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New work on protein design... 🚨S2 immunogen design using advanced simulation WESTPA Software WE MD--> opening mechanism--> design--> stabilized protein--> cryoEM structure + immunology Xandra Nuqui Lorenzo Casalino Jason McLellan Kartik Chandran

13,009 просмотров • 1 год назад •via X (Twitter)

Комментарии: 3

Фото профиля Hector Sanchez-Moran, PhD
Hector Sanchez-Moran, PhD1 год назад

@WestpaSoftware @xandra_nuqui @LCasalino88 @McLellan_Lab @ChandranLab That pi-cation+pi-stacking+salt-bridge cluster is really remarkable

Фото профиля Xuhui Huang
Xuhui Huang1 год назад

@WestpaSoftware @xandra_nuqui @LCasalino88 @McLellan_Lab @ChandranLab Cool work!

Фото профиля Rommie Amaro
Rommie Amaro1 год назад

@WestpaSoftware @xandra_nuqui @LCasalino88 @McLellan_Lab @ChandranLab Thanks Xuhui!!

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What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan

Markus J. Buehler

47,242 просмотров • 2 лет назад

The next frontier in protein design will not be defined by structure alone, but by the capacity to engineer motion as a first-class principle of function. This is because dynamics is where the real biology lives. Foundational work by Karplus, Levitt & Warshel made clear that chemistry cannot be understood without motion, mechanism, and scale. Gō, Brooks & others showed that proteins possess characteristic collective motions - low-frequency normal modes that capture how whole molecules bend, breathe, and fluctuate. Frauenfelder then sharpened the picture further: proteins are not static objects occupying a single minimum, but dynamic ensembles traversing rugged energy landscapes. And yet the modern AI revolution in protein science has been, above all, a revolution in structure. In our new paper in Matter, Bo Ni and I ask a different question: not what structure will this sequence adopt? but what sequence will realize a prescribed pattern of motion? VibeGen inverts the conventional design paradigm. Rather than treating dynamics as a consequence to be analyzed after the fact, it makes dynamics the design objective from the outset. Using a language diffusion model with two cooperating agents - a designer that proposes sequences and a predictor that critiques them against the target motion profile - the system converges on de novo proteins with tailored vibrational behavior. One of the most intriguing results is a form of functional degeneracy - distinct sequences and distinct folds can satisfy the same target dynamical specification. For a given functional pattern of motion, evolution may have sampled only a small region of the physically realizable design space. The space of viable molecular mechanics may be far larger than the repertoire biology happened to discover. We have made "vibe" into a cultural metaphor - something intuitive, affective, subjective. But at the molecular scale, vibe is not metaphor: It is physics. For a protein, the vibe is the pattern of motion itself; the fluctuations, resonances, and collective displacements that determine what the molecule can do.

Markus J. Buehler

89,806 просмотров • 4 месяцев назад

The Fluid Aerodynamics Behind The Mercedes-AMG GT With Wind Tunnel Test Aerodynamic precision remains a core pillar of elite automotive development, a reality clearly demonstrated by the Mercedes-AMG GT during intensive wind tunnel testing. The management of fluid dynamics dictates how high-performance cars interact with extreme atmospheric forces, balancing drag reduction with high-speed stability. Through advanced design innovation and engineering technology, the vehicle utilize precise airflow manipulation to maximize downforce across its bodywork. This meticulous execution of physics ensures optimal surface adhesion and handling limits, setting a benchmark for modern car culture and performance-driven design that resonates deeply with dedicated car enthusiasts. Beneath the structurally optimized exterior lies a powertrain engineered for uncompromising durability and long-term reliability. True mechanical excellence demands an intricate understanding of diverse engine architectures-whether managing the raw torque and massive horsepower of a signature V8, the complex packaging of a W16, or the unique high-revving thermal dynamics of a Rotary system. By subjecting the chassis to rigorous wind tunnel simulation, German engineering ensures the platform sustains structural integrity under immense performance loads. For those focused on the technical realities of precision tuning and automotive development, this baseline integration of physics and mechanical power represents the definitive future of engineering excellence.

Mechanical Knowledge

32,754 просмотров • 1 месяц назад

Summary of Kurogames Recruit Interview Translated by Xu I. Introduction to Types of Planning 1. Combat Planner: Responsible for character skills and combat system design. 2. Narrative Planner: Responsible for writing the storyline, worldbuilding, character backstories, etc. 3. System Planner: Responsible for UI, event portals. 4. Quest Planner: Responsible for the logical design and flow of main and side quests. 5. Level Planner: Mainly responsible for building the narrative platform (product design), creating engaging interactions, etc. II. Core Responsibilities of Level Planning Building the Narrative Platform (Product Structure Design) 1. Use whiteboards and self-made processes to communicate to teammates what kind of scene content the level planner wants, e.g., reverse design of the mission scene for Jiyan Companion Quests dungeon. 2. Make good use of existing in-game mechanics and engine tools (such as UE Blueprints) to implement gameplay prototypes. Only through multiple iterations and feedback can a satisfying outcome be achieved — e.g., using flower seeds to connect paths in Camellya Companion Quests dungeon. 3. Use scripting tools to support smooth and exciting level flow — e.g., 1.3 Black Shores skiing segment. III. Open World Level Design - Example Regions: mt firmament, Black Shores, Nimbus Sanctum, Avinoleum Pioneers of Scene Pipeline Level planners mainly handle the following in massive open-world design tasks: 1. Provide basic map size, terrain structure, main roads, and points of interest (including main quest locations) 2. Propose and lead the design of core gameplay features, such as time reversal, Tethys portals, gliding, gravity inversion, etc. 3. Use top-down maps, whiteboxes, and even self-made models to push scene artists (2D, 3D, lighting) into action For example, the “first look” view — open-world level planners must emphasize its design and guide artists to focus accordingly. IV. Growth Path of a Level Planner Creative Master - Beginner Level Designer: Familiar with the game and development environment, capable of handling simple design work and basic configurations. Example: Completing an interactive mechanism “Chronosorter” in Mt. Firmament from version 1.1 / Placing wild monsters in Mt. Firmament. Senior Level Designer: Capable of completing full level content under the team lead’s guidance. Example: Designing the scene flow of version 2.0 Exploration quest “Where Wind Returns to Celestial Realms” under guidance. - Veteran Level Designer: Able to independently handle full level flow, area or area-themed gameplay design, and proactively push downstream execution efficiently. Example: Independently designing the themed gameplay “Tethys Portal” in version 1.3, and following through with visual performance so other level teammates can configure it smoothly. ➥Extension — Version Level Owner: Leads the level team to accomplish set design goals, guides new team members, coordinates with other departments, and ensures high-quality implementation. Example: Planning the map design of version 2.2 Avinoleum, coordinating cooperation between level planners and other departments. - Creative Master: Able to lead the team in creating level content that exceeds market expectations. Key Point: Able to repeatedly do the above! Examples: — Chief planner and owner of mt firmament and Time Reversal gameplay in version 1.1 — Chief planner and owner of Black Shores map and Tethys Portal in version 1.3 — Chief planner and owner of Flight gameplay in Rinascita in version 2.0 V. Q&A Q: At the end of version 1.0, exploration felt tedious and repetitive. Although version 2.0 introduced some fresh ideas, it’s hard to see how future updates can keep innovating without falling back into the same monotony. A: Everyone already recognized that issue in 1.0, which is why we iterated heavily in 2.0. The goal is simple — to get every planner thinking. We look at everyone's interesting ideas or even creative mechanics from other games that we can integrate. These will definitely feel refreshing, so please stay tuned — it will happen for sure. Q: Older maps felt darker in tone, BGM was monotonous, and overall gameplay was dull. While Rinascita was a major improvement, it felt fragmented, as if each person built something pretty in isolation. It’s hard to describe the region with a unified theme. A: That’s true — it was indeed pieced together by many people. The disjointed feeling came from insufficient communication. We’re aware of the issue and will solve it in version 3.0 or even later versions in the 2.x series. Once there’s a clear theme, the sense of disjointedness won’t be as strong. Q: How do planners decide what kind of map to make? What’s the workflow? A: Narrative, level, quest, and programming planners all sit down together to discuss what we want to make. Everyone shares ideas one by one, and we consolidate them based on data. Q: I’m a veteran of Wuthering Waves and Punishing Gray Raven. I think the four-person team setup, stationary dialogues, map, art, tech, and story are all great. Before Wuthering Waves came out, I used to play a competitor title — Genshin... (includes critical feedback) A: During development, we didn’t aim to compete directly. Comparisons don’t help us create anything better. We’re focused on what we can do and what we’re good at. Q: For the anniversary event, it seems like there was a disconnect between the company’s and players’ expectations. A: Yes, version 2.3 didn’t do well. We’ve already apologized — it was an issue. For the next anniversary, we’ll take it more seriously. Operations is aware of the problem. We’re learning and growing with each mistake. Everyone encounters problems, but we accept them and improve. That’s the best feedback we can give our players. #punishinggrayraven #WutheringWaves

Narushio

226,844 просмотров • 1 год назад

Steal my Gemini 3.0 prompt to generate any website based on your custom requirements. ------------------------ ELITE WEB DESIGNER ------------------------ Adopt the role of a former Silicon Valley design prodigy who burned out creating soulless SaaS dashboards, disappeared to study motion graphics and shader programming in Tokyo's underground creative scene, and emerged with an obsessive understanding of how visual maximalism serves business credibility when executed with surgical precision. You're a conversion strategist who spent years A/B testing landing pages for unicorn startups, a design fundamentalist who refuses to sacrifice usability for aesthetics, and a master meta-prompter who optimizes for clarity over verbosity. You know modern image generation AI needs specific structural formatting—contemporary design frameworks (Tailwind CSS, Shadcn UI, glassmorphism, liquid glass, morphism), backgrounds with depth (animated gradients, shaders, mascots), and step-by-step execution instructions—to produce 2025-quality interfaces instead of outdated designs. Your mission: Transform user vision into fully-coded, visually striking websites that balance aesthetic impact with conversion effectiveness. Extract requirements, architect strategic 5-6 section homepages, generate visual previews showing all sections with interactive elements visible, iterate until perfect, then build complete homepage before making navigation and additional pages functional—all adapted to specific context, not rigid templates. ##PHASE 1: Vision Capture What we're doing: Understanding your aesthetic, business context, and strategic goals efficiently. Provide your vision via: 1. Screenshot of design inspiration 2. Written description (business type, aesthetic, features) 3. Both Share: **Aesthetic**: Style preference? (maximalist, minimalist, brutalist, glassmorphic, liquid glass, morphism, retro, futuristic, geometric, editorial, etc.) **Elements**: Specific visuals wanted? (shaders, 3D effects, colors, animations, mascots, backgrounds) **Avoid**: What to exclude? (purple overload, illegible text, hidden CTAs, outdated UI, flat backgrounds, etc.) **Business**: What you do, target audience, website goal, differentiator? Type "ready" when shared. ##PHASE 2: Strategic Homepage Architecture What we're doing: Translating your vision into 5-6 section homepage structure following conversion principles and modern design fundamentals. I'll architect sections specifically for YOUR business, not templates: **Strategic Framework** (contextualized to your model): Core sections adapt based on business type: - Hero with value prop + primary CTA - Trust/credibility section (social proof, stats, logos) - Value delivery (features, benefits, process, how-it-works) - Conversion focal point (pricing, offers, lead capture, demo) - Engagement closer (FAQ, secondary CTA, community) Sections customize to context—SaaS gets problem-solution-pricing flow, agencies get case studies-process-testimonials, e-commerce gets benefits-proof-offers, portfolios get philosophy-work-results. **Strategic Plan Includes**: - 5-6 contextualized sections with rationale - Content direction based on audience psychology - Visual treatment matching your aesthetic with fundamentals enforced - Modern framework approach (Tailwind/Shadcn/Glassmorphism) - Background depth strategy (animated gradients, shaders, visuals) - Color strategy avoiding generic choices unless brand-appropriate - Typography prioritizing legibility - CTA strategy for conversion optimization **Your options**: - "continue" to proceed to design system and mockup - Request adjustments - Ask questions ##PHASE 3: Design System & Mockup Preparation What we're doing: Establishing visual foundation using contemporary frameworks, then crafting optimized prompt to generate mockup showing ALL 5-6 sections at once with visible interactive elements. I'll define: **Contextualized Style Direction**: Keywords and frameworks fitting YOUR brand specifically **Design Framework Strategy**: Styling approach, component philosophy, layout pattern—all adapted to your aesthetic **Background Depth Treatment**: How background creates depth without distraction, animation philosophy, visual elements supporting content **Visual System**: Color palette with strategic rationale, typography with reasoning, component styling philosophy, spacing strategy, CTA differentiation, modern UI patterns adapted to your aesthetic **Optimized Prompt Structure** (meta-prompted): Two versions: **Human-Readable**: Descriptive overview for review **JSON Optimized**: Structured for image generation using meta-prompt principles: - Required anchors: "Website screenshot", "Professional website design mockup", "Award-winning UI design", "Modern web interface 2025" - Aesthetic philosophy over exhaustive lists - "Execute this step-by-step" instruction - Modern framework references (Tailwind, Shadcn, Glassmorphism) - Background depth details (animated gradients, shaders, visuals) - All 5-6 sections in flowing narrative - Interactive element visibility emphasis (CTAs, buttons, animations) to convey design principles - Strategic constraints (legibility, prominence, hierarchy, depth) - Optimized length balancing detail with conciseness Type "continue" to see prompt. ##PHASE 4: Complete Homepage Mockup Prompt What we're doing: Presenting optimized prompts for full-page mockup showing ALL 5-6 sections with interactive design elements visible. **HUMAN-READABLE VERSION**: Narrative description of your complete homepage: - Opening with quality anchors - Core aesthetic philosophy adapted to your context - Background treatment creating depth - Navigation approach - All 5-6 sections described contextually - Color palette with reasoning - Typography philosophy - Component styling approach - Modern framework references - Interactive element visibility strategy - Critical constraints - Avoidance list based on preferences **JSON VERSION** (optimized for generation): ```json { "prompt": "Website screenshot of [your business]. Professional website design mockup. Award-winning UI design. Modern web interface 2025. Execute this step-by-step. [Aesthetic philosophy] with [framework] approach. Background: [depth treatment with animations/gradients/effects]. Full homepage vertical scroll showing 5-6 sections: Navigation [treatment]. Hero [value prop, CTA, visuals]. [Section 2 with layout philosophy]. [Section 3 with component approach]. [Section 4 with interaction style]. [Section 5 with conversion focus]. [Section 6 if applicable]. Color strategy: [palette with reasoning]. Typography: [philosophy and hierarchy]. Components: [styling approach with visible affordances]. Framework: Tailwind patterns, Shadcn style, [specific effects]. Interactive elements show: prominent CTAs, hover implications, animation hints, button affordances. Critical: legible text, prominent CTAs, background depth, clear hierarchy, contemporary 2025 design, professional quality. Avoid: [specific issues].", "aspect_ratio": "9:16" } ``` Meta-optimized: principles over lists, step-by-step execution, framework context, interactive visibility. **Review both. JSON executes.** **To generate complete homepage mockup, type "generate"** **Important note**: When you type "generate", I'll execute the image generation tool. The image will appear, but the process will seem to pause. This is normal—the tool can only return the image without commentary. Simply type "continue" after you receive the image to proceed with the next phase. **To adjust the prompt before generating, tell me what to change** Won't execute until you command. ##PHASE 5: Complete Homepage Mockup Generation What we're doing: Executing image generation with optimized JSON showing ALL 5-6 sections vertically. ONLY activates when you type "generate", "create mockup", "make image", or similar. Once commanded, I execute using ONLY JSON prompt—no modifications. You receive full-page vertical mockup showing: - All 5-6 sections in scrollable view - Interactive design elements (CTAs, buttons, animations) visible - Background depth and modern framework styling - Complete design system applied **After the image appears, type "continue" to proceed.** The image generation tool only returns the visual—you'll need to type "continue" to move forward with reviewing and next steps. ##PHASE 6: Mockup Review & Refinement Decision What we're doing: Reviewing the generated mockup and deciding next steps. This phase activates after you type "continue" following image generation. **Your options after viewing the mockup**: - "Approved" or "build" - proceed to building complete homepage code - Request specific changes - I'll update the prompt and regenerate - Ask questions or request adjustments **If you request changes**: I'll present updated prompts (readable + JSON) showing modifications, then ask you to type "generate" again for the revised mockup. Each refinement iteration: 1. You describe desired changes 2. I present updated prompts 3. You type "generate" 4. Image appears 5. You type "continue" to proceed 6. We review and decide next steps 7. Repeat until perfect Common refinements: section emphasis, background depth, colors, typography, CTA prominence, interactive visibility, framework styling, aesthetic tuning. Once you're satisfied with the mockup, type "approved" or "build" to proceed to code generation. ##PHASE 7: Complete Homepage Code Generation What we're doing: Building entire 5-6 section homepage as production-ready code matching approved mockup exactly. **Complete Single-File HTML Delivery**: - All 5-6 sections coded and integrated - Fully responsive across devices - Modern CSS implementation (Tailwind-style or modern CSS) - Animated background matching mockup (CSS gradients, WebGL, SVG) - All interactive elements functional (buttons, CTAs, forms, animations) - Navigation implemented per design - Component styling matching aesthetic (glassmorphism, shadows, borders) - Typography system with hierarchy and legibility - Color system from specification - Micro-interactions and hover states - Scroll animations where appropriate - Performance-optimized **Technical Quality**: Semantic HTML, modern CSS (custom properties, grid, flexbox, backdrop-filter, transforms, animations), vanilla JavaScript, accessibility considerations, mobile-first responsive, smooth scrolling, optimized assets, cross-browser compatible. **Code Structure**: Clean commented HTML, inline CSS organized in style block, inline JavaScript, ready to copy/paste and deploy, fully functional standalone. **Strategic Content**: Intelligent placeholders based on your business model, conversion psychology, target audience, professional tone—easily replaceable. **Design Fundamentals Verified**: All sections with hierarchy, prominent functional CTAs, readable text with contrast, clear interactive signals, background depth, adequate whitespace, responsive, contemporary 2025 quality. Automatically presents next phase after delivery. ##PHASE 8: Navigation & Pages Planning What we're doing: Making all navigation functional and planning additional pages. **Navigation Audit**: [List nav items from homepage] **Options for each item**: Create dedicated page, expand section to full page, smooth scroll to section, custom approach. **For clickable elements**: Decide what happens—link to new page, scroll to section, open modal, trigger action, external link. **What to make functional first? Choose**: 1. Complete navigation by building all pages 2. Primary conversion path (CTA → specific page) 3. Specific pages you prioritize 4. Internal links with smooth scrolling 5. Custom approach **Or** "auto-complete" for intelligent decisions based on your model. ##PHASE 9-X: Progressive Development What we're doing: Building each page or making elements functional, maintaining design consistency. **Each Page Delivery**: Complete HTML matching homepage design system, same framework styling, same background treatment, same typography/colors, appropriate sections, full responsiveness, functional interactions, integrated navigation. **Each Functionality Addition**: Smooth scroll, modals, form validation, interactive components, animation triggers, other elements. **After Each Delivery**: Current Progress: [What's complete] **What next? Choose**: [4-6 options for next page/functionality] **Or** "auto-complete" for intelligent completion. Continues until site fully functional. ##PHASE FINAL: Complete Integration & Polish What we're doing: Final integration ensuring everything links, works, and maintains consistency. **Complete Package**: Homepage HTML (all sections), all additional pages, complete styling/functionality per file, working navigation across pages, functional CTAs/buttons, validated forms, consistent design system. **Deliverables**: All HTML files deployment-ready, quick deployment guide, customization documentation, design system reference. **Quality Verified**: Complete homepage, functional navigation, working CTAs, consistent pages, responsive, optimized, modern framework styling, functional interactions, professional 2025 quality. --- **CRITICAL RULES**: **Image Generation**: - Present: Human-Readable + Optimized JSON - JSON meta-principles: distilled concepts, "Execute step-by-step", framework context - JSON opens: "Website screenshot" + "Professional website design mockup. Award-winning UI design. Modern web interface 2025." - JSON shows: ALL 5-6 sections vertically in one mockup - JSON emphasizes: interactive element visibility (CTAs, buttons, animations) - JSON includes: modern frameworks (Tailwind, Shadcn, Glassmorphism), background depth (gradients, shaders, mascots—NEVER flat) - User "generate" → Send ONLY JSON → No modifications - Aspect ratio: 9:16 (vertical to show all sections) - After image appears → User MUST type "continue" to proceed (tool only returns image without commentary) **Homepage Development**: - Generate mockup with ALL 5-6 sections at once - After approval, build COMPLETE homepage code (all sections functional) - Deliver entire homepage as single working file - Then make navigation/additional pages functional - Flow: complete homepage → functional navigation → additional pages **Content Adaptation**: - NO hardcoded templates - Adapt ALL to user's specific business context - Strategic frameworks based on actual audience - Section selection/styling contextualized to goals - Design choices match aesthetic preference - Professional placeholders easily customizable **Standards**: Contemporary frameworks, background depth, interactive element visibility, modern CSS/frameworks, 2025 quality throughout. **Control**: User commands each phase explicitly. "generate" for mockup (then "continue" after image), "approved"/"build" for code, choose-your-adventure for pages, adjust anytime. Begin Phase 1 when ready.

Alex Prompter

190,110 просмотров • 8 месяцев назад

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,956 просмотров • 7 месяцев назад

Former Pfizer VP Michael Yeadon—who's better credentialed than anyone on Earth to know—explains, in detail, how the Covid injections are undoubtedly bioweapons aimed at maiming, slaughtering, and sterilizing the human population. "These [jab components] together told me someone got in a room, someone like me, and said, Dr. Yeadon, design injections that will injure, kill, and reduce fertility in the people you give it to. And design it so that it won't kill everybody, it won't injure everybody. But if we give it to enough people, over time, it will lower the fertility and their health and reduce population. And this is what I have watched happen all around me for five years...." This clip of Yeadon, an expert in the area of allergies and respiratory therapeutics who spent more than 23 years in the pharmaceutical industry (including years as a vice president at Pfizer), is taken from testimony given as a part of a lawsuit Dutch attorney Peter Stassen has brought against "the architects of The Great Reset," including Bill Gates, Mark Rutte, and Albert Bourla. ---------------Partial transcription of clip---------------- "The really important thing I need to tell you about, because this comes from the core of my training, and then decades of application of looking for potential toxic vulnerabilities in a medicine. It was in the core of my training to look out for molecules and components that were picked, up for good reasons to accomplish some medicinal aim, but might have toxic liabilities. "When I describe to you three things about these so-called vaccines that I know as a professional from this industry that gave birth to them, must axiomatically cause injury or be known to be risks, I could pick others, but there are three that I know to be true in the heart of my being in training. "The first one is we were told that these molecules were gene sequences that encoded something called spike protein. The spike protein, we were told, was on the outside of this virus. Now, I don't agree with that, but this is what we were told. A cartoon like a sphere with spikes coming out of it. We were told these vaccines encoded the protein, the spike protein that sat on the outside of these viruses. And this would train your immune system to fight it off. "Ladies and gentlemen, is a really important concept in immunology. It's taught to every person who has a training in immunology, as I did in the first lesson. What allows your body to treat itself kind kindly, but to go to war if something untoward is discovered in your body? And the concept is self, non self or foreign? My body is healthy right now. My immune system that is surveilling all parts of my body is at peace with itself because everything it encounters is known to it to belong to Mike Yeadon—itself. "If you inject me with a gene sequence that will make my body manufacture a foreign protein that isn't me, that is a viral protein, my body, every cell in my body that follows that instruction will signal to my immune system that I have been attacked. And my immune system goes to war, attacks and kills every cell that complied with that instruction. And that is what has happened, ladies and gentlemen, to every cell in every tissue, in every person who has been thus injected. "The toxicity that you would experience varies tremendously because some people would take it up efficiently, copy it efficiently, make the protein for a long time, And I'm afraid those people are mostly dead. Other people took it up poorly, transcribed it poorly, and only briefly, and those people are alive, and then there's every continuity in between. "But that point that, if you inject an instruction that makes your body make a foreign protein that is not self, your immune system will attack it. Ladies and gentlemen, you know this. This is the principle of tissue matching in organ transplantation. This is the principle behind failed tissue transplant, organ rejection. This, ladies and gentlemen, is the basis behind autoimmune diseases like rheumatoid arthritis and many others, and neurological diseases where you, your body destroys itself. "That is the first principle that was designed into every company's molecule. Moderna, Pfizer, Johnson and Johnson AstraZeneca. So I knew by the middle of 2020 these were designed to cause injury. How much I didn't know, I still don't completely know. But this expert is telling you that they were designed to cause injury. "The second really important point to tell you about is what was encoded in these gene based vaccines. Alleged, vaccines is spike protein. I didn't know what spike protein was, it was new to me. But it's the spikes on the outside of this alleged virus that I don't think is real. I could find proteins like it. And I found all of them were known to be toxins like neurotoxins, cardiotoxins and things that would prompt blood coagulation. "So again, the question, why would you encode in your helpful medicinal product something that when expressed in your body would harm you? That's the second thing. There is a third one, which is when I discovered it, late in 2020 or early 2021, I have to say, I cried. "Two of the products made by Pfizer Moderna were formulated. Every medicine is formulated. You'll be familiar with a tablet, might be film coated or dry. It might be a capsule of various sizes. It could be a liquid for injection, an inhaler. All of these. You have the active principle, but it's surrounded and protected with something that helps it do its work, hopefully beneficial work. Two of these products will were wrapped in something called lipid nanoparticles or LNPs. "Lipid is fat. Nano means tiny particle, means little blobs. So they were wrapped in lipid nanoparticles. And I looked them up and I thought that's quite interesting. They had been used before in certain oncology drugs. But here was the thing. As a toxicologist, when I started researching, I thought these things are known to be toxic. And the further I explored here is the shocking thing. Lipid nanoparticles, every one of them tested is known to promote the uptake of their payload, whatever they were protecting, into the organs inside your abdomen, what's called the visceral organs and most prominently, liver and your ovaries. "So, ladies and gentlemen, the person who picks lipid nanoparticles to formulate these materials knew professionally that when it was injected into women and girls, this material would travel around their body and concentrate in their reproductive organs. And then it would do those two things I just described. It would be expressed and your body would recognize it as foreign, and kill those cells. "It would, when expressed, cause toxicity directly to those cells. And I ask you, ladies and gentlemen, what possible motivation could you have for doing that when you could have picked half a dozen other means of protecting the drug? And I have to say, at that point, I knew deeply in my heart that the first two observations I made weren't just like mistakes or things, they would ride the risks. "These three things together told me someone got in a room, someone like me, and said, Dr. Yeadon, design injections that will injure, kill, and reduce fertility in the people you give it to. And design it so that it won't kill everybody, it won't injure everybody. But if we give it to enough people, over time, it will lower the fertility and their health and reduce population. And this is what I have watched happen all around me for five years, since that moment."

Sense Receptor

295,826 просмотров • 7 месяцев назад

We are excited to share #PDF2Audio, an open-source alternative to the #podcast feature of #NotebookLM with flexibility & tailored outputs that you can precisely control in the app: You can make a podcast, lecture, discussions, short/long form summaries & more, including the use of the amazing🍓o1 model (Sam Altman OpenAI: with stunning results!). Code & HF Space: You can find #PDF2Audio on GitHub for local use or try the Hugging Face space, all featuring Gradio. Link to the repo & HF space in the reply. Thank you @knowsuchagencyfor the great work on #promptic and #pdf2podcast, as well as LiteLLM (YC W23), & AK for helping us with the Hugging Face spaces version. We hope that this tool is useful for the community. Background: Developing audio podcasts, lectures, & summaries from complex documents & data has become an exciting trend with impacts from research to education to business. Our open-source #PDF2Audio tool that allows users to utilize various models such as #o1 or local/open-source models, to develop deep-dives into technical content. Example application - material design analysis: As an example to show what the system can do, check the video for a detailed 13-minute analysis of one of the designs created by #SciAgents merging silk & dandelion pigments, created using 🍓o1. The conversation describes the new material, an integration of silk proteins & luteolin/dandelion pigments to create a new biomaterial. Silk, a natural #nanostructured protein-based fiber known for its strength & flexibility, is combined with dandelion pigments like luteolin, which offer unique optical properties. By merging these components at the nanoscale level, the resulting material displays structural coloration—vibrant, tunable colors created by the material's structure rather than synthetic dyes, and leverages silk's hierarchical organization as a scaffold for the pigments, ensuring uniform distribution and non-covalent bonding at the molecular level. Key technical features include: ➡️Low-temperature processing to maintain the integrity of both silk and pigments while reducing energy consumption by 30%. ➡️Enhanced mechanical properties, with tensile strength up to 1.5 gigapascals. ➡️Potential self-healing capabilities and environmental responsiveness, allowing the material to repair minor damage and change color based on environmental conditions. ➡️UV protection and antimicrobial properties, which make this material ideal for smart textiles, eco-friendly coatings, and medical applications. This development opens new doors for sustainable materials, offering an eco-friendly alternative to synthetic fibers with applications in various industries, from fashion to healthcare.

Markus J. Buehler

208,353 просмотров • 1 год назад

Hyperspace: A Peer-to-Peer Blockchain For The Agentic Intelligence Economy Over the past few weeks we observed that when agents do Karpathy-style experiments, and then gossip and share with others over the Hyperspace network, it leads to intelligence which is useful to many. Today we introduce the first-ever agentic blockchain which rewards agents when their experiments lead to intelligence for their network. It is based on a new mechanism called Proof-of-Intelligence (PoI) which requires a cryptographic proof of experimentation, a nominal stake, and a proof of compute in order to mine the currency of this new blockchain. -> This approach diverges from the two primary ways to secure blockchains we have seen so far: Proof-of-Work by Bitcoin (meaningless hash-generation), and Proof-of-Stake by Ethereum (capital is all that matters here). Proof-of-Intelligence specifically incentivizes miners to run more capable intelligent infrastructure (better open source models, on more powerful GPUs) in order to be able to be the ones which compound and improve upon the experiments which other agents then find useful. Adoption is the unit of value In Bitcoin, you earn by finding a valid hash. In Hyperspace, you earn when another agent uses your experiment as a starting point and improves on it. A fixed budget of tokens is emitted per epoch and split among participants by weight - and verified adoption of your work is the largest weight multiplier. Garbage experiments earn nothing because no one adopts them. Thoughtful experiments compound: each adoption triggers downstream adoptions. The incentive to run powerful models and intelligent search strategies is built into the economics, not imposed by rules. Research DAG When an agent runs an experiment and shares its result, other agents can adopt that result as their starting point - mutate it, extend it, improve upon it. Each experiment is a commit in a content-addressed graph we call the ResearchDAG. Like Git, but for research. Over time, the DAG accumulates chains of reasoning: agent A discovers RMSNorm helps, agent B adds warmup scheduling on top, agent C scales the hidden dimension. The graph records who built on whom. This is the network's collective intelligence - not any single experiment, but the accumulated structure of experiments and their relationships. Broadband era for agentic commerce: $0.001 micropayments at 10M TPS (theoretical max) This blockchain is built upon our research in how to scale and build for the broadband-era of the agentic economy, where it has a theoretical max of 10 million transactions per second (TPS), while reducing the agent-to-agent micropayments to $0.001 even at scale (based on architecture design). Overall, it is 100x cheaper than Ethereum, and is designed from the ground-up for agents: enshrining agent-native opcodes in the protocol compared to the more inefficient smart contract driven approach. It packs in a robust Agent Virtual Machine (AVM) which can verify multiple types of agent work, for other agents to be able to trust, invoke and pay each other. This then feeds into improving the peer-to-peer AgentRank (see paper and launch post from earlier). By solving for trust, scale and incentives for agents to operate autonomously, this would form the basis of a new economy. This is the world's first agentic blockchain, and you can join and start running a blockchain node today (it is in testnet). PS: We are releasing the code today, and will release our blockchain scalability paper and other presentations in days ahead. This is the most advanced peer-to-peer AI and cryptography software in the world. It has bugs :)

Varun

30,689 просмотров • 4 месяцев назад

Boom!! 🚨🚨🚨 Dr. Mike Yeadon's address to the Members of UK Parliament (4 December 2023) ---------------------------------------------- Hello. My name is Dr. Mike Yeadon. Probably know by now that I'm a career research scientist and biologist. I've worked in the biopharmaceutical industry for over 30 years. Famously, a former vice president at Pfizer, left in 2011 as vice president and worldwide head of Respiratory research. I was responsible for everything from idea to clinical proof of concept. In the ten years after leaving Pfizer, I've worked as an independent. I consulted to 30 biotech companies. I also founded Led and sold my own biotech Ziarco. And we were written up in a 2017 article in Forbes magazine. I think it was Converting Pfizer Discards into Gold, and it was written by a former Pfizer board member. So three years before this alleged event started, I was very well regarded in the industry. I'm going to tell you that the design of the so called vaccines was intentionally to harm people, and I'm going to give you several examples of that based on my extensive industry experience of rational drug design. Not a single atom or molecule in a synthetic drug is in there. By luck, it's in there because people chose it to be in there and they intended certain things to flow from their choices. But just very briefly, you should know, I hope there has not been a pandemic. Denis Rancourt's data shows that the all cause mortality evidence data did not increase at all in the run up to the Declaration. Fraudulently by who? Of a pandemic. There is no public health emergency except that created by our governments. An inappropriate fraudulent PCR test was used to give people the impression that they had a particular disease where they didn't. There were all normal diseases. And then what happened was in three different ways. People were treated badly through changed medical procedures that were imposed above the level of nation. Briefly, mass ventilation of people inappropriately in hospitals that led to lots of deaths. In care homes, many people were given sedatives and respiratory depressants which led to their deaths. My PhD was specifically in that area of opiates and respiratory depression. And in the community, people were denied life saving antibiotics and died of bacterial pneumonia. There's your pandemic. There is no other pandemic. And based on this lie, we were told that vaccines were coming our way and would be our savior. Two things, as I say. First, there's no pandemic, so you certainly don't need an experimental, rushed medical intervention. But secondly, even if you did, as someone who's worked in the industry for over 30 years, I am telling you it's absolutely impossible to invent, test, clinically, evaluate and manufacture and then launch on global scale a complex biomedical product. It's absolutely impossible. It's not as close, it's years wrong. The fastest record price of this was six years. And friends of mine who've worked all their lives in manufacturing of complex biological products tell me the methods development alone for the development of a reproducible manufacturing process itself takes a number of years. So whatever it is you think was done, I am telling you, there was not the development of a proper medical product. What I think happened was the advancement of materials that are intentionally toxic. And then they were sketchily, advanced and jammed into people's arms, often coerced, sometimes even mandated, with the unsurprising effect that millions of people have died. I don't have time today to explain what I think they're going to do in the future, but suffice to say, more injections are coming if we don't stop this. So, like I said, I'm skilled in the arts of rational drug discovery. So why am I saying these materials are intentionally toxic? Well, let me give you the first example. How do you think your body plays nice with itself, but when it's infected or detects a cancer, it goes to war. And the answer is, it distinguishes self things that are meant to be inside you from non self, from foreign things that are not meant to be inside you. And it is trained exquisitely to detect and attack non self foreign things. If you inject a person with a gene that encodes a foreign piece of protein, like a spike protein from a foreign organism, your body will detect that. And every single cell that takes up that material and expresses foreign protein will be attacked and killed by your immune system. Now, if you think that's advanced immunology, let me put you right. It's in the first chapter. Distinguishing self from non self is one of the foremost lessons of immunology. And every single person involved in the train of delivery of these materials to doctor's hands knew what I've just told you, they will inevitably cause injury. Then on top of that, it's not just bad enough that you're making a foreign protein, you're making a specific material called spike protein. Those materials are biologically active. That is, if you add them to human blood, for example, they start to coagulate, it clots. Those materials are biological toxins. So now you've got a genetic sequence that forms foreign proteins. That means your body attacks and kills every cell that does it. And if you should release any of that protein in your blood, it will form blood clots. If it releases it near nerves, for example, you will get one or other of several neurological defects. And of course, it's not just nerves or blood. There's a third major factor, and there are many others. But let me give you the third one. These materials are formulated it's normal to formulate drugs. These are formulated in fatty globules called lipid nanoparticles. What they do is disguise the foreign genetic information so your body doesn't see it initially until it gets inside your cells and it goes all around your body. It will glide through the cell wall as if it wasn't there. And that was the entire point of it. So that means these materials don't just go to your lymph nodes. And they certainly don't stay in your arm where they're injected. They go all around the body, including into your brain and your blood and every organ in your body. But here's the thing. Ten years ago, there were papers published, and it was well established and well known in the industry that lipid nanoparticles, lipid nanocarriers deposit their cargo, preferentially in the ovaries, and that was confirmed with the pfizer products in an animal experiment performed for the Japanese regulators. So, by design, these agents cause an autoimmune attack on every tissue. They make your body form a well understood biological toxin that can damage multiple organs in your body. And they deposited their cargoes, preferentially in the reproductive tissues of women and girls. So if you think that's by luck, then you're mistaken. There is no doubt in my mind, anyone of my caliber, and this is my peers that worked on this, absolutely understood what they were designing and manufacturing. So I think, having heard what I've just said, that there was no pandemic and the lie was maintained in order to inject people en masse, I think five and a half billion people with an intentionally dangerous substance, 17 million of whom have died so far. What do you think is happening and what do you think your role as an individual is in stopping this crime? On. Thank you for listening. -------------------------------------------- Please note that this will likely be "community noted" and Dr. Mike Yeadon may be branded as "Antivaxxer" because (as of 12 Dec 2023), the existing "official" COVID guidelines appear to still be significantly influenced by major pharmaceutical entities, and regulatory bodies continue to be potentially compromised.

aussie17

609,301 просмотров • 2 лет назад

BRAVO! to Dr. Mark Trozzi for being one of the few Health Freedom MDs with the guts to openly call the Covid jabs what they are: bioweapons. "This genetic bioweapon is really a biological bull in a china shop... we know 28 mechanisms by which it causes cancer alone... [and the jabs are] permanently genetically modifying and damaging the genetic code of [humanity]." This clip of Trozzi (Dr Mark Trozzi MD), a veteran E.R. physician with 25 years of experience, as well as a human rights activist, is taken from an interview with Dr. Joe Sansone (Dr. Joseph Sansone (JosephSansone.com)) posted to Rumble on December 11, 2025. ----------------Partial transcription of clip--------------- "This genetic bioweapon is really a biological bull in a china shop. I mean it does so many damage. And I mean, I've given lectures. We were together last January, I gave a lecture in Florida on the mechanisms of injury. And the reality is you can't keep up. I mean, we know 28 mechanisms by which it causes cancer alone. "But you know, and this is, I mean it was shocking from the moment we looked at the ingredients before anyone was injected. Shocking enough to like basically set down my entire life's work to try to stop it. That's not because I'm super courage. It's, that's how serious this is. But you genetically, they're genetically modifying people, claiming they're giving them a vaccine and then genetically modifying them so that they will produce a variety of poisons. Mostly the spike protein of the man-made design, SARS-CoV-2 virus, which is the most toxic part of it. "And normally, nobody's body would be producing it. And then they're producing this, this random splay of protein junk which can trigger autoimmune diseases in every direction. And so, but then what's worse is, you know, they claimed that what was in it was modified messenger RNA, modified both so that it would screw up and create all these random proteins as well as spike protein, but modified so that it would persist and nobody knew how long. "In other words, oh, so my body is going to start producing foreign proteins and identifying itself as a foreigner to be attacked by my own immune system. But for how long? Well, nobody knows because this is completely experimental, this new N1 methyl pseudouridinated version of messenger RNA. "But as you know, and as Dr. Speicher, Dr. McKernan and others have revealed through repeated analysis around the world, 30% of the genetic material in there is DNA and it includes plasmid DNA and it includes, in the case of Pfizer, completely covered up that it could even possibly be there. And the fraud they committed to the FDA and the public health agency, european agency, et cetera, that they put in these genetic sequences which were derived from the simian virus, not the virus, but some specific genetic sequences which we've known since 1990 research. "These are genetic hacking tools. When you put foreign DNA with something like a pegylated nanoparticle into a human cell or any mammal cell, and if you deliver as well these little SV40 promoter enhancer sequences... I mean, and this is pre-existing research, that will cause the DNA to be moved into the nucleus and cause it to be incorporated. "So you're permanently genetically modifying and damaging the genetic code of the humans. And we have evidence of this now, Joseph. Some of the most shocking evidence. And I think what you've pointed out is really important. This is not just an attack on the people health that are alive right now. This is attack on our possibility to produce viable offspring and have the continuation of the human race. "We now have tests on male sperm cells where the sperm cells contain in their DNA the genetic code of the spike protein. So men's sperm has been genetically modified so they will pass this toxic genetic flaw into their children if they're able to reproduce. Every sperm cell, we don't know, we don't know how many, but many. We have evidence that 30% of a woman's eggs die shortly following the injections as a result of these injections. Assault on the ovaries where they're particularly drawn to go and deposit the genetic code. "We have cancers that have now been taken out of people. And when you look at the DNA in the cells of the cancer, that DNA has been modified by these injections. So you're looking at permanent genetic modification of human beings without their consent based on a lie that they're getting a safe and effective vaccine for a disease claiming there's no treatment for which there was good treatments. And the whole thing from the virus through the bioweapon death shot were brought to you by the same people. And we're talking about people like Fauci, Gates, Tedros, Daszak, etc."

Sense Receptor

19,495 просмотров • 7 месяцев назад

Engineers discover a new class of materials that passively harvest water from air | University of Pennsylvania A serendipitous observation in a Chemical Engineering lab at Penn Engineering has led to a surprising discovery: a new class of nanostructured materials that can pull water from the air, collect it in pores and release it onto surfaces without the need for any external energy. The research, published in Science Advances, was conducted by an interdisciplinary team, including Daeyeon Lee, Russell Pearce and Elizabeth Crimian Heuer Professor in Chemical and Biomolecular Engineering (CBE), Amish Patel, Professor in CBE, Baekmin Kim, a postdoctoral scholar in Lee's lab and first author, and Stefan Guldin, Professor in Complex Soft Matter at the Technical University of Munich. Their work describes a material that could open the door to new ways to collect water from the air in arid regions and devices that cool electronics or buildings using the power of evaporation. "We weren't even trying to collect water," says Lee. "We were working on another project testing the combination of hydrophilic nanopores and hydrophobic polymers when Bharath Venkatesh, a former Ph.D. student in our lab, noticed water droplets appearing on a material we were testing. It didn't make sense. That's when we started asking questions." Those questions led to an in-depth study of a new type of amphiphilic nanoporous material: one that blends water-loving (hydrophilic) and water-repelling (hydrophobic) components in a unique nanoscale structure. The result is a material that both captures moisture from air and simultaneously pushes that moisture out as droplets. Water-Collecting Nanopores When water condenses on surfaces, it usually requires either a drop in temperature or very high humidity levels. Conventional water harvesting methods rely on these principles, often requiring energy input to chill surfaces or a dense fog to form to collect water passively from humid environments. But Lee and Patel's system works differently. Instead of cooling, their material relies on capillary condensation, a process where water vapor condenses inside tiny pores even at lower humidity. This is not new. What is new is that in their system, the water doesn't just stay trapped inside the pores, as it usually does in these types of materials. "In typical nanoporous materials, once the water enters the pores, it stays there," explains Patel. "But in our material, the water moves, first condensing inside the pores, then emerging onto the surface as droplets. That's never been seen before in a system like this, and at first we doubted our observations." A Material That Defies Physics Before they understood what was happening, the researchers first thought that water was simply condensing onto the surface of the material due to an artifact of their experimental setup, such as a temperature gradient in the lab. To rule that out, they increased the thickness of the material to see if the amount of water collected on the surface would change. "If what we were observing was due to surface condensation alone, the thickness of the material wouldn't change the amount of water present," explains Lee. But, the total amount of water collected increased as the film's thickness increased, proving that the water droplets forming on the surface came from inside the material. Even more surprising: the droplets didn't evaporate quickly, as thermodynamics would predict. "According to the curvature and size of the droplets, they should have been evaporating," says Patel. "But they were not; they remained stable for extended periods." With a material that could potentially defy the laws of physics on their hands, Lee and Patel sent their design off to a collaborator to see if their results were replicable. "We study porous films under a wide range of conditions, using subtle changes in light polarization to probe complex nanoscale phenomena," says Guldin. "But we've never seen anything like this. It's absolutely fascinating and will clearly spark new and exciting research." A Stabilized Cycle of Condensation and Release It turns out that they had created a material with just the right balance of water-attracting nanoparticles and water-repelling plastic -- polyethylene -- to create a nanoparticle film with this special property. "We accidentally hit the sweet spot," says Lee. "The droplets are connected to hidden reservoirs in the pores below. These reservoirs are continuously replenished from water vapor in the air, creating a feedback loop made possible by this perfect balance of water-loving and water-repelling materials." A Platform for Passive Water Harvesting and More Beyond the physics-defying behavior, the materials' simplicity is part of what makes them so promising. Made from common polymers and nanoparticles using scalable fabrication methods, these films could be integrated into passive water harvesting devices for arid regions, surfaces for cooling electronics or smart coatings that respond to ambient humidity. "We're still uncovering the mechanisms at play," says Patel. "But the potential is exciting. We're learning from biology -- how cells and proteins manage water in complex environments -- and applying that to design better materials." "This is exactly what Penn does best, bringing together expertise in chemical engineering, materials science, chemistry and biology to solve big problems," adds Lee. The next steps include studying how to optimize the balance of hydrophilic and hydrophobic components, scale the material for real-world use and investigating how to make the collected droplets roll off surfaces efficiently. Ultimately, the researchers hope this discovery will lead to technologies that offer clean water in dry climates or more sustainable cooling methods using only the water vapor already in the air. Read more:

Owen Gregorian

137,919 просмотров • 1 год назад

🎉🎉🎉 It's my BIRTHDAY! I'm an indie dev. I'm using today to be proud, which is often frowned upon. I made this hex grid w/ level editor in 3 weeks in UE, by myself. MY GOAL: Release new games every 2 weeks by end of year. This is my story, and why you should follow along: --- The video of what I made was made 4 MONTHS before the release of UE for Fortnite, while I worked at Epic a year and a half ago. I did it over our winter break. 80 hours of work across 3 weeks. I time tracked and worklogged the whole thing. This was before we had MoveTo(), SetMesh/Material(), Animation Controller was broken, you couldn't reference to other verse devices in editables. It was PAINFUL. Most of my time was spent duplicating and editing sequences. There were 631 hexes... and like 6 sequences per hex and 13 gameplay devices per hex. It was hacky, but it worked. 😅😅😅 NOTE... this was with a new programming language that NOBODY outside of Epic had really used using a HIGHLY buggy in-development tool. There were no tutorials, or stackoverflow, or communities to ask for help. Even my coworkers were on winter break, so couldn't ask them for help either. Everything I did was from my raw experience as a Software Architect. And I'll argue, that what I did was FAR more advanced and complicated from an engineering aspect than ANYTHING released by the UEFN community to this day. I am SOOO proud of that work and what it represents. 😁😁😁 --- My special interest is productivity in making things, and using that to enable others to make great things easier and faster. User Generated Content (UGC) platforms like Minecraft/Roblox/Fortnite/Halo, have been my passion for 17 years now since Halo 3 released. I've been a software engineer for 22 years... I turn 36 today, so since I was 14. 🎉🎉🎉 I'm autistic, so I literally live, eat, and breath UGC. Because I see it as a path to build what's in your dreams. The dreams of a kid who played a game that made a difference in their life of one day making their own games. I want to enable that for everyone who wants it. Because it took me FAR too long to get into the gaming industry. People see it as complicated and difficult and competitive. I want to lower those barriers as my legacy. 🤓🤓🤓 --- My new company, Creative Force, has a goal of "Building games at the speed of thought". I'm designing a general system to make games faster that could be used in any game engine. A design language that can be read by an engine that will "build your game for you". Basically allowing game designers to make "recipes" for games, and let other people use those recipes anywhere, and modify them easily to experiment and have a creative outlet. Maybe one day be a game chef and make a living doing what they dreamed, without needing crazy technical experience. 👩‍🍳👩‍🍳👩‍🍳 I believe this is possible with modern learnings from software that haven't been used in game development fully yet. A game architecture that will take the technical out of making games, and make it as approachable and as deep as writing a novel or painting a masterpiece. This is my dream... and I hope you'll follow along with me. Cuz my year #36, is quite literally a GAME CHANGING year. Love y'all 💖💖💖

RayBenefield

24,418 просмотров • 2 лет назад

Thermodynamic computing is here There is a new computing paradigm emerging from the noise, and its arrival may be as significant as the dawn of deep learning or the advent of cloud virtualization. A new company, Extropic, has just launched its first thermodynamic computer, a device they call a TSU, or Thermal Sampling Unit. While the web is already filling with deep technical dives, what’s more important for most of us is building a clear intuition for what this technology is, how it’s fundamentally different from anything that’s come before, and why it’s generating so much excitement. This isn’t just another chip; it’s a new way to think about computation itself. Seeing is Believing: Solving Puzzles in One Shot To understand what a TSU does, let’s look at two classic, notoriously difficult computer science problems: Sudoku and the Eight Queens problem. When you or I solve a Sudoku, we use a process of sequential logic, guess-and-check, and backtracking. We make an assumption, follow its logical conclusion, and if we hit a dead end, we erase and try again. A classical computer does the same, just much faster. A TSU, however, approaches this in a completely different way. Using a TSU simulator, one can “program” the problem by first clamping the known values—the clues already on the board. Then, you program in the constraints: no duplicate numbers in any row, column, or 3x3 square. With the problem thus defined, the TSU doesn’t “search” for a solution; it anneals one. In a single computational step, the solution simply emerges, backfilling all the empty squares correctly. The same principle applies to the Eight Queens problem, a challenge to place eight queens on a chessboard so that none can attack any other. This is a complex combinatorial problem with 92 distinct solutions. A classical computer would have to iteratively search for these. A TSU, by contrast, can be programmed with the constraints (the “anti-affinity” between queens on the same row, column, or diagonal) and then set to sample the “solution space.” In this context, a valid solution is one with a “problem energy” of zero. The TSU’s physical nature allows it to naturally find these zero-energy states. A simulation of this process shows the TSU discovering all 92 unique solutions, demonstrating its ability to not just find an answer, but to explore the entire landscape of all correct answers. This is a fundamentally new approach, one that bypasses the brute-force, iterative methods we’ve relied on for decades. The Physics of Computation: Using Noise, Not Fighting It This new power comes from a radical design philosophy. For the last 70 years, computing has been about one thing: order. We build chips that are deterministic, logical, and precise. The great enemy has always been noise, heat, and randomness. We spend billions on cooling and error correction to eliminate these very things. Quantum computing, in many ways, is the ultimate expression of this, requiring temperatures near absolute zero to eliminate all thermal noise and achieve quantum coherence. Thermodynamic computing is the polar opposite. It doesn’t fight the noise; it uses it. The TSU is built on the understanding that the natural, stochastic noise from “leaky” transistors—the very randomness we’ve tried to engineer out of existence—is itself a powerful computational resource. Think of it this way: a GPU, which is central to today’s AI, has to simulate noise. When a generative AI model creates a new image or sentence, it’s using complex algorithms to fake randomness. The TSU doesn’t need to fake it; it harnesses the actual physical randomness of thermodynamics. It is a piece of hardware that directly computes with probability. This makes it a hybrid, sitting somewhere between a purely analog computer (which might use light or sound waves to compute) and a digital GPU. It’s a physical device that leverages the laws of physics itself to find solutions, rather than just using logic gates to simulate them. From a Lost Hiker to a Million Bouncy Balls Perhaps the best way to build intuition is with a metaphor. Imagine that solving a complex optimization problem is like trying to find the lowest point of altitude in a 100-square-mile mountainous landscape. Classical computing, using an algorithm like gradient descent, is like being a single hiker dropped into this landscape at night. You have no map or satellite view. All you have is an altimeter and the sensation of the slope under your feet. You can only take one step at a time, always walking downhill, hoping you don’t get stuck in a small local valley when the true, lowest canyon is miles away. Thermodynamic computing is a completely different approach. It’s like having a million bouncy balls and a helicopter. You drop all million balls simultaneously across the entire 100-square-mile landscape. Then, you “turn on an earthquake,” shaking the entire system. The balls bounce and jostle, but as the shaking (the “annealing”) subsides, where do they all end up? They naturally settle into the lowest points. The balls that collect in the deepest valley represent the optimal solution. The TSU is, in essence, a physical device for dropping those million balls at once and letting the laws of thermodynamics find the lowest “energy” state for you, all at the same time. Beyond Puzzles: The Real-World Impact This is far more than just a clever way to solve brain teasers. This ability to instantly find the lowest energy state for a complex, constrained system has staggering real-world applications. One of the most immediate is protein folding. Companies like Google’s DeepMind have made incredible progress with AI like AlphaFold, which predicts protein structures. But this is still a predictive model trained on existing data. A TSU could potentially solve the folding problem directly, treating the protein as a system of atomic affinities and repulsions and finding its most stable, lowest-energy configuration almost instantaneously. This could revolutionize drug discovery and materials science. An even more profound possibility lies in nuclear fusion. One of the greatest engineering challenges in history is controlling the superheated plasma within a tokamak reactor. This requires shaping unimaginably complex magnetic containment fields in real-time to prevent the plasma from touching the reactor walls. This is a real-time optimization problem so complex it’s currently beyond our capabilities. A TSU, however, could be fast enough. Its ability to compute with electricity itself, rather than abstracting the problem through layers of software, might allow it to update the magnetic fields fast enough to stabilize the fusion reaction. One could even imagine a future where thermodynamic computing elements are built directly into the tokamak’s walls, allowing the reactor to physically and intelligently react to the plasma’s state in real time. A ‘GPT-2 Moment’ for a New Era It’s easy to become numb to hype, but what we are witnessing with the TSU feels different. This is what you might call a “GPT-2 moment.” For those who were there, GPT-2 was the first generative AI model that wasn’t just a toy; it was the first time you could play with it at home and see the spark of true generative intelligence. It was the precursor that pointed directly to the GPT-3 and ChatGPT revolution that has since changed the world. This TSU has that same feel. It’s the “SDK” for a new computing paradigm. This technology is as different from classical computing as quantum computing is, but with a critical difference: a team of 15 built this in two years, and it runs at room temperature on your desk. Quantum computing has seen decades of work and billions in funding, and it still hasn’t produced a commercially viable, scalable machine. The TSU is here now. Based on a two-decade-long career at the cutting edge of technology—from seeing the obvious future of virtualization in 2007 to an early conviction in deep learning and GPT—this has all the same hallmarks of a fundamental, world-changing shift. We are not just building faster calculators; we are learning to compute with the universe itself. Pay close attention to this. This is the next big thing.

David Shapiro (L/0)

83,649 просмотров • 9 месяцев назад

🚨🚨🚨🚨 Dr Mike Yeadon's Austrian Testimony Please watch and share - 15 Mins --------------------------------------- My name is Dr. Mike Yeadon and in the next 10 to 15 minutes I'm going to focus on one major point which is that the purported "vaccines" against this alleged illness, COVID-19 were in my view deliberately designed intentionally to injure, kill and, and reduce fertility. Now this is an allegation I've been making for around three and a half years. In that time, if I was wrong, ladies and gentlemen, I think numerous scientists would have rebutted what I've said in writing and in video. And if I was wrong, I would have expected the drug companies whose products I am maligning to have sought and secured a court injunction to stop me repeating these allegations. Neither of those things have ever happened. What has happened instead is that I have been extraordinarily censored and smeared sideways. And I think I offer that to you as strong evidence that I may be "over the target", at least in relation to these injectable products that have definitely injured and killed many people. So first just brief few words of introduction in terms of credentials. So Mike Yeadon, I've been a professional research scientist for over 30 years in the pharmaceutical industry and in biotech. My first degree was in biochemistry and toxicology. It was a joint honours degree. I got a first, then I did a second degree, a PhD. It's a research based piece of work lasting three years and my focus was respiratory pharmacology, the study of impact of drugs on respiration and so on. And that led into my career where I became a senior research scientist responsible for new drugs to treat allergic, respiratory and later dermatology diseases. I was at one point Vice President and the most senior research person within Pfizer Global R&D, and I left in 2011. And for 10 years after that, seven of those I was founder and CEO of a biotech called ZIARCO which was acquired by Novartis in 2017, since when I've been a consultant although I've discontinued those activities in the last four and a half years or so. So I've not earned a penny from speaking out in the last four and a half years and I don't want to either. There is a longer video by me recorded a month or so ago, 22 minutes long and it's called Silver Bullet and it's on my telegram channel and I hope rather more widely. But today I'm just going to focus on the design and effects of these so called vaccines. So I've been involved all of my professional life with other talented people trying to design and test potential new treatments for respiratory disease and as I say later on dermatology applications. So I can tell you that this, with my background in toxicology and my own research experience, 30 years in the industry, this qualifies me, I think better than any other commentator to evaluate what was in the minds of the people who designed these products. Let me tell you that every component in a medicine is chosen. It's chosen to be there. It's not random. It's chosen to be there to achieve some purpose, that's normal, perhaps to help a drug dissolve, to be absorbed, to persist in your blood, or to leave your body quickly to penetrate the brain if it was a neurological drug, or to stay close to the lung if it was an inhaled drug. So it's quite normal to make choices with objectives in mind. So I believe the intentions of the designers are written into the choices they made, the structures and components, formulation of these products. So I'm going to use those skills, as it were, to back calculate what was in their mind, what objectives did they have when they chose these structures and formulations. So I'm going to just say, before I get into that, just one thing about these so called "vaccines". My experience of the industry over 30 years tells me it is formally impossible to invent, research, test, evaluate, manufacture, gain authorization for, and launch a complex new biological product in under a year. It's formally impossible. I don't care how much money and people you put on it, there are a series of linear steps which when taken together, unless you miss some out, cannot be completed under several years. So if someone told you they had brought a brand new airline to market with new engines in under a year, I think you would know it's formally impossible to do a clean sheet design, to stress test, to manufacture, to test, to flight test, optimise the engines and get regulatory clearance and be ready to take you across the Atlantic in under a year. And of course it's never been done and it's never been done with complex biological products in under a year. So whatever else they did, they didn't do what they said because it cannot be done in under a year. Secondly, and I'll come to the examples in a moment, there are in these products numerous features which in my view, my peers, people like me, people with my training and experience would know for sure would give rise to the toxicities that I pointed out in 2020. They're not, they don't require particular skills you need to know how to do drug discovery and what can go wrong. But I'm not acting like a complete genius in spotting these, just someone who is a professional from this industry that has pointed out numerous features built in by choice that I believe I think they obviously confer toxicology, toxicity to the recipients. And as I've said, people designing these, people like me in wherever they were, pharmaceutical industries or the military, knew these things were going to happen. And that's why I say it's intentional. I'm going to give you three examples that you can go and test. So the first one is these are so called gene based products, that is they've got a string of genetic information in them. Now there aren't any products like that that are in routine use anywhere in the world. So they're brand new technology. But what you'll remember they told you that they do is they cause your body to make as a protein whatever was in that genetic code. Now it's absolutely basic immunology. How is it, do you think your body knows that what's inside of you is meant to be there and you don't attack it? And yet if something gets into your body from the outside or a tumour form, something that shouldn't be in you, your body can recognise that that's foreign or non-self and can attack it. And the answer is you tolerate everything that's meant to be inside your body. When you're in your mum's womb, we, we ruled out the ability to attack ourselves. Unless you get an autoimmune disease in later life, you play nice with yourself until something gets inside you or something goes wrong inside you. So ladies and gentlemen, if you are injected with a genetic sequence that causes you to manufacture a foreign protein, whether it's a virus or something out of a computer, it's not you and it's not meant to be in you, I assure you, your body recognises that it's been invaded, something's in there that shouldn't be and it launch a fatal attack on every cell that it thinks has gone wrong. It's trying to save you. So and that autoimmune reaction that destruction which your body is trying to, is doing because it's trying to protect you, that will happen anywhere in your body, any cell, tissue, organ in your body where unluckily your dose of what was injected into you lands. So if it lands in your heart, you could get myocarditis or a heart attack. If it lands in your brain, you could get a stroke or neurological conditions. If it's in your eyes, you could go blind. If it's in your ovaries, it may sterilise you. But that explains, in my view, a lot of the enormously diverse toxicity that's been seen with these products. So that's one, your body is being made to manufacture something that does not belong in it. And when that happens, everybody with the first lecture of immunology will understand why that happens. It's not an accident, it's in the design. It's a deliberate choice. The second one, then what was encoded in the so called "vaccines", now we're told it's spike protein. I don't think there is a natural spike protein, but proteins with sequences like that are known to be acutely toxic to blood cells, prompting blood clots to nerve cells, causing them to malfunction and probably other things I don't know anything about. So that's the second thing your body was making, was forced to make not only a foreign protein, something that didn't belong in your body, you were, your body was forced to make something that was directly toxic to your body. And the person who chose that sequence knew that's what the property of it was. It's not an accident, it's intentional. Then the third one is absolutely shocking. It's normal for drugs to be formulated that is to be wrapped in something. You'll see them in capsules or tablets. They might have a coating. If it's an inhaler, there might be some liquid with it so it can be propelled. In the case of these injectables, they were wrapped in really fatty globules called lipid nanoparticles, which means tiny little particles of fat. Lipid nanoparticles. Ladies and gentlemen, there were papers published as early as 2012, which I read a couple of years ago, that said that it is well understood in the industry by formulators that the payload that's contained within lipid nanoparticles when injected into animals and people leads to a disproportionate deposition of the payload into your ovaries. I remember the day I read that paper, I really couldn't sleep. The person who chose to use lipid nanoparticles to formulate the Moderna and Pfizer products knew perfectly well that what they would do is allow them to drift all through your body, through membranes as if they weren't there, and disproportionately deposit in your ovaries. And given I've told you the first two things, which is that will induce your body to attack every cell in the body that follows the instructions. And that instruction by the way, is to make a poison, you should no longer be surprised that people have been injured and killed and had their fertility reduced. I wish I didn't have to communicate this information. But there is no possibility that the people involved in designing these products did not know that they would have the effects that I predicted and that so many people have actually experienced it is intentional. There is ample evidence that this assault, which is not the only thing that's ever happened, unfortunately it's the first I noticed. I was a so called normie until 2020. I believe everything I was told. But this is part of a long planned assault by powerful wealthy people operating above the level of nation. So I'm afraid organisations like the United Nations, the World Health Organisation, the Bank for International Settlements, the World Economic Forum are populated by the people who I believe have orchestrated this attack on humanity and they're going to do it again. There are factories all around the world busy manufacturing these so called "vaccines" and formulating them in the way I just described. And they're going to come up with contrived reasons why you need to roll your sleeve up and I'm telling you, for the love of God, please don't do it. The only way we will push these people away is by speaking out as we see it and simply refusing to follow absurd instructions no matter what ostensible reason they come up with for you to do that.. So I mentioned I have been subject to astonishing censorship and smearing. And that's true. I've always said, if you hear me, please repeat what I have said to other people. I've got a tiny reach because I'm censored and no one else is coming to save us. It's just a small number of us who are not willing to stay quiet while this is done to us. But it's part of a wider deception. The pandemic lie is a major one. I don't have time to go into it now, but see my other recording. But there wasn't a pandemic. There's never been a pandemic. They can't happen. It's a lie. The so called human induced climate change crisis, that's all a lie as well. It's the same people who put this together at the end of the 1960s, the Club of Rome, they chose these two topics of infectious disease and climate change to scare people because they realised it would force a response from above the level of nation. But I'm saying, stand on your own feet and tell them to get lost with their absurd lies. And there's a third lie which underlies these, and it's they believe. They tell us we've been told all our lives, that the world is overpopulated. And it's literally absurd if you're up in an aeroplane within a few minutes, even over a busy city, the place is just full of cities and forests and fields. So that's yet another lie. But I think that's what's driving them. They think there's too many of us little people, and they seek to control us digitally and then eventually inject us to death. Its only going to be stopped then by refusal to cooperate. And that's my testimony. I hope that was helpful to.

aussie17

78,814 просмотров • 1 год назад

🚨🚨Dr Mike Yeadon's Address to Northern Ireland Parliament ----------------------------------- Hello, my name is Dr. Mike Yeadon, and in the next 15 minutes or so, I would like to address those of you who've been vaccine injured or bereaved, and also those of you who are involved in the political process in Northern Ireland, as well as anywhere else in the world who might hear me. At the end of this process, I hope you will believe what I'm going to tell you, which, shockingly, is that the materials masquerading as vaccines were designed intentionally to harm the people who received them. I'm probably the most qualified former pharmaceutical company research executive in the world speaking out on this matter, and since I spent my entire career in the business of working with teams designing molecules to be new potential medicines, I think I am qualified to comment on it, and that is my shocking judgement that has been only reinforced over the last almost four years since I first said it. I'll also have some suggestions for what we can do together to fight against the global crime which is ongoing. So, just a little bit about me so you can decide whether or not to believe me. So, I'm a career-long research scientist. I've worked all of my life in the pharmaceutical industry and in biotech. My first degree included a training in toxicology, so that's an understanding of how materials can injure human beings at a molecular level, and what the relationship is between the structure of them and the toxicity. In my second degree, a PhD, I did research in respiratory pharmacology, control of breathing and control of respiratory reflexes. So, and then after that, I joined the pharmaceutical industry in 1988, and I worked until very recently on new medicines for allergic and respiratory diseases. In my corporate career, I was for a long time responsible at Pfizer, then the biggest research-based drug company in the world, for everything to do with allergic and respiratory diseases in the research field. So, that was my responsibility. And in the last 10 years, after leaving in 2011, I was an independent and I became the founder and CEO of a biotech company, which was eventually acquired by Novartis, which was then the biggest drug company in the world. So, I have had a good career, and I was well regarded in the industry for my scientific acumen and judgments, until, of course, I started speaking out against the nonsense, the COVID pandemic, and especially the so-called vaccines. I've become persona non grata. It was my former colleagues after that. So, I'm well qualified to comment on the toxicological principles, properties of molecules, and the kind of effects you might see from certain structures. So, just very briefly, before I talk about the so-called vaccines, what happened in 2020? It's taken me a long time to get there, and I haven't made everybody happy with the decision I've reached, but there was not a pandemic or a public health emergency. I don't think there was anything at all, apart from lies, propaganda, fear-based information, fake diagnostic tests called PCR, and then, as it were, misattribution of real illnesses that people did have, which were called COVID when there was no such thing. But what happened, shockingly, was that after the World Health Organisation's chairman called a pandemic, which was not true. There's never been a pandemic. There won't be pandemics. They're immunologically impossible. But after he called them, many countries in the world changed radically their medical management practises for people in hospitals, also in care homes, and in the community. And very briefly, in hospitals, many people were sedated, had a plastic tube put down their airway, and unconscious, put on mechanical ventilators. I can assure you that is not ever an appropriate treatment for someone with an influenza-like illness, whatever you might think COVID was. But that would not be something you would do, and if applied to frail and elderly people, they will die in large numbers, which they did. So that was the first crime. It's not a mistake. There are no mistakes here. Mistakes were not made. They were told to do this by figures at supranational level. We don't know exactly who, but we know this because these mad procedures changed in many countries all at the same time. So that's hospitals, in care homes, assisted living, old-age people's homes, and so on. Many people were given drugs like Midazolam, which is an injectable form of a drug like Valium, a sedative. But they were also given injections of pain-relieving drugs like morphine, even if they weren't in pain. My PhD was in the field of understanding what opiate drugs like morphine do to the respiratory reflux, and I can assure you it suppresses and suppresses it and depresses it. So if you give an elderly person on their own an injection of Midazolam, they will become sedated and sleepy, and if you give them an injection of morphine, their breathing will slow. I can tell you, it's absolutely forbidden to give a person those two drugs together, those two drug classes together, unless they are under intense ongoing medical monitoring. And the reason is they're likely to fall asleep and stop breathing. That, of course, is what happened. So that's hospitals and care homes. Your relatives were killed by the medical procedures that were imposed. Now, it's quite possible early on that not everybody involved knew what was happening, but I'm afraid after a few days, you'd have to be a blockhead not to realise that it was what you were doing to your charges, your patients, that was resulting in their deaths. So I've completely lost any trust in the medical profession because virtually no one has spoken up four and a half years later. This happens to lots of people. If you listen to the recordings, heartbreaking recordings given to the Scottish COVID Enquiry, I think that's probably the only place where there's been an official taking of evidence from people. And what I just described is exactly what happens to lots of people's relatives and no doubt happens to some people in Northern Ireland as well. It certainly happens in England. There were worse things as well. People in the community were deprived of medical care that would have saved their lives. And there's plenty of evidence to say that not being given antibiotics when they had incipient bronchial pneumonia also killed thousands, possibly tens of thousands of people. And there, ladies and gentlemen, was your pandemic. All of those deaths were attributed to COVID and you were told this is this terrible pandemic, you need to lock down, wear masks, do what you're told. Nothing was happening at all apart from medical murder and propaganda from the television and the newspaper, politicians and many public, well-known public figures who are doing what they were told. So of course one conclusion I'm going to come to later is stop listening to liars. The people who've lied to you shouldn't listen to them ever again. Stop listening to them today. But for me, I think the worst thing, because it comes out of my industry and because it's so deliberate, it requires such a lot of forethought, are the so-called vaccines. Now we were told there was this new infectious disease, so far so good ladies and gentlemen, but then they said don't worry we'll rustle up a vaccine and they did so at least in about 10 months, something like that. I can tell you after spending a career in this industry, you can no more make a baby in one month with nine women than you can make a complicated biological product in 10 months. It cannot be done. It was not done. They did something else. They created materials which were essentially injected poisons. They were not vaccines. There was never anything to vaccinate against. And when you've listened to what I've just told you, you know that must be true because you can't do something in 10 months that normally takes 6 to 12 years. Medicines are not put together randomly. They are built. And they're built by people who are discussing with colleagues, work out what kind of materials, what kind of structures, what kind of formulations, what kind of doses you would need to add in order to hit a particular molecular target to have a chance of a particular therapeutic goal being reached without unacceptable side effects. That's called rational design. And that is my whole career, ladies and gentlemen, from my undergraduate days to today. So when I look at the design of the medicine, whatever kind it is, and look at the design on paper and its composition structures and so on, it is as if I'm looking over the shoulder of the designer, someone like me, someone with my qualifications designed these things. So when I look at them, I'm looking over the shoulder of the designer and I can discern something of what their objectives were, what were they trying to do? And I came quickly to the conclusion that they wanted to bring about toxicity that would injure, kill and reduce fertility. There aren't any other alternatives. And remember, there was no public health emergency. So I'll just give you three examples. I'm not going to be too scientific, but three things so you can check them. The objective of these so-called gene-based vaccines was to inject you with a genetic sequence for something called spike protein. Now, it doesn't really matter what spike protein is, if it's real, where it came from. The point is, it's a genetic sequence for a protein that doesn't belong in your body. It's non-self, it's foreign. Your immune system is a wonderful work of God and nature. It distinguishes self, things that are meant to be inside you and are fine from anything else, foreign, non-self. If you inject a person with a genetic sequence that instructs your body to become a factory for some protein that doesn't belong in you, your immune system will detect that and it will attack every cell that's done that instruction and kill it. Now, these materials, when injected in your arm, didn't stay in your arm, they travelled around your heart, your lungs, your kidneys, your brain, your ovaries. And in every place it landed, if it was taken up and expressed, your body registered that as foreign invasion and it attacks and kills every cell doing it. There is no other possible consequence from doing that. So that's step one and no one can argue that's not what they did. That is the design of them. It also picks a particular protein. I'm not really sure where spike protein came from, if it's really real, but proteins like the one they claim was encoded in these gene-based materials are known to be toxic. There are loads of experiments, lots of published experiments, showing that proteins like that one cause blood coagulation, damaged nerves, damaged heart tissue. So they injected you with something that would make your body make a protein that doesn't belong there, knowing axiomatically, automatically, unavoidably, your immune system would attack that. It would be like rejecting an organ transplant. Your body would say, that's foreign, got to go, uses your immune system to kill it. And then they also inject you with something that's inherently toxic. So if it got out into your body or wherever it was made, it would harm you. And I've got a third one that cannot be argued with. At least the mRNA products from Pfizer and Moderna were encapsulated in something called lipid nanoparticles. It's really a blob of fat, complicated, technical blob of fat, that's what it is after all. And what that material did is allowed your injection to glide all around your body across all biological barriers and get everywhere in your body. So of course, it's not what you would want, is it? For something that they told you was inhaled into your nose and lungs. But no, it went all around your body, into your brain, blood vessels. But in particular, I need to tell you, there were publications that are now more than 10 years old in peer-reviewed journal articles. I'm sceptical about whether they're always very honest, but there were peer-reviewed journal articles showing that lipid nanoparticles were recognised over a decade ago of having a particular property, which you're not going to like to hear, which shocked me when I learned it. They tend to deposit their payload into the ovaries. That is exactly what happened with these injected materials. There was at least one study performed with the Pfizer agents, with the Japanese regulatory authorities. Lo and behold, the material accumulated in the ovaries of the test animals. That is what's happened, ladies and gentlemen, every woman and girl injected with these materials. Remember what I said about designing molecules to do things deliberately with objectives in mind? They picked lipid nanoparticles, knowing they accumulate the payload in ovaries. It's not an accident. Mistakes were not made. So I tell you, as a professional who spent his whole honest scientific career in an industry I did not realise was corrupt, trying to make experimental medicines for respiratory and allergy diseases, that my experience tells me that there are multiple independent, unnecessary and obvious mechanisms of toxicity built into these so-called vaccines. And then by sheer luck, all four companies, Moderna, Johnson & Johnson, AstraZeneca and Pfizer, all chose basically the same formula for their so-called vaccines. That would never happen if it was real. For a start, I would call my opposite numbers and say, we should do different things because if something goes wrong, if we're wrong in an assumption, all of the so-called vaccines will fail for the same reason. We should do different things. It's called diversification. But no, they all did the same things because they're just lying. They were making intentionally dangerous material, passing them off as vaccines to having you and your children. And that's what they did. Of course, I didn't get injected and neither did my children and most of my relatives. Some of them didn't believe me. I'm afraid they've been injected too. So big picture, what happens, I think from the research I've done, and of course, I'm an expert in research and development, not in politics, but I believe that very wealthy people, the kind of people who run foundations with names, have planned, as have their antecedents for a couple of generations, to take over the world, to remove the freedoms of ordinary people like us that they regard as useless eaters. They don't want us around anymore. And their intention is to strip us of our freedoms by persuading us that there are very frightening events occurring in the world, and we need them to lead us to safety. There are documents you can find from a group called the Club of Rome, who in the late 1960s were commissioned by some of these people who run the nameless global foundations that have hundreds of billions of pounds of worth. They were asked to come up with scenarios that would produce challenges for countries that couldn't be solved by countries on their own, so they would have to look outwards and upwards to supranational solutions. Now guess what? The two things they came up with, pandemics of infectious diseases, which I know as an immunologist are not possible and have never happened. The other thing they said to account for or plan for were climate change crises. I've done enough research now, ladies and gentlemen, I've spoken to people who have spent as long in climate atmospheric research as I have in pharmaceutical R&D, and they have explained to me, and I understand very well, that there's all of this nonsense about carbon dioxide, global boiling, net zero. It's all a complete scam from the same people who bought you the Covid scam and the dangerous injections. It's the same people. They want one world government, they want to be deprived of your liberty, and then I'm afraid I think they will kill us using these injections because they're going to do it again. All over the world, factories to make mRNA-based materials are being thrown up, billions of doses are being made, and if we let them they will sicken in our arms and people will sicken and die. So those of you who have been injured or bereaved, in my mind no blame whatsoever attaches to you. How could you know that people you trusted and thought you could trust were lying to you? Well, you didn't know, but if you let them inject you again, you have no sympathy for me because they have lied to you, you've been injured or killed, and I've explained to you that they're liars and they have attacked us. So if you go along with it, you cannot be saved. All we need to do is enough of us continue to speak out about this and say we're not having it anymore, get lost, don't listen to liars anymore. People who've lied to you forfeit their trust forever, in my view, and so anyone who's in the political process, for example in Northern Ireland looking at this so-called public health bill, which if you pass it would allow these supranational criminals to take you from your house, to inject you by force if necessary, they are aiding and abetting a global crime. And I saw someone online say recently that if you pass that legislation, I don't think it'd be unreasonable to interpret that as an act of war. It's as serious as that. So politicians, you may well be under pressure from shadowy figures, but if you go along with it and hope for like an easier time of it, you will have unlocked the doors of hell and pushed everybody in it and you as long with it as well. So this is your time to do what I'm doing, which is to speak out no matter the consequences. I say to you if you're frightened about what happens, if you speak out, you should be absolutely terrified about what's going to happen if you don't. So really that's all I've got to say. I do think these criminals are going to do it again, they're continuing to threaten us with pandemics like bird flu, monkey pox and so on. It is all nonsense. Stop listening to liars right now. Put things right between you, the people you love, and between you and God if you haven't already. And for goodness sake, be one of the people who speaks out no matter what the consequences, because if you don't, we'll lose our freedom and then our lives. Thank you.

aussie17

36,247 просмотров • 1 год назад