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Joe Rogan asks Harvard scientist David Sinclair if someone could "inject something in your coffee" to age you decades overnight. His answer: "We know how to do that." SINCLAIR: "We found that that happens largely due to DNA damage... We could use this to rapidly age a mouse, which...

267,215 просмотров • 1 день назад •via X (Twitter)

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Joe Rogan yells "Holy sh*t!" after Harvard professor of genetics David Sinclair says sudden blindness has DOUBLED because of GLP-1 drugs. Then Rogan pulls up the data himself — and what he reads out loud is even worse. SINCLAIR: "Glaucoma and also sudden blindness. It's called NAION, which is now twice as more prevalent because of the GLP-1 drugs." ROGAN: "Really?!" SINCLAIR: "It's not well known. Obviously companies don't want to talk about it. But yes, sudden blindness has doubled, seemingly because of these meds." ROGAN: "Holy shit!" SINCLAIR: "Careful." ROGAN: "Sudden blindness has doubled because of GLP-1s?" SINCLAIR: "Due to NAION, which is like a stroke in your eye, and then your other eye can go. Which is pretty scary. And there's nothing you can do about it. Hopefully our drug does work for those people." ROGAN: "And, obviously correlation does not equal causation, but it seems to be." SINCLAIR: "Yeah, there's a scientist at Harvard. You could look up his work. Joe Rizzo. It looks like it's repeatable across the planet." ROGAN: "Wow, that's terrible. Terrible because there's so many people out there that are just telling everyone they should get on GLP-1s… Like online podcasters saying, 'Everyone should get on GLP-1s… It's going to transform society.' I'm like, 'We just started taking these! The f*ck are you saying?!'" SINCLAIR: "Yeah, it's not risk free. Same with ED drugs." ROGAN: "Here goes. Recent studies suggest that a potential risk — rare link between GLP-1 receptor agonist medications such as Ozempic, Wegovy, blah, blah, blah, and… an eye stroke [that] can cause sudden, painless loss of vision in one eye, while absolute risk remains very low." ROGAN: "Well, very low is like… What does that mean?" SINCLAIR: "One in 10,000 people." ROGAN: "One in 10,000?" SINCLAIR: "Oh no. Total of 10,000." ROGAN: "Oh, total of 10,000 so far? How many people are taking this stuff?" [Rogan continues reading] "The drugs were 68.6 times more likely to develop this [eye stroke] and 8 times more likely to develop… diabetic retinopathy." ROGAN: "Oh, my God. Then… Wow." ROGAN: "Yeah, man. These things are just — they're just rolling out…"

The Vigilant Fox 🦊

1,316,337 просмотров • 1 день назад

New: Joe Rogan is having the most frustrating day ever when alien author Diana Pasulka won’t give a straight answer about how aliens lie to humans and then Joe’s coffee machine breaks: PASULKA: “Aliens can deceive humans through their dreams.” ROGAN: “How do you know if it’s aliens though? If I’m having a dream about Godzilla that might just be my imagination.” PASULKA: “I’m trying to explain…” ROGAN: “I’m trying to ask you how are they deceiving us?” PASULKA: “I just told you.” ROGAN: “Are they manipulating us telepathically or through a dream? Those are two very different things.” PASULKA: “It could be either.” ROGAN: “But how do you know you’re not just having a normal crazy dream. How do we know if it’s being manufactured by an entity?” PASULKA: “We don’t know what’s true vs what’s false.” ROGAN: “Then how are you sure this is deception and not just our imagination?” PASULKA: “I don’t know.” ROGAN: “So how are people saying they lie?” PASULKA: “They say deceitful things.” ROGAN: “This is very frustrating.” PASULKA: “I know you’re frustrated, but I wouldn’t want any of these experiences to happen to me?” ROGAN: “You wouldn’t want to meet an alien?” PASULKA: “I wouldn’t want to meet them.” ROGAN: “You’re literally a person who writes books about aliens. I’d meet them. I’m not scared. They just interact with you. I’m down with that.” PASULKA: “Is that coffee you’re drinking?” ROGAN: “Jamie this coffee is ice cold.” JAMIE: “I boiled it twice.” ROGAN: “It’s literally ice cold. Maybe it’s the aliens deceiving us.”

Fan Commentary: Joe Rogan Recaps

547,492 просмотров • 9 дней назад

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

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275,620 просмотров • 22 часов назад