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I'm fascinated by Urolithin A. It's a compound that stimulates mitophagy (mitochondrial autophagy), helping clear out and replace damaged or dysfunctional mitochondria. Recent studies show that urolithin A improves endurance performance and even keeps immune cells "younger" with age. The data are early and emerging, but promising enough that...

114,954 views • 4 months ago •via X (Twitter)

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Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

The All-In Podcast

58,412 views • 1 year ago

The Hidden Secret to Never Getting Cancer: Protect Your Mitochondria Cancer doesn’t just appear out of nowhere—it starts when a normal cell’s mitochondria break down and become dysfunctional. According to Dr. Eric Berg, the key to cancer prevention lies in safeguarding these cellular powerhouses. Here’s how: 1. Optimize Vitamin D Levels Maintain blood levels of 70–80 ng/mL. Vitamin D is a mitochondrial supercharger, bolstering your immune system and keeping cells functioning optimally. 2. Harness the Power of Fasting Regular intermittent fasting, combined with periodic prolonged fasts (like a 2-day water fast monthly), triggers autophagy—your body’s natural cleanup process—removing damaged cells and rejuvenating mitochondria. 3. Cut Refined Carbs & Starches High-carb diets are mitochondrial kryptonite. Switch to a low-carb approach to reduce oxidative stress and protect cellular energy production. 4. Load Up on Mitochondria-Boosting Foods Garlic, onions, and cruciferous veggies (broccoli, kale, Brussels sprouts) are packed with sulfur compounds that detoxify and fortify mitochondria. 5. Avoid Excess Iron Iron overload—from supplements, fortified foods, or cast-iron cookware—accelerates mitochondrial damage. Monitor your intake to keep iron in check. 6. Exercise Consistently Movement isn’t just for fitness; it’s a mitochondrial elixir. Regular exercise enhances their efficiency, reduces inflammation, and lowers cancer risk. The science is clear: Cancer thrives in a body with weak mitochondria. Strengthen them, and you build an impenetrable defense. Your health is in your hands.

Camus

213,745 views • 9 months ago