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How Mitochondria Produce Energy

12,142 Aufrufe • vor 5 Monaten •via X (Twitter)

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People who felt more purpose in life had mitochondria in their brain that transformed energy more efficiently. The reverse may also be true: Having mitochondria that flow energy more easily may change how you see life. This is the finding Martin Picard — Columbia University professor of behavioural medicine & pioneer of mitochondrial psychobiology — and his team uncovered. They studied the brains of people after they died. Every year before death, participants reported how much purpose they felt, how connected they felt to others, how optimistic they were about the future. Then Picard & his team looked at their mitochondria. Specifically in the dorsolateral prefrontal cortex — the region involved in executive function and active reasoning. The people who felt more purpose had mitochondria with greater energy transformation capacity (specifically higher abundance of Complex I proteins). In Picard’s terms: lower energy resistance — energy flowing more easily through the brain tissue involved in how you think and decide. The human study couldn't tell which direction caused which. But animal studies suggest the relationship can run both ways. Chronic stress and defeat change mitochondria in the brain — Picard and others showed this in animal studies. Stress the animal, make it feel defeated, and the mitochondria in its brain change. Then reverse it. Boost or inhibit mitochondrial function directly in the brain. Anxiety shifts. Social behavior changes. Picard's conclusion: "How you feel can change mitochondria. The mitochondria can change probably how you feel."

no.mind

18,728 Aufrufe • vor 2 Monaten

The new Huberman Lab episode is out: Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard (Martin Picard) 0:00 Martin Picard 3:50 What is Energy?, Energy Flow & Transformation 7:53 Energy, Vitality, Emotions, Sensory Perception 14:18 Sponsors: Helix Sleep & Lingo 17:19 “Mito-Centric” View of World, Mitochondrial Energy & Information Patterns 25:26 Organelles, Mitochondria & Energy Transformation; Maternal Genes 31:12 Mitotypes & Differentiation, Mitochondria as “Social Organisms” 36:52 Food & Dysfunctional Energy Transformation 40:02 Lifestyle Choices & Interests, Physiological Growth 46:39 Pregnancy, Amenorrhea; Illness & Tiredness 51:07 Sponsor: AG1 52:29 Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick 56:27 Tool: Feel Your Energy; Breath & Energy 1:02:31 Flow of Energy; Trade-Offs, Life Purpose & Enjoyment 1:10:15 Biology, Meaningful Experiences & Energy Flow 1:16:27 Sponsor: Function 18:15 Inflammation, Energetic Flow 1:20:43 Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging 1:28:56 Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants 1:37:06 Energetic Stress Signals, GDF-15, Cancer, Heart Failure 1:42:18 Genes, Lifestyle & Aging 1:47:54 Gray Hair Reversal, Stress; Inflammation & Aging 1:57:37 Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation 2:05:16 Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep 2:10:58 Diet & Individualization, Clinical Trials; Mitochondria & Nutrition, Keto 2:20:14 Alcohol & Energy Budget; Stress 2:25:02 Exercise, Increase Mitochondria, Overtraining; Resistance & Growth 2:33:06 Sponsor: Waking Up 2:34:41 Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue 2:41:31 Energy Flow & Experiences, Balance 2:49:13 Transform Through Resistance, Energetic Awareness, Connection 2:56:05 Food Overconsumption & Mitochondria Disruption; Tissues & Mitochondria 3:01:02 Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation 3:06:10 Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields 3:12:16 Acknowledgements 3:14:15 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

Andrew D. Huberman, Ph.D.

910,228 Aufrufe • vor 10 Monaten