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Mechanistic and structural insights into degrader-targeted protein ubiquitinability, now out in Science Advances! Let's make more degraders that hit the bull's eye 🎯 Alessio Ciulli Centre for Targeted Protein Degradation

27,427 views • 1 year ago •via X (Twitter)

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Israel has carried out at least 16 attacks since dawn that targeted vital civilian infrastructure and healthcare institutions in south Lebanon and the Bekaa Valley. The morning began with heavy artillery shelling that explicitly targeted the immediate perimeters of the Nabatieh Government Hospital and the Nabih Berri University Government Hospital, in south Lebanon. The attacks in the south then expanded into the Bekaa, where a drone strike targeted the plains between Hizzine and Taraya, followed by a series of heavy airstrikes on the Barghaz Valley. In Western Bekaa, Mashghara was hit repeatedly by Israeli drone strikes, accounting for six of today's attacks alone. Meanwhile, consecutive airstrikes targeted residential areas in Toura, Shoukin, Deir Qanoun al-Nahr, and Abbassiyeh. On the ground, the Lebanese Army successfully intervened to dismantle an unexploded Israeli munition dropped directly inside a critical water treatment station in Ibl al-Saqi. This operation led to them discovering an Israeli surveillance drone monitoring the Halta area of Hasbaya. This wave of Israeli aggression builds on yesterday's attacks, which reached the hundreds, including 15 massive airstrikes and a massacre that killed nine people in Tayr Debba. Since March 2, US-backed Israeli attacks have killed at least 3,666 people killed and more than 11,321 injured. There have been over 160 direct attacks on healthcare facilities and medical teams, which includes the complete destruction of more than 100 emergency vehicles.

roqayah chamseddine

22,778 views • 2 months ago

Every bodybuilder on the internet tells you to eat a gram per pound of bodyweight. The research says you can stop at 0.7. For a 170 pound man that is 170 grams a day against 119. Fifty grams. Every day. Forever. A pooled analysis of forty-nine resistance training studies found that gains improved as protein went up, and then stopped improving at around 0.7 grams per pound. Past that point the line went flat. More protein in, no more muscle out. The error bar around that plateau stretched up to a gram per pound. The number in circulation is the top of that error bar, repeated for thirty years until it became the target. So the extra fifty grams does not build anything. Your liver strips the nitrogen off it and burns the rest, which is an expensive way to produce two hundred calories. Two hundred calories you could have taken as butter, which arrives with vitamin A, D, E and K2 already dissolved in it. At 119 grams you get there from food without trying. Three eggs, a ribeye, a lump of cheese, and you are past it before dinner. At 170 you are weighing chicken breast on a kitchen scale and drinking your supper. The men who set that number were building physiques on more than food, and the protein was never the part doing the work. There is also a ceiling, because your liver can only convert so much protein an hour. Trappers living on lean rabbit worked that out centuries before anyone measured it. So eat the meat, eat plenty of it, and then add the butter. That is the only thing on the plate with no ceiling on it, and the one part nobody has ever tried to sell you.

Sama Hoole

211,325 views • 7 days ago

Intense escalation last night between Iran-US Updates after 10 PM Tehran time: • The US targeted the barracks of the Iranian Army's 388th Brigade in Bampour specifically the conscript soldiers' dormitory, resulting several casualties. • The US targeted a mineral water production facility near a village in Ilam Province. • The US targeted 2 warehouses containing grains and wheat flour in Khuzestan province. • Gov Spox: More than 30 civilians were killed in the US attacks in south Iran. • The IRGC says it targeted: 🇧🇭 Several weapon storage, ship parts & aircraft parts warehouses at Sheikh Isa Airbase, in Bahrain 🇰🇼 Deployment site of MQ-9 drones at Ali Al-Salem base, in Kuwait 🇰🇼 Destroyed warehouse belonging to the Kuwait & Gulf Link Holding Company (KGL), which is the largest US Army support center in West Asia, in Mina Abdullah, Kuwait 🇰🇼 Destroyed the satellite communications center, a missile & air defense radar, a MIM-104 Patriot air defense system, logistics units, and M142 HIMARS missile launchers at a US base (likely Camp Buehring), in Kuwait 🇯🇴 Aircraft shelters hosting F-35A, F-15E & F-16C fighter jets, and MQ-9A Reaper UCAVs at the Muwaffaq Salti Air Base, in Jordan 🇧🇭 The management center, C&C center, and ammunition & fuel storages at the US Navy 5th support base, in Bahrain —— IRGC also announcee that the US should expect the closure of oil & gas routes outside the Strait of Hormoz, in response to the US reinstating the blockade against Iran & charging its own tolls. 🇦🇪 Government sources claim Fujairah Port oil terminal was targeted with missiles in the UAE, halting operations 🇰🇼 The Kuwait Army says Iran hit one of its navy ships which injured 4 units of its armed forces —— • Footage 1 shows an Iranian Shahed-136 drone strike an industrial facility in Kuwait. • Footage 2 shows Patriot PAC-3 failing & missing 4 Iranian ballistic missiles that struck the King Faisal Air Base in Jordan • Footage 3: Plumes of smoke coming from a facility targeted by Iranian missiles in Kuwait • Image 4: NASA FIRMS satellite confirms large at warehouses of the KGL, used by the US Army support centre for logistics (h/t: AMK Mapping 🇳🇿)

Arya Yadegaar

149,073 views • 1 month ago