA and send said DNA to gene banks. This DNA, Smith hypothesizes, can now be used by Larry Ellison's Stargate program to create genome-tailored "vaccines." This clip of Smith (Zowe Smith), who is also the author of The Covid Code: My Life in the Thrill Kill Medical Cult, is taken from a conversation with Charlie Robinson (Macroaggressions Podcast with Charlie Robinson) posted to the Macroaggressions Rumble channel on December 3, 2025. ---------------Partial transcription of clip---------------- "Genetics is, you know, all basically eugenics. And so fast forward to 2020 when I started realizing, oh, there's these false positives with the test. And I knew that you didn't even need to have a test to be diagnosed with it. The doctors had to look at you and say, oh, I think you have Covid. So that's so smart that you were thinking, oh, it's gotta be a genetic screen. "Because at some point down the line, I've actually found documentation from the CDC that ordered every CLIA certified lab to send genetics, sequences to one of two different gene banks. G I S A I— G I S A I D. So GI SAID, or NCBI, one of those two gene banks. And it did say in the fine print, like, oh, these sequences for Covid. "But I asked David Rasnick, who I did an interview with, and he actually knew Kary Mullis and worked with Kary Mullis at one point, who invented PCR. And I asked him this specifically. I said, so obviously the PCR can run an entire DNA sequence. And here's this instruction. I showed him the document. I said, okay, they're sending these sequences and people are trolling me. You know, the Internet masses are commenting back saying, oh, no, that was just the sequence for Covid, for the variant of COVID because they had like six of them listed out. "And I asked him, do you think they're actually, like, after they run the PCR test and they get this sequence and then they have to send it to the gene bank, do you think they're actually spending the time to edit it and cut out just that section? Or do you think they're just sending the whole thing and then the gene bank can decide which section they want to take as their sequence? And he goes, they don't have the time to go in and edit all of that. I mean, they could, but most likely, no. Most likely they're just sending the whole thing. "Then the gene bank that, that they send it to, and he's shown evidence of how much DNA has been sent to these gene banks. They're tracking all of it carefully. So, yeah, that's absolutely what they're doing. Well, NCBI and GISAID, I haven't looked into who owns them, but there's another one that was creating PCR tests. And I believe that all of the PCR tests were doing the same thing, sending, genetic information back to some, some hive mind, whether that's NCBI or, you know, some other gene bank. "So it's generally the testing places that are, you know, having it send back. So there is the Human Genome Project in China, which is now, I forget the name, it's, it changed its name, but it's the biggest biotech company in China now. And they made PCR test kits, PCR and the IgG, which is the antibody test, and they send it to America. And who do you think is getting those results back? "So our DNA is going to some Chinese database. And even our own American military has flagged that gene bank as being a problem because they have all our individual information. And when you go to that gene bank and the other ones are really similar when you look at like why they exist and what they think they're doing with our DNA. Because I was really interested in why are they collecting all of this? They're obviously going to use it against us in some way. "So what is that? How do we get ahead of that or how do we stop it? And it says on the the one in China anyway. And the other ones basically say it and not in so clear terms that they are collecting our DNA because they need this massive amount population genomics so they can create vaccines and therapeutics or drugs, biologics tailored to our individual genome. "And then we have Larry Ellison come out with Donald Trump on day two of the administration saying exactly that. We're going to use AI to analyze your blood, which is how they get the DNA gene sequences. It's AI that creates the DNA gene sequences, that sends it to the gene banks. That's why it's electronic and they can send it, because it's using AI. It's not like, you know, a sample that they're sending. Physically, it's a digital code. It all comes together."

Sense Receptor

35,149 Aufrufe • vor 9 Monaten

There's a whole new set of longevity therapeutics coming after GLP-1s that will hopefully "knock back your functional age by 20-30 years," says Peter H. Diamandis, MD: "For the first time ever, we [have] an age reversal technology going into human trials. It's [David Sinclair's] OSK trial that's being done by Life Biosciences." "They demonstrated that 3 of the 4 Yamanaka factors are able to reverse the age of cells. They did this work first in mice, then primates... demonstrating that in your eyes, in particular for a couple different conditions — macular degeneration and NAION disease — that you can reverse the age of your visual system. This month, they're going into humans." "Because it's an age reversal technology, while it's being tested in the eye, the concept is that it will work on all organs in the body."
1:33

There's a whole new set of longevity therapeutics coming after GLP-1s that will hopefully "knock back your functional age by 20-30 years," says Peter H. Diamandis, MD: "For the first time ever, we [have] an age reversal technology going into human trials. It's [David Sinclair's] OSK trial that's being done by Life Biosciences." "They demonstrated that 3 of the 4 Yamanaka factors are able to reverse the age of cells. They did this work first in mice, then primates... demonstrating that in your eyes, in particular for a couple different conditions — macular degeneration and NAION disease — that you can reverse the age of your visual system. This month, they're going into humans." "Because it's an age reversal technology, while it's being tested in the eye, the concept is that it will work on all organs in the body."

TBPN

65,448 Aufrufe • vor 5 Monaten

“The Chinese are skeptical of our calls for international cooperation on AI. They think they're in a race with us. And if they think they're in a race with us, it's kind of hard for us not to be in a race with them. And that's just the way it is.” “And at the end of the day, the Chinese government is a dictatorship that's nationalist and socialist and doesn't really want to cooperate with us much. They want to beat us. They want to compete with us. So, we can try. It's worth trying.” “But the record shows, according to 100% of the evidence, that when you sign an AI or a nuclear or a cyber-hacking document with the Chinese government, it turns out not to be held up. It turns out that they're not actually trustworthy.”
0:39

“The Chinese are skeptical of our calls for international cooperation on AI. They think they're in a race with us. And if they think they're in a race with us, it's kind of hard for us not to be in a race with them. And that's just the way it is.” “And at the end of the day, the Chinese government is a dictatorship that's nationalist and socialist and doesn't really want to cooperate with us much. They want to beat us. They want to compete with us. So, we can try. It's worth trying.” “But the record shows, according to 100% of the evidence, that when you sign an AI or a nuclear or a cyber-hacking document with the Chinese government, it turns out not to be held up. It turns out that they're not actually trustworthy.”

Josh Rogin

24,025 Aufrufe • vor 5 Tagen

What started as a standard White House announcement quickly turned into one of the most revealing Oval Office moments of the year. Trump was there to declare that Washington, D.C. will host the 2027 NFL Draft. But when reporters started firing off questions, the real fireworks began. First up: immigration. A reporter asked Trump about a new program offering undocumented immigrants $1,000 to self-deport. His answer was blunt—and surprisingly layered. “Yeah, we have millions of people that have come into this country illegally through an administration that didn't know what they were doing. They didn't have a clue. And now we find out officially they didn't, because the president was incompetent. But I could have told you that before.” He explained the idea behind the plan: offer people money to leave—and if they take the offer and prove to be hard-working, they might be allowed back in the right way. “But what we thought we'd do is to self-deport where we're going to pay each one a certain amount of money, and we're going to get him a beautiful flight back to where they came from. And they have a period of time.” “And if they make it, we're going to work with them so that maybe someday, with a little work, they can come back in if they're good people, if they're the kind of people that we want in our company, industrious people that could love our country. And if they're not, they won't. But it will give them a path to becoming, you know, to coming back into the country.” He made it clear that there would be no second chances for those who ignore the opportunity. “So we're going to have, self-deportation, where they deport themselves out of our country, and we'll work with them, and we're going to try. And if if we think they're good, they have, you know, the people we want in our country, they're going to come back into our country. We'll give them a little easier route. But if they don't work and if we take them out after the date, then, they're never coming back.”
1:59

What started as a standard White House announcement quickly turned into one of the most revealing Oval Office moments of the year. Trump was there to declare that Washington, D.C. will host the 2027 NFL Draft. But when reporters started firing off questions, the real fireworks began. First up: immigration. A reporter asked Trump about a new program offering undocumented immigrants $1,000 to self-deport. His answer was blunt—and surprisingly layered. “Yeah, we have millions of people that have come into this country illegally through an administration that didn't know what they were doing. They didn't have a clue. And now we find out officially they didn't, because the president was incompetent. But I could have told you that before.” He explained the idea behind the plan: offer people money to leave—and if they take the offer and prove to be hard-working, they might be allowed back in the right way. “But what we thought we'd do is to self-deport where we're going to pay each one a certain amount of money, and we're going to get him a beautiful flight back to where they came from. And they have a period of time.” “And if they make it, we're going to work with them so that maybe someday, with a little work, they can come back in if they're good people, if they're the kind of people that we want in our company, industrious people that could love our country. And if they're not, they won't. But it will give them a path to becoming, you know, to coming back into the country.” He made it clear that there would be no second chances for those who ignore the opportunity. “So we're going to have, self-deportation, where they deport themselves out of our country, and we'll work with them, and we're going to try. And if if we think they're good, they have, you know, the people we want in our country, they're going to come back into our country. We'll give them a little easier route. But if they don't work and if we take them out after the date, then, they're never coming back.”

Vigilant Fox 🦊

351,051 Aufrufe • vor 1 Jahr

Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair
2:59

Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair

Longevity

32,630 Aufrufe • vor 6 Monaten

David Sacks says he's heard from Anthropic employees who thought they could 10x ARR in one year to $600 billion from when they were at $60 billion, now currently sitting at $80 billion and not slowing down. "I have heard from other people at the company -- I heard that when they were at about $60 billion of ARR, that they thought they could get to $600 billion in one year." "Meaning they thought they were on that 10x ramp from the middle of this year." "Now they're at over $80 [billion] and it doesn't seem to be slowing down." "So the big question is how fast can they grow next year -- does it go all the way from $100 or $120 [billion] to a trillion dollars?" "Look, if they merely got to $400 to $500 billion, that would make them the biggest software company." Baker: "If they get to $200 billion, that's an amazing outcome."
0:36

David Sacks says he's heard from Anthropic employees who thought they could 10x ARR in one year to $600 billion from when they were at $60 billion, now currently sitting at $80 billion and not slowing down. "I have heard from other people at the company -- I heard that when they were at about $60 billion of ARR, that they thought they could get to $600 billion in one year." "Meaning they thought they were on that 10x ramp from the middle of this year." "Now they're at over $80 [billion] and it doesn't seem to be slowing down." "So the big question is how fast can they grow next year -- does it go all the way from $100 or $120 [billion] to a trillion dollars?" "Look, if they merely got to $400 to $500 billion, that would make them the biggest software company." Baker: "If they get to $200 billion, that's an amazing outcome."

Fireside Alpha

389,147 Aufrufe • vor 1 Monat